{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T07:57:56Z","timestamp":1791187076074,"version":"4.1.0"},"reference-count":47,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2012,9,6]],"date-time":"2012-09-06T00:00:00Z","timestamp":1346889600000},"content-version":"vor","delay-in-days":1955,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Obesity"],"published-print":{"date-parts":[[2007,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Objective:<\/jats:italic>We previously reported that a single preprandial injection (120 \u03bcg) of pramlintide, an analog of the \u03b2\u2010cell hormone amylin, reduced ad libitum food intake in obese subjects. To further characterize the meal\u2010related effects of amylin signaling in humans, we studied a lower pramlintide dose (30 \u03bcg) in normal\u2010weight subjects.<\/jats:p><jats:p><jats:italic>Research Methods and Procedures:<\/jats:italic>In a randomized, double\u2010blind, placebo\u2010controlled, cross\u2010over study, 15 healthy men (age, 24 \u00b1 7 years; BMI, 22.2 \u00b1 1.8 kg\/m<jats:sup>2<\/jats:sup>) underwent a standardized buffet meal test on two occasions. After an overnight fast, subjects received a single subcutaneous injection of pramlintide (30 \u03bcg) or placebo, followed immediately by a standardized pre\u2010load meal. After 1 hour, subjects were offered an ad libitum buffet meal, and total caloric intake and meal duration were measured.<\/jats:p><jats:p><jats:italic>Results:<\/jats:italic>Compared with placebo, pramlintide reduced total caloric intake (1411 \u00b1 94 vs. 1190 \u00b1 117 kcal; \u0394, \u2212221 \u00b1 101 kcal; \u221214 \u00b1 9%;<jats:italic>p<\/jats:italic>= 0.05) and meal duration (36 \u00b1 2 vs. 31 \u00b1 3 minutes; \u0394, \u22125.1 \u00b1 1.4 minutes;<jats:italic>p<\/jats:italic>&lt; 0.005). Visual analog scale profiles of hunger trended lower and fullness higher during the first hour after pramlintide administration. In response to the buffet, hunger and fullness changed to a similar degree after pramlintide and placebo, despite subjects on pramlintide consuming 14% fewer kilocalories. Visual analog scale nausea ratings remained near baseline, without differences between treatments. Plasma peptide YY, cholecystokinin, and ghrelin concentrations did not differ with treatment, whereas glucagon\u2010like peptide\u20101 concentrations after meals were lower in response to pramlintide than to placebo.<\/jats:p><jats:p><jats:italic>Discussion:<\/jats:italic>These observations add support to the concept that amylin agonism may have a role in human appetite control.<\/jats:p>","DOI":"10.1038\/oby.2007.626","type":"journal-article","created":{"date-parts":[[2008,7,16]],"date-time":"2008-07-16T08:06:11Z","timestamp":1216195571000},"page":"1179-1186","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":60,"title":["Low\u2010dose Pramlintide Reduced Food Intake and Meal Duration in Healthy, Normal\u2010Weight 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