{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T22:22:23Z","timestamp":1769725343618,"version":"3.49.0"},"reference-count":41,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2012,9,6]],"date-time":"2012-09-06T00:00:00Z","timestamp":1346889600000},"content-version":"vor","delay-in-days":1985,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Obesity"],"published-print":{"date-parts":[[2007,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Objective:<\/jats:italic> It has been hypothesized that increased free insulin\u2010like growth factor (IGF)\u2010I levels generated from an increase in IGF\u2010binding protein (IGFBP) protease activity could be the inhibitory mechanism for the decreased growth hormone (GH) secretion observed in obese subjects.<\/jats:p><jats:p><jats:italic>Research Methods and Procedures:<\/jats:italic> In this study, we determined basal and 24\u2010hour levels of free IGF\u2010I and \u2010II, total IGF\u2010I and \u2010II, IGFBP\u20101, as well as basal IGFBP\u20102, \u22123, and \u22124, acid\u2010labile subunit (ALS), IGFBP\u20101, \u22122, and \u22123 protease activity, and 24\u2010hour GH release in obese women before and after a diet\u2010induced weight loss. Sixteen obese women (age, 29.5 \u00b1 1.4 years) participated in a weight loss program and 16 age\u2010matched non\u2010obese women served as controls.<\/jats:p><jats:p><jats:italic>Results:<\/jats:italic> Circulating free IGF\u2010I and 24\u2010hour GH release were significantly decreased in obese women at before weight loss compared with non\u2010obese women (1.29 \u00b1 0.12 vs. 0.60 \u00b1 0.09 \u03bcg\/L; <jats:italic>p<\/jats:italic> &lt; 0.001 and 862 \u00b1 90 vs. 404 \u00b1 77 mU\/24 hours; <jats:italic>p<\/jats:italic> &lt; 0.001, respectively). Free IGF\u2010I and 24\u2010hour GH release were not inversely correlated to each other. IGFBP\u20101 and \u22122 levels were decreased, whereas ALS, IGFBP\u20103 and \u22124, and IGFBP\u20101, \u22122, and \u22123 protease activity were similar in obese and non\u2010obese women. Eight of the 16 obese women achieved an average weight loss of 30 \u00b1 5 kg during 26 to 60 weeks of dieting. After the considerable weight loss, significant differences in free IGF\u2010I, GH release, and IGFBP\u20101 and \u22122 levels were no longer present between previously obese and non\u2010obese women.<\/jats:p><jats:p><jats:italic>Discussion:<\/jats:italic> We showed that circulating free IGF\u2010I is markedly decreased in severely obese women and does not per se mediate the concomitant hyposomatotropism. The decreased levels of free IGF\u2010I seem to be transient and restored to normal levels after weight loss.<\/jats:p>","DOI":"10.1038\/oby.2007.607","type":"journal-article","created":{"date-parts":[[2008,7,15]],"date-time":"2008-07-15T15:08:05Z","timestamp":1216134485000},"page":"879-886","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Effect of Weight Loss on Free Insulin\u2010Like Growth Factor\u2010I in Obese Women With Hyposomatotropism"],"prefix":"10.1002","volume":"15","author":[{"given":"Michael H.","family":"Rasmussen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anders","family":"Juul","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jannik","family":"Hilsted","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,9,6]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.80.4.1407"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2002.157"},{"key":"e_1_2_7_4_2","first-page":"E824","article-title":"Influence of obesity and body fat distribution on growth hormone kinetics in humans","volume":"277","author":"Langendonk J. 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