{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T17:47:15Z","timestamp":1791308835877,"version":"4.3.1"},"reference-count":33,"publisher":"Springer Science and Business Media LLC","issue":"31","license":[{"start":{"date-parts":[[2011,11,28]],"date-time":"2011-11-28T00:00:00Z","timestamp":1322438400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2011,11,28]],"date-time":"2011-11-28T00:00:00Z","timestamp":1322438400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Oncogene"],"published-print":{"date-parts":[[2012,8,2]]},"DOI":"10.1038\/onc.2011.538","type":"journal-article","created":{"date-parts":[[2011,11,28]],"date-time":"2011-11-28T11:46:27Z","timestamp":1322480787000},"page":"3647-3654","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Reexpression of oncoprotein MafB in proliferative \u03b2-cells and Men1 insulinomas in mouse"],"prefix":"10.1038","volume":"31","author":[{"given":"J","family":"Lu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z","family":"Hamze","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Bonnavion","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N","family":"Herath","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Pouponnot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F","family":"Assade","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Fontani\u00e8re","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Bertolino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Cordier-Bussat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C X","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2011,11,28]]},"reference":[{"key":"BFonc2011538_CR1","doi-asserted-by":"publisher","first-page":"3853","DOI":"10.1073\/pnas.0700013104","volume":"104","author":"I Artner","year":"2007","unstructured":"Artner I, Blanchi B, Raum JC, Guo M, Kaneko T, Cordes S et al. (2007). MafB is required for islet beta cell maturation. Proc Natl Acad Sci USA 104: 3853\u20133858.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFonc2011538_CR2","doi-asserted-by":"publisher","first-page":"297","DOI":"10.2337\/diabetes.55.02.06.db05-0946","volume":"55","author":"I Artner","year":"2006","unstructured":"Artner I, Le Lay J, Hang Y, Elghazi L, Schisler JC, Henderson E et al. (2006). MafB: an activator of the glucagon gene expressed in developing islet alpha- and beta-cells. Diabetes 55: 297\u2013304.","journal-title":"Diabetes"},{"key":"BFonc2011538_CR3","doi-asserted-by":"publisher","first-page":"1880","DOI":"10.1210\/me.2003-0154","volume":"17","author":"P Bertolino","year":"2003","unstructured":"Bertolino P, Tong WM, Galendo D, Wang ZQ, Zhang CX . (2003a). Heterozygous Men1 mutant mice develop a range of endocrine tumors mimicking multiple endocrine neoplasia type 1. Mol Endocrinol 17: 1880\u20131892.","journal-title":"Mol Endocrinol"},{"key":"BFonc2011538_CR4","first-page":"4836","volume":"63","author":"P Bertolino","year":"2003","unstructured":"Bertolino P, Tong WM, Herrera PL, Casse H, Zhang CX, Wang ZQ . (2003b). Pancreatic beta-cell-specific ablation of the multiple endocrine neoplasia type 1 (MEN1) gene causes full penetrance of insulinoma development in mice. Cancer Res 63: 4836\u20134841.","journal-title":"Cancer Res"},{"key":"BFonc2011538_CR5","doi-asserted-by":"crossref","first-page":"4457","DOI":"10.1182\/blood.V91.12.4457.412k48_4457_4463","volume":"91","author":"M Chesi","year":"1998","unstructured":"Chesi M, Bergsagel PL, Shonukan OO, Martelli ML, Brents LA, Chen T et al. (1998). Frequent dysregulation of the c-maf proto-oncogene at 16q23 by translocation to an Ig locus in multiple myeloma. Blood 91: 4457\u20134463.","journal-title":"Blood"},{"key":"BFonc2011538_CR6","doi-asserted-by":"publisher","first-page":"6075","DOI":"10.1128\/MCB.23.17.6075-6085.2003","volume":"23","author":"JS Crabtree","year":"2003","unstructured":"Crabtree JS, Scacheri PC, Ward JM, McNally SR, Swain GP, Montagna C et al. (2003). Of mice and MEN1: insulinomas in a conditional mouse knockout. Mol Cell Biol 23: 6075\u20136085.","journal-title":"Mol