{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T06:41:21Z","timestamp":1773297681945,"version":"3.50.1"},"reference-count":46,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2012,9,6]],"date-time":"2012-09-06T00:00:00Z","timestamp":1346889600000},"content-version":"vor","delay-in-days":463,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Obesity"],"published-print":{"date-parts":[[2011,6]]},"abstract":"<jats:p>Obesity is associated with well\u2010known cardiovascular risk factors and a lower life expectancy. This study investigated whether nonoperative nutritional treatment of obesity without comorbidities influenced the carotid intima\u2010media thickness (c\u2010IMT) in the long run. Fifty\u2010four subjects of an original cohort of 251 subjects were re\u2010evaluated 10 years after a medical nutritional treatment (MNT) with cognitive\u2010behavioral approach for uncomplicated obesity. Forty subjects were classified as failure (10\u2010year body weight change &gt;0.5 kg) and 14 (body weight change \u22640.5 kg) as a success of the MNT. Ten years after MNT, c\u2010IMT significantly increased (0.06 \u00b1 0.02 mm; <jats:italic>P<\/jats:italic> = 0.004) in the failure group and significantly decreased (\u22120.07 \u00b1 0.03 mm; <jats:italic>P<\/jats:italic> = 0.027) in the success group. Ten\u2010year change in c\u2010IMT correlated significantly with 10\u2010year change in body weight (<jats:italic>r<\/jats:italic> = 0.28; <jats:italic>P<\/jats:italic> = 0.040). Multiple stepwise linear regression analysis demonstrated that age, final BMI, and group (success or failure) influenced independently the 10\u2010year c\u2010IMT. In conclusion, this study is in agreement with the possibility that the successful MNT of obesity may be an effective choice in the long run and seems to indicate that it may be able to reduce the cardiovascular risk as reflected by the change in c\u2010IMT.<\/jats:p>","DOI":"10.1038\/oby.2010.313","type":"journal-article","created":{"date-parts":[[2010,12,23]],"date-time":"2010-12-23T15:33:12Z","timestamp":1293118392000},"page":"1187-1192","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Long\u2010Term Effects of a Multidisciplinary Treatment of Uncomplicated Obesity on Carotid Intima\u2010Media Thickness"],"prefix":"10.1002","volume":"19","author":[{"given":"Silvio","family":"Buscemi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John 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