{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T20:26:29Z","timestamp":1791404789628,"version":"4.3.3"},"reference-count":38,"publisher":"Springer Science and Business Media LLC","issue":"13","license":[{"start":{"date-parts":[[2010,11,29]],"date-time":"2010-11-29T00:00:00Z","timestamp":1290988800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2010,11,29]],"date-time":"2010-11-29T00:00:00Z","timestamp":1290988800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Oncogene"],"published-print":{"date-parts":[[2011,3,31]]},"DOI":"10.1038\/onc.2010.532","type":"journal-article","created":{"date-parts":[[2010,11,30]],"date-time":"2010-11-30T13:36:56Z","timestamp":1291124216000},"page":"1566-1576","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":258,"title":["Ligand-independent activation of c-Met by fibronectin and \u03b15\u03b21-integrin regulates ovarian cancer invasion and metastasis"],"prefix":"10.1038","volume":"30","author":[{"given":"A K","family":"Mitra","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"Sawada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Tiwari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"Mui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"Gwin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"Lengyel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2010,11,29]]},"reference":[{"key":"BFonc2010532_CR1","doi-asserted-by":"publisher","first-page":"604","DOI":"10.1038\/nrc2353","volume":"8","author":"CJ Avraamides","year":"2008","unstructured":"Avraamides CJ, Garmy-Susini B, Varner JA . (2008). Integrins in angiogenesis and lymphangiogenesis. Nat Rev Cancer 8: 604\u2013617.","journal-title":"Nat Rev Cancer"},{"key":"BFonc2010532_CR2","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1479-5876-5-61","volume":"5","author":"V Bhaskar","year":"2007","unstructured":"Bhaskar V, Zhang D, Fox M, Seto P, Wong M, Wales PE et al. (2007). A function blocking anti-mouse integrin \u03b15\u03b21 antibody inhibits angiogenesis and impedes tumor growth in vivo. J Transl Med 5: 1\u201311.","journal-title":"J Transl Med"},{"key":"BFonc2010532_CR3","doi-asserted-by":"publisher","first-page":"915","DOI":"10.1038\/nrm1261","volume":"4","author":"C Birchmeier","year":"2003","unstructured":"Birchmeier C, Birchmeier W, Gherardi E, Vande Woude GF . (2003). Met, metastasis, motility and more. Nat Rev Mol Cell Biol 4: 915\u2013925.","journal-title":"Nat Rev Mol Cell Biol"},{"key":"BFonc2010532_CR4","first-page":"2017","volume":"3","author":"KR Brader","year":"1997","unstructured":"Brader KR, Wolf JK, Hung M-C, Yu D, Crispens MA, van Golen KL et al. (1997). Adenovirus E1A expression enhances the sensitivity of an ovarian cancer cell line to multiple cytotoxic agents through an apoptotic mechanism. Clin Cancer Res 3: 2017\u20132024.","journal-title":"Clin Cancer Res"},{"key":"BFonc2010532_CR5","doi-asserted-by":"publisher","first-page":"496","DOI":"10.1016\/j.devcel.2007.08.012","volume":"13","author":"PT Caswell","year":"2007","unstructured":"Caswell PT, Spence HJ, Parsons M, White DP, Clark K, Cheng KW et al. (2007). Rab25 associates with \u03b15\u03b21 integrin to promote invasive migration in 3D microenvironments. Dev Cell 13: 496\u2013510.","journal-title":"Dev Cell"},{"key":"BFonc2010532_CR6","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1007\/s11373-005-9061-7","volume":"13","author":"P-C Chan","year":"2006","unstructured":"Chan P-C, Chen SY, Chen C-H, Chen HC . (2006). Crosstalk