{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T22:45:53Z","timestamp":1790376353834,"version":"4.1.0"},"reference-count":50,"publisher":"Springer Science and Business Media LLC","issue":"26","license":[{"start":{"date-parts":[[2010,5,10]],"date-time":"2010-05-10T00:00:00Z","timestamp":1273449600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2010,5,10]],"date-time":"2010-05-10T00:00:00Z","timestamp":1273449600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Oncogene"],"published-print":{"date-parts":[[2010,7,1]]},"DOI":"10.1038\/onc.2010.130","type":"journal-article","created":{"date-parts":[[2010,5,10]],"date-time":"2010-05-10T10:16:11Z","timestamp":1273486571000},"page":"3758-3769","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":46,"title":["Novel alternatively spliced ADAM8 isoforms contribute to the aggressive bone metastatic phenotype of lung cancer"],"prefix":"10.1038","volume":"29","author":[{"given":"I","family":"Hern\u00e1ndez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J L","family":"Moreno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Zandueta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"Montuenga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F","family":"Lecanda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2010,5,10]]},"reference":[{"key":"BFonc2010130_CR1","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1016\/S0014-5793(02)03047-8","volume":"524","author":"A Amour","year":"2002","unstructured":"Amour A, Knight CG, English WR, Webster A, Slocombe PM, Knauper V et al. (2002). The enzymatic activity of ADAM8 and ADAM9 is not regulated by TIMPs. FEBS Lett 524: 154\u2013158.","journal-title":"FEBS Lett"},{"key":"BFonc2010130_CR2","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1038\/nrm1548","volume":"6","author":"CP Blobel","year":"2005","unstructured":"Blobel CP . (2005). ADAMs: key components in EGFR signalling and development. Nat Rev Mol Cell Biol 6: 32\u201343.","journal-title":"Nat Rev Mol Cell Biol"},{"key":"BFonc2010130_CR3","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1042\/bj3570353","volume":"357","author":"Y Cao","year":"2001","unstructured":"Cao Y, Kang Q, Zolkiewska A . (2001). Metalloprotease-disintegrin ADAM 12 interacts with alpha-actinin-1. Biochem J 357: 353\u2013361.","journal-title":"Biochem J"},{"key":"BFonc2010130_CR4","doi-asserted-by":"publisher","first-page":"1588","DOI":"10.1002\/(SICI)1097-0142(19971015)80:8+<1588::AID-CNCR9>3.0.CO;2-G","volume":"80","author":"RE Coleman","year":"1997","unstructured":"Coleman RE . (1997). Skeletal complications of malignancy. Cancer 80: 1588\u20131594.","journal-title":"Cancer"},{"key":"BFonc2010130_CR5","doi-asserted-by":"publisher","first-page":"814","DOI":"10.1359\/jbmr.2001.16.5.814","volume":"16","author":"SJ Choi","year":"2001","unstructured":"Choi SJ, Han JH, Roodman GD . (2001). ADAM8: a novel osteoclast stimulating factor. J Bone Miner Res 16: 814\u2013822.","journal-title":"J Bone Miner Res"},{"key":"BFonc2010130_CR6","doi-asserted-by":"publisher","first-page":"639","DOI":"10.1016\/S0002-9440(10)64005-9","volume":"158","author":"JE De Larco","year":"2001","unstructured":"De Larco JE, Wuertz BR, Rosner KA, Erickson SA, Gamache DE, Manivel JC et al. (2001). A potential role for interleukin-8 in the metastatic phenotype of breast carcinoma cells. Am J Pathol 158: 639\u2013646.","journal-title":"Am J Pathol"},{"key":"BFonc2010130_CR7","doi-asserted-by":"publisher","first-page":"863","DOI":"10.1016\/j.jaci.2006.12.665","volume":"119","author":"SC Foley","year":"2007","unstructured":"Foley SC, Mogas AK, Olivenstein R, Fiset PO, Chakir J, Bourbeau J et al. (2007). Increased