{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T00:37:09Z","timestamp":1783557429423,"version":"3.55.0"},"reference-count":41,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2012,9,11]],"date-time":"2012-09-11T00:00:00Z","timestamp":1347321600000},"content-version":"vor","delay-in-days":163,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Obesity"],"published-print":{"date-parts":[[2012,4]]},"abstract":"<jats:p>Depressed individuals are frequently excluded from weight loss trials because of fears that weight reduction may precipitate mood disorders, as well as concerns that depressed participants will not lose weight satisfactorily. The present study examined participants in the Look AHEAD study to determine whether moderate weight loss would be associated with incident symptoms of depression and suicidal ideation, and whether symptoms of depression at baseline would limit weight loss at 1 year. Overweight\/obese adults with type 2 diabetes (<jats:italic>n<\/jats:italic> = 5,145) were randomly assigned to an Intensive Lifestyle Intervention (ILI) or a usual care group, Diabetes Support and Education (DSE). Of these, 5,129 participants completed the Beck Depression Inventory (BDI) and had their weight measured at baseline and 1 year. Potentially significant symptoms of depression were defined by a BDI score \u226510. Participants in ILI lost 8.6 \u00b1 6.9% of initial weight at 1 year, compared to 0.7 \u00b1 4.8% for DSE (<jats:italic>P<\/jats:italic> &lt; 0.001, effect size = 1.33), and had a reduction of 1.4 \u00b1 4.7 points on the BDI, compared to 0.4 \u00b1 4.5 for DSE (<jats:italic>P<\/jats:italic> &lt; 0.001, effect size = 0.23). At 1 year, the incidence of potentially significant symptoms of depression was significantly lower in the ILI than DSE group (6.3% vs. 9.6%) (relative risk (RR) = 0.66, 95% confidence interval (CI) = 0.5, 0.8; <jats:italic>P<\/jats:italic> &lt; 0.001). In the ILI group, participants with and without symptoms of depression lost 7.8 \u00b1 6.7% and 8.7 \u00b1 6.9%, respectively, a difference not considered clinically meaningful. Intentional weight loss was not associated with the precipitation of symptoms of depression, but instead appeared to protect against this occurrence. Mild (or greater) symptoms of depression at baseline did not prevent overweight\/obese individuals with type 2 diabetes from achieving significant weight loss.<\/jats:p>","DOI":"10.1038\/oby.2011.315","type":"journal-article","created":{"date-parts":[[2011,10,20]],"date-time":"2011-10-20T14:32:20Z","timestamp":1319121140000},"page":"783-793","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":92,"title":["One\u2010Year Changes in Symptoms of Depression and Weight in Overweight\/Obese Individuals With Type 2 Diabetes in the Look AHEAD Study"],"prefix":"10.1002","volume":"20","author":[{"given":"Lucy F.","family":"Faulconbridge","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas A.","family":"Wadden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard R.","family":"Rubin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rena R.","family":"Wing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael P.","family":"Walkup","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony N.","family":"Fabricatore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mace","family":"Coday","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brent","family":"Van Dorsten","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David L.","family":"Mount","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda J.","family":"Ewing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Look AHEAD Research Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,9,11]]},"reference":[{"key":"e_1_2_8_2_2","doi-asserted-by":"crossref","DOI":"10.5749\/j.ctv9b2tqv","volume-title":"Biology of Human Starvation","author":"Keys A","year":"1950"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(57)90359-5"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1139\/H07-137"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2007.307"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.1080\/08964280903334527"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/0022-4537.00115"},{"key":"e_1_2_8_8_2","volume-title":"The Obesity Myth: Why America's Obsession with Weight is Hazardous to Your Health","author":"Campos P","year":"2005"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinternmed.2009.329"},{"issue":"1","key":"e_1_2_8_10_2","doi-asserted-by":"crossref","first-page":"S17","DOI":"10.33549\/physiolres.931486","article-title":"Hormonal and psychobehavioral predictors of weight loss in response to a short\u2010term weight reduction program in obese