between hepatocyte growth factor and integrin signaling pathways. J Biomed Sci 13: 215\u2013223.","journal-title":"J Biomed Sci"},{"key":"BFonc2010532_CR7","doi-asserted-by":"crossref","first-page":"20567","DOI":"10.1016\/S0021-9258(17)32031-8","volume":"269","author":"P-Y Chan","year":"1994","unstructured":"Chan P-Y, Kanner SB, Whitney G, Aruffo A . (1994). A transmembrane-anchored chimeric focal adhesion kinase is constitutively activated and phosphorylated at tyrosine residues identical to pp125fak*. J Biol Chem 269: 20567\u201320574.","journal-title":"J Biol Chem"},{"key":"BFonc2010532_CR8","doi-asserted-by":"publisher","first-page":"5155","DOI":"10.1128\/MCB.02186-05","volume":"26","author":"SY Chen","year":"2006","unstructured":"Chen SY, Chen H-C . (2006). Direct interaction of focal adhesion kinase (FAK) with met is required for FAK to promote hepatocyte growth factor-induced cell invasion. Mol Cell Biol 26: 5155\u20135167.","journal-title":"Mol Cell Biol"},{"key":"BFonc2010532_CR9","doi-asserted-by":"publisher","first-page":"927","DOI":"10.1161\/01.ATV.0000016045.93313.F2","volume":"22","author":"SE Francis","year":"2002","unstructured":"Francis SE, Goh KL, Hodivala-Dilke KM, Bader BL, Stark M, Davidson D et al. (2002). Central roles of \u03b15\u03b21 integrin and fibronectin in vascular development in mouse embryos and embryoid bodies. Arterioscler Thromb Vasc Biol 22: 927\u2013933.","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"BFonc2010532_CR10","first-page":"4261","volume":"23","author":"FE Franke","year":"2003","unstructured":"Franke FE, Von Georgi R, Zygmunt M, M\u00fcnstedt K . (2003). Association between fibronectin expression and prognosis in ovarian carcinoma. Anticancer Res 23: 4261\u20134268.","journal-title":"Anticancer Res"},{"key":"BFonc2010532_CR11","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1146\/annurev.cellbio.19.031103.133334","volume":"19","author":"FG Giancotti","year":"2003","unstructured":"Giancotti FG, Tarone G . (2003). Positional control of cell fate through joint integrin\/receptor protein kinase signaling. Annu Rev Cell Dev Biol 19: 173\u2013206.","journal-title":"Annu Rev Cell Dev Biol"},{"key":"BFonc2010532_CR12","first-page":"53","volume":"35","author":"R Hafter","year":"1984","unstructured":"Hafter R, Klaubert W, Gollwitzer R, Graeff H . (1984). Crosslinked fibrin derivatives and fibronectin in ascitic fluid from patients with ovarian cancer compared to ascitic fluid in liver cirrhosis. Thromb Haemost 35: 53\u201364.","journal-title":"Thromb Haemost"},{"key":"BFonc2010532_CR13","doi-asserted-by":"crossref","unstructured":"Huttenlocher A, Lakonishok M, Kinder M, Wu S, Truong T, Knudsen K et al. (1998). Integrin and cadherin synergy regulates contact inhibition of migration and motile activity. 141: 515\u2013526.","DOI":"10.1083\/jcb.141.2.515"},{"key":"BFonc2010532_CR14","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1016\/S0092-8674(02)00971-6","volume":"110","author":"RO Hynes","year":"2002","unstructured":"Hynes RO . (2002). Integrins: bidirectional, allosteric signaling machines. Cell 110: 673\u2013687.","journal-title":"Cell"},{"key":"BFonc2010532_CR15","doi-asserted-by":"publisher","first-page":"225","DOI":"10.3322\/caac.20006","volume":"59","author":"A Jemal","year":"2009","unstructured":"Jemal A, Siegel R, Ward E, Hao Y, Xu J, Thun MJ et al. (2009). Cancer statistics, 2009. CA Cancer J Clin 59: 225\u2013249.","journal-title":"CA Cancer J