{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T04:51:09Z","timestamp":1773204669178,"version":"3.50.1"},"reference-count":27,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2012,9,6]],"date-time":"2012-09-06T00:00:00Z","timestamp":1346889600000},"content-version":"vor","delay-in-days":1863,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Obesity"],"published-print":{"date-parts":[[2007,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Objective:<\/jats:italic> There are limited data concerning the relationships between amylin, weight status, lipids, insulin, and insulin resistance in obese humans. Therefore, the aim was to study these relationships in cross\u2010sectional and longitudinal analyses.<\/jats:p><jats:p><jats:italic>Research Methods and Procedures:<\/jats:italic> Fasting amylin, insulin, glucose, triglycerides, low\u2010density lipoprotein (LDL)\u2010 and high\u2010density lipoprotein (HDL)\u2010cholesterol, and percentage body fat based on skinfold measurements were determined in 37 obese children (median age, 11.5 years) and compared with 16 lean children of the same age and gender. Furthermore, we analyzed the changes of these variables in the obese children after participating in a one\u2010year weight loss intervention program.<\/jats:p><jats:p><jats:italic>Results:<\/jats:italic> Obese children had significantly (<jats:italic>p<\/jats:italic> &lt; 0.01) higher amylin, triglycerides, LDL\u2010cholesterol, and insulin levels as compared with the lean children. In multiple linear regression analysis, amylin was significantly (<jats:italic>p<\/jats:italic> &lt; 0.05) correlated to insulin and triglycerides, but not to age, gender, pubertal stage, or BMI. Changes of amylin correlated significantly (<jats:italic>p<\/jats:italic> &lt; 0.001) to changes of insulin (<jats:italic>r<\/jats:italic> = 0.54) and triglycerides (<jats:italic>r<\/jats:italic> = 0.49), but not to changes of BMI or percentage body fat. Substantial weight loss in 17 children led to a significant (<jats:italic>p<\/jats:italic> &lt; 0.05) decrease of amylin, triglycerides, and insulin, in contrast to the 20 children without substantial weight loss.<\/jats:p><jats:p><jats:italic>Conclusion:<\/jats:italic> Amylin levels were related to insulin concentrations in both cross\u2010sectional and longitudinal analyses, suggesting a relationship between amylin and insulin secretion. Amylin levels were reversibly increased in obesity and related to triglyceride concentrations.<\/jats:p>","DOI":"10.1038\/oby.2007.239","type":"journal-article","created":{"date-parts":[[2008,7,17]],"date-time":"2008-07-17T22:35:42Z","timestamp":1216334142000},"page":"2006-2011","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Amylin and Its Relation to Insulin and Lipids in Obese Children Before and After Weight Loss"],"prefix":"10.1002","volume":"15","author":[{"given":"Thomas","family":"Reinehr","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gideon","family":"de Sousa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Petra","family":"Niklowitz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian L.","family":"Roth","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,9,6]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2002.147"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1262-3636(07)70112-X"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.84.23.8628"},{"key":"e_1_2_7_5_2","first-page":"524","article-title":"Roles of amylin in diabetes and in regulation of nutrient load","volume":"14","author":"Young A.","year":"1998","journal-title":"Nutrition"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1054\/npep.1999.0046"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1210\/endo.142.11.8593"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0196-9781(91)90148-I"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0196-9781(98)00018-7"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/s001250050646"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.1993.265.3.E446"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2003-0649-F"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1681.2000.03255.x"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/335632a0"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.263"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.2001.280.4.E562"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/84.3.490"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005176-200307000-00013"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.320.7244.1240"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1007\/s001120170107"},{"key":"e_1_2_7_21_2","first-page":"45","article-title":"The LMS method for constructing normalized growth standards","volume":"44","author":"Cole T. J.","year":"1990","journal-title":"Eur J Clin Nutr"},{"key":"e_1_2_7_22_2","first-page":"709","article-title":"Skinfold equations for estimation of body fatness in children and youth","volume":"60","author":"Slaughter M. H.","year":"1988","journal-title":"Hum Biol"},{"key":"e_1_2_7_23_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00280883"},{"key":"e_1_2_7_24_2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2003.028803"},{"key":"e_1_2_7_25_2","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2005.222"},{"key":"e_1_2_7_26_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9136(199706)14:2 <S9::AID-DIA397>3.0.CO;2-D"},{"key":"e_1_2_7_27_2","doi-asserted-by":"publisher","DOI":"10.2337\/diab.39.6.752"},{"key":"e_1_2_7_28_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1464-5491.2002.00745.x"}],"container-title":["Obesity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1038%2Foby.2007.239","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1038\/oby.2007.239","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,17]],"date-time":"2023-10-17T20:44:40Z","timestamp":1697575480000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1038\/oby.2007.239"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,8]]},"references-count":27,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2007,8]]}},"alternative-id":["10.1038\/oby.2007.239"],"URL":"https:\/\/doi.org\/10.1038\/oby.2007.239","archive":["Portico"],"relation":{},"ISSN":["1930-7381","1930-739X"],"issn-type":[{"value":"1930-7381","type":"print"},{"value":"1930-739X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,8]]},"assertion":[{"value":"2012-09-06","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}