{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T02:20:08Z","timestamp":1789784408011,"version":"4.0.1"},"reference-count":39,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2012,9,6]],"date-time":"2012-09-06T00:00:00Z","timestamp":1346889600000},"content-version":"vor","delay-in-days":1132,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Obesity"],"published-print":{"date-parts":[[2009,8]]},"abstract":"<jats:p>Given the negative effects of a breast cancer diagnosis and its treatments on body weight and bone mass, we investigated the effects of a 6\u2010month randomized controlled aerobic exercise intervention vs. usual care on body composition in breast cancer survivors. Secondary aims were to examine the effects stratified by important prognostic and physiologic variables. Seventy\u2010five physically inactive postmenopausal breast cancer survivors were recruited through the Yale\u2013New Haven Hospital Tumor Registry and randomly assigned to an exercise (<jats:italic>n<\/jats:italic> = 37) or usual care (<jats:italic>n<\/jats:italic> = 38) group. The exercise group participated in 150 min\/week of supervised gym\u2010 and home\u2010based moderate\u2010intensity aerobic exercise. The usual care group was instructed to maintain their current physical activity level. Body composition was assessed at baseline and 6\u2010months through dual\u2010energy X\u2010ray absorptiometry (DXA) by one radiologist blinded to the intervention group of the participants. On an average, exercisers increased moderate\u2010intensity aerobic exercise by 129 min\/week over and above baseline levels compared with 45 min\/week among usual care participants (<jats:italic>P<\/jats:italic> &lt; 0.001). Exercisers experienced decreases in percent body fat (<jats:italic>P<\/jats:italic> = 0.0022) and increases in lean mass (<jats:italic>P<\/jats:italic> = 0.047) compared with increases in body fat and decreases in lean mass in usual care participants. Bone mineral density (BMD) was also maintained among exercisers compared with a loss among usual care participants (<jats:italic>P<\/jats:italic> = 0.043). In summary, moderate\u2010intensity aerobic exercise, such as brisk walking, produces favorable changes in body composition that may improve breast cancer prognosis.<\/jats:p>","DOI":"10.1038\/oby.2009.18","type":"journal-article","created":{"date-parts":[[2009,2,27]],"date-time":"2009-02-27T10:34:55Z","timestamp":1235730895000},"page":"1534-1541","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":147,"title":["Exercise Improves Body Fat, Lean Mass, and Bone Mass in Breast Cancer Survivors"],"prefix":"10.1002","volume":"17","author":[{"given":"Melinda L.","family":"Irwin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marty","family":"Alvarez\u2010Reeves","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Cadmus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eileen","family":"Mierzejewski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan T.","family":"Mayne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Herbert","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gina G.","family":"Chung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beth","family":"Jones","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. 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