Clin"},{"key":"BFonc2010532_CR16","doi-asserted-by":"publisher","first-page":"474","DOI":"10.1016\/j.ydbio.2007.06.003","volume":"308","author":"E Jin","year":"2007","unstructured":"Jin E, Choi Y, Park E, Bang O, Kang S . (2007). MMP-2 functions as a negative regulator of chondrogenic cell condensation via down-regulation of the FAK -integrin \u03b21 interaction. Devel Biol 308: 474\u2013484.","journal-title":"Devel Biol"},{"key":"BFonc2010532_CR17","doi-asserted-by":"publisher","first-page":"683","DOI":"10.4161\/cc.8.5.7703","volume":"8","author":"HA Kenny","year":"2009","unstructured":"Kenny HA, Lengyel E . (2009). MMP-2 functions as an early response protein in ovarian cancer metastasis. Cell Cycle 8: 683\u2013688.","journal-title":"Cell Cycle"},{"key":"BFonc2010532_CR18","doi-asserted-by":"publisher","first-page":"1345","DOI":"10.1016\/S0002-9440(10)65005-5","volume":"156","author":"S Kim","year":"2000","unstructured":"Kim S, Bell K, Mousa SA, Varner JA . (2000). Regulation of angiogenesis in vivo by ligation of integrin \u03b15\u03b21with the central cell-binding domain of fibronectin. Am J Pathol 156: 1345\u20131362.","journal-title":"Am J Pathol"},{"key":"BFonc2010532_CR19","doi-asserted-by":"publisher","first-page":"1053","DOI":"10.2353\/ajpath.2010.100105","volume":"177","author":"E Lengyel","year":"2010","unstructured":"Lengyel E . (2010). Ovarian cancer development and metastasis. Am J Pathol 177: 1053\u20131064.","journal-title":"Am J Pathol"},{"key":"BFonc2010532_CR20","doi-asserted-by":"publisher","first-page":"2712","DOI":"10.1158\/0008-5472.CAN-04-2691","volume":"65","author":"A Magnussen","year":"2005","unstructured":"Magnussen A, Kasman I, Norberg S, Baluk P, Murray R, McDonald D . (2005). Rapid access of antibodies to \u03b15\u03b21 integrin overexpressed on the luminal surface of tumor blood vessels. Cancer Res 65: 2712\u20132721.","journal-title":"Cancer Res"},{"key":"BFonc2010532_CR21","doi-asserted-by":"publisher","first-page":"516","DOI":"10.1016\/j.ceb.2006.08.011","volume":"18","author":"SK Mitra","year":"2006","unstructured":"Mitra SK, Schlaepfer D . (2006). Integrin-regulated FAK-Src signaling in normal and cancer cells. Curr Opin Cell Biol 18: 516\u2013523.","journal-title":"Curr Opin Cell Biol"},{"key":"BFonc2010532_CR22","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1111\/j.1349-7006.2008.00838.x","volume":"99","author":"Y Nakamura","year":"2008","unstructured":"Nakamura Y, Matsubara D, Goto A, Ota S, Sachiko O, Ishikawa S et al. (2008). Constitutive activation of c-Met is correlated with c-Met overexpression and dependent on cell-matrix adhesion in lung adenocarcinoma cell lines. Cancer Sci 99: 14\u201322.","journal-title":"Cancer Sci"},{"key":"BFonc2010532_CR23","doi-asserted-by":"publisher","first-page":"1463","DOI":"10.1074\/jbc.M704855200","volume":"283","author":"AR Radjabi","year":"2008","unstructured":"Radjabi AR, Sawada K, Jagadeeswaran S, Eichbichler A, Kenny HA, Montag A et al. (2008). Thrombin induces tumor invasion through the induction and association of matrix metalloproteinase-9 and \u03b21-integrin on the cell surface. J Biol Chem 283: 1463\u20131472.","journal-title":"J Biol Chem"},{"key":"BFonc2010532_CR24","doi-asserted-by":"publisher","first-page":"1383","DOI":"10.1158\/0008-5472.CAN-08-3612","volume":"69","author":"JM Ricono","year":"2009","unstructured":"Ricono JM, Huang M, Barnes LA, Lau SK, Weis S, Schlaepfer D et al. (2009). Specific cross-talk between epidermal growth factor