{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T07:13:50Z","timestamp":1777619630617,"version":"3.51.4"},"reference-count":18,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2012,9,6]],"date-time":"2012-09-06T00:00:00Z","timestamp":1346889600000},"content-version":"vor","delay-in-days":1741,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Obesity"],"published-print":{"date-parts":[[2007,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Obesity and type 2 diabetes constitute leading public health problems worldwide. Studies have shown that insulin resistance affiliated with these conditions is associated with skeletal muscle lipid accumulation, while the latter is associated with mitochondrial dysfunctions. However, the initiation and regulation of mitochondrial biogenesis rely heavily on \u223c1000 nuclear\u2010encoded mitochondrial regulatory proteins. In this study, we targeted the <jats:italic>ubiquinol\u2010cytochrome c reductase core protein I<\/jats:italic> gene, a nuclear\u2010encoded component of mitochondrial complex III, for its association with subcutaneous fat depth (SFD) and skeletal muscle lipid accumulation (SMLA) using cattle as a model. Four promoter polymorphisms were identified and genotyped on \u223c250 Wagyu \u00d7 Limousin F<jats:sub>2<\/jats:sub> progeny. Statistical analysis revealed that two completely linked polymorphic sites, <jats:italic>g.13487C<\/jats:italic>&gt;<jats:italic>T<\/jats:italic> and <jats:italic>g.13709G<\/jats:italic>&gt;<jats:italic>C<\/jats:italic> (<jats:italic>r<\/jats:italic><jats:sup>2<\/jats:sup> = 1), were significantly associated with both SFD (<jats:italic>p<\/jats:italic> &lt; 0.01) and SMLA (<jats:italic>p<\/jats:italic> &lt; 0.0001). The difference between <jats:italic>TTCC<\/jats:italic> and <jats:italic>CCGG<\/jats:italic> haplotypes was 0.178 cm for SFD and 0.624 scores for SMLA. Interestingly, the former haplotype produced higher promoter activities than the latter by 43% to 49% in three cell lines (<jats:italic>p<\/jats:italic> &lt; 0.05). In addition to Rett syndrome and breast\/ovarian cancer observed in other studies, we report evidence for the first time, to our knowledge, that overexpression of <jats:italic>ubiquinol\u2010cytochrome c reductase core protein I<\/jats:italic> might affect mitochondrial morphology and\/or physiology and lead to development of obesity and related conditions.<\/jats:p>","DOI":"10.1038\/oby.2007.344","type":"journal-article","created":{"date-parts":[[2008,7,17]],"date-time":"2008-07-17T22:55:04Z","timestamp":1216335304000},"page":"2896-2901","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Functional <i>UQCRC1<\/i> Polymorphisms Affect Promoter Activity and Body Lipid Accumulation"],"prefix":"10.1002","volume":"15","author":[{"given":"Tanja","family":"Kunej","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zeping","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer J.","family":"Michal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tyler F.","family":"Daniels","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nancy S.","family":"Magnuson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhihua","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,9,6]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000140114.83145.59"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.160.7.898"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-543X.2004.00071.x"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mito.2004.07.032"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.3109\/10409239409086800"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.281.5373.64"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-1033.1991.tb16099.x"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/bth457"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2006.47"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.51.4.1022"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.01665-05"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.4161\/cbt.5.8.2880"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2052.2005.01338.x"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0388.2006.00577.x"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2005.06.120"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2052.2006.01464.x"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2006.71"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1086\/302698"}],"container-title":["Obesity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1038%2Foby.2007.344","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1038\/oby.2007.344","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,31]],"date-time":"2023-10-31T06:30:06Z","timestamp":1698733806000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1038\/oby.2007.344"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,12]]},"references-count":18,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2007,12]]}},"alternative-id":["10.1038\/oby.2007.344"],"URL":"https:\/\/doi.org\/10.1038\/oby.2007.344","archive":["Portico"],"relation":{},"ISSN":["1930-7381","1930-739X"],"issn-type":[{"value":"1930-7381","type":"print"},{"value":"1930-739X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,12]]},"assertion":[{"value":"2012-09-06","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}