{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T11:10:30Z","timestamp":1790334630576,"version":"4.1.0"},"reference-count":50,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2012,9,6]],"date-time":"2012-09-06T00:00:00Z","timestamp":1346889600000},"content-version":"vor","delay-in-days":1010,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Obesity"],"published-print":{"date-parts":[[2009,12]]},"abstract":"<jats:p>Both obesity and aging increase intrahepatic fat (IHF) content, which leads to nonalcoholic fatty liver disease (NAFLD) and metabolic abnormalities such as insulin resistance. We evaluated the effects of diet and diet in conjunction with exercise on IHF content and associated metabolic abnormalities in obese older adults. Eighteen obese (BMI \u226530 kg\/m<jats:sup>2<\/jats:sup>) older (\u226565 years old) adults completed a 6\u2010month clinical trial. Participants were randomized to diet (D group; <jats:italic>n<\/jats:italic> = 9) or diet + exercise (D+E group; <jats:italic>n<\/jats:italic> = 9). Primary outcome was IHF quantified by magnetic resonance spectroscopy (MRS). Secondary outcomes included insulin sensitivity (assessed by oral glucose tolerance), body composition (assessed by dual\u2010energy X\u2010ray absorptiometry), physical function (VO<jats:sub>2peak<\/jats:sub> and strength), glucose, lipids, and blood pressure (BP). Body weight (D: \u22129 \u00b1 1%, D+E: \u221210 \u00b1 2%, both <jats:italic>P<\/jats:italic> &lt; 0.05) and fat mass (D: \u221213 \u00b1 3%, D+E \u221216 \u00b1 3%, both <jats:italic>P<\/jats:italic> &lt; 0.05) decreased in both groups but there was no difference between groups. IHF decreased to a similar extent in both groups (D: \u221246 \u00b1 11%, D+E: \u221245 \u00b1 8%, both <jats:italic>P<\/jats:italic> &lt; 0.05), which was accompanied by comparable improvements in insulin sensitivity (D: 66 \u00b1 25%, D+E: 68 \u00b1 28%, both <jats:italic>P<\/jats:italic> &lt; 0.05). The relative decreases in IHF correlated directly with relative increases in insulin sensitivity index (ISI) (<jats:italic>r<\/jats:italic> = \u22120.52; <jats:italic>P<\/jats:italic> &lt; 0.05). Improvements in VO<jats:sub>2peak<\/jats:sub>, strength, plasma triglyceride (TG), and low\u2010density lipoprotein\u2013cholesterol concentration, and diastolic BP occurred in the D+E group (all <jats:italic>P<\/jats:italic> &lt; 0.05) but not in the D group. Diet with or without exercise results in significant decreases in IHF content accompanied by considerable improvements in insulin sensitivity in obese older adults. The addition of exercise to diet therapy improves physical function and other obesity\u2010 and aging\u2010related metabolic abnormalities.<\/jats:p>","DOI":"10.1038\/oby.2009.126","type":"journal-article","created":{"date-parts":[[2009,4,23]],"date-time":"2009-04-23T14:27:50Z","timestamp":1240496870000},"page":"2162-2168","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":159,"title":["Diet and Exercise Interventions Reduce Intrahepatic Fat Content and Improve Insulin Sensitivity in Obese Older Adults"],"prefix":"10.1002","volume":"17","author":[{"given":"Krupa","family":"Shah","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abby","family":"Stufflebam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiffany 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