{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,21]],"date-time":"2025-09-21T18:05:28Z","timestamp":1758477928411},"reference-count":46,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2012,9,6]],"date-time":"2012-09-06T00:00:00Z","timestamp":1346889600000},"content-version":"vor","delay-in-days":1163,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Obesity"],"published-print":{"date-parts":[[2009,7]]},"abstract":"<jats:p>The pubertal transition has been identified as a time of risk for development of type 2 diabetes, particularly among vulnerable groups, such as African Americans (AAs). Documented ethnic differences in insulin secretory dynamics may predispose overweight AA adolescents to risk for type 2 diabetes. The objectives of this longitudinal study were to quantify insulin secretion and clearance in a cohort of 90 AA and European American (EA) children over the pubertal transition and to explore the association of genetic factors and adiposity with repeated measures of insulin secretion and clearance during this critical period. Insulin sensitivity was determined by intravenous glucose tolerance test (IVGTT) and minimal modeling; insulin secretion and clearance by C\u2010peptide modeling; genetic ancestry by admixture analysis. Mixed\u2010model longitudinal analysis indicated that African genetic admixture (AfADM) was independently and positively associated with first\u2010phase insulin secretion within the entire group (<jats:italic>P<\/jats:italic> &lt; 0.001), and among lean children (<jats:italic>P<\/jats:italic> &lt; 0.01). When examined within pubertal stage, this relationship became significant at Tanner stage 3. Total body fat was a significant determinant of first\u2010phase insulin secretion overall and among obese children (<jats:italic>P<\/jats:italic> &lt; 0.001). Total body fat, but not AfADM, was associated with insulin clearance (<jats:italic>P<\/jats:italic> &lt; 0.001). In conclusion, genetic factors, as reflected in AfADM, may explain greater first\u2010phase insulin secretion among peripubertal AA vs. EA; however, the influence of genetic factors is superseded by adiposity. The pubertal transition may affect the development of the \u03b2\u2010cell response to glucose in a manner that differs with ethnic\/genetic background.<\/jats:p>","DOI":"10.1038\/oby.2008.648","type":"journal-article","created":{"date-parts":[[2009,2,5]],"date-time":"2009-02-05T15:53:51Z","timestamp":1233849231000},"page":"1318-1325","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Obesity Attenuates the Contribution of African Admixture to the Insulin Secretory Profile in Peripubertal Children: A Longitudinal Analysis"],"prefix":"10.1002","volume":"17","author":[{"given":"Krista","family":"Casazza","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Radhika P.","family":"Phadke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jose 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