Cell Biol"},{"key":"BFonc2011538_CR7","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1016\/j.bbrc.2010.10.010","volume":"402","author":"G da Silva Xavier","year":"2010","unstructured":"da Silva Xavier G, Sun G, Qian Q, Rutter GA, Leclerc I . (2010). ChREBP regulates Pdx-1 and other glucose-sensitive genes in pancreatic beta-cells. Biochem Biophys Res Commun 402: 252\u2013257.","journal-title":"Biochem Biophys Res Commun"},{"key":"BFonc2011538_CR8","doi-asserted-by":"publisher","first-page":"683","DOI":"10.1038\/nrc2460","volume":"8","author":"A Eych\u00e8ne","year":"2008","unstructured":"Eych\u00e8ne A, Rocques N, Pouponnot C . (2008). A new MAFia in cancer. Nat Rev Cancer 8: 683\u2013693.","journal-title":"Nat Rev Cancer"},{"key":"BFonc2011538_CR9","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1677\/JOE-08-0289","volume":"199","author":"S Fontaniere","year":"2008","unstructured":"Fontaniere S, Duvillie B, Scharfmann R, Carreira C, Wang ZQ, Zhang CX . (2008). Tumour suppressor menin is essential for development of the pancreatic endocrine cells. J Endocrinol 199: 287\u2013298.","journal-title":"J Endocrinol"},{"key":"BFonc2011538_CR10","doi-asserted-by":"publisher","first-page":"1223","DOI":"10.1677\/erc.1.01294","volume":"13","author":"S Fontaniere","year":"2006","unstructured":"Fontaniere S, Tost J, Wierinckx A, Lachuer J, Lu J, Hussein N et al. (2006). Gene expression profiling in insulinomas of Men1 beta-cell mutant mice reveals early genetic and epigenetic events involved in pancreatic beta-cell tumorigenesis. Endocr Relat Cancer 13: 1223\u20131236.","journal-title":"Endocr Relat Cancer"},{"key":"BFonc2011538_CR11","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1016\/S0378-1119(99)00500-4","volume":"242","author":"K Huang","year":"2000","unstructured":"Huang K, Serria MS, Nakabayashi H, Nishi S, Sakai M . (2000). Molecular cloning and functional characterization of the mouse mafB gene. Gene 242: 419\u2013426.","journal-title":"Gene"},{"key":"BFonc2011538_CR12","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1016\/S1535-6108(04)00019-4","volume":"5","author":"EM Hurt","year":"2004","unstructured":"Hurt EM, Wiestner A, Rosenwald A, Shaffer AL, Campo E, Grogan T et al. (2004). Overexpression of c-maf is a frequent oncogenic event in multiple myeloma that promotes proliferation and pathological interactions with bone marrow stroma. Cancer Cell 5: 191\u2013199.","journal-title":"Cancer Cell"},{"key":"BFonc2011538_CR13","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1016\/j.ejca.2006.08.038","volume":"43","author":"N Hussein","year":"2007","unstructured":"Hussein N, Casse H, Fontaniere S, Morera AM, Asensio MJ, Bakeli S et al. (2007). Reconstituted expression of menin in Men1-deficient mouse Leydig tumour cells induces cell cycle arrest and apoptosis. Eur J Cancer 43: 402\u2013414.","journal-title":"Eur J Cancer"},{"key":"BFonc2011538_CR14","doi-asserted-by":"publisher","first-page":"806","DOI":"10.1126\/science.1146812","volume":"318","author":"SK Karnik","year":"2007","unstructured":"Karnik SK, Chen H, McLean GW, Heit JJ, Gu X, Zhang AY et al. (2007). Menin controls growth of pancreatic beta-cells in pregnant mice and promotes gestational diabetes mellitus. Science 318: 806\u2013809.","journal-title":"Science"},{"key":"BFonc2011538_CR15","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1002\/ijc.22288","volume":"120","author":"KA Loffler","year":"2007","unstructured":"Loffler KA, Biondi CA, Gartside M, Waring P, Stark M, Serewko-Auret MM et al. (2007). Broad tumor spectrum in a mouse model of multiple endocrine neoplasia type 1. Int J Cancer 120: 259\u2013267.","journal-title":"Int J Cancer"},{"key":"BFonc2011538_CR16","doi-asserted-by":"publisher","first-page":"1954","DOI":"10.1053\/j.gastro.2010.01.046","volume":"138","author":"J Lu","year":"2010","unstructured":"Lu J, Herrera PL, Carreira C, Bonnavion R, Seigne C, Calender A et al. (2010). Alpha cell-specific Men1 ablation triggers the transdifferentiation of glucagon-expressing cells and insulinoma development. Gastroenterology 138: 1954\u20131965.","journal-title":"Gastroenterology"},{"key":"BFonc2011538_CR17","doi-asserted-by":"publisher","first-page":"667","DOI":"10.1210\/en.2003-1099","volume":"145","author":"A Merglen","year":"2004","unstructured":"Merglen A, Theander S, Rubi B, Chaffard G, Wollheim CB, Maechler P . (2004). Glucose sensitivity and metabolism-secretion coupling studied during two-year continuous culture in INS-1E insulinoma cells. Endocrinology 145: 667\u2013678.","journal-title":"Endocrinology"},{"key":"BFonc2011538_CR18","doi-asserted-by":"publisher","first-page":"812","DOI":"10.1158\/0008-5472.CAN-05-2154","volume":"66","author":"N Morito","year":"2006","unstructured":"Morito N, Yoh K, Fujioka Y, Nakano T, Shimohata H, Hashimoto Y et al. (2006). Overexpression of c-Maf contributes to T-cell lymphoma in both mice and human. Cancer Res 66: 812\u2013819.","journal-title":"Cancer Res"},{"key":"BFonc2011538_CR19","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1158\/0008-5472.CAN-10-1057","volume":"71","author":"N Morito","year":"2011","unstructured":"Morito N, Yoh K, Maeda A, Nakano T, Fujita A, Kusakabe M et al. (2011). A novel transgenic mouse model of the human multiple myeloma chromosomal translocation t(14;16)(q32;q23). Cancer Res 71: 339\u2013348.","journal-title":"Cancer Res"},{"key":"BFonc2011538_CR20","doi-asserted-by":"publisher","first-page":"776","DOI":"10.1002\/ijc.22734","volume":"121","author":"AW Mould","year":"2007","unstructured":"Mould AW, Duncan R, Serewko-Auret M, Loffler KA, Biondi C, Gartside M et al. (2007). Global expression profiling of murine MEN1-associated tumors reveals a regulatory role for menin in transcription, cell cycle and chromatin remodelling. Int J Cancer 121: 776\u2013783.","journal-title":"Int J Cancer"},{"key":"BFonc2011538_CR21","doi-asserted-by":"publisher","first-page":"526","DOI":"10.1016\/j.ydbio.2006.02.028","volume":"293","author":"W Nishimura","year":"2006","unstructured":"Nishimura W, Kondo T, Salameh T, El Khattabi I, Dodge R, Bonner-Weir S et al. (2006). A switch from MafB to MafA expression accompanies differentiation to pancreatic beta-cells. Dev Biol 293: 526\u2013539.","journal-title":"Dev Biol"},{"key":"BFonc2011538_CR22","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1016\/j.ydbio.2007.12.009","volume":"314","author":"W Nishimura","year":"2008","unstructured":"Nishimura W, Rowan S, Salameh T, Maas RL, Bonner-Weir S, Sell SM et al. (2008). Preferential reduction of beta cells derived from Pax6-MafB pathway in MafB deficient mice. Dev Biol 314: 443\u2013456.","journal-title":"Dev Biol"},{"key":"BFonc2011538_CR23","doi-asserted-by":"publisher","first-page":"7882","DOI":"10.1038\/sj.onc.1206526","volume":"22","author":"M Nishizawa","year":"2003","unstructured":"Nishizawa M, Kataoka K, Vogt PK . (2003). MafA has strong cell transforming ability but is a weak transactivator. Oncogene 22: 7882\u20137890.","journal-title":"Oncogene"},{"key":"BFonc2011538_CR24","doi-asserted-by":"publisher","first-page":"1038","DOI":"10.1038\/nbt.1579","volume":"27","author":"S Pechhold","year":"2009","unstructured":"Pechhold S, Stouffer M, Walker G, Martel R, Seligmann B, Hang Y et al. (2009). Transcriptional analysis of intracytoplasmically stained, FACS-purified cells by high-throughput, quantitative nuclease protection. Nat Biotechnol 27: 1038\u20131042.","journal-title":"Nat Biotechnol"},{"key":"BFonc2011538_CR25","doi-asserted-by":"publisher","first-page":"1299","DOI":"10.1038\/sj.onc.1209171","volume":"25","author":"C Pouponnot","year":"2006","unstructured":"Pouponnot C, Sii-Felice K, Hmitou I, Rocques N, Lecoin L, Druillennec S et al. (2006). Cell context reveals a dual role for Maf in oncogenesis. Oncogene 25: 1299\u20131310.","journal-title":"Oncogene"},{"key":"BFonc2011538_CR26","doi-asserted-by":"publisher","first-page":"584","DOI":"10.1016\/j.molcel.2007.11.009","volume":"28","author":"N Rocques","year":"2007","unstructured":"Rocques N, Abou Zeid N, Sii-Felice