{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T06:40:30Z","timestamp":1770273630511,"version":"3.49.0"},"reference-count":47,"publisher":"Springer Science and Business Media LLC","issue":"42","license":[{"start":{"date-parts":[[2011,12,19]],"date-time":"2011-12-19T00:00:00Z","timestamp":1324252800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2011,12,19]],"date-time":"2011-12-19T00:00:00Z","timestamp":1324252800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Oncogene"],"published-print":{"date-parts":[[2012,10,18]]},"DOI":"10.1038\/onc.2011.592","type":"journal-article","created":{"date-parts":[[2011,12,19]],"date-time":"2011-12-19T11:57:32Z","timestamp":1324295852000},"page":"4550-4558","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":69,"title":["Dietary zinc deficiency fuels esophageal cancer development by inducing a distinct inflammatory signature"],"prefix":"10.1038","volume":"31","author":[{"given":"C","family":"Taccioli","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"X P","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K J","family":"Smalley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J L","family":"Farber","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C M","family":"Croce","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L Y","family":"Fong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2011,12,19]]},"reference":[{"key":"BFonc2011592_CR1","doi-asserted-by":"publisher","first-page":"2893","DOI":"10.1002\/ijc.25516","volume":"127","author":"J Ferlay","year":"2010","unstructured":"Ferlay J, Shin HR, Bray F, Forman D, Mathers C, Parkin DM . Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int J Cancer 2010; 127: 2893\u20132917.","journal-title":"Int J Cancer"},{"key":"BFonc2011592_CR2","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1016\/S0140-6736(00)04046-0","volume":"357","author":"F Balkwill","year":"2001","unstructured":"Balkwill F, Mantovani A . Inflammation and cancer: back to Virchow? Lancet 2001; 357: 539\u2013545.","journal-title":"Lancet"},{"key":"BFonc2011592_CR3","doi-asserted-by":"publisher","first-page":"860","DOI":"10.1038\/nature01322","volume":"420","author":"LM Coussens","year":"2002","unstructured":"Coussens LM, Werb Z . Inflammation and cancer. Nature 2002; 420: 860\u2013867.","journal-title":"Nature"},{"key":"BFonc2011592_CR4","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1038\/nature04870","volume":"441","author":"M Karin","year":"2006","unstructured":"Karin M . Nuclear factor-kappaB in cancer development and progression. Nature 2006; 441: 431\u2013436.","journal-title":"Nature"},{"key":"BFonc2011592_CR5","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1016\/S1383-5742(00)00019-3","volume":"462","author":"AM Mandard","year":"2000","unstructured":"Mandard AM, Hainaut P, Hollstein M . Genetic steps in the development of squamous cell carcinoma of the esophagus. Mutat Res 2000; 462: 335\u2013342.","journal-title":"Mutat Res"},{"key":"BFonc2011592_CR6","first-page":"207","volume":"8","author":"PN Magee","year":"1989","unstructured":"Magee PN . The experimental basis for the role of nitroso compounds in human cancer. Cancer Surv 1989; 8: 207\u2013239.","journal-title":"Cancer Surv"},{"issue":"8 Part 1","key":"BFonc2011592_CR7","first-page":"2633","volume":"40","author":"CS Yang","year":"1980","unstructured":"Yang CS . Research on esophageal cancer in China: a review. Cancer Res 1980; 40 (8 Part 1): 2633\u20132644.","journal-title":"Cancer Res"},{"key":"BFonc2011592_CR8","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1093\/jnci\/dji042","volume":"97","author":"CC Abnet","year":"2005","unstructured":"Abnet CC, Lai B, Qiao YL, Vogt S, Luo XM, Taylor PR et al. Zinc concentration in esophageal biopsy specimens measured by x-ray fluorescence and esophageal cancer risk. J Natl Cancer Inst 2005; 97: 301\u2013306.","journal-title":"J Natl Cancer Inst"},{"key":"BFonc2011592_CR9","doi-asserted-by":"publisher","first-page":"846","DOI":"10.1126\/science.175.4024.846","volume":"175","author":"J Kmet","year":"1972","unstructured":"Kmet