{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T02:51:04Z","timestamp":1791255064061,"version":"4.1.0"},"reference-count":41,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2012,10,17]],"date-time":"2012-10-17T00:00:00Z","timestamp":1350432000000},"content-version":"vor","delay-in-days":16,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Obesity"],"published-print":{"date-parts":[[2012,10]]},"abstract":"<jats:p>The lipase A, lysosomal acid, cholesterol esterase enzyme (LIPA) is involved in the hydrolysis of triglycerides (TGs) and cholesteryl esters (CEs) delivered to lysosomes. <jats:italic>LIPA<\/jats:italic> deficiency in human causes two distinct phenotypes characterized by intracellular storage of CE and derangements in the control of cholesterol production, namely the Wolman disease (WD) and the CE storage disease (CESD). To test the potential association of <jats:italic>LIPA<\/jats:italic> gene polymorphisms with obesity\u2010related metabolic complications, promoter, exons, and intronic flanking regions of the <jats:italic>LIPA<\/jats:italic> gene were first sequenced in 25 individuals. From the 14 common polymorphisms identified, 12 tagging single\u2010nucleotide polymorphisms (tSNPs) were genotyped in a cohort of 1,751 obese individuals. After adjustments for the effect of age, sex, diabetes, and medication, the C allele of SNP rs1051338 was associated with lower blood pressure (BP; systolic (SBP) <jats:italic>P<\/jats:italic> = 0.004; diastolic (DBP) <jats:italic>P<\/jats:italic> = 0.006). Three of the tested SNPs were associated with modifications of the plasma lipid profile. The G\/G genotype of rs2071509 was associated with higher high\u2010density lipoprotein cholesterol (HDL\u2010C) levels (<jats:italic>P<\/jats:italic> = 0.009) and minor allele of rs1131706 was also associated with higher HDL\u2010C (<jats:italic>P<\/jats:italic> = 0.004) and an association between rs3802656 and total cholesterol (total\u2010C)\/HDL\u2010C ratio was identified (<jats:italic>P<\/jats:italic> = 0.04). These results thus suggest that <jats:italic>LIPA<\/jats:italic> polymorphisms contribute to the interindividual variability observed in obesity\u2010related metabolic complications.<\/jats:p>","DOI":"10.1038\/oby.2012.52","type":"journal-article","created":{"date-parts":[[2012,3,7]],"date-time":"2012-03-07T12:27:30Z","timestamp":1331123250000},"page":"2075-2082","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Association of <i>LIPA<\/i> Gene Polymorphisms With Obesity\u2010Related Metabolic Complications Among Severely Obese 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