expression of ADAM33 and ADAM8 with disease progression in asthma. J Allergy Clin Immunol 119: 863\u2013871.","journal-title":"J Allergy Clin Immunol"},{"key":"BFonc2010130_CR8","doi-asserted-by":"publisher","first-page":"30469","DOI":"10.1074\/jbc.M213157200","volume":"278","author":"AM Fourie","year":"2003","unstructured":"Fourie AM, Coles F, Moreno V, Karlsson L . (2003). Catalytic activity of ADAM8, ADAM15, and MDC-L (ADAM28) on synthetic peptide substrates and in ectodomain cleavage of CD23. J Biol Chem 278: 30469\u201330477.","journal-title":"J Biol Chem"},{"key":"BFonc2010130_CR9","doi-asserted-by":"publisher","first-page":"13933","DOI":"10.1074\/jbc.275.18.13933","volume":"275","author":"MF Galliano","year":"2000","unstructured":"Galliano MF, Huet C, Frygelius J, Polgren A, Wewer UM, Engvall E . (2000). Binding of ADAM12, a marker of skeletal muscle regeneration, to the muscle-specific actin-binding protein, alpha -actinin-2, is required for myoblast fusion. J Biol Chem 275: 13933\u201313939.","journal-title":"J Biol Chem"},{"key":"BFonc2010130_CR10","doi-asserted-by":"publisher","first-page":"37459","DOI":"10.1074\/jbc.M305877200","volume":"278","author":"KJ Garton","year":"2003","unstructured":"Garton KJ, Gough PJ, Philalay J, Wille PT, Blobel CP, Whitehead RH et al. (2003). Stimulated shedding of vascular cell adhesion molecule 1 (VCAM-1) is mediated by tumor necrosis factor-alpha-converting enzyme (ADAM 17). J Biol Chem 278: 37459\u201337464.","journal-title":"J Biol Chem"},{"key":"BFonc2010130_CR11","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1186\/bcr637","volume":"5","author":"JM Gee","year":"2003","unstructured":"Gee JM, Knowlden JM . (2003). ADAM metalloproteases and EGFR signalling. Breast Cancer Res 5: 223\u2013224.","journal-title":"Breast Cancer Res"},{"key":"BFonc2010130_CR12","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1074\/jbc.273.1.157","volume":"273","author":"BJ Gilpin","year":"1998","unstructured":"Gilpin BJ, Loechel F, Mattei MG, Engvall E, Albrechtsen R, Wewer UM . (1998). A novel, secreted form of human ADAM 12 (meltrin alpha) provokes myogenesis in vivo. J Biol Chem 273: 157\u2013166.","journal-title":"J Biol Chem"},{"key":"BFonc2010130_CR13","doi-asserted-by":"publisher","first-page":"8053","DOI":"10.4049\/jimmunol.178.12.8053","volume":"178","author":"M Gomez-Gaviro","year":"2007","unstructured":"Gomez-Gaviro M, Dominguez-Luis M, Canchado J, Calafat J, Janssen H, Lara-Pezzi E et al. (2007). Expression and regulation of the metalloproteinase ADAM-8 during human neutrophil pathophysiological activation and its catalytic activity on L-selectin shedding. J Immunol 178: 8053\u20138063.","journal-title":"J Immunol"},{"key":"BFonc2010130_CR14","doi-asserted-by":"publisher","first-page":"1015","DOI":"10.1007\/s00109-007-0202-5","volume":"85","author":"I Gonzalez","year":"2007","unstructured":"Gonzalez I, Vicent S, de Alava E, Lecanda F . (2007). EWS\/FLI-1 oncoprotein subtypes impose different requirements for transformation and metastatic activity in a murine model. J Mol Med 85: 1015\u20131029.","journal-title":"J Mol Med"},{"key":"BFonc2010130_CR15","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1016\/S0378-1119(01)00871-X","volume":"283","author":"ID Haidl","year":"2002","unstructured":"Haidl ID, Huber G, Eichmann K . (2002). An ADAM family member with expression in thymic epithelial cells and related tissues. Gene 283: 163\u2013170.","journal-title":"Gene"},{"key":"BFonc2010130_CR16","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/S0092-8674(00)81683-9","volume":"100","author":"D Hanahan","year":"2000","unstructured":"Hanahan D, Weinberg RA . (2000). The