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The expression levels of \u223c12,000 transcripts were assessed using the MgU74Av2 mouse microarray chip. Ritonavir altered gene expression of inflammatory cytokines, stress response genes localized to endoplasmic reticulum, oxidative stress genes, apoptosis\u2010related genes, and expression of genes involved in cell adhesion and extracellular matrix remodeling. Microarray analysis also identified a novel gene downregulated by ritonavir, Cidea, whose expression levels may affect free\u2010fatty acid metabolism. These changes suggest a unique, stress\u2010related pattern in adipocytes induced by chronic exposure to the protease inhibitor, ritonavir.<\/jats:p>","DOI":"10.1038\/oby.2008.350","type":"journal-article","created":{"date-parts":[[2008,8,21]],"date-time":"2008-08-21T15:27:31Z","timestamp":1219332451000},"page":"2379-2387","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Effects of Ritonavir on Adipocyte Gene Expression: Evidence for a Stress\u2010related Response"],"prefix":"10.1002","volume":"16","author":[{"given":"Diane C.","family":"Adler\u2010Wailes","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Evan L.","family":"Guiney","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jashin","family":"Koo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jack 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