{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T07:12:28Z","timestamp":1779347548513,"version":"3.51.4"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2010,10,25]],"date-time":"2010-10-25T00:00:00Z","timestamp":1287964800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2010,10,25]],"date-time":"2010-10-25T00:00:00Z","timestamp":1287964800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Oncogene"],"published-print":{"date-parts":[[2011,2,24]]},"DOI":"10.1038\/onc.2010.473","type":"journal-article","created":{"date-parts":[[2010,10,25]],"date-time":"2010-10-25T10:20:05Z","timestamp":1288002005000},"page":"967-977","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["The reduced and altered activities of PAX5 are linked to the protein\u2013protein interaction motif (coiled-coil domain) of the PAX5\u2013PML fusion protein in t(9;15)-associated acute lymphocytic leukemia"],"prefix":"10.1038","volume":"30","author":[{"given":"J J","family":"Qiu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Chu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"X","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"X","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Dong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2010,10,25]]},"reference":[{"key":"BFonc2010473_CR1","doi-asserted-by":"publisher","first-page":"1589","DOI":"10.1101\/gad.6.9.1589","volume":"6","author":"B Adams","year":"1992","unstructured":"Adams B, Dorfler P, Aguzzi A, Kozmik Z, Urbanek P, Maurer-Fogy I et al. (1992). Pax-5 encodes the transcription factor BSAP and is expressed in B lymphocytes, the developing CNS, and adult testis. Genes Dev 6: 1589\u20131607.","journal-title":"Genes Dev"},{"key":"BFonc2010473_CR2","doi-asserted-by":"publisher","first-page":"5736","DOI":"10.1038\/sj.onc.1204599","volume":"20","author":"FG Barr","year":"2001","unstructured":"Barr FG . (2001). Gene fusions involving PAX and FOX family members in alveolar rhabdomyosarcoma. Oncogene 20: 5736\u20135746.","journal-title":"Oncogene"},{"key":"BFonc2010473_CR3","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1038\/ni1454","volume":"8","author":"C Cobaleda","year":"2007","unstructured":"Cobaleda C, Schebesta A, Delogu A, Busslinger M . (2007). Pax5: the guardian of B cell identity and function. Nat Immunol 8: 463\u2013470.","journal-title":"Nat Immunol"},{"key":"BFonc2010473_CR4","doi-asserted-by":"publisher","first-page":"2048","DOI":"10.1101\/gad.7.10.2048","volume":"7","author":"T Czerny","year":"1993","unstructured":"Czerny T, Schaffner G, Busslinger M . (1993). DNA sequence recognition by Pax proteins: bipartite structure of the paired domain and its binding site. Genes Dev 7: 2048\u20132061.","journal-title":"Genes Dev"},{"key":"BFonc2010473_CR5","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1016\/0092-8674(91)90113-D","volume":"66","author":"H de The","year":"1991","unstructured":"de The H, Lavau C, Marchio A, Chomienne C, Degos L, Dejean A . (1991). The PML-RAR alpha fusion mRNA generated by the t(15;17) translocation in acute promyelocytic leukemia encodes a functionally altered RAR. Cell 66: 675\u2013684.","journal-title":"Cell"},{"key":"BFonc2010473_CR6","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1016\/j.immuni.2006.01.012","volume":"24","author":"A Delogu","year":"2006","unstructured":"Delogu A, Schebesta A, Sun Q, Aschenbrenner K, Perlot T, Busslinger M . (2006). Gene repression by Pax5 in B cells is essential for blood cell homeostasis and is reversed in plasma cells. Immunity 24: 269\u2013281.","journal-title":"Immunity"},{"key":"BFonc2010473_CR7","doi-asserted-by":"publisher","first-page":"858","DOI":"10.1038\/sj.onc.1206182","volume":"22","author":"S Dong","year":"2003","unstructured":"Dong S, Qiu J, Stenoien DL, Brinkley WR, Mancini MA, Tweardy DJ . (2003). Essential role for the dimerization domain of NuMA-RARalpha in its oncogenic activities and localization to NuMA sites within the nucleus. Oncogene 22: 858\u2013868.","journal-title":"Oncogene"},{"key":"BFonc2010473_CR8","doi-asserted-by":"publisher","first-page":"4465","DOI":"10.1128\/MCB.24.10.4465-4475.2004","volume":"24","author":"S