hallmarks of cancer. Cell 100: 57\u201370.","journal-title":"Cell"},{"key":"BFonc2010130_CR17","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1016\/j.bbapap.2004.11.009","volume":"1751","author":"S Higashiyama","year":"2005","unstructured":"Higashiyama S, Nanba D . (2005). ADAM-mediated ectodomain shedding of HB-EGF in receptor cross-talk. Biochim Biophys Acta 1751: 110\u2013117.","journal-title":"Biochim Biophys Acta"},{"key":"BFonc2010130_CR18","doi-asserted-by":"publisher","first-page":"1378","DOI":"10.1002\/neu.20257","volume":"66","author":"CL Hinkle","year":"2006","unstructured":"Hinkle CL, Diestel S, Lieberman J, Maness PF . (2006). Metalloprotease-induced ectodomain shedding of neural cell adhesion molecule (NCAM). J Neurobiol 66: 1378\u20131395.","journal-title":"J Neurobiol"},{"key":"BFonc2010130_CR19","doi-asserted-by":"publisher","DOI":"10.1007\/b106833","volume-title":"The Adam Family Of Proteases","author":"NM Hooper","year":"2005","unstructured":"Hooper NM, Lendeckel U . (2005) (eds.) The Adam Family Of Proteases. Springer: Dordrecht, 344pp."},{"key":"BFonc2010130_CR20","doi-asserted-by":"publisher","first-page":"8363","DOI":"10.1158\/1078-0432.CCR-04-1436","volume":"10","author":"N Ishikawa","year":"2004","unstructured":"Ishikawa N, Daigo Y, Yasui W, Inai K, Nishimura H, Tsuchiya E et al. (2004). ADAM8 as a novel serological and histochemical marker for lung cancer. Clin Cancer Res 10: 8363\u20138370.","journal-title":"Clin Cancer Res"},{"key":"BFonc2010130_CR21","doi-asserted-by":"publisher","first-page":"23","DOI":"10.3322\/canjclin.52.1.23","volume":"52","author":"A Jemal","year":"2002","unstructured":"Jemal A, Thomas A, Murray T, Thun M . (2002). Cancer statistics, 2002. CA Cancer J Clin 52: 23\u201347.","journal-title":"CA Cancer J Clin"},{"key":"BFonc2010130_CR22","doi-asserted-by":"publisher","first-page":"3271","DOI":"10.1182\/blood-2005-09-3830","volume":"107","author":"A Karadag","year":"2006","unstructured":"Karadag A, Zhou M, Croucher PI . (2006). ADAM-9 (MDC-9\/meltrin-gamma), a member of the a disintegrin and metalloproteinase family, regulates myeloma-cell-induced interleukin-6 production in osteoblasts by direct interaction with the alpha(v)beta5 integrin. Blood 107: 3271\u20133278.","journal-title":"Blood"},{"key":"BFonc2010130_CR23","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1002\/dvdy.20221","volume":"232","author":"K Kelly","year":"2005","unstructured":"Kelly K, Hutchinson G, Nebenius-Oosthuizen D, Smith AJ, Bartsch JW, Horiuchi K et al. (2005). Metalloprotease-disintegrin ADAM8: expression analysis and targeted deletion in mice. Dev Dyn 232: 221\u2013231.","journal-title":"Dev Dyn"},{"key":"BFonc2010130_CR24","doi-asserted-by":"publisher","first-page":"744","DOI":"10.1095\/biolreprod.105.048892","volume":"74","author":"T Kim","year":"2006","unstructured":"Kim T, Oh J, Woo JM, Choi E, Im SH, Yoo YJ et al. (2006). Expression and relationship of male reproductive ADAMs in mouse. Biol Reprod 74: 744\u2013750.","journal-title":"Biol Reprod"},{"key":"BFonc2010130_CR25","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1165\/rcmb.2004-0026OC","volume":"31","author":"NE King","year":"2004","unstructured":"King NE, Zimmermann N, Pope SM, Fulkerson PC, Nikolaidis NM, Mishra A et al. (2004). Expression and regulation of a disintegrin and metalloproteinase (ADAM) 8 in experimental asthma. Am J Respir Cell Mol Biol 31: 257\u2013265.","journal-title":"Am J Respir Cell Mol Biol"},{"key":"BFonc2010130_CR26","doi-asserted-by":"publisher","first-page":"1685","DOI":"10.1016\/j.biocel.2008.01.025","volume":"40","author":"M Kveiborg","year":"2008","unstructured":"Kveiborg M, Albrechtsen