{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:22:08Z","timestamp":1791332528134,"version":"4.3.1"},"reference-count":39,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2012,9,6]],"date-time":"2012-09-06T00:00:00Z","timestamp":1346889600000},"content-version":"vor","delay-in-days":1924,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Obesity"],"published-print":{"date-parts":[[2007,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Objective:<\/jats:italic> The objective of this study was to assess long\u2010term metabolic consequences of total body irradiation (TBI) and bone marrow transplantation. Severe obesity develops due to both hypertrophy and hyperplasia of adipocytes. We hypothesized that TBI would arrest adipose tissue growth and would affect insulin resistance (IR).<\/jats:p><jats:p><jats:italic>Research Methods and Procedures:<\/jats:italic> We exposed 2\u2010month\u2010old female <jats:italic>ob\/ob<\/jats:italic> mice to 8 Grays of TBI followed by bone marrow transplantation and tested the animals for body weight (BW) gain, body composition, blood glucose, and insulin sensitivity.<\/jats:p><jats:p><jats:italic>Results:<\/jats:italic> Two months after TBI, irradiated mice stopped gaining BW, whereas non\u2010treated mice continued to grow. At the age of 9.5 months, body mass of irradiated mice was 60.6 \u00b1 1.4 grams, which was only 61% of that in non\u2010treated <jats:italic>ob\/ob<\/jats:italic> controls (99.4 \u00b1 1.6 grams). Body composition measurements by DXA showed that decreased BW was primarily due to an impaired fat accumulation. This could not result from the production of leptin by bone marrow\u2010derived adipocyte progenitors because inhibition of the obese phenotype was identical in recipients of both B6 and <jats:italic>ob\/ob<\/jats:italic> bone marrow. Inability of the irradiated mice to accumulate fat was associated with hepatomegaly, lower levels of monocyte chemoattractant protein\u20101 expression in adipose tissue, and increased IR.<\/jats:p><jats:p><jats:italic>Discussion:<\/jats:italic> Our data argue in favor of the hypothesis that inability of adipose tissue to expand may increase IR. This mouse model may be valuable for studies of late\u2010onset radiation\u2010induced IR in humans.<\/jats:p>","DOI":"10.1038\/oby.2007.170","type":"journal-article","created":{"date-parts":[[2008,7,17]],"date-time":"2008-07-17T17:03:11Z","timestamp":1216314191000},"page":"1419-1429","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Reduced Adiposity in <i>ob\/ob<\/i> Mice following Total Body Irradiation and Bone Marrow Transplantation"],"prefix":"10.1002","volume":"15","author":[{"given":"Vitaly","family":"Ablamunits","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stuart P.","family":"Weisberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob E.","family":"Lemieux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Terry P.","family":"Combs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Klebanov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,9,6]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.21.4.518"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-113-12-909"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0026-0495(77)90128-7"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2004-0683"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/212289a0"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/0026-0495(69)90016-X"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.83.2.503"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.7.7b.1318"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI7901"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.12.20.3168"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1034802"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/83685"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/79111"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI15924"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI1235"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI119870"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.23.8.1067"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)41516-5"},{"key":"e_1_2_7_20_2","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1093\/oxfordjournals.jhered.a106073","article-title":"Obese, a new mutation in the house mouse","volume":"41","author":"Ingalis A. 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