{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:09:37Z","timestamp":1790813377614,"version":"4.1.0"},"reference-count":26,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2012,9,6]],"date-time":"2012-09-06T00:00:00Z","timestamp":1346889600000},"content-version":"vor","delay-in-days":463,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Obesity"],"published-print":{"date-parts":[[2011,6]]},"abstract":"<jats:p>\n                    Use of meal replacements (MRs) in lifestyle modification programs (LMPs) for obese adults significantly increases weight loss, compared with prescription of an isocaloric conventional diet (CD). This 12\u2010month randomized trial examined 113 obese adolescents (mean \u00b1 s.d. age of 15.0 \u00b1 1.3 years and BMI of 37.1 \u00b1 5.1 kg\/m\n                    <jats:sup>2<\/jats:sup>\n                    ) who were assigned to a LMP, combined with meal plans of 1,300\u20131,500 kcal\/day of CD (self\u2010selected foods) or MR (three SlimFast shakes, one prepackaged meal, five vegetable\/fruit servings). After month 4 (phase 1), participants originally treated with MR were unmasked to their phase 2 (months 5\u201312) random assignment: continued use of MR (i.e., MR+MR) or transitioned to CD (i.e., MR+CD). Participants initially treated with CD in phase 1, continued with CD (i.e., CD). All three groups were treated for an additional 8 months (phase 2). Regression models were used to evaluate percentage change in BMI from baseline to month 4 (phase 1), months 5\u201312 (phase 2), and baseline to month 12. At month 4, participants assigned to MR (\n                    <jats:italic>N<\/jats:italic>\n                    = 65) achieved a mean (\u00b1s.e.) 6.3 \u00b1 0.6% reduction in BMI, compared to a significantly (\n                    <jats:italic>P<\/jats:italic>\n                    = 0.01) smaller 3.8 \u00b1 0.8% for CD participants (\n                    <jats:italic>N<\/jats:italic>\n                    = 37). In phase 2, BMI increased significantly (\n                    <jats:italic>P<\/jats:italic>\n                    &lt; 0.001) in all three conditions, resulting in no significant (\n                    <jats:italic>P<\/jats:italic>\n                    = 0.39) differences between groups in percentage change in BMI at month 12. Across groups, mean reduction in BMI from baseline to month 12 was 3.4 \u00b1 0.7% (\n                    <jats:italic>P<\/jats:italic>\n                    &lt; 0.01). Use of MR significantly improved short\u2010term weight loss, compared with CD, but its continued use did not improve maintenance of lost weight.\n                  <\/jats:p>","DOI":"10.1038\/oby.2010.288","type":"journal-article","created":{"date-parts":[[2010,12,9]],"date-time":"2010-12-09T10:26:54Z","timestamp":1291890414000},"page":"1193-1199","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":72,"title":["Meal Replacements in the Treatment of Adolescent Obesity: A Randomized Controlled Trial"],"prefix":"10.1002","volume":"19","author":[{"given":"Robert I.","family":"Berkowitz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas A.","family":"Wadden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine A.","family":"Gehrman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chanelle T.","family":"Bishop\u2010Gilyard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rene\u00e9 H.","family":"Moore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leslie G.","family":"Womble","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanna L.","family":"Cronquist","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalie L.","family":"Trumpikas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorraine E.","family":"Levitt\u2010Katz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa S.","family":"Xanthopoulos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,9,6]]},"reference":[{"key":"e_1_2_7_2_2","first-page":"CD001872","article-title":"Interventions for treating obesity in children","author":"Luttikhuis Oude H","year":"2009","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2007-2329C"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ijo.0800495"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2006-2409"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ijo.0802258"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/69.2.198"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199212313272701"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/52.3.421"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2007.03.051"},{"key":"e_1_2_7_11_2","volume-title":"Weight Reduction and Pride (WRAP) Program: Teens' Edition","author":"Wadden TA","year":"2001"},{"key":"e_1_2_7_12_2","volume-title":"Weight Reduction and Pride (WRAP) Program: Parents' Edition","author":"Wadden TA","year":"2001"},{"key":"e_1_2_7_13_2","unstructured":"Dietary Guidelines for Americans. Washington DC:U.S. Department of Agriculture Department of Health and Human Services 2005."},{"key":"e_1_2_7_14_2","volume-title":"Measuring Obesity: Classification and Distribution of Anthropometric Data Nutr UD, EUR\/ICP\/NUT 125","author":"World Health Organization","year":"1989"},{"key":"e_1_2_7_15_2","volume-title":"Database & Statistics Software for Public Health Professionals","author":"Info E","year":"2002"},{"key":"e_1_2_7_16_2","volume-title":"Children's Depression Inventory: Technical Manual","author":"Kovacs MS","year":"2003"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3999(85)90010-8"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ijo.0800659"},{"key":"e_1_2_7_19_2","first-page":"1","article-title":"2000 CDC Growth Charts for the United States: methods and development","author":"Kuczmarski RJ","year":"2002","journal-title":"Vital Health Stat 11"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/0031-9384(82)90259-1"},{"key":"e_1_2_7_21_2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2009.165340"},{"key":"e_1_2_7_22_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.JCN.0000278959.75253.1d"},{"key":"e_1_2_7_23_2","doi-asserted-by":"publisher","DOI":"10.1001\/archpedi.157.8.773"},{"key":"e_1_2_7_24_2","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2008.637"},{"key":"e_1_2_7_25_2","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2008.224"},{"key":"e_1_2_7_26_2","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2002.16"},{"key":"e_1_2_7_27_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-134-1-200101020-00007"}],"container-title":["Obesity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1038%2Foby.2010.288","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1038%2Foby.2010.288","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1038\/oby.2010.288","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T22:59:43Z","timestamp":1697497183000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1038\/oby.2010.288"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,6]]},"references-count":26,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2011,6]]}},"alternative-id":["10.1038\/oby.2010.288"],"URL":"https:\/\/doi.org\/10.1038\/oby.2010.288","archive":["Portico"],"relation":{},"ISSN":["1930-7381","1930-739X"],"issn-type":[{"value":"1930-7381","type":"print"},{"value":"1930-739X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,6]]},"assertion":[{"value":"2012-09-06","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}