{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T01:37:16Z","timestamp":1789349836488,"version":"build-2803163510"},"reference-count":43,"publisher":"Springer Science and Business Media LLC","issue":"32","license":[{"start":{"date-parts":[[2008,3,31]],"date-time":"2008-03-31T00:00:00Z","timestamp":1206921600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2008,3,31]],"date-time":"2008-03-31T00:00:00Z","timestamp":1206921600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Oncogene"],"published-print":{"date-parts":[[2008,7,24]]},"DOI":"10.1038\/onc.2008.81","type":"journal-article","created":{"date-parts":[[2008,3,31]],"date-time":"2008-03-31T11:41:09Z","timestamp":1206963669000},"page":"4392-4401","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["c-Myc and \u03b2-catenin cooperate with loss of p53 to generate multiple members of the primitive neuroectodermal tumor family in mice"],"prefix":"10.1038","volume":"27","author":[{"given":"H","family":"Momota","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A H","family":"Shih","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M A","family":"Edgar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E C","family":"Holland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2008,3,31]]},"reference":[{"key":"BFonc200881_CR1","first-page":"5649","volume":"54","author":"AM Adesina","year":"1994","unstructured":"Adesina AM, Nalbantoglu J, Cavenee WK . (1994). p53 gene mutation and mdm2 gene amplification are uncommon in medulloblastoma. Cancer Res 54: 5649\u20135651.","journal-title":"Cancer Res"},{"key":"BFonc200881_CR2","first-page":"84","volume":"113","author":"UE Anwer","year":"1989","unstructured":"Anwer UE, Smith TW, DeGirolami U, Wilkinson HA . (1989). Medulloblastoma with cartilaginous differentiation. Arch Pathol Lab Med 113: 84\u201388.","journal-title":"Arch Pathol Lab Med"},{"key":"BFonc200881_CR3","doi-asserted-by":"publisher","first-page":"857","DOI":"10.1093\/jnen\/59.10.857","volume":"59","author":"HG Brown","year":"2000","unstructured":"Brown HG, Kepner JL, Perlman EJ, Friedman HS, Strother DR, Duffner PK et al. (2000). \u2018Large cell\/anaplastic\u2019 medulloblastomas: a Pediatric Oncology Group Study. J Neuropathol Exp Neurol 59: 857\u2013865.","journal-title":"J Neuropathol Exp Neurol"},{"key":"BFonc200881_CR4","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s004010100419","volume":"103","author":"CG Carlotti Jr","year":"2002","unstructured":"Carlotti Jr CG, Neder L, Colli BO, dos Santos MB, Garcia AS, Elias Jr J et al. (2002). Evaluation of proliferative index and cell cycle protein expression in choroid plexus tumors in children. Acta Neuropathol (Berl) 103: 1\u201310.","journal-title":"Acta Neuropathol (Berl)"},{"key":"BFonc200881_CR5","doi-asserted-by":"publisher","first-page":"1913","DOI":"10.1101\/gad.903001","volume":"15","author":"C Dai","year":"2001","unstructured":"Dai C, Celestino JC, Okada Y, Louis DN, Fuller GN, Holland EC . (2001). PDGF autocrine stimulation dedifferentiates cultured astrocytes and induces oligodendrogliomas and oligoastrocytomas from neural progenitors and astrocytes in vivo. Genes Dev 15: 1913\u20131925.","journal-title":"Genes Dev"},{"key":"BFonc200881_CR6","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1186\/1471-2407-5-19","volume":"5","author":"CG Eberhart","year":"2005","unstructured":"Eberhart CG, Chaudhry A, Daniel RW, Khaki L, Shah KV, Gravitt PE . (2005). Increased p53 immunopositivity in anaplastic medulloblastoma and supratentorial PNET is not caused by JC virus. BMC Cancer 5: 19.","journal-title":"BMC Cancer"},{"key":"BFonc200881_CR7","doi-asserted-by":"publisher","first-page":"552","DOI":"10.1002\/cncr.10189","volume":"94","author":"CG Eberhart","year":"2002","unstructured":"Eberhart CG, Kepner JL, Goldthwaite PT, Kun LE, Duffner