{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T00:03:06Z","timestamp":1790380986682,"version":"4.1.0"},"reference-count":40,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2012,10,17]],"date-time":"2012-10-17T00:00:00Z","timestamp":1350432000000},"content-version":"vor","delay-in-days":77,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Obesity"],"published-print":{"date-parts":[[2012,8]]},"abstract":"<jats:p>Obesity induced inflammation may promote periodontal tissue destruction and bone resorption inducing tooth loss. We examined the association between measures of adiposity and self\u2010reported periodontal disease, using data from 36,910 healthy male participants of the Health Professionals Follow\u2010Up Study (HPFS) who were free of periodontal disease at baseline and followed for \u226420 years (1986\u20132006). Self\u2010reported height, weight, and periodontal disease data were collected at baseline, weight and periodontal disease were additionally collected on biennial follow\u2010up questionnaires and waist and hip circumference were self\u2010reported in 1987. These self\u2010reported measures have been previously validated. The multivariable adjusted associations between BMI (kg\/m<jats:sup>2<\/jats:sup>), waist circumference (WC), waist\u2010to\u2010hip ratio (WHR), and first report of periodontal disease diagnosis were evaluated using time\u2010varying Cox models. We observed 2,979 new periodontal disease diagnoses during 596,561 person\u2010years of follow\u2010up. Significant associations and trends were observed between all measures of adiposity and periodontal disease after adjusting for age, smoking, race, dental profession, physical activity, fruit and vegetable intake, alcohol consumption, and diabetes status at baseline. BMI \u226530 kg\/m<jats:sup>2<\/jats:sup> compared to BMI 18.5\u201324.9 kg\/m<jats:sup>2<\/jats:sup> was significantly associated with greater risk of periodontal disease (hazard ratios (HR) = 1.30; 95% confidence interval (CI): 1.17\u20131.45). Elevated WC and WHR were significantly associated with a greater risk of periodontal disease (HR for extreme quintiles: WC = 1.27, 95% CI: 1.11\u20131.46; WHR = 1.34, 95% CI: 1.17\u20131.54). The associations of BMI and WC were significant even among nondiabetics and never smokers. Given the high prevalence of overweight, obesity, and periodontal disease this association may be of substantial public health importance.<\/jats:p>","DOI":"10.1038\/oby.2011.291","type":"journal-article","created":{"date-parts":[[2011,10,6]],"date-time":"2011-10-06T12:29:16Z","timestamp":1317904156000},"page":"1718-1725","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":56,"title":["Prospective Associations Between Measures of Adiposity and Periodontal Disease"],"prefix":"10.1002","volume":"20","author":[{"given":"Monik","family":"Jimenez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank B.","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel","family":"Marino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaumudi J.","family":"Joshipura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,10,17]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.295.13.1549"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2007.505"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/acprof:oso\/9780195312911.003.0008"},{"key":"e_1_2_7_5_2","first-page":"685","author":"US Department of Health and Human Services","year":"2000","journal-title":"Oral Health in America: A Report of the Surgeon General"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1177\/154405910708600503"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.2007.00207.x"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2010.100321"},{"key":"e_1_2_7_9_2","author":"Health Professionals Follow\u2010up Study","year":"2008","journal-title":"Description of HPFS Study Design and Questionnaires"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a115598"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/00001648-199011000-00009"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1752-7325.2002.tb03431.x"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a117385"},{"key":"e_1_2_7_14_2","first-page":"i","article-title":"Obesity: preventing and managing the global epidemic. 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