{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T09:24:14Z","timestamp":1767864254433,"version":"3.49.0"},"reference-count":23,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2012,9,6]],"date-time":"2012-09-06T00:00:00Z","timestamp":1346889600000},"content-version":"vor","delay-in-days":1924,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Obesity"],"published-print":{"date-parts":[[2007,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Objective:<\/jats:italic> Our objective was to assess the efficacy and safety of sibutramine with a low\u2010calorie diet (LCD) and commercial meal\u2010replacement product in achieving weight loss and weight\u2010loss maintenance in obese patients.<\/jats:p><jats:p><jats:italic>Research Methods and Procedures:<\/jats:italic> Eight U.S. centers recruited 148 obese patients for a 3\u2010month comprehensive weight\u2010loss therapy (Phase I) comprising daily sibutramine 10 mg + LCD (two Slim\u2010Fast meal\u2010replacement shakes, one low\u2010calorie meal; total kcal\/d = 1200\u20131500). Patients (<jats:italic>N<\/jats:italic> = 113) who lost \u22655% of initial body weight during Phase I were randomized for a 9\u2010month period (Phase II) to daily sibutramine 15 mg + LCD (one meal\u2010replacement shake; two low\u2010calorie meals: total kcal\/d \u223c1200\u20131500) or daily placebo + three low\u2010calorie meals (total kcal\/d \u223c1200\u20131500). Both phases included behavior modification. Efficacy was assessed by body weight change during each phase and by the number of patients at endpoint maintaining \u226580% of the weight they had lost by the end of Phase I. Other outcomes included changes in cardiovascular and metabolic risk factors, adverse events, and vital signs.<\/jats:p><jats:p><jats:italic>Results:<\/jats:italic> Mean body weight change during Phase I was \u22128.3 kg (<jats:italic>p<\/jats:italic> &lt; 0.001). Patients randomized to sibutramine in Phase II had an additional \u22122.5 kg mean weight loss vs. a 2.8\u2010kg increase in the placebo group (<jats:italic>p<\/jats:italic> &lt; 0.001). More sibutramine patients maintained \u226580% of their Phase I weight loss at the end of Phase II (85.5% vs. placebo 36.7%, <jats:italic>p<\/jats:italic> &lt; 0.001). Most adverse events were mild or moderate in severity, and all serious adverse events were unrelated to sibutramine.<\/jats:p><jats:p><jats:italic>Discussion:<\/jats:italic> Sibutramine plus LCD with meal replacements and behavior modification is a safe and effective strategy for achieving and sustaining weight loss in obese patients.<\/jats:p>","DOI":"10.1038\/oby.2007.175","type":"journal-article","created":{"date-parts":[[2008,7,17]],"date-time":"2008-07-17T17:03:11Z","timestamp":1216314191000},"page":"1464-1472","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Sibutramine Plus Meal Replacement Therapy for Body Weight Loss and Maintenance in Obese Patients"],"prefix":"10.1002","volume":"15","author":[{"given":"James L.","family":"Early","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caroline M.","family":"Apovian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Louis J.","family":"Aronne","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Madelyn H.","family":"Fernstrom","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arthur","family":"Frank","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank L.","family":"Greenway","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Heber","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert F.","family":"Kushner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristine M.","family":"Cwik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julia K.","family":"Walch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ann C.","family":"Hewkin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vicky","family":"Blakesley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,9,6]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200105033441801"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa012512"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.20.4.537"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1993.00410070039006"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-134-1-200101020-00007"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.3310\/hta8210"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199108153250703"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-789X.2004.00127.x"},{"key":"e_1_2_7_10_2","first-page":"39","article-title":"Treatment of obesity by very low calorie diet, behavior therapy, and their combination: a five\u2010year perspective","volume":"13","author":"Wadden T. 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