{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T02:51:10Z","timestamp":1761706270293},"reference-count":23,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2012,9,6]],"date-time":"2012-09-06T00:00:00Z","timestamp":1346889600000},"content-version":"vor","delay-in-days":555,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Obesity"],"published-print":{"date-parts":[[2011,3]]},"abstract":"<jats:p>Recently, a genome\u2010wide association study (GWAS) that identified eight single\u2010nucleotide polymorphisms (SNPs) associated with BMI highlighted a possible neuronal influence on the development of obesity. We hypothesized these SNPs would govern the response of BMI and subcutaneous fat to resistance training in young individuals (age = 24 years). We genotyped the eight GWAS\u2010identified SNPs in the article by Willer <jats:italic>et al<\/jats:italic>. in a cohort (<jats:italic>n<\/jats:italic> = 796) that undertook a 12\u2010week resistance\u2010training program. Females with a copy of the rare allele (C) for rs17782313 (<jats:italic>MC4R<\/jats:italic>) had significantly higher BMIs (CC\/CT: <jats:italic>n<\/jats:italic> = 174; 24.70 \u00b1 0.33 kg\/m<jats:sup>2<\/jats:sup>, TT: <jats:italic>n<\/jats:italic> = 278; 23.41 \u00b1 0.26 kg\/m<jats:sup>2<\/jats:sup>, <jats:italic>P<\/jats:italic> = 0.002), and the SNP explained 1.9% of overall variation in BMI. Males with a copy of the rare allele (T) for rs6548238 (<jats:italic>TMEM18<\/jats:italic>) had lower amounts of subcutaneous fat pretraining (CT\/TT: <jats:italic>n<\/jats:italic> = 65; 156,534 \u00b1 7,415 mm<jats:sup>3<\/jats:sup>, CC: <jats:italic>n<\/jats:italic> = 136; 177,825 \u00b1 5,139 mm<jats:sup>3<\/jats:sup>, <jats:italic>P<\/jats:italic> = 0.019) and males with a copy of the rare allele (A) for rs9939609 (<jats:italic>FTO<\/jats:italic>) lost a significant amount of subcutaneous fat with exercise (AT\/AA: <jats:italic>n<\/jats:italic> = 83; \u2212798.35 \u00b1 2,624.30 mm<jats:sup>3<\/jats:sup>, TT: <jats:italic>n<\/jats:italic> = 47; 9,435.23 \u00b1 3,494.44 mm<jats:sup>3<\/jats:sup>, <jats:italic>P<\/jats:italic> = 0.021). Females with a copy of the G allele for a missense variant in the <jats:italic>SH2B1<\/jats:italic> (rs7498665) was associated with less change of subcutaneous fat volume with exercise (AG\/GG: <jats:italic>n<\/jats:italic> = 191; 9,813 \u00b1 2,250 mm<jats:sup>3<\/jats:sup> vs. AA: <jats:italic>n<\/jats:italic> = 126; 770 \u00b1 2,772 mm<jats:sup>3<\/jats:sup>; <jats:italic>P<\/jats:italic> = 0.011). These data support the original finding that there is an association between measures of obesity and a variant near the <jats:italic>MC4R<\/jats:italic> gene and extends these results to a younger population and implicates <jats:italic>FTO, TMEM18<\/jats:italic>, and <jats:italic>SH2B1<\/jats:italic> polymorphisms in subcutaneous fat regulation.<\/jats:p>","DOI":"10.1038\/oby.2010.180","type":"journal-article","created":{"date-parts":[[2010,8,19]],"date-time":"2010-08-19T14:34:59Z","timestamp":1282228499000},"page":"662-666","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["<i>MC4R<\/i> Variant Is Associated With BMI but Not Response to Resistance Training in Young Females"],"prefix":"10.1002","volume":"19","author":[{"given":"Funda E.","family":"Orkunoglu\u2010Suer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brennan 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