{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T02:53:24Z","timestamp":1778900004649,"version":"3.51.4"},"reference-count":41,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2012,12,31]],"date-time":"2012-12-31T00:00:00Z","timestamp":1356912000000},"content-version":"vor","delay-in-days":30,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Obesity"],"published-print":{"date-parts":[[2012,12]]},"abstract":"<jats:p>Obesity is a highly heritable trait and a growing public health problem. African Americans (AAs) are a genetically diverse, yet understudied population with a high prevalence of obesity (BMI &gt;30 kg\/m<jats:sup>2<\/jats:sup>). Recent studies based upon single\u2010nucleotide polymorphisms (SNPs) have identified genetic markers associated with obesity. However, a large proportion of the heritability of obesity remains unexplained. Copy number variation (CNV) has been cited as a possible source of missing heritability in common diseases such as obesity. We conducted a CNV genome\u2010wide association study of BMI in two African\u2010American cohorts from Genetic Epidemiology Network of Arteriopathy (GENOA) and Hypertension Genetic Epidemiology Network (HyperGEN). We performed independent and identical association analyses in each study, then combined the results in a meta\u2010analysis. We identified three CNVs associated with BMI, obesity, and other obesity\u2010related traits after adjusting for multiple testing. These CNVs overlap the <jats:italic>PARK2<\/jats:italic>, <jats:italic>GYPA<\/jats:italic>, and <jats:italic>SGCZ<\/jats:italic> genes. Our results suggest that CNV may play a role in the etiology of obesity in AAs.<\/jats:p>","DOI":"10.1038\/oby.2012.162","type":"journal-article","created":{"date-parts":[[2012,6,22]],"date-time":"2012-06-22T12:34:53Z","timestamp":1340368493000},"page":"2431-2437","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Copy Number Variations Associated With Obesity\u2010Related Traits in African Americans: A Joint Analysis Between GENOA and HyperGEN"],"prefix":"10.1002","volume":"20","author":[{"given":"Wei","family":"Zhao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nathan E.","family":"Wineinger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hemant K.","family":"Tiwari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas 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