PK, Friedman HS et al. (2002). Histopathologic grading of medulloblastomas: a Pediatric Oncology Group study. Cancer 94: 552\u2013560.","journal-title":"Cancer"},{"key":"BFonc200881_CR8","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1016\/j.molbrainres.2003.11.016","volume":"121","author":"AJ Frank","year":"2004","unstructured":"Frank AJ, Hernan R, Hollander A, Lindsey JC, Lusher ME, Fuller CE et al. (2004). The TP53-ARF tumor suppressor pathway is frequently disrupted in large\/cell anaplastic medulloblastoma. Brain Res Mol Brain Res 121: 137\u2013140.","journal-title":"Brain Res Mol Brain Res"},{"key":"BFonc200881_CR9","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1038\/sj.neo.7900200","volume":"4","author":"D Fults","year":"2002","unstructured":"Fults D, Pedone C, Dai C, Holland EC . (2002). MYC expression promotes the proliferation of neural progenitor cells in culture and in vivo. Neoplasia 4: 32\u201339.","journal-title":"Neoplasia"},{"key":"BFonc200881_CR10","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1111\/j.1750-3639.2003.tb00039.x","volume":"13","author":"M Gessi","year":"2003","unstructured":"Gessi M, Giangaspero F, Pietsch T . (2003). Atypical teratoid\/rhabdoid tumors and choroid plexus tumors: when genetics \u2018surprise\u2019 pathology. Brain Pathol 13: 409\u2013414.","journal-title":"Brain Pathol"},{"key":"BFonc200881_CR11","doi-asserted-by":"publisher","first-page":"1109","DOI":"10.1126\/science.277.5329.1109","volume":"277","author":"LV Goodrich","year":"1997","unstructured":"Goodrich LV, Milenkovic L, Higgins KM, Scott MP . (1997). Altered neural cell fates and medulloblastoma in mouse patched mutants. Science 277: 1109\u20131113.","journal-title":"Science"},{"key":"BFonc200881_CR12","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/S1535-6108(02)00024-7","volume":"1","author":"DR Green","year":"2002","unstructured":"Green DR, Evan GI . (2002). A matter of life and death. Cancer Cell 1: 19\u201330.","journal-title":"Cancer Cell"},{"key":"BFonc200881_CR13","doi-asserted-by":"publisher","first-page":"1509","DOI":"10.1126\/science.281.5382.1509","volume":"281","author":"TC He","year":"1998","unstructured":"He TC, Sparks AB, Rago C, Hermeking H, Zawel L, da Costa LT et al. (1998). Identification of c-MYC as a target of the APC pathway. Science 281: 1509\u20131512.","journal-title":"Science"},{"key":"BFonc200881_CR14","doi-asserted-by":"publisher","first-page":"727","DOI":"10.1016\/j.devcel.2005.02.013","volume":"8","author":"TP Hill","year":"2005","unstructured":"Hill TP, Spater D, Taketo MM, Birchmeier W, Hartmann C . (2005). Canonical Wnt\/beta-catenin signaling prevents osteoblasts from differentiating into chondrocytes. Dev Cell 8: 727\u2013738.","journal-title":"Dev Cell"},{"key":"BFonc200881_CR15","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1016\/0304-3835(96)04238-3","volume":"104","author":"YS Ho","year":"1996","unstructured":"Ho YS, Hsieh LL, Chen JS, Chang CN, Lee ST, Chiu LL et al. (1996). p53 gene mutation in cerebral primitive neuroectodermal tumor in Taiwan. Cancer Lett 104: 103\u2013113.","journal-title":"Cancer Lett"},{"key":"BFonc200881_CR16","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1038\/75596","volume":"25","author":"EC Holland","year":"2000","unstructured":"Holland EC, Celestino J, Dai C, Schaefer L, Sawaya RE, Fuller GN . (2000). Combined activation of Ras and Akt in neural progenitors induces glioblastoma formation in mice. Nat Genet 25: 55\u201357.","journal-title":"Nat Genet"},{"key":"BFonc200881_CR17","doi-asserted-by":"publisher","first-page":"3675","DOI":"10.1101\/gad.12.23.3675","volume":"12","author":"EC Holland","year":"1998","unstructured":"Holland EC, Hively WP, DePinho RA, Varmus HE . (1998). A constitutively active epidermal growth factor receptor cooperates with disruption of