J, Mahboubi E . Esophageal cancer in the Caspian littoral of Iran: initial studies. Science 1972; 175: 846\u2013853.","journal-title":"Science"},{"key":"BFonc2011592_CR10","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1093\/alcalc\/agh057","volume":"39","author":"G Poschl","year":"2004","unstructured":"Poschl G, Seitz HK . Alcohol and cancer. Alcohol Alcohol 2004; 39: 155\u2013165.","journal-title":"Alcohol Alcohol"},{"key":"BFonc2011592_CR11","doi-asserted-by":"publisher","first-page":"16770","DOI":"10.1073\/pnas.222679399","volume":"99","author":"E Ho","year":"2002","unstructured":"Ho E, Ames BN . Low intracellular zinc induces oxidative DNA damage, disrupts p53, NFkappa B, and AP1 DNA binding, and affects DNA repair in a rat glioma cell line. Proc Natl Acad Sci USA 2002; 99: 16770\u201316775.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFonc2011592_CR12","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1023\/A:1021215111729","volume":"21","author":"AS Prasad","year":"2002","unstructured":"Prasad AS, Kucuk O . Zinc in cancer prevention. Cancer Metastasis Rev 2002; 21: 291\u2013295.","journal-title":"Cancer Metastasis Rev"},{"key":"BFonc2011592_CR13","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1152\/physrev.1993.73.1.79","volume":"73","author":"BL Vallee","year":"1993","unstructured":"Vallee BL, Falchuk KH . The biochemical basis of zinc physiology. Physiol Rev 1993; 73: 79\u2013118.","journal-title":"Physiol Rev"},{"key":"BFonc2011592_CR14","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.it.2006.11.005","volume":"28","author":"L Rink","year":"2007","unstructured":"Rink L, Haase H . Zinc homeostasis and immunity. Trends Immunol 2007; 28: 1\u20134.","journal-title":"Trends Immunol"},{"key":"BFonc2011592_CR15","doi-asserted-by":"publisher","first-page":"1081","DOI":"10.1126\/science.271.5252.1081","volume":"271","author":"JM Berg","year":"1996","unstructured":"Berg JM, Shi Y . The galvanization of biology: a growing appreciation for the roles of zinc. Science 1996; 271: 1081\u20131085.","journal-title":"Science"},{"key":"BFonc2011592_CR16","first-page":"1471","volume":"61","author":"SF Stinson","year":"1978","unstructured":"Stinson SF, Squire RA, Sporn MB . Pathology of esophageal neoplasms and associated proliferative lesions induced in rats by N-methyl-N-benzylnitrosamine. J Natl Cancer Inst 1978; 61: 1471\u20131475.","journal-title":"J Natl Cancer Inst"},{"key":"BFonc2011592_CR17","doi-asserted-by":"publisher","first-page":"1737","DOI":"10.1093\/carcin\/22.11.1737","volume":"22","author":"GD Stoner","year":"2001","unstructured":"Stoner GD, Gupta A . Etiology and chemoprevention of esophageal squamous cell carcinoma. Carcinogenesis 2001; 22: 1737\u20131746.","journal-title":"Carcinogenesis"},{"key":"BFonc2011592_CR18","doi-asserted-by":"publisher","first-page":"223","DOI":"10.3109\/07357908409104376","volume":"2","author":"AE Pegg","year":"1984","unstructured":"Pegg AE . Methylation of the O6 position of guanine in DNA is the most likely initiating event in carcinogenesis by methylating agents. Cancer Invest 1984; 2: 223\u2013231.","journal-title":"Cancer Invest"},{"key":"BFonc2011592_CR19","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1002\/mc.2940090107","volume":"9","author":"JC Lozano","year":"1994","unstructured":"Lozano JC, Nakazawa H, Cros MP, Cabral R, Yamasaki H . G--&gt;A mutations in p53 and Ha-ras genes in esophageal papillomas induced by N-nitrosomethylbenzylamine in two strains of rats. Mol Carcinog 1994; 9: 33\u201339.","journal-title":"Mol Carcinog"},{"key":"BFonc2011592_CR20","doi-asserted-by":"publisher","first-page":"1525","DOI":"10.1093\/jnci\/93.20.1525","volume":"93","author":"LY Fong","year":"2001","unstructured":"Fong LY, Nguyen VT, Farber JL . Esophageal cancer prevention in zinc-deficient rats: rapid induction of apoptosis by replenishing zinc. J Natl Cancer Inst 2001; 93: 1525\u20131533.","journal-title":"J Natl Cancer Inst"},{"key":"BFonc2011592_CR21","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1093\/jnci\/dji006","volume":"97","author":"LY