{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T23:53:53Z","timestamp":1792194833493,"version":"4.4.0"},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"28","license":[{"start":{"date-parts":[[2010,5,10]],"date-time":"2010-05-10T00:00:00Z","timestamp":1273449600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2010,5,10]],"date-time":"2010-05-10T00:00:00Z","timestamp":1273449600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Oncogene"],"published-print":{"date-parts":[[2010,7,15]]},"DOI":"10.1038\/onc.2010.150","type":"journal-article","created":{"date-parts":[[2010,5,10]],"date-time":"2010-05-10T10:16:11Z","timestamp":1273486571000},"page":"4113-4120","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Genetic reporter system for oncogenic Igh\u2013Myc translocations in mice"],"prefix":"10.1038","volume":"29","author":[{"given":"M","family":"Takizawa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J S","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"Tessarollo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N","family":"McNeil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T J","family":"Waldschmidt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Casellas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"Ried","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Janz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2010,5,10]]},"reference":[{"key":"BFonc2010150_CR1","doi-asserted-by":"publisher","first-page":"994","DOI":"10.1038\/222994a0","volume":"222","author":"PN Anderson","year":"1969","unstructured":"Anderson PN, Potter M . (1969). Induction of plasma cell tumours in BALB-c mice with 2,6,10,14-tetramethylpentadecane (pristane). Nature 222: 994\u2013995.","journal-title":"Nature"},{"key":"BFonc2010150_CR2","doi-asserted-by":"publisher","first-page":"2717","DOI":"10.1073\/pnas.0812304106","volume":"106","author":"HL Cheng","year":"2009","unstructured":"Cheng HL, Vuong BQ, Basu U, Franklin A, Schwer B, Astarita J et al. (2009). Integrity of the AID serine-38 phosphorylation site is critical for class switch recombination and somatic hypermutation in mice. Proc Natl Acad Sci USA 106: 2717\u20132722.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFonc2010150_CR3","doi-asserted-by":"publisher","first-page":"7824","DOI":"10.1073\/pnas.79.24.7824","volume":"79","author":"R Dalla-Favera","year":"1982","unstructured":"Dalla-Favera R, Bregni M, Erikson J, Patterson D, Gallo RC, Croce CM . (1982). Human c-myc onc gene is located on the region of chromosome 8 that is translocated in Burkitt lymphoma cells. Proc Natl Acad Sci USA 79: 7824\u20137827.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFonc2010150_CR4","doi-asserted-by":"publisher","first-page":"510","DOI":"10.1038\/35006670","volume":"404","author":"MJ Difilippantonio","year":"2000","unstructured":"Difilippantonio MJ, Zhu J, Chen HT, Meffre E, Nussenzweig MC, Max EE et al. (2000). DNA repair protein Ku80 suppresses chromosomal aberrations and malignant transformation. Nature 404: 510\u2013514.","journal-title":"Nature"},{"key":"BFonc2010150_CR5","doi-asserted-by":"publisher","first-page":"2023","DOI":"10.1101\/gad928101","volume":"15","author":"RN Eisenman","year":"2001","unstructured":"Eisenman RN . (2001). Deconstructing myc. Genes Dev 15: 2023\u20132030.","journal-title":"Genes Dev"},{"key":"BFonc2010150_CR6","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1016\/j.molcel.2006.01.005","volume":"21","author":"S Franco","year":"2006","unstructured":"Franco S, Gostissa M, Zha S, Lombard DB, Murphy MM, Zarrin AA et al. (2006). H2AX prevents DNA breaks from progressing to chromosome breaks and translocations. Mol Cell 21: 201\u2013214.","journal-title":"Mol Cell"},{"key":"BFonc2010150_CR7","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1016\/j.smim.2005.09.003","volume":"17","author":"RN Germain","year":"2005","unstructured":"Germain RN, Castellino F, Chieppa M, Egen JG, Huang AY, Koo LY et al. (2005). An extended vision for dynamic high-resolution intravital immune imaging. Semin Immunol 17: 431\u2013441.","journal-title":"Semin Immunol"},{"key":"BFonc2010150_CR8","doi-asserted-by":"publisher","first-page":"2265","DOI":"10.1073\/pnas.0812763106","volume":"106","author":"M Gostissa","year":"2009","unstructured":"Gostissa M, Ranganath S, Bianco JM, Alt FW . (2009a). Chromosomal location targets different MYC family gene members for oncogenic translocations. Proc Natl Acad Sci USA 106: 2265\u20132270.