G1 cell-cycle arrest pathways to induce glioma-like lesions in mice. Genes Dev 12: 3675\u20133685.","journal-title":"Genes Dev"},{"key":"BFonc200881_CR18","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S0960-9822(00)00002-6","volume":"4","author":"T Jacks","year":"1994","unstructured":"Jacks T, Remington L, Williams BO, Schmitt EM, Halachmi S, Bronson RT et al. (1994). Tumor spectrum analysis in p53-mutant mice. Curr Biol 4: 1\u20137.","journal-title":"Curr Biol"},{"key":"BFonc200881_CR19","first-page":"93","volume":"4","author":"RC Janzer","year":"1985","unstructured":"Janzer RC, Kleihues P . (1985). Primitive neuroectodermal tumor with choroid plexus differentiation. Clin Neuropathol 4: 93\u201398.","journal-title":"Clin Neuropathol"},{"key":"BFonc200881_CR20","first-page":"1061","volume":"120","author":"V Jay","year":"1996","unstructured":"Jay V, Ho M, Chan F, Malkin D . (1996). P53 expression in choroid plexus neoplasms: an immunohistochemical study. Arch Pathol Lab Med 120: 1061\u20131065.","journal-title":"Arch Pathol Lab Med"},{"key":"BFonc200881_CR21","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1002\/ijc.1342","volume":"93","author":"A Koch","year":"2001","unstructured":"Koch A, Waha A, Tonn JC, Sorensen N, Berthold F, Wolter M et al. (2001). Somatic mutations of WNT\/wingless signaling pathway components in primitive neuroectodermal tumors. Int J Cancer 93: 445\u2013449.","journal-title":"Int J Cancer"},{"key":"BFonc200881_CR22","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1186\/1471-2407-2-33","volume":"2","author":"JE Kratz","year":"2002","unstructured":"Kratz JE, Stearns D, Huso DL, Slunt HH, Price DL, Borchelt DR et al. (2002). Expression of stabilized beta-catenin in differentiated neurons of transgenic mice does not result in tumor formation. BMC Cancer 2: 33.","journal-title":"BMC Cancer"},{"key":"BFonc200881_CR23","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1046\/j.1365-2990.2002.00413.x","volume":"28","author":"JA Kraus","year":"2002","unstructured":"Kraus JA, Felsberg J, Tonn JC, Reifenberger G, Pietsch T . (2002). Molecular genetic analysis of the TP53, PTEN, CDKN2A, EGFR, CDK4 and MDM2 tumour-associated genes in supratentorial primitive neuroectodermal tumours and glioblastomas of childhood. Neuropathol Appl Neurobiol 28: 325\u2013333.","journal-title":"Neuropathol Appl Neurobiol"},{"key":"BFonc200881_CR24","doi-asserted-by":"publisher","first-page":"82","DOI":"10.3171\/jns.2001.95.1.0082","volume":"95","author":"JR Leonard","year":"2001","unstructured":"Leonard JR, Cai DX, Rivet DJ, Kaufman BA, Park TS, Levy BK . (2001). Perry Large cell\/anaplastic medulloblastomas and medullomyoblastomas: clinicopathological and genetic features. J Neurosurg 95: 82\u201388.","journal-title":"J Neurosurg"},{"key":"BFonc200881_CR25","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1007\/s00401-007-0243-4","volume":"114","author":"DN Louis","year":"2007","unstructured":"Louis DN, Ohgaki H, Wiestler OD, Cavenee WK, Burger PC, Jouvet A et al. (2007). The 2007 WHO classification of tumours of the central nervous system. Acta Neuropathol 114: 97\u2013109 (Review). Erratum in: Acta Neuropathol (2007) November; 114: 547.","journal-title":"Acta Neuropathol"},{"key":"BFonc200881_CR26","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1101\/gad.14.8.994","volume":"14","author":"S Marino","year":"2000","unstructured":"Marino S, Vooijs M, van Der Gulden H, Jonkers J, Berns A . (2000). Induction of medulloblastomas in p53-null mutant mice by somatic inactivation of Rb in the external granular layer cells of the cerebellum. Genes Dev 14: 994\u20131004.","journal-title":"Genes Dev"},{"key":"BFonc200881_CR27","doi-asserted-by":"publisher","first-page":"5179","DOI":"10.1158\/0008-5472.CAN-06-4177","volume":"67","author":"TD McCall","year":"2007","unstructured":"McCall