{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T01:23:29Z","timestamp":1773797009002,"version":"3.50.1"},"reference-count":25,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2012,9,6]],"date-time":"2012-09-06T00:00:00Z","timestamp":1346889600000},"content-version":"vor","delay-in-days":1193,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Obesity"],"published-print":{"date-parts":[[2009,6]]},"abstract":"<jats:p>Adrenomedullin (ADM) is a vasoactive peptide found to be related to obesity and its comorbidities: type 2 diabetes, hypertension, atherosclerosis, and coronary heart disease. ADM is increased both in plasma and in adipose tissue of obese individuals when compared to lean subjects and is considered as a member of the adipokine family. We determined plasma midregional proadrenomedullin (MR\u2010proADM) concentrations in a cohort of 357 subjects with BMI ranging from 17.5 to 42.3 kg\/m<jats:sup>2<\/jats:sup> and no additional medical history. In parallel, 28 severely obese patients scheduled to undergo laparoscopic Roux\u2010en\u2010Y gastric bypass (RYGB) surgery were studied at two time points: before and 1 year after surgery. Outcome measurements were: MR\u2010proADM, cortisol, leptin, C\u2010reactive protein (CRP) thyroid\u2010stimulating hormone (TSH), creatinine and metabolic parameters. BMI correlated significantly to plasma MR\u2010proADM levels (<jats:italic>r<\/jats:italic> = 0.714, <jats:italic>P<\/jats:italic> &lt; 0.001), also after adjustment for age and gender (<jats:italic>r<\/jats:italic> = 0.767, <jats:italic>P<\/jats:italic> &lt; 0.001). In obese subjects, there was a positive relationship between MR\u2010proADM and leptin (<jats:italic>r<\/jats:italic> = 0.511, <jats:italic>P<\/jats:italic> = 0.006). Following RYGB, plasma MR\u2010proADM decreased from 0.76 \u00b1 0.03 to 0.62 \u00b1 0.02 pg\/ml (<jats:italic>P<\/jats:italic> &lt; 0.0001). RYGB\u2010induced changes in MR\u2010proADM correlated significantly to changes in leptin (<jats:italic>r<\/jats:italic> = 0.533, <jats:italic>P<\/jats:italic> = 0.004) and in CRP (<jats:italic>r<\/jats:italic> = 0.429, <jats:italic>P<\/jats:italic> = 0.023). We conclude that BMI is an independent predictor of circulating MR\u2010proADM levels. Weight loss after RYGB is associated with a significant decrease in plasma MR\u2010proADM, which is related to surgery\u2010induced changes in both circulating leptin and systemic inflammation.<\/jats:p>","DOI":"10.1038\/oby.2009.22","type":"journal-article","created":{"date-parts":[[2009,2,26]],"date-time":"2009-02-26T15:10:22Z","timestamp":1235661022000},"page":"1184-1188","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Plasma MR\u2010proADM Correlates to BMI and Decreases in Relation to Leptin After Gastric Bypass Surgery"],"prefix":"10.1002","volume":"17","author":[{"given":"Greisa","family":"Vila","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michaela","family":"Riedl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christina","family":"Maier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joachim","family":"Struck","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nils G.","family":"Morgenthaler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ammon","family":"Handisurya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerhard","family":"Prager","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernhard","family":"Ludvik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Clodi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anton","family":"Luger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,9,6]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1210\/er.2006-0033"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1993.1451"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.peptides.2007.03.005"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2004.07.002"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.2337\/db06-0857"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1291\/hypres.26.S129"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.82.1.95"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2003.017921"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.23.2.253"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.peptides.2007.12.006"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00213.2005"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2005.051110"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc06-1899"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa066254"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2007.589"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.sla.0000137343.63376.19"},{"issue":"1","key":"e_1_2_6_18_2","doi-asserted-by":"crossref","first-page":"S43","DOI":"10.2337\/diacare.29.s1.06.s43","article-title":"Diagnosis and classification of diabetes mellitus (Position Statement)","volume":"29","author":"American Diabetes Association","year":"2006","journal-title":"Diabetes Care"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1291\/hypres.25.887"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1530\/eje.1.02170"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature05485"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00435.2007"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.54.8.2277"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2004.11.024"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1530\/eje.0.1470071"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.2174\/156800906778742442"}],"container-title":["Obesity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1038%2Foby.2009.22","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1038%2Foby.2009.22","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1038\/oby.2009.22","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,17]],"date-time":"2023-10-17T02:38:42Z","timestamp":1697510322000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1038\/oby.2009.22"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,6]]},"references-count":25,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2009,6]]}},"alternative-id":["10.1038\/oby.2009.22"],"URL":"https:\/\/doi.org\/10.1038\/oby.2009.22","archive":["Portico"],"relation":{},"ISSN":["1930-7381","1930-739X"],"issn-type":[{"value":"1930-7381","type":"print"},{"value":"1930-739X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,6]]},"assertion":[{"value":"2012-09-06","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}