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To identify novel contributors to cardiovascular and metabolic abnormalities in obesity, we analyzed the adipose proteome and identified soluble epoxide hydrolase (sEH) in the epididymal fat pad from C57BL\/6J mice that received either a regular diet or a \u201cwestern diet.\u201d sEH was synthesized in adipocytes and expression levels increased upon differentiation of 3T3\u2010L1 preadipocytes. Although normalized sEH mRNA and protein levels did not differ in the fat pads from mice receiving a regular or a \u201cwestern diet,\u201d total adipose sEH activity was higher in the obese mice, even after normalization for body weight. Furthermore, peroxisome proliferator\u2013activated receptor \u03b3 (PPAR\u03b3) agonists increased the expression of sEH in mature 3T3\u2010L1 adipocytes <jats:italic>in vitro<\/jats:italic> and in adipose tissue <jats:italic>in vivo<\/jats:italic>. Considering the established role for sEH in inflammation, cardiovascular diseases, and lipid metabolism, and the suggested involvement of sEH in the development of type 2 diabetes, our study has identified adipose sEH as a potential novel therapeutic target that might affect the development of metabolic and cardiovascular abnormalities in obesity.<\/jats:p>","DOI":"10.1038\/oby.2009.227","type":"journal-article","created":{"date-parts":[[2009,7,30]],"date-time":"2009-07-30T15:47:38Z","timestamp":1248968858000},"page":"489-498","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":85,"title":["Expression and Regulation of Soluble Epoxide Hydrolase in Adipose Tissue"],"prefix":"10.1002","volume":"18","author":[{"given":"Bart M.","family":"De 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