{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T18:38:13Z","timestamp":1793039893217,"version":"4.5.0"},"reference-count":44,"publisher":"Springer Science and Business Media LLC","issue":"27","license":[{"start":{"date-parts":[[2010,5,17]],"date-time":"2010-05-17T00:00:00Z","timestamp":1274054400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2010,5,17]],"date-time":"2010-05-17T00:00:00Z","timestamp":1274054400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Oncogene"],"published-print":{"date-parts":[[2010,7,8]]},"DOI":"10.1038\/onc.2010.137","type":"journal-article","created":{"date-parts":[[2010,5,17]],"date-time":"2010-05-17T10:13:02Z","timestamp":1274091182000},"page":"3990-3996","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":64,"title":["The viral tropism of two distinct oncolytic viruses, reovirus and myxoma virus, is modulated by cellular tumor suppressor gene status"],"prefix":"10.1038","volume":"29","author":[{"given":"M","family":"Kim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C T","family":"Williamson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Prudhomme","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D G","family":"Bebb","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"Riabowol","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P W K","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S P","family":"Lees-Miller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y","family":"Mori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M M","family":"Rahman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"McFadden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R N","family":"Johnston","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2010,5,17]]},"reference":[{"key":"BFonc2010137_CR1","doi-asserted-by":"publisher","first-page":"12243","DOI":"10.1128\/JVI.78.22.12243-12251.2004","volume":"78","author":"MA Abou El Hassan","year":"2004","unstructured":"Abou El Hassan MA, van der Meulen-Muileman I, Abbas S, Kruyt FA . (2004). Conditionally replicating adenoviruses kill tumor cells via a basic apoptotic machinery-independent mechanism that resembles necrosis-like programmed cell death. J Virol 78: 12243\u201312251.","journal-title":"J Virol"},{"key":"BFonc2010137_CR2","doi-asserted-by":"publisher","first-page":"4146","DOI":"10.1182\/blood-2002-02-0503","volume":"100","author":"T Alain","year":"2002","unstructured":"Alain T, Hirasawa K, Pon KJ, Nishikawa SG, Urbanski SJ, Auer Y et al. (2002). Reovirus therapy of lymphoid malignancies. Blood 100: 4146\u20134153.","journal-title":"Blood"},{"key":"BFonc2010137_CR3","doi-asserted-by":"publisher","first-page":"3059","DOI":"10.1182\/blood-2008-07-170183","volume":"113","author":"S Be\u00e0","year":"2009","unstructured":"Be\u00e0 S, Salaverria I, Armengol L, Pinyol M, Fern\u00e1ndez V, Hartmann EM et al. (2009). Uniparental disomies, homozygous deletions, amplifications, and target genes in mantle cell lymphoma revealed by integrative high-resolution whole-genome profiling. Blood 113: 3059\u20133069.","journal-title":"Blood"},{"key":"BFonc2010137_CR4","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1126\/science.274.5286.373","volume":"274","author":"JR Bischoff","year":"1996","unstructured":"Bischoff JR, Kirn DH, Williams A, Heise C, Horn S, Muna M et al. (1996). An adenovirus mutant that replicates selectively in p53-deficient human tumor cells. Science 274: 373\u2013376.","journal-title":"Science"},{"key":"BFonc2010137_CR5","doi-asserted-by":"publisher","first-page":"1935","DOI":"10.1038\/sj.onc.1202515","volume":"18","author":"PE Carroll","year":"1999","unstructured":"Carroll PE, Okuda M, Horn HF, Biddinger P, Stambrook PJ, Gleich LL et al. (1999). Centrosome hyperamplification in human cancer: chromosome instability induced by p53 mutation and\/or Mdm2 overexpression. Oncogene 18: 