{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T07:35:05Z","timestamp":1792136105386,"version":"4.4.0"},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2012,9,6]],"date-time":"2012-09-06T00:00:00Z","timestamp":1346889600000},"content-version":"vor","delay-in-days":249,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Obesity"],"published-print":{"date-parts":[[2012,1]]},"abstract":"<jats:p>Obesity is a major risk factor for developing coronary artery disease. The impact of obesity on prognosis among those with established coronary disease is less clear. The objective of this study was to evaluate the effect of obesity on repeat revascularization in patients undergoing percutaneous coronary intervention (PCI) with drug\u2010eluting stents (DES). We examined 6,083 patients who were divided into three groups according to BMI: normal (BMI 18.5\u201324.9 kg\/m<jats:sup>2<\/jats:sup>, <jats:italic>n<\/jats:italic> = 1,592); overweight (BMI 25\u201329.9 kg\/m<jats:sup>2<\/jats:sup>, <jats:italic>n<\/jats:italic> = 3,026) and obese (BMI &gt;30 kg\/m<jats:sup>2<\/jats:sup>, <jats:italic>n<\/jats:italic> = 1,465). The follow\u2010up focused on clinical\u2010driven repeat revascularization, including target lesion revascularization (TLR) and nonTLR. Median follow\u2010up was 26 months (interquartile range 20\u201332). There was no significant difference in the incidence of TLR among normal, overweight, and obese patients (6.3% vs. 6.1% vs. 7.1%; <jats:italic>P<\/jats:italic> = 0.423). In contrast, the incidence of nonTLR was significantly higher in obese patients compared with normal and overweight (8.4% vs. 6.0% vs. 5.8%, <jats:italic>P<\/jats:italic> = 0.003). Multivariate analysis showed that obesity was an independent predictor of nonTLR during follow\u2010up (hazard ratio = 1.39; 95% confidence interval = 1.06\u20131.83; <jats:italic>P<\/jats:italic> = 0.019), along with diabetes and hypercholesterolemia. Concomitant use of statins was independently associated with decreased risk of nonTLR (hazard ratio = 0.75; 95% confidence interval = 0.62\u20130.92; <jats:italic>P<\/jats:italic> = 0.005). In conclusion, among patients undergoing PCI with DES, obesity was not associated with TLR, but was associated with a higher risk of nonTLR.<\/jats:p>","DOI":"10.1038\/oby.2011.187","type":"journal-article","created":{"date-parts":[[2011,6,30]],"date-time":"2011-06-30T12:38:09Z","timestamp":1309437489000},"page":"141-146","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Effect of Obesity on Repeat Revascularization in Patients Undergoing Percutaneous Coronary Intervention With Drug\u2010Eluting Stents"],"prefix":"10.1002","volume":"20","author":[{"given":"Zhi Jian","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu Jie","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying 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