receptor and integrin \u03b1v\u03b25 promotes carcinoma cell invasion and metastasis. Cancer Res 69: 1383\u20131391.","journal-title":"Cancer Res"},{"key":"BFonc2010532_CR25","doi-asserted-by":"publisher","first-page":"20763","DOI":"10.1074\/jbc.271.34.20763","volume":"271","author":"D Rusciano","year":"1996","unstructured":"Rusciano D, Lorenzoni P, Burger MM . (1996). Constitutive activation of c-Met in liver metastatic B16 melanoma cells depends on both substrate adhesion and cell density and is regulated by a cytosolic tyrosine phosphatase activity. J Biol Chem 271: 20763\u201320769.","journal-title":"J Biol Chem"},{"key":"BFonc2010532_CR26","doi-asserted-by":"publisher","first-page":"1450","DOI":"10.1038\/sj.gt.3301553","volume":"8","author":"Y Saga","year":"2001","unstructured":"Saga Y, Mizukami H, Suzuki H, Urabe M, Kume A, Nakamura T et al. (2001). Expression of HGF\/NK4 in ovarian cancer cells suppresses intraperitoneal dissemination and extends host survival. Gene Ther 8: 1450\u20131455.","journal-title":"Gene Ther"},{"key":"BFonc2010532_CR27","doi-asserted-by":"publisher","first-page":"2329","DOI":"10.1158\/0008-5472.CAN-07-5167","volume":"68","author":"K Sawada","year":"2008","unstructured":"Sawada K, Mitra AK, Radjabi AR, Bhaskar V, Kistner E, Tretiakova MS et al. (2008). Loss of E-cadherin promotes ovarian cancer metastasis via alpha 5-integrin, which is a therapeutic target. Cancer Res 68: 2329\u20132339.","journal-title":"Cancer Res"},{"key":"BFonc2010532_CR28","doi-asserted-by":"publisher","first-page":"1670","DOI":"10.1158\/0008-5472.CAN-06-1147","volume":"67","author":"K Sawada","year":"2007","unstructured":"Sawada K, Radjabi AR, Shinomiya N, Kistner E, Kenny HA, Salgia R et al. (2007). C-Met overexpression is a prognostic factor in ovarian cancer and an effective target for inhibition of peritoneal dissemination and invasion. Cancer Res 67: 1670\u20131680.","journal-title":"Cancer Res"},{"key":"BFonc2010532_CR29","first-page":"5255","volume":"61","author":"D Taverna","year":"2001","unstructured":"Taverna D, Hynes RO . (2001). Reduced blood vessel formation and tumor growth in \u03b15-integrin-negative teratocarcinomas and embryoid bodies. Cancer Res 61: 5255\u20135261.","journal-title":"Cancer Res"},{"key":"BFonc2010532_CR30","doi-asserted-by":"publisher","first-page":"643","DOI":"10.1016\/S0092-8674(01)00567-0","volume":"107","author":"L Trusolino","year":"2001","unstructured":"Trusolino L, Bertotti A, Comoglio PM . (2001). A signaling adapter function for \u03b16\u03b24 integrin in the control of HGF-dependent invasive growth. Cell 107: 643\u2013654.","journal-title":"Cell"},{"key":"BFonc2010532_CR31","doi-asserted-by":"publisher","first-page":"1576","DOI":"10.1126\/science.7527156","volume":"266","author":"K Vuori","year":"1994","unstructured":"Vuori K, Ruoslahti E . (1994). Association of insulin receptor substrate-1 with integrins. Science 266: 1576\u20131578.","journal-title":"Science"},{"key":"BFonc2010532_CR32","doi-asserted-by":"publisher","first-page":"8425","DOI":"10.1073\/pnas.93.16.8425","volume":"93","author":"R Wang","year":"1996","unstructured":"Wang R, Kobayashi R, Bishop M . (1996). Cellular adherence elicits ligand-independent activation of the Met cell -surface receptor. Proc Natl Acad Sci USA 93: 8425\u20138430.