1935\u20131944.","journal-title":"Oncogene"},{"key":"BFonc2010137_CR6","doi-asserted-by":"publisher","first-page":"1332","DOI":"10.1126\/science.282.5392.1332","volume":"282","author":"MC Coffey","year":"1998","unstructured":"Coffey MC, Strong JE, Forsyth PA, Lee PW . (1998). Reovirus therapy of tumors with activated Ras pathway. Science 282: 1332\u20131334.","journal-title":"Science"},{"key":"BFonc2010137_CR7","doi-asserted-by":"publisher","first-page":"1136","DOI":"10.1002\/hep.22176","volume":"47","author":"N Dharel","year":"2008","unstructured":"Dharel N, Kato N, Muroyama R, Taniguchi H, Otsuka M, Wang Y et al. (2008). Potential contribution of tumor suppressor p53 in the host defense against hepatitis C virus. Hepatology 47: 1136\u20131149.","journal-title":"Hepatology"},{"key":"BFonc2010137_CR8","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1016\/S1044-579X(03)00040-3","volume":"13","author":"AM Duursma","year":"2003","unstructured":"Duursma AM, Agami R . (2003). Ras interference as cancer therapy. Semin Cancer Biol 13: 267\u2013273.","journal-title":"Semin Cancer Biol"},{"key":"BFonc2010137_CR9","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1128\/jvi.28.2.444-449.1978","volume":"28","author":"MR Duncan","year":"1978","unstructured":"Duncan MR, Stanish SM, Cox DC . (1978). Differential sensitivity of normal and transformed human cells to reovirus infection. J Virol 28: 444\u2013449.","journal-title":"J Virol"},{"key":"BFonc2010137_CR10","doi-asserted-by":"publisher","first-page":"627","DOI":"10.1038\/sj.mt.6300403","volume":"16","author":"P Forsyth","year":"2008","unstructured":"Forsyth P, Rold\u00e1n G, George D, Wallace C, Palmer CA, Morris D et al. (2008). Phase I trial of intratumoral administration of reovirus in patients with histologically confirmed recurrent malignant gliomas. Mol Ther 16: 627\u2013632.","journal-title":"Mol Ther"},{"key":"BFonc2010137_CR11","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1007\/BF01314776","volume":"54","author":"G Hashiro","year":"1977","unstructured":"Hashiro G, Loh PC, Yau JT . (1977). The preferential cytotoxicity of reovirus for certain transformed cell lines. Arch Virol 54: 307\u2013315.","journal-title":"Arch Virol"},{"key":"BFonc2010137_CR12","first-page":"1043","volume":"3","author":"S Huang","year":"2004","unstructured":"Huang S, Qu LK, Koromilas AE . (2004). Induction of p53-dependent apoptosis in HCT116 tumor cells by RNA viruses and possible implications in virus mediated oncolysis. Cell Cycle 3: 1043\u20131045.","journal-title":"Cell Cycle"},{"key":"BFonc2010137_CR13","doi-asserted-by":"publisher","first-page":"5877","DOI":"10.1128\/JVI.77.10.5877-5888.2003","volume":"77","author":"JB Johnston","year":"2003","unstructured":"Johnston JB, Barrett JW, Chang W, Chung CS, Zeng W, Masters J et al. (2003). Role of the serine-threonine kinase PAK-1 in myxoma virus replication. J Virol 77: 5877\u20135888.","journal-title":"J Virol"},{"key":"BFonc2010137_CR14","volume-title":"American Society for Virology (ASV) 2007 Annual Meeting","author":"M Kim","year":"2007","unstructured":"Kim M, Alain T, Urbanski SJ, Kossakowska AE, Lee PWK, Forsyth PA et al. (2007a). An attenuated reovirus isolated from persistent reovirus infection exerts viral oncolysis with reduced pathogenicity. American Society for Virology (ASV) 2007 Annual Meeting; July 2007; Oregon State University: Corvallis, OR."},{"key":"BFonc2010137_CR15","doi-asserted-by":"publisher","first-page":"4124","DOI":"10.1038\/sj.onc.1210189","volume":"26","author":"M Kim","year":"2007","unstructured":"Kim M, Egan C, Alain T, Urbanski SJ, Lee PW, Forsyth PA et al. (2007b). Acquired resistance to reoviral oncolysis in Ras-transformed fibrosarcoma cells. Oncogene 26: 4124\u20134134.","journal-title":"Oncogene"},{"key":"BFonc2010137_CR16","doi-asserted-by":"publisher","first-page":"2313","DOI":"10.1038\/leu.2009.219","volume":"23","author":"M Kim","year":"2009","unstructured":"Kim M, Madlambayan GJ, Rahman MM, Smallwood SE, Meacham AM, Hosaka K et