{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T13:34:26Z","timestamp":1776864866183,"version":"3.51.2"},"reference-count":43,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2012,9,6]],"date-time":"2012-09-06T00:00:00Z","timestamp":1346889600000},"content-version":"vor","delay-in-days":1955,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Obesity"],"published-print":{"date-parts":[[2007,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Objective:<\/jats:italic> To assess changes in body composition with weight loss in obese subjects randomized to a laparoscopic adjustable gastric band surgical program or a medical program using a very\u2010low\u2010energy diet and orlistat.<\/jats:p><jats:p><jats:italic>Research Methods and Procedures:<\/jats:italic> Using body composition measurements by DXA, neutron activation for total body nitrogen, and whole body \u03b3 counting for total body potassium, we studied changes in fat mass, fat distribution, fat\u2010free mass, total bone mineral content, total body protein, and body cell mass at 6 (<jats:italic>n<\/jats:italic> = 61 paired) and 24 months (<jats:italic>n<\/jats:italic> = 53 paired) after randomization.<\/jats:p><jats:p><jats:italic>Results:<\/jats:italic> At 24 months, the surgical group had lost significantly more weight (surgical, 20.3 \u00b1 6.5 kg; medical, 5.9 \u00b1 8.0 kg). There was favorable fat\u2010free mass to fat mass loss ratios for both groups (surgical, 1:5.5; medical, 1:5.9). Changes in total body nitrogen or potassium were favorable in each group. A small reduction in mean bone mineral content occurred throughout the study but was not associated with extent of weight loss or treatment group. At 6 months, weight loss for both groups was similar (surgical, 14.1 \u00b1 4.5 kg; medical, 13.3 \u00b1 7.3 kg). The medical program subjects lost less fat\u2010free mass and skeletal muscle and had increased total body protein. The proportion of body fat to limb fat remained remarkably constant throughout the study.<\/jats:p><jats:p><jats:italic>Discussion:<\/jats:italic> Weight loss programs used in this study induced fat loss without significant deleterious effects on the components of fat\u2010free mass.<\/jats:p>","DOI":"10.1038\/oby.2007.639","type":"journal-article","created":{"date-parts":[[2008,7,16]],"date-time":"2008-07-16T08:06:11Z","timestamp":1216195571000},"page":"1187-1198","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":68,"title":["Changes in Body Composition with Weight Loss: Obese Subjects Randomized to Surgical and Medical Programs"],"prefix":"10.1002","volume":"15","author":[{"given":"John B.","family":"Dixon","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Boyd J. 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