women","volume":"57","author":"Hainer V","year":"2008","journal-title":"Physiol Res"},{"key":"e_1_2_8_11_2","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1037\/0022-006X.62.1.165","article-title":"One\u2010year behavioral treatment of obesity: comparison of moderate and severe caloric restriction and the effects of weight maintenance therapy","volume":"62","author":"Wadden TA","year":"1994","journal-title":"J Consult Clin Psychol"},{"key":"e_1_2_8_12_2","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.28.4.830"},{"key":"e_1_2_8_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4603(95)00081-X"},{"key":"e_1_2_8_14_2","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.15.2.253"},{"key":"e_1_2_8_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2008.647"},{"key":"e_1_2_8_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ijo.0802570"},{"key":"e_1_2_8_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ijo.0802473"},{"key":"e_1_2_8_18_2","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.25.11.1992"},{"key":"e_1_2_8_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ijo.0801128"},{"key":"e_1_2_8_20_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.285.9.1172"},{"key":"e_1_2_8_21_2","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2007.8"},{"key":"e_1_2_8_22_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.161.2.218"},{"key":"e_1_2_8_23_2","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.24.6.1069"},{"key":"e_1_2_8_24_2","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.26.1.104"},{"key":"e_1_2_8_25_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc07-0048"},{"key":"e_1_2_8_26_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinternmed.2008.544"},{"key":"e_1_2_8_27_2","volume-title":"FDA Briefing Document: Zimulti (rimonabant) Tablets, 20 mg","author":"US Food and Drug Administration Advisory Committee","year":"2007"},{"key":"e_1_2_8_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)61721-8"},{"key":"e_1_2_8_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0197-2456(03)00064-3"},{"key":"e_1_2_8_30_2","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2008.637"},{"key":"e_1_2_8_31_2","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.25.12.2165"},{"key":"e_1_2_8_32_2","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1961.01710120031004"},{"key":"e_1_2_8_33_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006842-199701000-00004"},{"key":"e_1_2_8_34_2","volume-title":"Beck Depression Inventory Manual","author":"Beck AT","year":"1987"},{"key":"e_1_2_8_35_2","volume-title":"Binge Eating Disorder Clinical Interview","author":"Spitzer RL","year":"1994"},{"key":"e_1_2_8_36_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005650-199206000-00002"},{"key":"e_1_2_8_37_2","doi-asserted-by":"publisher","DOI":"10.1037\/0022-006X.67.6.894"},{"key":"e_1_2_8_38_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc07-1827"},{"key":"e_1_2_8_39_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa050156"},{"key":"e_1_2_8_40_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.286.11.1331"},{"key":"e_1_2_8_41_2","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.65.12.1447"},{"key":"e_1_2_8_42_2","unstructured":"Department of Health and Human Service Public Health Service Food and Drug Administration Center for Drug Evaluation and Research Memorandum 16 November 2006: Overview for December 13 Meeting of Psychopharmacologic Drugs Advisory Committee (PDAC). Appendix 2: Request to Sponsors \u2013 Advice for the pharmaceutical industry in exploring their placebo\u2010controlled clinical trials databases for suicidality and preparing data sets for analysis by FDA. <http:www.fda.govohrmsdocketsac06briefing2006\u20104272b1\u201001\u2010fda.pdf>"}],"container-title":["Obesity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1038%2Foby.2011.315","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1038%2Foby.2011.315","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1038\/oby.2011.315","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,17]],"date-time":"2023-10-17T05:15:05Z","timestamp":1697519705000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1038\/oby.2011.315"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,4]]},"references-count":41,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2012,4]]}},"alternative-id":["10.1038\/oby.2011.315"],"URL":"https:\/\/doi.org\/10.1038\/oby.2011.315","archive":["Portico"],"relation":{},"ISSN":["1930-7381","1930-739X"],"issn-type":[{"value":"1930-7381","type":"print"},{"value":"1930-739X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,4]]},"assertion":[{"value":"2012-09-11","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}