{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T11:50:55Z","timestamp":1772106655557,"version":"3.50.1"},"reference-count":26,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2012,9,6]],"date-time":"2012-09-06T00:00:00Z","timestamp":1346889600000},"content-version":"vor","delay-in-days":1863,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Obesity"],"published-print":{"date-parts":[[2007,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Objective:<\/jats:italic> Previous studies evaluated the effect of obesity on left ventricular (LV) mass and systolic function in healthy subjects and in patients with coexistent chronic LV pressure overload due to hypertension, but no data exist regarding subjects with underlying volume overload. This study assessed the impact of overweight\u2010obesity on LV mass and systolic function in patients with coexistent chronic LV volume overload.<\/jats:p><jats:p><jats:italic>Research Methods and Procedures:<\/jats:italic> In 885 subjects with degenerative aortic regurgitation, a common cause of LV volume overload, LV mass, ejection fraction, and myocardial contractility were determined by echocardiography.<\/jats:p><jats:p><jats:italic>Results:<\/jats:italic> LV mass was greater in overweight (193.5 \u00b1 54.2 g) and further increased in obese subjects (208.4 \u00b1 63.6 g) in comparison with normal\u2010weight patients (177.7 \u00b1 54.9 g) (<jats:italic>p<\/jats:italic> &lt; 0.0001), and these differences were still evident after adjustment for LV workload, gender, and body size. Despite no differences in ejection fraction, LV myocardial contractility was lower in overweight (92.6 \u00b1 14.8%) and obese subjects (91.7 \u00b1 14.4%) than normal\u2010weight individuals (95.6 \u00b1 16.0%) (<jats:italic>p<\/jats:italic> = 0.0058). The magnitudes of these effects were not different from those found in age\u2010, gender\u2010, and body size\u2010matched controls, suggesting additive interaction, rather than synergistic, between overweight\u2010obesity and the underlying condition of volume overload. Multivariate analysis showed that BMI independently predicted LV mass and that the negative effect on LV myocardial contractility was mediated by LV hypertrophy.<\/jats:p><jats:p><jats:italic>Discussion:<\/jats:italic> Overweight and obesity are associated with LV hypertrophy and contractile impairment in patients with underlying chronic LV volume overload.<\/jats:p>","DOI":"10.1038\/oby.2007.241","type":"journal-article","created":{"date-parts":[[2008,7,17]],"date-time":"2008-07-17T22:35:42Z","timestamp":1216334142000},"page":"2019-2026","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Impact of Obesity on Left Ventricular Mass and Function in Subjects With Chronic Volume Overload"],"prefix":"10.1002","volume":"15","author":[{"given":"Piercarlo","family":"Ballo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Motto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sergio","family":"Mondillo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sergio A.","family":"Faraguti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,9,6]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa020245"},{"key":"e_1_2_7_3_2","first-page":"39","article-title":"Obesity and cardiac failure","volume":"98","author":"Galinier M.","year":"2005","journal-title":"Arch Mal Coeur Vaiss"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2005.09.122"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1136\/heart.89.10.1152"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2004.201"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.38.3.417"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2004.01.011"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jhh.1002055"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.28.2.276"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.31.4.929"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004872-200306000-00001"},{"key":"e_1_2_7_13_2","first-page":"51","article-title":"Clinical Guidelines on the Identification, Evaluation, and Treatment of Overweight and Obesity in Adults: the Evidence Report","volume":"6","author":"National Institutes of Health","year":"1998","journal-title":"Obes Res"},{"key":"e_1_2_7_14_2","volume-title":"Definition, Diagnosis and Classification of Diabetes Mellitus and Its Complications. 1. 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