{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T21:50:41Z","timestamp":1763070641946},"reference-count":32,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2012,9,6]],"date-time":"2012-09-06T00:00:00Z","timestamp":1346889600000},"content-version":"vor","delay-in-days":614,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Obesity"],"published-print":{"date-parts":[[2011,1]]},"abstract":"<jats:p>Pericardial fat (Pfat) overlies the cardiac surface including atria and their inter\u2010 and intra\u2010conduction system. Through its local inflammatory effects, Pfat may predispose to atrial abnormalities that could be detected as changes in P\u2010wave morphology in the 12\u2010lead electrocardiogram (ECG). We evaluated the association between Pfat and ECG measurements of P wave and PR interval (referred to as P\u2010wave indexes): PR duration (PR\u2010dur), P\u2010wave duration (P\u2010dur), and P\u2010wave terminal force (P\u2010term), in the Multiethnic Study of Atherosclerosis (MESA). Participants with available Pfat measured by computed tomography (CT) and P\u2010wave indexes measured by ECG were included (<jats:italic>N<\/jats:italic> = 996). Differences in P\u2010wave indexes per 1 standard deviation difference in Pfat were tested in unadjusted linear regression analysis first, then adjusted for demographics (age, sex, and ethnicity), and further adjusted for measures of adiposity (BMI or waist circumference (WC)), or cardiovascular risk factors (hypertension (HTN), diabetes, and smoking). All P\u2010wave indexes were significantly associated with Pfat in unadjusted analyses (regression\u2010coefficient (\u03b2) (95% CI): PR\u2010dur (ms) 2.53 (1.02, 4.04), P\u2010dur (ms) 2.59 (1.84, 3.35), P\u2010term (\u00b5V\u00b7s) 0.25 (0.13, 0.36)). After demographics adjustment, P\u2010dur (1.68 (0.87, 2.49)) and P\u2010term (0.16 (0.04,0.28)), but not PR\u2010dur (1.11 (\u22120.52, 2.74)) were associated with Pfat. No associations were significant after adjustment for BMI, WC, or cardiovascular disease (CVD) risk factors. BMI and WC, separately, were significantly associated with P\u2010wave indexes in all models, including those that included Pfat as a covariate. BMI, but not WC, was associated with P\u2010wave indexes when the two were entered into the same model. In conclusion, Pfat is associated with P\u2010wave indexes, but not after adjusting for measures of adiposity or CVD risk factors. Among Pfat, BMI and WC, BMI had the most robust association with P\u2010wave indexes. These findings raise doubts about potential local effects of Pfat on atrial electrophysiology and morphology<\/jats:p>","DOI":"10.1038\/oby.2010.121","type":"journal-article","created":{"date-parts":[[2010,5,27]],"date-time":"2010-05-27T14:33:22Z","timestamp":1274970802000},"page":"179-184","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Pericardial Fat and Atrial Conduction Abnormalities in the Multiethnic Study of Atherosclerosis (MESA)"],"prefix":"10.1002","volume":"19","author":[{"given":"Michael J.","family":"Babcock","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elsayed Z.","family":"Soliman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingzhong","family":"Ding","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard A.","family":"Kronmal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David C.","family":"Goff\u2010Jr","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,9,6]]},"reference":[{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9150(00)00709-7"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2008.278"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.743062"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2007.03.019"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncpcardio0319"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1053\/pcad.2001.24598"},{"key":"e_1_2_8_8_2","first-page":"251","article-title":"Adiponectin expression in human epicardial adipose tissue in vivo is lower in patients with coronary artery disease","volume":"29","author":"Iacobellis G","year":"2005","journal-title":"Cytokine"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2840-5-1"},{"key":"e_1_2_8_10_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-144-7-200604040-00011"},{"key":"e_1_2_8_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11695-009-9924-5"},{"key":"e_1_2_8_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2006.04.016"},{"key":"e_1_2_8_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncpcardio0132"},{"key":"e_1_2_8_14_2","first-page":"3507","article-title":"Overweight, obesity and risk factors for atrial fibrillation or flutter\u2014secondary publication. 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