Dong","year":"2004","unstructured":"Dong S, Stenoien DL, Qiu J, Mancini MA, Tweardy DJ . (2004). Reduced intranuclear mobility of APL fusion proteins accompanies their mislocalization and results in sequestration and decreased mobility of retinoid X receptor alpha. Mol Cell Biol 24: 4465\u20134475.","journal-title":"Mol Cell Biol"},{"key":"BFonc2010473_CR9","doi-asserted-by":"publisher","first-page":"6313","DOI":"10.1038\/sj.onc.1203029","volume":"18","author":"F Grignani","year":"1999","unstructured":"Grignani F, Gelmetti V, Fanelli M, Rogaia D, De Matteis S, Ferrara FF et al. (1999). Formation of PML \/RAR alpha high molecular weight nuclear complexes through the PML coiled-coil region is essential for the PML \/RAR alpha-mediated retinoic acid response. Oncogene 18: 6313\u20136321.","journal-title":"Oncogene"},{"key":"BFonc2010473_CR10","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1016\/j.bbrc.2007.10.184","volume":"365","author":"Y Huang","year":"2008","unstructured":"Huang Y, Qiu J, Chen G, Dong S . (2008). Coiled-coil domain of PML is essential for the aberrant dynamics of PML-RARalpha, resulting in sequestration and decreased mobility of SMRT. Biochem Biophys Res Commun 365: 258\u2013265.","journal-title":"Biochem Biophys Res Commun"},{"key":"BFonc2010473_CR11","doi-asserted-by":"publisher","first-page":"11921","DOI":"10.1073\/pnas.0711039105","volume":"105","author":"N Kawamata","year":"2008","unstructured":"Kawamata N, Ogawa S, Zimmermann M, Niebuhr B, Stocking C, Sanada M et al. (2008). Cloning of genes involved in chromosomal translocations by high-resolution single nucleotide polymorphism genomic microarray. Proc Natl Acad Sci USA 105: 11921\u201311926.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFonc2010473_CR12","doi-asserted-by":"publisher","first-page":"1073","DOI":"10.1002\/j.1460-2075.1994.tb06356.x","volume":"13","author":"MH Koken","year":"1994","unstructured":"Koken MH, Puvion-Dutilleul F, Guillemin MC, Viron A, Linares-Cruz G, Stuurman N et al. (1994). The t(15;17) translocation alters a nuclear body in a retinoic acid-reversible fashion. EMBO J 13: 1073\u20131083.","journal-title":"EMBO J"},{"key":"BFonc2010473_CR13","doi-asserted-by":"publisher","first-page":"2853","DOI":"10.1073\/pnas.0810558106","volume":"106","author":"C Kwok","year":"2009","unstructured":"Kwok C, Zeisig BB, Qiu J, Dong S, So CW . (2009). Transforming activity of AML1-ETO is independent of CBFbeta and ETO interaction but requires formation of homo-oligomeric complexes. Proc Natl Acad Sci USA 106: 2853\u20132858.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFonc2010473_CR14","doi-asserted-by":"publisher","first-page":"2601","DOI":"10.1128\/MCB.19.4.2601","volume":"19","author":"J Lauring","year":"1999","unstructured":"Lauring J, Schlissel MS . (1999). Distinct factors regulate the murine RAG-2 promoter in B- and T-cell lines. Mol Cell Biol 19: 2601\u20132612.","journal-title":"Mol Cell Biol"},{"key":"BFonc2010473_CR15","doi-asserted-by":"publisher","first-page":"1059","DOI":"10.1126\/science.278.5340.1059","volume":"278","author":"AT Look","year":"1997","unstructured":"Look AT . (1997). Oncogenic transcription factors in the human acute leukemias. Science 278: 1059\u20131064.","journal-title":"Science"},{"key":"BFonc2010473_CR16","doi-asserted-by":"crossref","first-page":"3167","DOI":"10.1182\/blood.V93.10.3167.410k44_3167_3215","volume":"93","author":"A Melnick","year":"1999","unstructured":"Melnick A, Licht JD . (1999). Deconstructing a disease: RARalpha, its fusion partners, and their roles in the pathogenesis of acute promyelocytic leukemia. Blood 93: 3167\u20133215.","journal-title":"Blood"},{"key":"BFonc2010473_CR17","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1126\/science.1067518","volume":"297","author":"I Mikkola","year":"2002","unstructured":"Mikkola I, Heavey B, Horcher M, Busslinger M . (2002). Reversion of B cell commitment upon loss of Pax5 expression. Science 297: 