{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,18]],"date-time":"2023-10-18T05:47:58Z","timestamp":1697608078430},"reference-count":11,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2012,9,6]],"date-time":"2012-09-06T00:00:00Z","timestamp":1346889600000},"content-version":"vor","delay-in-days":463,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Obesity"],"published-print":{"date-parts":[[2011,6]]},"abstract":"<jats:p>Retinol\u2010binding protein 4 (RBP4) is a plasma protein which is elevated in obesity and type 2 diabetes. We aimed to investigate whether RBP4 represents a mechanism underlying the associations between low birth weight (LBW), high\u2010fat diet, and insulin resistance. Forty\u2010six young, lean men with low (<jats:italic>n<\/jats:italic> = 20) or normal (<jats:italic>n<\/jats:italic> = 26) birth weight underwent a 5\u2010day high\u2010fat high\u2010calorie (HFHC) dietary intervention. <jats:italic>In vivo<\/jats:italic> glucose metabolism was assessed by euglycemic\u2010hyperinsulinemic clamp, glucose tracer and intravenous glucose tolerance test techniques. Body composition was measured by a dual\u2010energy x\u2010ray absorptiometry scan, and plasma RBP4 by an enzyme\u2010linked immunosorbent assay. RBP4 was not associated with birth weight, but with BMI (\u03b2 = 0.9 \u00b5g\/ml (0.08;1.8) (95% confidence interval), <jats:italic>P<\/jats:italic> = 0.03) and plasma levels of low\u2010density lipoprotein cholesterol (\u03b2 = 5.3 \u00b5g\/ml (1.9;8.7), <jats:italic>P<\/jats:italic> = 0.03) and triglycerides (\u03b2 = 15.4 \u00b5g\/ml (9.5;21.3), <jats:italic>P<\/jats:italic> &lt; 0.001). Under baseline diet conditions, RBP4 was associated with decreased disposition index (D<jats:sub>i<\/jats:sub>) (\u03b2 = \u22122.4% (\u22124.5%;\u22120.2%), <jats:italic>P<\/jats:italic> = 0.04) and increased basal hepatic glucose production rate (HGP) (\u03b2 = 0.02 mg kg<jats:sup>\u22121<\/jats:sup> min<jats:sup>\u22121<\/jats:sup> (0.002;0.04), <jats:italic>P<\/jats:italic> = 0.03), but not associated with peripheral glucose disposal rate or hepatic insulin resistance index. RBP4 levels were not influenced by overfeeding or related to peripheral and hepatic insulin resistance provoked by the dietary intervention. In conclusion, plasma RBP4 in young men associates with components of the metabolic syndrome, but is not determined by birth weight and seems not to be involved in short\u2010term high\u2010fat diet\u2010induced insulin resistance.<\/jats:p>","DOI":"10.1038\/oby.2010.311","type":"journal-article","created":{"date-parts":[[2010,12,16]],"date-time":"2010-12-16T15:40:02Z","timestamp":1292514002000},"page":"1304-1306","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Retinol\u2010Binding Protein 4 in Young Men With Low Versus Normal Birth Weight: Physiological Response to Short\u2010Term Overfeeding"],"prefix":"10.1002","volume":"19","author":[{"given":"Rasmus","family":"Ribel\u2010Madsen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charlotte","family":"Br\u00f8ns","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Friedrichsen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pernille","family":"Poulsen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Allan","family":"Vaag","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,9,6]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature03711"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa054862"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.2337\/db08-1019"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-1326.2008.00901.x"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/86.5.1310"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2006-2668"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.303.6809.1019"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-007-9031-0"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2009.169078"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2008-0630"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2009-2413"}],"container-title":["Obesity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1038%2Foby.2010.311","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1038%2Foby.2010.311","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1038\/oby.2010.311","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,17]],"date-time":"2023-10-17T03:00:29Z","timestamp":1697511629000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1038\/oby.2010.311"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,6]]},"references-count":11,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2011,6]]}},"alternative-id":["10.1038\/oby.2010.311"],"URL":"https:\/\/doi.org\/10.1038\/oby.2010.311","archive":["Portico"],"relation":{},"ISSN":["1930-7381","1930-739X"],"issn-type":[{"value":"1930-7381","type":"print"},{"value":"1930-739X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,6]]},"assertion":[{"value":"2012-09-06","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}