al. (2009). Myxoma virus targets primary human leukemic stem and progenitor cells while sparing normal hematopoietic stem and progenitor cells. Leukemia 23: 2313\u20132317.","journal-title":"Leukemia"},{"key":"BFonc2010137_CR17","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1101\/sqb.2005.70.002","volume":"70","author":"R Kitagawa","year":"2005","unstructured":"Kitagawa R, Kastan MB . (2005). The ATM-dependent DNA damage signaling pathway. Cold Spring Harb Symp Quant Biol 70: 99\u2013109.","journal-title":"Cold Spring Harb Symp Quant Biol"},{"key":"BFonc2010137_CR18","doi-asserted-by":"publisher","first-page":"9309","DOI":"10.1074\/jbc.M300003200","volume":"278","author":"S Kozlov","year":"2003","unstructured":"Kozlov S, Gueven N, Keating K, Ramsay J, Lavin MF . (2003). ATP activates ataxia-telangiectasia mutated (ATM) in vitro. Importance of autophosphorylation. J Biol Chem 278: 9309\u20139317.","journal-title":"J Biol Chem"},{"key":"BFonc2010137_CR19","doi-asserted-by":"publisher","first-page":"3006","DOI":"10.1038\/sj.onc.1209334","volume":"25","author":"DW Li","year":"2006","unstructured":"Li DW, Liu JP, Schmid PC, Schlosser R, Feng H, Liu WB et al. (2006). Protein serine\/threonine phosphatase-1 dephosphorylates p53 at Ser-15 and Ser-37 to modulate its transcriptional and apoptotic activities. Oncogene 25: 3006\u20133022.","journal-title":"Oncogene"},{"key":"BFonc2010137_CR20","doi-asserted-by":"publisher","first-page":"9982","DOI":"10.1158\/0008-5472.CAN-05-1201","volume":"65","author":"X Lun","year":"2005","unstructured":"Lun X, Yang W, Alain T, Shi ZQ, Muzik H, Barrett JW et al. (2005). Myxoma virus is a novel oncolytic virus with significant antitumor activity against experimental human gliomas. Cancer Res 65: 9982\u20139990.","journal-title":"Cancer Res"},{"key":"BFonc2010137_CR21","doi-asserted-by":"publisher","first-page":"8818","DOI":"10.1158\/0008-5472.CAN-07-1214","volume":"67","author":"XQ Lun","year":"2007","unstructured":"Lun XQ, Zhou H, Alain T, Sun B, Wang L, Barrett JW et al. (2007). Targeting human medulloblastoma: oncolytic virotherapy with myxoma virus is enhanced by rapamycin. Cancer Res 67: 8818\u20138827.","journal-title":"Cancer Res"},{"key":"BFonc2010137_CR22","doi-asserted-by":"publisher","first-page":"7817","DOI":"10.1038\/sj.onc.1209064","volume":"24","author":"F McCormick","year":"2005","unstructured":"McCormick F . (2005). Future prospects for oncolytic therapy. Oncogene 24: 7817\u20137819.","journal-title":"Oncogene"},{"key":"BFonc2010137_CR23","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1038\/nrmicro1099","volume":"3","author":"G McFadden","year":"2005","unstructured":"McFadden G . (2005). Poxvirus tropism. Nat Rev Microbiol 3: 201\u2013213.","journal-title":"Nat Rev Microbiol"},{"key":"BFonc2010137_CR24","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/S1383-5742(01)00075-8","volume":"511","author":"SM Morris","year":"2002","unstructured":"Morris SM . (2002). A role for p53 in the frequency and mechanism of mutation. Mutat Res 511: 45\u201362.","journal-title":"Mutat Res"},{"key":"BFonc2010137_CR25","doi-asserted-by":"publisher","first-page":"1929","DOI":"10.1084\/jem.20080383","volume":"205","author":"C Mu\u00f1oz-Fontela","year":"2008","unstructured":"Mu\u00f1oz-Fontela C, Macip S, Mart\u00ednez-Sobrido L, Brown L, Ashour J, Garc\u00eda-Sastre A et al. (2008). Transcriptional role of p53 in interferon-mediated antiviral immunity. J Exp Med 205: 1929\u20131938.","journal-title":"J Exp Med"},{"key":"BFonc2010137_CR26","doi-asserted-by":"publisher","first-page":"11099","DOI":"10.1073\/pnas.0404310101","volume":"101","author":"KL Norman","year":"2004","unstructured":"Norman KL, Hirasawa K, Yang AD, Shields MA, Lee PW . (2004). Reovirus oncolysis: the Ras\/RalGEF\/p38 pathway dictates host cell permissiveness to reovirus infection. Proc Natl Acad Sci USA 101: 11099\u201311104.