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFonc2010532_CR33","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1016\/S0002-9440(10)62965-3","volume":"167","author":"P Wingerter","year":"2005","unstructured":"Wingerter P, Kazman I, Norberg S, Magnussen A, Zanivan S, Rissone A et al. (2005). Uniform overexpression and rapid accessibility of \u03b15\u03b21 integrin on blood vessels in tumors. Am J Pathol 167: 193\u2013211.","journal-title":"Am J Pathol"},{"key":"BFonc2010532_CR34","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1016\/j.yexcr.2004.06.002","volume":"299","author":"AST Wong","year":"2004","unstructured":"Wong AST, Roskelley CD, Pelech SL, Miller D, Leung PCK, Auersperg N . (2004). Progressive changes in Met-dependent signaling in a human ovarian surface epithelial model of malignant transformation. Exp Cell Res 299: 248\u2013256.","journal-title":"Exp Cell Res"},{"key":"BFonc2010532_CR35","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1242\/dev.119.4.1093","volume":"119","author":"JT Yang","year":"1993","unstructured":"Yang JT, Rayburn H, Hynes RO . (1993). Embryonic mesodermal defects in \u03b15 integrin-deficient mice. Development 119: 1093\u20131105.","journal-title":"Development"},{"key":"BFonc2010532_CR36","doi-asserted-by":"publisher","first-page":"10813","DOI":"10.1158\/0008-5472.CAN-07-0172","volume":"67","author":"Y Yokoyama","year":"2007","unstructured":"Yokoyama Y, Sedgewick G, Ramakrishnan S . (2007). Endostatin binding to ovarian cancer cells inhibits peritoneal attachment and dissemination. Cancer Res 67: 10813\u201310822.","journal-title":"Cancer Res"},{"key":"BFonc2010532_CR37","first-page":"891","volume":"53","author":"D Yu","year":"1992","unstructured":"Yu D, Wolf JK, Scanlon M, Price JE, Hung M-C . (1992). Enhanced c-erb B-2\/neu expression in human ovarian cancer cells correlates with more severe malignancy that can be suppressed by E1A. Cancer Res 53: 891\u2013898.","journal-title":"Cancer Res"},{"key":"BFonc2010532_CR38","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1593\/neo.09948","volume":"12","author":"M Zillhardt","year":"2010","unstructured":"Zillhardt M, Christensen J, Lengyel E . (2010). An orally available small molecule inhibitor of c-Met, PF-2341066, reduces tumor burden in a pre-clinical model of ovarian cancer metastasis. Neoplasia 12: 1\u201310.","journal-title":"Neoplasia"}],"container-title":["Oncogene"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/onc2010532.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/onc2010532","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/onc2010532.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,21]],"date-time":"2022-03-21T17:35:26Z","timestamp":1647884126000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/onc2010532"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,11,29]]},"references-count":38,"journal-issue":{"issue":"13","published-print":{"date-parts":[[2011,3,31]]}},"alternative-id":["BFonc2010532"],"URL":"https:\/\/doi.org\/10.1038\/onc.2010.532","relation":{},"ISSN":["0950-9232","1476-5594"],"issn-type":[{"value":"0950-9232","type":"print"},{"value":"1476-5594","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,11,29]]},"assertion":[{"value":"20 May 2010","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 September 2010","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 October 2010","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 November 2010","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Facet Biotech Corp. provided funding and antibodies for the animal experiments ().","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}