{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T22:55:29Z","timestamp":1770504929092,"version":"3.49.0"},"reference-count":38,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2012,9,6]],"date-time":"2012-09-06T00:00:00Z","timestamp":1346889600000},"content-version":"vor","delay-in-days":402,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Obesity"],"published-print":{"date-parts":[[2011,8]]},"abstract":"<jats:p>We assessed (i) the association between early arterial disease and factors linked to adiposity, dietary habits, and family in a young cohort of 151 obese children and adolescents with less than or equal to one cardiovascular (CV) risk factor, (ii) whether in subjects with carotid calcifications there was an imbalance of calcium\u2010phosphorus homeostasis. Measurement included: carotid ultrasound, oral glucose tolerance test, anthropometry, body composition, dietary history, white blood cells count, lipids, uric acid, adiponectin, insulin, C\u2010reactive protein, plasminogen activator inhibitor 1 (PAI\u20101), 25\u2010hydroxyvitamin D, parathyroid hormone (PTH), calcium and phosphorus. Obese children with carotid artery intima media thickness (cIMT) values &gt;75\u00b0 percentile (0.55 mm), compared to those with lower cIMT, were more obese, more often pubertal and had higher prevalence of family history of CV disease (CVD) (<jats:italic>P<\/jats:italic> &lt; 0.05), higher plasma PAI\u20101 and uric acid (<jats:italic>P<\/jats:italic> &lt; 0.001) and lower adiponectin (<jats:italic>P<\/jats:italic> &lt; 0.05) and high\u2010density lipoprotein (HDL) cholesterol levels (<jats:italic>P<\/jats:italic> &lt; 0.05). After adjustment for sex, age, puberty, obesity, and insulin levels, only PAI\u2010I remained significantly different between the two groups (10.9 (7.2\u201329.8) vs. 6.2 (4.3\u201310.6) ng\/ml, <jats:italic>P<\/jats:italic> &lt; 0.001). Dietary intake did not affect cIMT values. Eight percent of subjects showed nonatherosclerotic carotid calcifications with patchy pattern. These children had a worse lipid profile (<jats:italic>P<\/jats:italic> &lt; 0.05) and higher plasma PTH levels (48.6 \u00b1 21.5 vs 38.5 \u00b1 16.9 pg\/ml, <jats:italic>P<\/jats:italic> &lt; 0.05) that were inversely associated with 25\u2010hydroxyvitamin D levels (<jats:italic>r<\/jats:italic> = 0.245, <jats:italic>P<\/jats:italic> &lt; 0.01). Present results suggest that (i) several adiposity\u2010related factors may play a role in promoting the development of early arterial diseases in young subjects with a benign phenotype of obesity, (ii) a PTH rise resulting from a subclinical imbalance in calcium\u2010phosphorus homeostasis may affect the biological process of vascular calcifications.<\/jats:p>","DOI":"10.1038\/oby.2010.342","type":"journal-article","created":{"date-parts":[[2011,1,27]],"date-time":"2011-01-27T15:29:23Z","timestamp":1296142163000},"page":"1684-1689","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Factors Associated With Early Atherosclerosis and Arterial Calcifications in Young Subjects With a Benign Phenotype of 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