TD, Pedone CA, Fults DW . (2007). Apoptosis suppression by somatic cell transfer of Bcl-2 promotes Sonic hedgehog-dependent medulloblastoma formation in mice. Cancer Res 67: 5179\u20135185.","journal-title":"Cancer Res"},{"key":"BFonc200881_CR28","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1002\/mc.2940080203","volume":"8","author":"H Ohgaki","year":"1993","unstructured":"Ohgaki H, Eibl RH, Schwab M, Reichel MB, Mariani L, Gehring M et al. (1993). Mutations of the p53 tumor suppressor gene in neoplasms of the human nervous system. Mol Carcinog 8: 74\u201380.","journal-title":"Mol Carcinog"},{"key":"BFonc200881_CR29","doi-asserted-by":"publisher","first-page":"386","DOI":"10.1016\/j.bbrc.2005.06.097","volume":"334","author":"S Pauklin","year":"2005","unstructured":"Pauklin S, Kristjuhan A, Maimets T, Jaks V . (2005). ARF and ATM\/ATR cooperate in p53-mediated apoptosis upon oncogenic stress. Biochem Biophys Res Commun 334: 386\u2013394.","journal-title":"Biochem Biophys Res Commun"},{"key":"BFonc200881_CR30","doi-asserted-by":"publisher","first-page":"1076","DOI":"10.3171\/jns.2004.100.6.1076","volume":"100","author":"A Pillai","year":"2004","unstructured":"Pillai A, Rajeev K, Chandi S, Unnikrishnan M . (2004). Intrinsic brainstem choroid plexus papilloma. Case report. J Neurosurg 100: 1076\u20131078.","journal-title":"J Neurosurg"},{"key":"BFonc200881_CR31","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1016\/S1476-5586(03)80052-0","volume":"5","author":"G Rao","year":"2003","unstructured":"Rao G, Pedone CA, Coffin CM, Holland EC, Fults DW . (2003). c-Myc enhances sonic hedgehog-induced medulloblastoma formation from nestin-expressing neural progenitors in mice. Neoplasia 5: 198\u2013204.","journal-title":"Neoplasia"},{"key":"BFonc200881_CR32","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1097\/00005072-199802000-00009","volume":"57","author":"J Reifenberger","year":"1998","unstructured":"Reifenberger J, Janssen G, Weber RG, Bostrom J, Engelbrecht V, Lichter P et al. (1998). Primitive neuroectodermal tumors of the cerebral hemispheres in two siblings with TP53 germline mutation. J Neuropathol Exp Neurol 57: 179\u2013187.","journal-title":"J Neuropathol Exp Neurol"},{"key":"BFonc200881_CR33","first-page":"3526","volume":"57","author":"RC Rostomily","year":"1997","unstructured":"Rostomily RC, Bermingham-McDonogh O, Berger MS, Tapscott SJ, Reh TA, Olson JM . (1997). Expression of neurogenic basic helix-loop-helix genes in primitive neuroectodermal tumors. Cancer Res 57: 3526\u20133531.","journal-title":"Cancer Res"},{"key":"BFonc200881_CR34","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1002\/(SICI)1097-0142(19990715)86:2<331::AID-CNCR18>3.0.CO;2-#","volume":"86","author":"C Russo","year":"1999","unstructured":"Russo C, Pellarin M, Tingby O, Bollen AW, Lamborn KR, Mohapatra G et al. (1999). Comparative genomic hybridization in patients with supratentorial and infratentorial primitive neuroectodermal tumors. Cancer 86: 331\u2013339.","journal-title":"Cancer"},{"key":"BFonc200881_CR35","first-page":"4721","volume":"51","author":"RL Saylors III","year":"1991","unstructured":"Saylors III RL, Sidransky D, Friedman HS, Bigner SH, Bigner DD, Vogelstein B et al. (1991). Infrequent p53 gene mutations in medulloblastomas. Cancer Res 51: 4721\u20134723.","journal-title":"Cancer Res"},{"key":"BFonc200881_CR36","doi-asserted-by":"publisher","first-page":"2359","DOI":"10.1093\/hmg\/8.13.2359","volume":"8","author":"N Sevenet","year":"1999","unstructured":"Sevenet N, Lellouch-Tubiana A, Schofield D, Hoang-Xuan K, Gessler M, Birnbaum D et al. (1999). Spectrum of hSNF5\/INI1 somatic mutations in human cancer and genotype-phenotype correlations. Hum Mol Genet 8: 2359\u20132368.","journal-title":"Hum Mol