{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,9]],"date-time":"2025-11-09T03:16:20Z","timestamp":1762658180693},"reference-count":31,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2012,9,6]],"date-time":"2012-09-06T00:00:00Z","timestamp":1346889600000},"content-version":"vor","delay-in-days":1771,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Obesity"],"published-print":{"date-parts":[[2007,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Objective:<\/jats:italic> To examine the importance of lipin 1 (<jats:italic>LPIN1<\/jats:italic>) gene variation in energy and glucose metabolism. Transgenic animal models have shown that lipin, a protein encoded by the <jats:italic>LPIN1<\/jats:italic> gene, promotes fat synthesis and storage in adipose tissue while decreasing energy expenditure and lipid oxidation in skeletal muscle. <jats:italic>Lpin1<\/jats:italic> was identified as the mutated gene in the fatty liver dystrophy mouse, which exhibits lipin deficiency and features of human lipodystrophy.<\/jats:p><jats:p><jats:italic>Research Methods and Procedures:<\/jats:italic> We genotyped five <jats:italic>LPIN1<\/jats:italic> polymorphisms and tested for association with resting metabolic rate (RMR), fat oxidation, fasting plasma insulin and glucose concentration, and obesity\u2010related phenotypes, including BMI, body fat percentage, sum of six skinfolds, and waist circumference in 712 subjects of the Quebec Family Study.<\/jats:p><jats:p><jats:italic>Results:<\/jats:italic> The strongest results were generation\u2010specific. In parents, RMR of the G\/G IVS13 + 3333A&gt;G homozygotes was 107 kcal\/d higher than in A\/A homozygotes and 39 kcal\/d higher than in A\/G heterozygotes (<jats:italic>p<\/jats:italic> = 0.0003). In offspring, carriers of the C allele of the IVS18 + 181C&gt;T variant had significantly higher (<jats:italic>p<\/jats:italic> &lt; 0.0003) insulin levels than T\/T homozygotes. These associations remained significant after adjusting for multiple testing. Several other associations between body composition measures and the IVS18 + 181C&gt;T variant were significant (<jats:italic>p<\/jats:italic> = 0.05 to 0.003), suggesting a strong pattern of relationships.<\/jats:p><jats:p><jats:italic>Discussion:<\/jats:italic> These findings support the hypothesis that sequence variation in the <jats:italic>LPIN1<\/jats:italic> gene contributes to variation in RMR and obesity\u2010related phenotypes potentially in an age\u2010dependent manner.<\/jats:p>","DOI":"10.1038\/oby.2007.324","type":"journal-article","created":{"date-parts":[[2008,7,17]],"date-time":"2008-07-17T22:54:10Z","timestamp":1216335250000},"page":"2723-2732","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Association of <i>Lipin 1<\/i> Gene Polymorphisms with Measures of Energy and Glucose Metabolism"],"prefix":"10.1002","volume":"15","author":[{"given":"Ruth J.F.","family":"Loos","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tuomo","family":"Rankinen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Louis","family":"P\u00e9russe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angelo","family":"Tremblay","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean\u2010Pierre","family":"Despr\u00e9s","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claude","family":"Bouchard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,9,6]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2006.71"},{"key":"e_1_2_7_3_2","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1016\/S0022-2275(20)39126-4","article-title":"Naturally occurring mutations in mice affecting lipid transport and metabolism","volume":"37","author":"Reue K.","year":"1996","journal-title":"J Lipid Res"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/83685"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2275(20)32011-3"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1996.tb14262.x"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M503885200"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2004.12.002"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M403506200"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1116203"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddi448"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.2337\/db05-1688"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2006.08.005"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/s100380200052"},{"key":"e_1_2_7_15_2","first-page":"470","volume-title":"Molecular and Genetic Aspects of Obesity: Pennington Center Nutrition Series","author":"Bouchard C.","year":"1996"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI117038"},{"key":"e_1_2_7_17_2","first-page":"615","article-title":"Determination of plasma glucose by hexokinase\u2010glucose\u20106\u2010phosphate dehydrogenase method","volume":"101","author":"Richterich R.","year":"1971","journal-title":"Schweiz Med Wochenschr"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-33-5-732"},{"key":"e_1_2_7_19_2","volume-title":"Evaluation and Regulation of Body Build and Composition","author":"Behnke A. 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