R, Couchman JR, Wewer UM . (2008). Cellular roles of ADAM12 in health and disease. Int J Biochem Cell Biol 40: 1685\u20131702.","journal-title":"Int J Biochem Cell Biol"},{"key":"BFonc2010130_CR27","doi-asserted-by":"publisher","first-page":"29","DOI":"10.2174\/187152507779315822","volume":"5","author":"X Lu","year":"2007","unstructured":"Lu X, Lu D, Scully MF, Kakkar VV . (2007). Structure-activity relationship studies on ADAM protein-integrin interactions. Cardiovasc Hematol Agents Med Chem 5: 29\u201342.","journal-title":"Cardiovasc Hematol Agents Med Chem"},{"key":"BFonc2010130_CR28","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1016\/S1074-7613(00)80154-5","volume":"12","author":"F Mainiero","year":"2000","unstructured":"Mainiero F, Soriani A, Strippoli R, Jacobelli J, Gismondi A, Piccoli M et al. (2000). RAC1\/P38 MAPK signaling pathway controls beta1 integrin-induced interleukin-8 production in human natural killer cells. Immunity 12: 7\u201316.","journal-title":"Immunity"},{"key":"BFonc2010130_CR29","first-page":"2033","volume":"30","author":"J Mandelin","year":"2003","unstructured":"Mandelin J, Li TF, Hukkanen MV, Liljestrom M, Chen ZK, Santavirta S et al. (2003). Increased expression of a novel osteoclast-stimulating factor, ADAM8, in interface tissue around loosened hip prostheses. J Rheumatol 30: 2033\u20132038.","journal-title":"J Rheumatol"},{"key":"BFonc2010130_CR30","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1016\/j.imlet.2005.07.006","volume":"102","author":"O Matsuno","year":"2006","unstructured":"Matsuno O, Miyazaki E, Nureki S, Ueno T, Kumamoto T, Higuchi Y . (2006). Role of ADAM8 in experimental asthma. Immunol Lett 102: 67\u201373.","journal-title":"Immunol Lett"},{"key":"BFonc2010130_CR31","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1159\/000097359","volume":"142","author":"O Matsuno","year":"2007","unstructured":"Matsuno O, Miyazaki E, Nureki S, Ueno T, Ando M, Ito K et al. (2007). Elevated soluble ADAM8 in bronchoalveolar lavage fluid in patients with eosinophilic pneumonia. Int Arch Allergy Immunol 142: 285\u2013290.","journal-title":"Int Arch Allergy Immunol"},{"key":"BFonc2010130_CR32","doi-asserted-by":"publisher","first-page":"584","DOI":"10.1038\/nrc867","volume":"2","author":"GR Mundy","year":"2002","unstructured":"Mundy GR . (2002). Metastasis to bone: causes, consequences and therapeutic opportunities. Nat Rev Cancer 2: 584\u2013593.","journal-title":"Nat Rev Cancer"},{"key":"BFonc2010130_CR33","doi-asserted-by":"publisher","first-page":"16083","DOI":"10.1074\/jbc.M400560200","volume":"279","author":"S Naus","year":"2004","unstructured":"Naus S, Richter M, Wildeboer D, Moss M, Schachner M, Bartsch JW . (2004). Ectodomain shedding of the neural recognition molecule CHL1 by the metalloprotease-disintegrin ADAM8 promotes neurite outgrowth and suppresses neuronal cell death. J Biol Chem 279: 16083\u201316090.","journal-title":"J Biol Chem"},{"key":"BFonc2010130_CR34","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1515\/BC.2006.045","volume":"387","author":"S Naus","year":"2006","unstructured":"Naus S, Reipschlager S, Wildeboer D, Lichtenthaler SF, Mitterreiter S, Guan Z et al. (2006). Identification of candidate substrates for ectodomain shedding by the metalloprotease-disintegrin ADAM8. Biol Chem 387: 337\u2013346.","journal-title":"Biol Chem"},{"key":"BFonc2010130_CR35","doi-asserted-by":"publisher","first-page":"C1","DOI":"10.1152\/ajpcell.00620.2005","volume":"291","author":"H Ohtsu","year":"2006","unstructured":"Ohtsu H, Dempsey PJ, Eguchi S . (2006). ADAMs as mediators of EGF receptor transactivation by G protein-coupled receptors. Am J Physiol Cell Physiol 291: