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The study was a pilot randomized trial. Participants (<jats:italic>n<\/jats:italic> = 50) were primary care patients with obesity and at least one comorbid condition (diabetes, hypertension, dyslipidemia, or obstructive sleep apnea). Each participant received eight weight loss counseling visits as well as portion\u2010controlled foods for weight loss. Participants were randomized to full subsidy or partial subsidy (2 vs. 1 meal per day provided). The primary outcome was weight change after 4 months. Secondary outcomes included changes in blood pressure, waist circumference, and health\u2010related quality of life. Participants in the full and partial subsidy groups lost 5.9 and 5.3\u00a0kg, equivalent to 5.3% and 5.1% of initial weight, respectively (<jats:italic>P<\/jats:italic> = 0.71). Changes in secondary outcomes were similar in the two groups. A partial subsidy was feasible and induced a clinically similar amount of weight loss, compared to a full subsidy. 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