110\u2013113.","journal-title":"Science"},{"key":"BFonc2010473_CR18","doi-asserted-by":"publisher","first-page":"758","DOI":"10.1038\/nature05690","volume":"446","author":"CG Mullighan","year":"2007","unstructured":"Mullighan CG, Goorha S, Radtke I, Miller CB, Coustan-Smith E, Dalton JD et al. (2007). Genome-wide analysis of genetic alterations in acute lymphoblastic leukaemia. Nature 446: 758\u2013764.","journal-title":"Nature"},{"key":"BFonc2010473_CR19","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1038\/leu.2008.306","volume":"23","author":"K Nebral","year":"2009","unstructured":"Nebral K, Denk D, Attarbaschi A, Konig M, Mann G, Haas OA et al. (2009). Incidence and diversity of PAX5 fusion genes in childhood acute lymphoblastic leukemia. Leukemia 23: 134\u2013143.","journal-title":"Leukemia"},{"key":"BFonc2010473_CR20","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1111\/j.1365-2141.2007.06731.x","volume":"139","author":"K Nebral","year":"2007","unstructured":"Nebral K, Konig M, Harder L, Siebert R, Haas OA, Strehl S . (2007). Identification of PML as novel PAX5 fusion partner in childhood acute lymphoblastic leukaemia. Br J Haematol 139: 269\u2013274.","journal-title":"Br J Haematol"},{"key":"BFonc2010473_CR21","doi-asserted-by":"publisher","first-page":"556","DOI":"10.1038\/44076","volume":"401","author":"SL Nutt","year":"1999","unstructured":"Nutt SL, Heavey B, Rolink AG, Busslinger M . (1999). Commitment to the B-lymphoid lineage depends on the transcription factor Pax5. Nature 401: 556\u2013562.","journal-title":"Nature"},{"key":"BFonc2010473_CR22","doi-asserted-by":"publisher","first-page":"1719","DOI":"10.4049\/jimmunol.180.3.1719","volume":"180","author":"C Pridans","year":"2008","unstructured":"Pridans C, Holmes ML, Polli M, Wettenhall JM, Dakic A, Corcoran LM et al. (2008). Identification of Pax5 target genes in early B cell differentiation. J Immunol 180: 1719\u20131728.","journal-title":"J Immunol"},{"key":"BFonc2010473_CR23","doi-asserted-by":"publisher","first-page":"1891","DOI":"10.1038\/sj.leu.2403073","volume":"17","author":"J Qiu","year":"2003","unstructured":"Qiu J, Gunaratne P, Peterson LE, Khurana D, Walsham N, Loulseged H et al. (2003). Novel potential ALL low-risk markers revealed by gene expression profiling with new high-throughput SSH-CCS-PCR. Leukemia 17: 1891\u20131900.","journal-title":"Leukemia"},{"key":"BFonc2010473_CR24","doi-asserted-by":"publisher","first-page":"3941","DOI":"10.1091\/mbc.e07-03-0245","volume":"18","author":"J Qiu","year":"2007","unstructured":"Qiu J, Huang Y, Chen G, Chen Z, Tweardy DJ, Dong S . (2007). Aberrant chromatin remodeling by retinoic acid receptor alpha fusion proteins assessed at the single-cell level. Mol Biol Cell 18: 3941\u20133951.","journal-title":"Mol Biol Cell"},{"key":"BFonc2010473_CR25","doi-asserted-by":"publisher","first-page":"908","DOI":"10.1038\/cr.2010.81","volume":"20","author":"J Qiu","year":"2010","unstructured":"Qiu J, Shi G, Jia Y, Li J, Wu M, Dong S et al. (2010a). The X-linked mental retardation gene PHF8 is a histone demethylase involved in neuronal differentiation. Cell Res 20: 908\u2013918.","journal-title":"Cell Res"},{"key":"BFonc2010473_CR26","doi-asserted-by":"publisher","first-page":"3982","DOI":"10.1038\/sj.onc.1209431","volume":"25","author":"J Qiu","year":"2006","unstructured":"Qiu J, Wong J, Tweardy DJ, Dong S . (2006). Decreased intranuclear mobility of acute myeloid leukemia 1-containing fusion proteins is accompanied by reduced mobility and compartmentalization of core binding factor beta. Oncogene 25: 3982\u20133993.","journal-title":"Oncogene"},{"key":"BFonc2010473_CR27","doi-asserted-by":"publisher","first-page":"643","DOI":"10.1182\/blood-2009-07-232652","volume":"115","author":"JJ Qiu","year":"2010","unstructured":"Qiu JJ, Lu X, Zeisig BB, Ma Z, Cai X, Chen S et al. (2010b). Leukemic transformation by the APL fusion protein PRKAR1A-RARalpha critically depends on recruitment of RXRalpha. Blood 115: 643\u2013652.","journal-title":"Blood"},{"key":"BFonc2010473_CR28","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1038\/nrc1778","volume":"6","author":"EJ Robson","year":"2006","unstructured":"Robson EJ, He SJ, Eccles MR . (2006). A PANorama of PAX genes in cancer and development. Nat Rev Cancer 6: 52\u201362.","journal-title":"Nat Rev Cancer"},{"key":"BFonc2010473_CR29","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/j.immuni.2007.05.019","volume":"27","author":"A Schebesta","year":"2007","unstructured":"Schebesta A, McManus S, Salvagiotto G, Delogu A, Busslinger GA, Busslinger M . (2007). Transcription factor Pax5 activates the chromatin of key genes involved in B cell signaling, adhesion, migration, and immune function. Immunity 27: 49\u201363.","journal-title":"Immunity"},{"key":"BFonc2010473_CR30","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1016\/S1074-7613(02)00418-1","volume":"17","author":"M Schebesta","year":"2002","unstructured":"Schebesta M, Pfeffer PL, Busslinger M . (2002). Control of pre-BCR signaling by Pax5-dependent activation of the BLNK gene. Immunity 17: 473\u2013485.","journal-title":"Immunity"},{"key":"BFonc2010473_CR31","doi-asserted-by":"publisher","first-page":"919","DOI":"10.1182\/blood-2004-03-0992","volume":"104","author":"CW So","year":"2004","unstructured":"So CW, Cleary ML . (2004). Dimerization: a versatile switch for oncogenesis. Blood 104: 919\u2013922.","journal-title":"Blood"},{"key":"BFonc2010473_CR32","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1016\/S1535-6108(03)00019-9","volume":"3","author":"CW So","year":"2003","unstructured":"So CW, Karsunky H, Passegue E, Cozzio A, Weissman IL, Cleary ML . (2003a). MLL-GAS7 transforms multipotent hematopoietic progenitors and induces mixed lineage leukemias in mice. Cancer Cell 3: 161\u2013171.","journal-title":"Cancer Cell"},{"key":"BFonc2010473_CR33","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1016\/S1535-6108(03)00188-0","volume":"4","author":"CW So","year":"2003","unstructured":"So CW, Lin M, Ayton PM, Chen EH, Cleary ML . (2003b). Dimerization contributes to oncogenic activation of MLL chimeras in acute leukemias. Cancer Cell 4: 99\u2013110.","journal-title":"Cancer Cell"},{"key":"BFonc2010473_CR34","doi-asserted-by":"publisher","first-page":"901","DOI":"10.1016\/0092-8674(94)90079-5","volume":"79","author":"P Urbanek","year":"1994","unstructured":"Urbanek P, Wang ZQ, Fetka I, Wagner EF, Busslinger M . (1994). Complete block of early B cell differentiation and altered patterning of the posterior midbrain in mice lacking Pax5 \/BSAP. Cell 79: 901\u2013912.","journal-title":"Cell"},{"key":"BFonc2010473_CR35","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1016\/j.ccr.2007.06.006","volume":"12","author":"BB Zeisig","year":"2007","unstructured":"Zeisig BB, Kwok C, Zelent A, Shankaranarayanan P, Gronemeyer H, Dong S et al. (2007). Recruitment of RXR by Homotetrameric RARalpha fusion proteins is essential for transformation. Cancer Cell 12: 36\u201351.","journal-title":"Cancer Cell"}],"container-title":["Oncogene"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/onc2010473.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/onc2010473","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/onc2010473.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,21]],"date-time":"2022-03-21T17:17:26Z","timestamp":1647883046000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/onc2010473"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,10,25]]},"references-count":35,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2011,2,24]]}},"alternative-id":["BFonc2010473"],"URL":"https:\/\/doi.org\/10.1038\/onc.2010.473","relation":{},"ISSN":["0950-9232","1476-5594"],"issn-type":[{"value":"0950-9232","type":"print"},{"value":"1476-5594","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,10,25]]},"assertion":[{"value":"7 December 2009","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 August 2010","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 September 2010","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 October 2010","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}