C1\u201310.","journal-title":"Am J Physiol Cell Physiol"},{"key":"BFonc2010130_CR36","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1002\/ijc.21324","volume":"118","author":"T Ohtsuka","year":"2006","unstructured":"Ohtsuka T, Shiomi T, Shimoda M, Kodama T, Amour A, Murphy G et al. (2006). ADAM28 is overexpressed in human non-small cell lung carcinomas and correlates with cell proliferation and lymph node metastasis. Int J Cancer 118: 263\u2013273.","journal-title":"Int J Cancer"},{"key":"BFonc2010130_CR37","doi-asserted-by":"publisher","first-page":"1657","DOI":"10.1359\/jbmr.060718","volume":"21","author":"H Rao","year":"2006","unstructured":"Rao H, Lu G, Kajiya H, Garcia-Palacios V, Kurihara N, Anderson J et al. (2006). Alpha9beta1: a novel osteoclast integrin that regulates osteoclast formation and function. J Bone Miner Res 21: 1657\u20131665.","journal-title":"J Bone Miner Res"},{"key":"BFonc2010130_CR38","doi-asserted-by":"publisher","first-page":"985","DOI":"10.1016\/j.pharmthera.2006.02.009","volume":"111","author":"K Reiss","year":"2006","unstructured":"Reiss K, Ludwig A, Saftig P . (2006). Breaking up the tie: disintegrin-like metalloproteinases as regulators of cell migration in inflammation and invasion. Pharmacol Ther 111: 985\u20131006.","journal-title":"Pharmacol Ther"},{"key":"BFonc2010130_CR39","first-page":"529","volume":"11","author":"A Roemer","year":"2004","unstructured":"Roemer A, Schwettmann L, Jung M, Roigas J, Kristiansen G, Schnorr D et al. (2004a). Increased mRNA expression of ADAMs in renal cell carcinoma and their association with clinical outcome. Oncol Rep 11: 529\u2013536.","journal-title":"Oncol Rep"},{"key":"BFonc2010130_CR40","doi-asserted-by":"publisher","first-page":"2162","DOI":"10.1097\/01.ju.0000144602.01322.49","volume":"172","author":"A Roemer","year":"2004","unstructured":"Roemer A, Schwettmann L, Jung M, Stephan C, Roigas J, Kristiansen G et al. (2004b). The membrane proteases ADAMS and hepsin are differentially expressed in renal cell carcinoma Are they potential tumor markers? J Urol 172: 2162\u20132166.","journal-title":"J Urol"},{"key":"BFonc2010130_CR41","doi-asserted-by":"publisher","first-page":"769","DOI":"10.1083\/jcb.200307137","volume":"164","author":"U Sahin","year":"2004","unstructured":"Sahin U, Weskamp G, Kelly K, Zhou HM, Higashiyama S, Peschon J et al. (2004). Distinct roles for ADAM10 and ADAM17 in ectodomain shedding of six EGFR ligands. J Cell Biol 164: 769\u2013779.","journal-title":"J Cell Biol"},{"key":"BFonc2010130_CR42","doi-asserted-by":"publisher","first-page":"48210","DOI":"10.1074\/jbc.M203355200","volume":"277","author":"U Schlomann","year":"2002","unstructured":"Schlomann U, Wildeboer D, Webster A, Antropova O, Zeuschner D, Knight CG et al. (2002). The metalloprotease disintegrin ADAM8. Processing by autocatalysis is required for proteolytic activity and cell adhesion. J Biol Chem 277: 48210\u201348219.","journal-title":"J Biol Chem"},{"key":"BFonc2010130_CR43","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1101\/gad.1039703","volume":"17","author":"DF Seals","year":"2003","unstructured":"Seals DF, Courtneidge SA . (2003). The ADAMs family of metalloproteases: multidomain proteins with multiple functions. Genes Dev 17: 7\u201330.","journal-title":"Genes Dev"},{"key":"BFonc2010130_CR44","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/j.yexcr.2009.09.017","volume":"316","author":"D Stautz","year":"2010","unstructured":"Stautz D, Sanjay A, Hansen MT, Albrechtsen R, Wewer U, Kveiborg M . (2010). ADAM12 localizes with c-Src to actin-rich structures at the cell periphery and regulates Src kinase activity. Exp Cell Res 316: 