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFonc2010137_CR27","doi-asserted-by":"publisher","first-page":"847","DOI":"10.1016\/S1359-6446(05)03483-5","volume":"10","author":"KL Norman","year":"2005","unstructured":"Norman KL, Lee PW . (2005). Not all viruses are bad guys: the case for reovirus in cancer therapy. Drug Discov Today 10: 847\u2013855.","journal-title":"Drug Discov Today"},{"key":"BFonc2010137_CR28","doi-asserted-by":"publisher","first-page":"611","DOI":"10.1016\/j.ccr.2004.11.012","volume":"6","author":"CC O\u2032Shea","year":"2004","unstructured":"O\u2032Shea CC, Johnson L, Bagus B, Choi S, Nicholas C, Shen A et al. (2004). Late viral RNA export, rather than p53 inactivation, determines ONYX-015 tumor selectivity. Cancer Cell 6: 611\u2013623.","journal-title":"Cancer Cell"},{"key":"BFonc2010137_CR29","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1093\/jnci\/53.2.347","volume":"53","author":"TW Reid","year":"1974","unstructured":"Reid TW, Albert DM, Rabson AS, Russell P, Craft J, Chu EW et al. (1974). Characteristics of an established cell line of retinoblastoma. J Natl Cancer Inst 53: 347\u2013360.","journal-title":"J Natl Cancer Inst"},{"key":"BFonc2010137_CR30","doi-asserted-by":"publisher","first-page":"1509","DOI":"10.1038\/sj.onc.1209185","volume":"25","author":"JA Royds","year":"2006","unstructured":"Royds JA, Hibma M, Dix BR, Hananeia L, Russell IA, Wiles A et al. (2006). p53 promotes adenoviral replication and increases late viral gene expression. Oncogene 25: 1509\u20131520.","journal-title":"Oncogene"},{"key":"BFonc2010137_CR31","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1038\/cgt.2009.46","volume":"17","author":"M Shmulevitz","year":"2010","unstructured":"Shmulevitz M, Marcato P, Lee PW . (2010). Activated Ras signaling significantly enhances reovirus replication and spread. Cancer Gene Ther 17: 69\u201370.","journal-title":"Cancer Gene Ther"},{"key":"BFonc2010137_CR32","doi-asserted-by":"publisher","first-page":"382","DOI":"10.1038\/cgt.2008.84","volume":"16","author":"L Song","year":"2009","unstructured":"Song L, Ohnuma T, Gelman IH, Holland JF . (2009). Reovirus infection of cancer cells is not due to activated Ras pathway. Cancer Gene Ther 16: 382.","journal-title":"Cancer Gene Ther"},{"key":"BFonc2010137_CR33","doi-asserted-by":"publisher","first-page":"3351","DOI":"10.1093\/emboj\/17.12.3351","volume":"17","author":"JE Strong","year":"1998","unstructured":"Strong JE, Coffey MC, Tang D, Sabinin P, Lee PW . (1998). The molecular basis of viral oncolysis: usurpation of the Ras signaling pathway by reovirus. EMBO J 17: 3351\u20133362.","journal-title":"EMBO J"},{"key":"BFonc2010137_CR34","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1128\/jvi.70.1.612-616.1996","volume":"70","author":"JE Strong","year":"1996","unstructured":"Strong JE, Lee PWK . (1996). The v-erbB oncogene confers enhanced cellular susceptibility to reovirus infection. J Virol 70: 612\u2013616.","journal-title":"J Virol"},{"key":"BFonc2010137_CR35","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1006\/viro.1993.1602","volume":"197","author":"JE Strong","year":"1993","unstructured":"Strong JE, Tang D, Lee PWK . (1993). Evidence that the epidermal growth factor receptor on host cells confers reovirus infection efficiency. Virology 197: 405\u2013411.","journal-title":"Virology"},{"key":"BFonc2010137_CR36","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1038\/sj.mt.6300348","volume":"16","author":"M Stanford","year":"2008","unstructured":"Stanford M, Shaban M, Barrett JW, Gilbert PA, Bondy-Denomy J, Mackenzie L et al. (2008). Myxoma virus oncolysis of primary and metastatic B16F10 mouse tumors in vivo. Mol Ther 16: 52\u201359.","journal-title":"Mol Ther"},{"key":"BFonc2010137_CR37","doi-asserted-by":"publisher","first-page":"1415","DOI":"10.1517\/14712598.7.9.1415","volume":"7","author":"MM Stanford","year":"2007","unstructured":"Stanford MM, McFadden G . (2007). Myxoma virus and oncolytic virotherapy: a new biologic weapon in the war against cancer. Expert Opin Biol Ther 7: 1415\u20131425.","journal-title":"Expert Opin Biol Ther"},{"key":"BFonc2010137_CR38","first-page":"103","volume":"8","author":"J Sypula","year":"2004","unstructured":"Sypula J, Wang F, Ma Y, Bell J, McFadden G . (2004). Myxoma virus tropism in human tumor cells. Gene Ther Mol Biol 8: 103\u2013114.","journal-title":"Gene Ther Mol Biol"},{"key":"BFonc2010137_CR39","doi-asserted-by":"publisher","first-page":"516","DOI":"10.1038\/nature01850","volume":"424","author":"A Takaoka","year":"2003","unstructured":"Takaoka A, Hayakawa S, Yanai H, Stoiber D, Negishi H, Kikuchi H et al. (2003). Integration of interferon-alpha\/beta signalling to p53 responses in tumour suppression and antiviral defence. Nature 424: 516\u2013523.","journal-title":"Nature"},{"key":"BFonc2010137_CR40","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1016\/j.leukres.2005.08.016","volume":"30","author":"CA Tucker","year":"2006","unstructured":"Tucker CA, Bebb G, Klasa RJ, Chhanabhai M, Lestou V, Horsman DE et al. (2006). Four human t(11;14)(q13;q32)-containing cell lines having classic and variant features of mantle cell lymphoma. Leuk Res 30: 449\u2013457.","journal-title":"Leuk Res"},{"key":"BFonc2010137_CR41","doi-asserted-by":"publisher","first-page":"7127","DOI":"10.1158\/1078-0432.CCR-08-0524","volume":"14","author":"L Vidal","year":"2008","unstructured":"Vidal L, Pandha HS, Yap TA, White CL, Twigger K, Vile RG et al. (2008). A phase I study of intravenous oncolytic reovirus type 3 Dearing in patients with advanced cancer. Clin Cancer Res 14: 7127\u20137137.","journal-title":"Clin Cancer Res"},{"key":"BFonc2010137_CR42","doi-asserted-by":"publisher","first-page":"5928","DOI":"10.1128\/JVI.02587-08","volume":"83","author":"F Wang","year":"2009","unstructured":"Wang F, Barrett JW, Ma Y, Dekaban GA, McFadden G . (2009). Induction of alpha\/beta interferon by myxoma virus is selectively abrogated when primary mouse embryo fibroblasts become immortalized. J Virol 83: 5928\u20135932.","journal-title":"J Virol"},{"key":"BFonc2010137_CR43","doi-asserted-by":"publisher","first-page":"4640","DOI":"10.1073\/pnas.0509341103","volume":"103","author":"G Wang","year":"2006","unstructured":"Wang G, Barrett JW, Stanford M, Werden SJ, Johnston JB, Gao X et al. (2006). Infection of human cancer cells with myxoma virus requires Akt activation via interaction with a viral ankyrin-repeat host range factor. Proc Natl Acad Sci USA 103: 4640\u20134645.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFonc2010137_CR44","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1038\/371021a0","volume":"371","author":"E White","year":"1994","unstructured":"White E . (1994). Tumour biology. p53, guardian of Rb. Nature 371: 21\u201322.","journal-title":"Nature"}],"container-title":["Oncogene"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/onc2010137.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/onc2010137","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/onc2010137.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,29]],"date-time":"2022-07-29T06:38:16Z","timestamp":1659076696000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/onc2010137"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,5,17]]},"references-count":44,"journal-issue":{"issue":"27","published-print":{"date-parts":[[2010,7,8]]}},"alternative-id":["BFonc2010137"],"URL":"https:\/\/doi.org\/10.1038\/onc.2010.137","relation":{},"ISSN":["0950-9232","1476-5594"],"issn-type":[{"value":"0950-9232","type":"print"},{"value":"1476-5594","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,5,17]]},"assertion":[{"value":"5 June 2009","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 March 2010","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 March 2010","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 May 2010","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}