Genet"},{"key":"BFonc200881_CR37","doi-asserted-by":"publisher","first-page":"5190","DOI":"10.1158\/0008-5472.CAN-05-3545","volume":"66","author":"O Shakhova","year":"2006","unstructured":"Shakhova O, Leung C, van Montfort E, Berns A, Marino S . (2006). Lack of Rb and p53 delays cerebellar development and predisposes to large cell anaplastic medulloblastoma through amplification of N-Myc and Ptch2. Cancer Res 66: 5190\u20135200.","journal-title":"Cancer Res"},{"key":"BFonc200881_CR38","doi-asserted-by":"publisher","first-page":"1666","DOI":"10.1128\/MCB.26.5.1666-1678.2006","volume":"26","author":"X Su","year":"2006","unstructured":"Su X, Gopalakrishnan V, Stearns D, Aldape K, Lang FF, Fuller G et al. (2006). Abnormal expression of REST\/NRSF and Myc in neural stem\/progenitor cells causes cerebellar tumors by blocking neural differentiation. Mol Cell Biol 26: 1666\u20131678.","journal-title":"Mol Cell Biol"},{"key":"BFonc200881_CR39","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1016\/S0092-8674(02)01014-0","volume":"111","author":"M van de Wetering","year":"2002","unstructured":"van de Wetering M, Sancho E, Verweij C, de Lau W, Oving I, Hurlstone A et al. (2002). The beta-catenin\/TCF-4 complex imposes a crypt progenitor phenotype on colorectal cancer cells. Cell 111: 241\u2013250.","journal-title":"Cell"},{"key":"BFonc200881_CR40","doi-asserted-by":"publisher","first-page":"1061","DOI":"10.1097\/00005072-199811000-00009","volume":"57","author":"A Vital","year":"1998","unstructured":"Vital A, Bringuier PP, Huang H, San Galli F, Rivel J, Ansoborlo S et al. (1998). Astrocytomas and choroid plexus tumors in two families with identical p53 germline mutations. J Neuropathol Exp Neurol 57: 1061\u20131069.","journal-title":"J Neuropathol Exp Neurol"},{"key":"BFonc200881_CR41","first-page":"6385","volume":"62","author":"HL Weiner","year":"2002","unstructured":"Weiner HL, Bakst R, Hurlbert MS, Ruggiero J, Ahn E, Lee WS et al. (2002). Induction of medulloblastomas in mice by sonic hedgehog, independent of Gli1. Cancer Res 62: 6385\u20136389.","journal-title":"Cancer Res"},{"key":"BFonc200881_CR42","first-page":"513","volume":"61","author":"C Wetmore","year":"2001","unstructured":"Wetmore C, Eberhart DE, Curran T . (2001). Loss of p53 but not ARF accelerates medulloblastoma in mice heterozygous for patched. Cancer Res 61: 513\u2013516.","journal-title":"Cancer Res"},{"key":"BFonc200881_CR43","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1227\/00006123-199301000-00021","volume":"32","author":"H Yuasa","year":"1993","unstructured":"Yuasa H, Tokito S, Tokunaga M . (1993). Primary carcinoma of the choroid plexus in Li\u2013Fraumeni syndrome. Neurosurgery 32: 131\u2013134.","journal-title":"Neurosurgery"}],"container-title":["Oncogene"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/onc200881.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/onc200881","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/onc200881.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,21]],"date-time":"2022-03-21T16:12:18Z","timestamp":1647879138000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/onc200881"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,3,31]]},"references-count":43,"journal-issue":{"issue":"32","published-print":{"date-parts":[[2008,7,24]]}},"alternative-id":["BFonc200881"],"URL":"https:\/\/doi.org\/10.1038\/onc.2008.81","relation":{},"ISSN":["0950-9232","1476-5594"],"issn-type":[{"value":"0950-9232","type":"print"},{"value":"1476-5594","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,3,31]]},"assertion":[{"value":"18 September 2007","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 January 2008","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 February 2008","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 March 2008","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}