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFonc2010150_CR9","doi-asserted-by":"publisher","first-page":"803","DOI":"10.1038\/nature08633","volume":"462","author":"M Gostissa","year":"2009","unstructured":"Gostissa M, Yan CT, Bianco JM, Cogne M, Pinaud E, Alt FW . (2009b). Long-range oncogenic activation of Igh-c-myc translocations by the Igh 3\u2032 regulatory region. Nature 462: 803\u2013807.","journal-title":"Nature"},{"key":"BFonc2010150_CR10","doi-asserted-by":"publisher","first-page":"1213","DOI":"10.1016\/j.dnarep.2006.05.017","volume":"5","author":"S Janz","year":"2006","unstructured":"Janz S . (2006). Myc translocations in B cell and plasma cell neoplasms. DNA Repair (Amst) 5: 1213\u20131224.","journal-title":"DNA Repair (Amst)"},{"key":"BFonc2010150_CR11","doi-asserted-by":"publisher","first-page":"7361","DOI":"10.1073\/pnas.90.15.7361","volume":"90","author":"S Janz","year":"1993","unstructured":"Janz S, M\u00fcller J, Shaughnessy J, Potter M . (1993). Detection of recombinations between c-myc and immunoglobulin switch alpha in murine plasma cell tumors and preneoplastic lesions by polymerase chain reaction. Proc Natl Acad Sci USA 90: 7361\u20137365.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFonc2010150_CR12","doi-asserted-by":"publisher","first-page":"2842","DOI":"10.1038\/sj.onc.1206345","volume":"22","author":"AL Kovalchuk","year":"2003","unstructured":"Kovalchuk AL, Kim JS, Janz S . (2003). E mu\/S mu transposition into Myc is sometimes a precursor for T(12;15) translocation in mouse B cells. Oncogene 22: 2842\u20132850.","journal-title":"Oncogene"},{"key":"BFonc2010150_CR13","doi-asserted-by":"publisher","first-page":"1127","DOI":"10.1038\/sj.leu.2401767","volume":"14","author":"AL Kovalchuk","year":"2000","unstructured":"Kovalchuk AL, Kishimoto T, Janz S . (2000a). Lymph nodes and Peyer's patches of IL-6 transgenic BALB\/c mice harbor T(12;15) translocated plasma cells that contain illegitimate exchanges between the immunoglobulin heavy-chain mu locus and c-myc. Leukemia 14: 1127\u20131135.","journal-title":"Leukemia"},{"key":"BFonc2010150_CR14","doi-asserted-by":"publisher","first-page":"2369","DOI":"10.1038\/sj.onc.1201409","volume":"15","author":"AL Kovalchuk","year":"1997","unstructured":"Kovalchuk AL, M\u00fcller JR, Janz S . (1997). Deletional remodeling of c-myc-deregulating translocations. Oncogene 15: 2369\u20132377.","journal-title":"Oncogene"},{"key":"BFonc2010150_CR15","doi-asserted-by":"publisher","first-page":"909","DOI":"10.1038\/sj.leu.2401676","volume":"14","author":"AL Kovalchuk","year":"2000","unstructured":"Kovalchuk AL, Mushinski EB, Janz S . (2000b). Clonal diversification of primary BALB\/c plasmacytomas harboring T(12;15) chromosomal translocations. Leukemia 14: 909\u2013921.","journal-title":"Leukemia"},{"key":"BFonc2010150_CR16","doi-asserted-by":"publisher","first-page":"5580","DOI":"10.1038\/sj.onc.1204640","volume":"20","author":"R Kuppers","year":"2001","unstructured":"Kuppers R, Dalla-Favera R . (2001). Mechanisms of chromosomal translocations in B cell lymphomas. Oncogene 20: 5580\u20135594.","journal-title":"Oncogene"},{"key":"BFonc2010150_CR17","doi-asserted-by":"publisher","first-page":"1071","DOI":"10.1101\/gad.1095203","volume":"17","author":"DL Levens","year":"2003","unstructured":"Levens DL . (2003). Reconstructing MYC. Genes Dev 17: 1071\u20131077.","journal-title":"Genes Dev"},{"key":"BFonc2010150_CR18","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1038\/nrc2091","volume":"7","author":"F Mitelman","year":"2007","unstructured":"Mitelman F, Johansson B, Mertens F . (2007). The impact of translocations and gene fusions on cancer causation. Nat Rev Cancer 7: 233\u2013245.","journal-title":"Nat Rev Cancer"},{"key":"BFonc2010150_CR19","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1182\/blood.V89.1.291","volume":"89","author":"JR M\u00fcller","year":"1997","unstructured":"M\u00fcller JR, Jones GM, Janz S, Potter M . (1997a). Migration of cells with immunoglobulin\/c-myc recombinations in lymphoid tissues of mice. Blood 89: 291\u2013296.","journal-title":"Blood"},{"key":"BFonc2010150_CR20","first-page":"419","volume":"56","author":"JR M\u00fcller","year":"1996","unstructured":"M\u00fcller JR, Jones GM, Potter M, Janz S . (1996). Detection of immunoglobulin\/c-myc recombinations in mice that are resistant to plasmacytoma induction. Cancer Res 56: 419\u2013423.","journal-title":"Cancer Res"},{"key":"BFonc2010150_CR21","first-page":"251","volume":"224","author":"JR M\u00fcller","year":"1997","unstructured":"M\u00fcller JR, Mushinski EB, Jones GM, Williams JA, Janz S, Hausner PF et al. (1997b). Generation of immunoglobulin\/c-myc recombinations in murine Peyer's patch follicles. Curr Top Microbiol Immunol 224: 251\u2013255.","journal-title":"Curr Top Microbiol Immunol"},{"key":"BFonc2010150_CR22","doi-asserted-by":"publisher","first-page":"553","DOI":"10.1016\/S0092-8674(00)00078-7","volume":"102","author":"M Muramatsu","year":"2000","unstructured":"Muramatsu M, Kinoshita K, Fagarasan S, Yamada S, Shinkai Y, Honjo T . (2000). Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme. Cell 102: 553\u2013563.","journal-title":"Cell"},{"key":"BFonc2010150_CR23","doi-asserted-by":"publisher","first-page":"13588","DOI":"10.1073\/pnas.94.25.13588","volume":"94","author":"A Nussenzweig","year":"1997","unstructured":"Nussenzweig A, Sokol K, Burgman P, Li L, Li GC . (1997). Hypersensitivity of Ku80-deficient cell lines and mice to DNA damage: the effects of ionizing radiation on growth, survival, and development. Proc Natl Acad Sci USA 94: 13588\u201313593.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFonc2010150_CR24","doi-asserted-by":"publisher","first-page":"921","DOI":"10.1084\/jem.186.6.921","volume":"186","author":"H Ouyang","year":"1997","unstructured":"Ouyang H, Nussenzweig A, Kurimasa A, Soares VC, Li X, Cordon-Cardo C et al. (1997). Ku70 is required for DNA repair but not for T cell antigen receptor gene recombination in vivo. J Exp Med 186: 921\u2013929.","journal-title":"J Exp Med"},{"key":"BFonc2010150_CR25","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1016\/j.cell.2004.08.006","volume":"118","author":"AR Ramiro","year":"2004","unstructured":"Ramiro AR, Jankovic M, Eisenreich T, Difilippantonio S, Chen-Kiang S, Muramatsu M et al. (2004). AID is required for c-myc\/IgH chromosome translocations in vivo. Cell 118: 431\u2013438.","journal-title":"Cell"},{"key":"BFonc2010150_CR26","doi-asserted-by":"publisher","first-page":"1028","DOI":"10.1016\/j.cell.2008.09.062","volume":"135","author":"DF Robbiani","year":"2008","unstructured":"Robbiani DF, Bothmer A, Callen E, Reina-San-Martin B, Dorsett Y, Difilippantonio S et al. (2008). AID is required for the chromosomal breaks in c-myc that lead to c-myc\/IgH translocations. Cell 135: 1028\u20131038.","journal-title":"Cell"},{"key":"BFonc2010150_CR27","first-page":"8656","volume":"63","author":"S Silva","year":"2003","unstructured":"Silva S, Kovalchuk AL, Kim JS, Klein G, Janz S . (2003). BCL2 accelerates inflammation-induced BALB\/c plasmacytomas and promotes novel tumors with coexisting T(12;15) and T(6;15) translocations. Cancer Res 63: 8656\u20138663.","journal-title":"Cancer Res"},{"key":"BFonc2010150_CR28","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1073\/pnas.89.1.232","volume":"89","author":"S Suematsu","year":"1992","unstructured":"Suematsu S, Matsusaka T, Matsuda T, Ohno S, Miyazaki J, Yamamura K et al. (1992). Generation of plasmacytomas with the chromosomal translocation t(12;15) in interleukin 6 transgenic mice. Proc Natl Acad Sci USA 89: 232\u2013235.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFonc2010150_CR29","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1038\/nature08159","volume":"460","author":"JH Wang","year":"2009","unstructured":"Wang JH, Gostissa M, Yan CT, Goff P, Hickernell T, Hansen E et al. (2009). Mechanisms promoting translocations in editing and switching peripheral B cells. Nature 460: 231\u2013236.","journal-title":"Nature"},{"key":"BFonc2010150_CR30","doi-asserted-by":"publisher","first-page":"542","DOI":"10.1002\/cyto.a.20419","volume":"71","author":"JT Wessels","year":"2007","unstructured":"Wessels JT, Busse AC, Mahrt J, Dullin C, Grabbe E, Mueller GA . (2007). In vivo imaging in experimental preclinical tumor research\u2014a review. Cytometry A 71: 542\u2013549.","journal-title":"Cytometry A"},{"key":"BFonc2010150_CR31","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1182\/blood.V96.3.808","volume":"96","author":"TG Willis","year":"2000","unstructured":"Willis TG, Dyer MJ . (2000). The role of immunoglobulin translocations in the pathogenesis of B-cell malignancies. Blood 96: 808\u2013822.","journal-title":"Blood"}],"container-title":["Oncogene"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/onc2010150.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/onc2010150","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/onc2010150.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,21]],"date-time":"2022-03-21T17:04:31Z","timestamp":1647882271000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/onc2010150"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,5,10]]},"references-count":31,"journal-issue":{"issue":"28","published-print":{"date-parts":[[2010,7,15]]}},"alternative-id":["BFonc2010150"],"URL":"https:\/\/doi.org\/10.1038\/onc.2010.150","relation":{},"ISSN":["0950-9232","1476-5594"],"issn-type":[{"value":"0950-9232","type":"print"},{"value":"1476-5594","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,5,10]]},"assertion":[{"value":"8 August 2009","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 March 2010","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 April 2010","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 May 2010","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}