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Meta\u2010analysis was performed on placebo\u2010controlled trials with data for attrition, remission, and weight loss. Qualitative review was performed on remaining controlled treatment literature. A total of 33 studies were considered of which 14 studies with a total of 1,279 patients were included in the meta\u2010analysis of pharmacotherapy\u2010only treatment and 8 studies with a total of 683 patients were included in the qualitative review of pharmacotherapy combined with psychotherapy interventions. No evidence suggested significant differences between medication and placebo for attrition. Evidence suggested that pharmacological treatments have a clinically significant advantage over placebo for achieving short\u2010term remission from binge eating (48.7% vs. 28.5%) and for weight loss, although weight losses are not substantial. No data exist to allow evaluation of longer\u2010term effects of pharmacotherapy\u2010only treatment for BED. Combining medications with psychotherapy interventions failed to significantly enhance binge outcomes, although specific medications (orlistat, topiramate) enhanced weight losses achieved with cognitive behavioral therapy and behavioral weight loss. In summary, BED patients can be advised that certain pharmacotherapies may enhance likelihood of stopping binge eating short term, but that longer\u2010term effects are unknown. Although some weight loss may occur, it is unlikely to be substantial with available medications. Combining medications with cognitive or behavioral treatments is unlikely to enhance binge outcomes, but specific medications (orlistat, topiramate) may enhance weight losses, albeit modestly.<\/jats:p>","DOI":"10.1038\/oby.2008.333","type":"journal-article","created":{"date-parts":[[2008,8,21]],"date-time":"2008-08-21T15:27:31Z","timestamp":1219332451000},"page":"2024-2038","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":152,"title":["Review and Meta\u2010analysis of Pharmacotherapy for Binge\u2010eating Disorder"],"prefix":"10.1002","volume":"16","author":[{"given":"Deborah L.","family":"Reas","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos M.","family":"Grilo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,9,6]]},"reference":[{"key":"e_1_2_7_2_2","volume-title":"Diagnostic and Statistical Manual of Mental Disorders","author":"American Psychiatric Association","year":"1994"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2006.03.040"},{"key":"e_1_2_7_4_2","doi-asserted-by":"crossref","first-page":"2181","DOI":"10.1176\/ajp.2006.163.12.2181","article-title":"Binge eating disorder: a stable syndrome","volume":"163","author":"Pope HG","year":"2006","journal-title":"Am J Psychiatry"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1037\/0022-006X.69.6.1066"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v67n0410"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291701004640"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1037\/0022-006X.73.6.1107"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.63.3.313"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1037\/0003-066X.62.3.199"},{"key":"e_1_2_7_11_2","volume-title":"Eating disorders\u2014core interventions in the treatment and management of anorexia nervosa, bulimia nervosa and related eating disorders. 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