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Food intake and feeding patterns were monitored using a novel automated feeding system that allowed continuous recording of food intake.<\/jats:p><jats:p><jats:italic>Results:<\/jats:italic> Food intake was strongly suppressed. A steady\u2010state level of reduced food intake was achieved within 3 weeks and was maintained for the remaining 4 weeks of the treatment period. During the 4\u2010week steady\u2010state period with liraglutide treatment, daily food intake was 7.3 \u00b1 0.3 megajoule (MJ) compared with 18.4 \u00b1 0.6 MJ in the pre\u2010treatment period and 19.2 \u00b1 0.5 MJ in the post\u2010treatment period (<jats:italic>p<\/jats:italic> &lt; 0.001). The food intake in the treatment period was equivalent to the amount of food that would have been offered to normal\u2010weight pigs for maintenance. Body weight decreased 4.3 \u00b1 1.2 kg (4% to 5%) during the 7 weeks of treatment and increased 7.0 \u00b1 1.0 kg during the 7 weeks of post\u2010treatment (<jats:italic>p<\/jats:italic> &lt; 0.01). Appetite suppression was quickly reversed within 4 days after termination of liraglutide administration.<\/jats:p><jats:p><jats:italic>Discussion:<\/jats:italic> Overall, liraglutide was well tolerated and had a profound and persistent anorectic effect that resulted in weight loss. These results, in conjunction with the previously established glucose\u2010lowering efficacy of liraglutide, suggest that the anorectic actions of liraglutide will be very important in clinical trials of both obese patients with type 2 diabetes and obese non\u2010diabetic patients.<\/jats:p>","DOI":"10.1038\/oby.2007.204","type":"journal-article","created":{"date-parts":[[2008,7,17]],"date-time":"2008-07-17T17:18:51Z","timestamp":1216315131000},"page":"1710-1716","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":81,"title":["Liraglutide, a Once\u2010daily Human Glucagon\u2010like Peptide\u20101 Analog, Minimizes Food Intake in Severely Obese Minipigs"],"prefix":"10.1002","volume":"15","author":[{"given":"Kirsten","family":"Raun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pia","family":"von Voss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lotte Bjerre","family":"Knudsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,9,6]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00401145"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)07952-7"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.regpep.2004.07.014"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1021\/jm030630m"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)03491-7"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.27.1.155"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.295.7.761"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/379069a0"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1210\/en.2003-0007"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI990"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.86.9.4382"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1079\/BJN20031064"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.sla.0000183349.16877.84"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.5227"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.2337\/diab.44.9.1126"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-001-0719-z"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.53.5.1187"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1021\/jm9909645"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2006-924230"},{"key":"e_1_2_7_21_2","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.50.11.2530"},{"key":"e_1_2_7_22_2","doi-asserted-by":"publisher","DOI":"10.1258\/0023677052886565"},{"key":"e_1_2_7_23_2","first-page":"150","article-title":"The obese Goettingen minipig as a model of the metabolic syndrome: dietary effects on obesity, insulin sensitivity, and growth hormone profile","volume":"51","author":"Johansen T.","year":"2001","journal-title":"Comp Med"},{"key":"e_1_2_7_24_2","first-page":"35","article-title":"Components of metabolic syndrome and coronary artery disease in female Ossabaw swine fed excess atherogenic diet","volume":"56","author":"Dyson M. 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