{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T07:16:17Z","timestamp":1761894977390},"reference-count":21,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2012,9,6]],"date-time":"2012-09-06T00:00:00Z","timestamp":1346889600000},"content-version":"vor","delay-in-days":798,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Obesity"],"published-print":{"date-parts":[[2010,7]]},"abstract":"<jats:p>Retinol\u2010binding protein 4 (RBP4) is a novel adipokine that likely contributes to systemic insulin resistance and dyslipidemia. The role of genetic variations in <jats:italic>RBP4<\/jats:italic> on phenotypes of glucose and lipid metabolism is not clear in humans. The purpose of this study was to examine five single\u2010nucleotide polymorphisms (SNPs) in the <jats:italic>RBP4<\/jats:italic> gene to determine their relationship with markers of insulin resistance and serum lipids in the CODING Study. The CODING Study consists of 1,836 subjects recruited from the genetically homogeneous population of Newfoundland and Labrador (NL), Canada. Serum glucose, insulin, homeostasis model assessment of insulin resistance (HOMA<jats:sub>IR<\/jats:sub>), HOMA for \u03b2 cell function (HOMA<jats:sub>\u03b2<\/jats:sub>), total cholesterol (Chol), high\u2010density lipoprotein cholesterol (HDL\u2010C), low\u2010density lipoprotein cholesterol (LDL\u2010C), and triglycerides were determined after a 12\u2010h fast. Five SNPs within <jats:italic>RBP4<\/jats:italic> (rs3758539, G\/A 5\u2032 flanking region; rs61461737, A\/G intron; rs10882280, C\/A intron; rs11187545, A\/G intron; and rs12265684, C\/G intron) were genotyped using TaqMan validated or functionally tested SNP genotyping assays. After correcting for multiple testing, we observed a significant association between the minor allele of two noncoding SNPs (rs10882280 and rs11187545) and higher serum HDL\u2010C (<jats:italic>P<\/jats:italic> = 0.043 and 0.042, respectively). No significant associations were observed with any other parameter related to lipid metabolism. We also found no significant association between any variant sites and markers of insulin resistance. Our results suggest that genetic variations in <jats:italic>RBP4<\/jats:italic> may play a role in the differences in serum HDL\u2010C levels in the NL population.<\/jats:p>","DOI":"10.1038\/oby.2009.398","type":"journal-article","created":{"date-parts":[[2009,11,5]],"date-time":"2009-11-05T16:39:19Z","timestamp":1257439159000},"page":"1393-1397","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Association of <i>RBP4<\/i> Gene Variants and Serum HDL Cholesterol Levels in the Newfoundland Population"],"prefix":"10.1002","volume":"18","author":[{"given":"Jennifer L.","family":"Shea","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. Concepci\u00f3n","family":"Loredo\u2010Osti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guang","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,9,6]]},"reference":[{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature03711"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa054862"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/86.5.1310"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.2337\/db06-0616"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2006-2522"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.51.3.833"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.1086\/302316"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymgme.2006.11.003"},{"key":"e_1_2_8_10_2","doi-asserted-by":"publisher","DOI":"10.2337\/db06-1647"},{"key":"e_1_2_8_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00439-006-0264-4"},{"key":"e_1_2_8_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-5491.2007.02314.x"},{"key":"e_1_2_8_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-008-9097-3"},{"key":"e_1_2_8_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-007-0743-8"},{"key":"e_1_2_8_15_2","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.P900014-JLR200"},{"key":"e_1_2_8_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2007.125"},{"key":"e_1_2_8_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2009.101"},{"key":"e_1_2_8_18_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00280883"},{"key":"e_1_2_8_19_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-008-1042-8"},{"key":"e_1_2_8_20_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2007-1219"},{"key":"e_1_2_8_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2009.02.029"},{"key":"e_1_2_8_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2006.10.011"}],"container-title":["Obesity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1038%2Foby.2009.398","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1038%2Foby.2009.398","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1038\/oby.2009.398","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,17]],"date-time":"2023-10-17T14:35:21Z","timestamp":1697553321000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1038\/oby.2009.398"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,7]]},"references-count":21,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2010,7]]}},"alternative-id":["10.1038\/oby.2009.398"],"URL":"https:\/\/doi.org\/10.1038\/oby.2009.398","archive":["Portico"],"relation":{},"ISSN":["1930-7381","1930-739X"],"issn-type":[{"value":"1930-7381","type":"print"},{"value":"1930-739X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,7]]},"assertion":[{"value":"2012-09-06","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}