55\u201367.","journal-title":"Exp Cell Res"},{"key":"BFonc2010130_CR45","doi-asserted-by":"publisher","first-page":"5859","DOI":"10.1016\/j.febslet.2007.11.062","volume":"581","author":"S Takeda","year":"2007","unstructured":"Takeda S, Igarashi T, Mori H . (2007). Crystal structure of RVV-X: an example of evolutionary gain of specificity by ADAM proteinases. FEBS Lett 581: 5859\u20135864.","journal-title":"FEBS Lett"},{"key":"BFonc2010130_CR46","doi-asserted-by":"publisher","first-page":"1162","DOI":"10.1111\/j.1582-4934.2007.00082.x","volume":"11","author":"N Valkovskaya","year":"2007","unstructured":"Valkovskaya N, Kayed H, Felix K, Hartmann D, Giese NA, Osinsky SP et al. (2007). ADAM8 expression is associated with increased invasiveness and reduced patient survival in pancreatic cancer. J Cell Mol Med 11: 1162\u20131174.","journal-title":"J Cell Mol Med"},{"key":"BFonc2010130_CR47","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1016\/j.bone.2003.12.029","volume":"35","author":"S Verrier","year":"2004","unstructured":"Verrier S, Hogan A, McKie N, Horton M . (2004). ADAM gene expression and regulation during human osteoclast formation. Bone 35: 34\u201346.","journal-title":"Bone"},{"key":"BFonc2010130_CR48","doi-asserted-by":"publisher","first-page":"2275","DOI":"10.1158\/0008-5472.CAN-07-6493","volume":"68","author":"S Vicent","year":"2008","unstructured":"Vicent S, Luis-Ravelo D, Anton I, Garcia-Tunon I, Borras-Cuesta F, Dotor J et al. (2008). A novel lung cancer signature mediates metastatic bone colonization by a dual mechanism. Cancer Res 68: 2275\u20132285.","journal-title":"Cancer Res"},{"key":"BFonc2010130_CR49","doi-asserted-by":"publisher","first-page":"516","DOI":"10.1097\/01.jnen.0000229240.51490.d3","volume":"65","author":"D Wildeboer","year":"2006","unstructured":"Wildeboer D, Naus S, Amy Sang QX, Bartsch JW, Pagenstecher A . (2006). Metalloproteinase disintegrins ADAM8 and ADAM19 are highly regulated in human primary brain tumors and their expression levels and activities are associated with invasiveness. J Neuropathol Exp Neurol 65: 516\u2013527.","journal-title":"J Neuropathol Exp Neurol"},{"key":"BFonc2010130_CR50","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1093\/intimm\/2.6.585","volume":"2","author":"S Yoshida","year":"1990","unstructured":"Yoshida S, Setoguchi M, Higuchi Y, Akizuki S, Yamamoto S . (1990). Molecular cloning of cDNA encoding MS2 antigen, a novel cell surface antigen strongly expressed in murine monocytic lineage. Int Immunol 2: 585\u2013591.","journal-title":"Int Immunol"}],"container-title":["Oncogene"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/onc2010130.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/onc2010130","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/onc2010130.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,21]],"date-time":"2022-03-21T17:54:35Z","timestamp":1647885275000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/onc2010130"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,5,10]]},"references-count":50,"journal-issue":{"issue":"26","published-print":{"date-parts":[[2010,7,1]]}},"alternative-id":["BFonc2010130"],"URL":"https:\/\/doi.org\/10.1038\/onc.2010.130","relation":{},"ISSN":["0950-9232","1476-5594"],"issn-type":[{"value":"0950-9232","type":"print"},{"value":"1476-5594","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,5,10]]},"assertion":[{"value":"23 September 2009","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 March 2010","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 March 2010","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 May 2010","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}