K, Lecoin L, Felder-Schmittbuhl MP, Eychene A et al. (2007). GSK-3-mediated phosphorylation enhances Maf-transforming activity. Mol Cell 28: 584\u2013597.","journal-title":"Mol Cell"},{"key":"BFonc2011538_CR27","doi-asserted-by":"publisher","first-page":"5707","DOI":"10.1158\/0008-5472.CAN-05-4518","volume":"66","author":"RW Schnepp","year":"2006","unstructured":"Schnepp RW, Chen YX, Wang H, Cash T, Silva A, Diehl JA et al. (2006). Mutation of tumor suppressor gene Men1 acutely enhances proliferation of pancreatic islet cells. Cancer Res 66: 5707\u20135715.","journal-title":"Cancer Res"},{"key":"BFonc2011538_CR28","doi-asserted-by":"publisher","first-page":"817","DOI":"10.1016\/j.devcel.2007.04.011","volume":"12","author":"M Teta","year":"2007","unstructured":"Teta M, Rankin MM, Long SY, Stein GM, Kushner JA . (2007). Growth and regeneration of adult beta cells does not involve specialized progenitors. Dev Cell 12: 817\u2013826.","journal-title":"Dev Cell"},{"key":"BFonc2011538_CR29","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1016\/j.exphem.2008.08.006","volume":"37","author":"E van Stralen","year":"2009","unstructured":"van Stralen E, van de Wetering M, Agnelli L, Neri A, Clevers HC, Bast BJ . (2009). Identification of primary MAFB target genes in multiple myeloma. Exp Hematol 37: 78\u201386.","journal-title":"Exp Hematol"},{"key":"BFonc2011538_CR30","doi-asserted-by":"publisher","first-page":"4372","DOI":"10.1073\/pnas.94.9.4372","volume":"94","author":"H Wang","year":"1997","unstructured":"Wang H, Iynedjian PB . (1997). Modulation of glucose responsiveness of insulinoma beta-cells by graded overexpression of glucokinase. Proc Natl Acad Sci USA 94: 4372\u20134377.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFonc2011538_CR31","doi-asserted-by":"publisher","first-page":"20358","DOI":"10.1073\/pnas.1012257107","volume":"107","author":"Y Yang","year":"2010","unstructured":"Yang Y, Gurung B, Wu T, Wang H, Stoffers DA, Hua X . (2010). Reversal of preexisting hyperglycemia in diabetic mice by acute deletion of the Men1 gene. Proc Natl Acad Sci USA 107: 20358\u201320363.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFonc2011538_CR32","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1016\/j.mce.2006.12.032","volume":"265\u2013266","author":"Y Yang","year":"2007","unstructured":"Yang Y, Hua X . (2007). In search of tumor suppressing functions of menin. Mol Cell Endocrinol 265\u2013266: 34\u201341.","journal-title":"Mol Cell Endocrinol"},{"key":"BFonc2011538_CR33","doi-asserted-by":"publisher","first-page":"4969","DOI":"10.1128\/MCB.25.12.4969-4976.2005","volume":"25","author":"C Zhang","year":"2005","unstructured":"Zhang C, Moriguchi T, Kajihara M, Esaki R, Harada A, Shimohata H et al. (2005). MafA is a key regulator of glucose-stimulated insulin secretion. Mol Cell Biol 25: 4969\u20134976.","journal-title":"Mol Cell Biol"}],"container-title":["Oncogene"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/onc2011538.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/onc2011538","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/onc2011538.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,21]],"date-time":"2022-03-21T18:38:08Z","timestamp":1647887888000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/onc2011538"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,11,28]]},"references-count":33,"journal-issue":{"issue":"31","published-print":{"date-parts":[[2012,8,2]]}},"alternative-id":["BFonc2011538"],"URL":"https:\/\/doi.org\/10.1038\/onc.2011.538","relation":{},"ISSN":["0950-9232","1476-5594"],"issn-type":[{"value":"0950-9232","type":"print"},{"value":"1476-5594","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,11,28]]},"assertion":[{"value":"1 February 2011","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 October 2011","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 October 2011","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 November 2011","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}