{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T12:19:09Z","timestamp":1790165949463,"version":"4.1.0"},"reference-count":49,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2012,9,6]],"date-time":"2012-09-06T00:00:00Z","timestamp":1346889600000},"content-version":"vor","delay-in-days":1558,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Obesity"],"published-print":{"date-parts":[[2008,6]]},"abstract":"<jats:p><jats:bold>Objective:<\/jats:bold> This study investigated the effect of different sodium content diets on rat adipose tissue carbohydrate metabolism and insulin sensitivity.<\/jats:p><jats:p><jats:bold>Methods and Procedures:<\/jats:bold> Male Wistar rats were fed on normal\u2010 (0.5% Na<jats:sup>+<\/jats:sup>; NS), high\u2010 (3.12% Na<jats:sup>+<\/jats:sup>; HS), or low\u2010sodium (0.06% Na<jats:sup>+<\/jats:sup>; LS) diets for 3, 6, and 9 weeks after weaning. Blood pressure (BP) was measured using a computerized tail\u2010cuff system. An intravenous insulin tolerance test (ivITT) was performed in fasted animals. At the end of each period, rats were killed and blood samples were collected for glucose and insulin determinations. The white adipose tissue (WAT) from abdominal and inguinal subcutaneous (SC) and periepididymal (PE) depots were weighed and processed for adipocyte isolation and measurement of <jats:italic>in vitro<\/jats:italic> rates of insulin\u2010stimulated 2\u2010deoxy\u2010<jats:sc>d<\/jats:sc>\u2010[<jats:sup>3<\/jats:sup>H]\u2010glucose uptake (2DGU) and conversion of \u2010[U\u2010<jats:sup>14<\/jats:sup>C]\u2010glucose into <jats:sup>14<\/jats:sup>CO<jats:sub>2<\/jats:sub>.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> After 6 weeks, HS diet significantly increased the BP, SC and PE WAT masses, PE adipocyte size, and plasma insulin concentration. The sodium dietary content did not influence the whole\u2010body insulin sensitivity. A higher half\u2010maximal effective insulin concentration (EC<jats:sub>50<\/jats:sub>) from the dose\u2010response curve of 2DGU and an increase in the insulin\u2010stimulated glucose oxidation rate were observed in the isolated PE adipocytes from HS rats.<\/jats:p><jats:p><jats:bold>Discussion:<\/jats:bold> The chronic salt overload enhanced the adipocyte insulin sensitivity for glucose uptake and the insulin\u2010induced glucose metabolization, contributing to promote adipocyte hypertrophy and increase the mass of several adipose depots, particularly the PE fat pad.<\/jats:p>","DOI":"10.1038\/oby.2008.69","type":"journal-article","created":{"date-parts":[[2008,3,27]],"date-time":"2008-03-27T15:41:19Z","timestamp":1206632479000},"page":"1186-1192","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":61,"title":["High Sodium Intake Enhances Insulin\u2010stimulated Glucose Uptake in Rat Epididymal Adipose Tissue"],"prefix":"10.1002","volume":"16","author":[{"given":"Miriam H.","family":"Fonseca\u2010Alaniz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Takada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Andreotti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tarcila B.F.","family":"De Campos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda B.","family":"Campa\u00f1a","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina N.","family":"Borges\u2010Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio B.","family":"Lima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,9,6]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-789X.2005.00221.x"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1023\/B:REMD.0000032410.75638.da"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.26.7.2021"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2005.02.009"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.328.7440.634"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.297.6644.319"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.161.4.589"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00394-002-0372-4"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.17.1_Suppl.I21"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004872-200106000-00009"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(89)91852-7"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200101043440101"},{"key":"e_1_2_7_14_2","first-page":"E730","article-title":"Effect of sodium intake on insulin sensitivity","volume":"264","author":"Donovan DS","year":"1993","journal-title":"Am J Physiol"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI117593"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.50.3.573"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000022880.45113.C9"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004872-199104000-00004"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/0895-7061(95)00152-F"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2362.1995.tb01523.x"},{"key":"e_1_2_7_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0895-7061(99)00016-3"},{"key":"e_1_2_7_22_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.35.1.424"},{"key":"e_1_2_7_23_2","doi-asserted-by":"publisher","DOI":"10.1042\/CS20020320"},{"key":"e_1_2_7_24_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00396.2003"},{"key":"e_1_2_7_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0895-7061(97)00090-3"},{"key":"e_1_2_7_26_2","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-68-2-374"},{"key":"e_1_2_7_27_2","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/S0021-9258(18)51687-2","article-title":"Metabolism of isolated fat cells. 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