Fong","year":"2005","unstructured":"Fong LY, Zhang L, Jiang Y, Farber JL . Dietary zinc modulation of COX-2 expression and lingual and esophageal carcinogenesis in rats. J Natl Cancer Inst 2005; 97: 40\u201350.","journal-title":"J Natl Cancer Inst"},{"key":"BFonc2011592_CR22","doi-asserted-by":"publisher","first-page":"953","DOI":"10.1053\/j.gastro.2008.11.039","volume":"136","author":"C Taccioli","year":"2009","unstructured":"Taccioli C, Wan SG, Liu CG, Alder H, Volinia S, Farber JL et al. Zinc replenishment reverses overexpression of the proinflammatory mediator S100A8 and esophageal preneoplasia in the rat. Gastroenterology 2009; 136: 953\u2013966.","journal-title":"Gastroenterology"},{"key":"BFonc2011592_CR23","doi-asserted-by":"publisher","first-page":"436","DOI":"10.1038\/nature07205","volume":"454","author":"A Mantovani","year":"2008","unstructured":"Mantovani A, Allavena P, Sica A, Balkwill F . Cancer-related inflammation. Nature 2008; 454: 436\u2013444.","journal-title":"Nature"},{"key":"BFonc2011592_CR24","doi-asserted-by":"publisher","first-page":"1622","DOI":"10.1016\/j.bcp.2006.05.017","volume":"72","author":"C Gebhardt","year":"2006","unstructured":"Gebhardt C, Nemeth J, Angel P, Hess J . S100A8 and S100A9 in inflammation and cancer. Biochem Pharmacol 2006; 72: 1622\u20131631.","journal-title":"Biochem Pharmacol"},{"key":"BFonc2011592_CR25","doi-asserted-by":"publisher","first-page":"540","DOI":"10.1038\/nrc1388","volume":"4","author":"F Balkwill","year":"2004","unstructured":"Balkwill F . Cancer and the chemokine network. Nat Rev Cancer 2004; 4: 540\u2013550.","journal-title":"Nat Rev Cancer"},{"key":"BFonc2011592_CR26","doi-asserted-by":"publisher","first-page":"7908","DOI":"10.1038\/sj.onc.1203286","volume":"18","author":"CS Williams","year":"1999","unstructured":"Williams CS, Mann M, DuBois RN . The role of cyclooxygenases in inflammation, cancer, and development. Oncogene 1999; 18: 7908\u20137916.","journal-title":"Oncogene"},{"key":"BFonc2011592_CR27","doi-asserted-by":"publisher","first-page":"2645","DOI":"10.1073\/pnas.0437939100","volume":"100","author":"E Voronov","year":"2003","unstructured":"Voronov E, Shouval DS, Krelin Y, Cagnano E, Benharroch D, Iwakura Y et al. IL-1 is required for tumor invasiveness and angiogenesis. Proc Natl Acad Sci U S A 2003; 100: 2645\u20132650.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"BFonc2011592_CR28","doi-asserted-by":"publisher","first-page":"749","DOI":"10.1038\/nri1703","volume":"5","author":"M Karin","year":"2005","unstructured":"Karin M, Greten FR . NF-kappaB: linking inflammation and immunity to cancer development and progression. Nat Rev Immunol 2005; 5: 749\u2013759.","journal-title":"Nat Rev Immunol"},{"key":"BFonc2011592_CR29","doi-asserted-by":"publisher","first-page":"656","DOI":"10.1056\/NEJMra0910283","volume":"364","author":"HK Eltzschig","year":"2011","unstructured":"Eltzschig HK, Carmeliet P . Hypoxia and inflammation. N Engl J Med 2011; 364: 656\u2013665.","journal-title":"N Engl J Med"},{"key":"BFonc2011592_CR30","first-page":"4195","volume":"21","author":"M Cintorino","year":"2001","unstructured":"Cintorino M, Tripod SA, Santopietro R, Antonio P, Lutfi A, Chang F et al. Cytokeratin expression patterns as an indicator of tumour progression in oesophageal squamous cell carcinoma. Anticancer Res 2001; 21: 4195\u20134201.","journal-title":"Anticancer Res"},{"key":"BFonc2011592_CR31","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1038\/nprot.2008.211","volume":"4","author":"W Huang da","year":"2009","unstructured":"Huang da W, Sherman BT, Lempicki RA . Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat Protoc 2009; 4: 44\u201357.","journal-title":"Nat Protoc"},{"key":"BFonc2011592_CR32","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1038\/nrc3078","volume":"11","author":"ET Roussos","year":"2011","unstructured":"Roussos ET, Condeelis JS, Patsialou A . Chemotaxis in cancer. Nat Rev Cancer 2011; 11: 573\u2013587.","journal-title":"Nat Rev Cancer"},{"key":"BFonc2011592_CR33","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1038\/35068566","volume":"410","author":"TA Samad","year":"2001","unstructured":"Samad TA, Moore KA, Sapirstein A, Billet S, Allchorne A, Poole S et al. Interleukin-1beta-mediated induction of Cox-2 in the CNS contributes to inflammatory pain hypersensitivity. Nature 2001; 410: 471\u2013475.","journal-title":"Nature"},{"key":"BFonc2011592_CR34","doi-asserted-by":"publisher","first-page":"408","DOI":"10.1016\/j.ccr.2008.10.011","volume":"14","author":"S Tu","year":"2008","unstructured":"Tu S, Bhagat G, Cui G, Takaishi S, Kurt-Jones EA, Rickman B et al. Overexpression of interleukin-1beta induces gastric inflammation and cancer and mobilizes myeloid-derived suppressor cells in mice. Cancer Cell 2008; 14: 408\u2013419.","journal-title":"Cancer Cell"},{"key":"BFonc2011592_CR35","doi-asserted-by":"publisher","first-page":"3071","DOI":"10.1158\/0008-5472.CAN-05-2871","volume":"66","author":"B Wang","year":"2006","unstructured":"Wang B, Hendricks DT, Wamunyokoli F, Parker MI . A growth-related oncogene\/CXC chemokine receptor 2 autocrine loop contributes to cellular proliferation in esophageal cancer. Cancer Res 2006; 66: 3071\u20133077.","journal-title":"Cancer Res"},{"key":"BFonc2011592_CR36","first-page":"198","volume":"59","author":"KC Zimmermann","year":"1999","unstructured":"Zimmermann KC, Sarbia M, Weber AA, Borchard F, Gabbert HE, Schror K . Cyclooxygenase-2 expression in human esophageal carcinoma. Cancer Res 1999; 59: 198\u2013204.","journal-title":"Cancer Res"},{"key":"BFonc2011592_CR37","doi-asserted-by":"publisher","first-page":"1840","DOI":"10.1093\/jnci\/dji431","volume":"97","author":"JT Kaifi","year":"2005","unstructured":"Kaifi JT, Yekebas EF, Schurr P, Obonyo D, Wachowiak R, Busch P et al. Tumor-cell homing to lymph nodes and bone marrow and CXCR4 expression in esophageal cancer. J Natl Cancer Inst 2005; 97: 1840\u20131847.","journal-title":"J Natl Cancer Inst"},{"key":"BFonc2011592_CR38","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1002\/ijc.22246","volume":"120","author":"A Kumar","year":"2007","unstructured":"Kumar A, Chatopadhyay T, Raziuddin M, Ralhan R . Discovery of deregulation of zinc homeostasis and its associated genes in esophageal squamous cell carcinoma using cDNA microarray. Int J Cancer 2007; 120: 230\u2013242.","journal-title":"Int J Cancer"},{"key":"BFonc2011592_CR39","doi-asserted-by":"publisher","first-page":"664","DOI":"10.1016\/j.yexcr.2010.11.013","volume":"317","author":"P Allavena","year":"2011","unstructured":"Allavena P, Germano G, Marchesi F, Mantovani A . Chemokines in cancer related inflammation. Exp Cell Res 2011; 317: 664\u2013673.","journal-title":"Exp Cell Res"},{"key":"BFonc2011592_CR40","doi-asserted-by":"publisher","first-page":"4279","DOI":"10.1158\/0008-5472.CAN-05-4398","volume":"66","author":"H Miyazaki","year":"2006","unstructured":"Miyazaki H, Patel V, Wang H, Edmunds RK, Gutkind JS, Yeudall WA . Down-regulation of CXCL5 inhibits squamous carcinogenesis. Cancer Res 2006; 66: 4279\u20134284.","journal-title":"Cancer Res"},{"key":"BFonc2011592_CR41","doi-asserted-by":"publisher","first-page":"664","DOI":"10.1038\/nri887","volume":"2","author":"A Richmond","year":"2002","unstructured":"Richmond A . Nf-kappa B, chemokine gene transcription and tumour growth. Nat Rev Immunol 2002; 2: 664\u2013674.","journal-title":"Nat Rev Immunol"},{"key":"BFonc2011592_CR42","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1016\/j.etp.2004.07.001","volume":"56","author":"K Yamamoto","year":"2004","unstructured":"Yamamoto K, Kitayama W, Denda A, Morisaki A, Kuniyasu H, Inoue M et al. Suppressive effects of a selective cyclooxygenase-2 inhibitor, etodolac, on 4-nitroquinoline 1-oxide-induced rat tongue carcinogenesis. Exp Toxicol Pathol 2004; 56: 145\u2013151.","journal-title":"Exp Toxicol Pathol"},{"key":"BFonc2011592_CR43","doi-asserted-by":"publisher","first-page":"1251","DOI":"10.1002\/hep.23099","volume":"50","author":"J Nemeth","year":"2009","unstructured":"Nemeth J, Stein I, Haag D, Riehl A, Longerich T, Horwitz E et al. S100A8 and S100A9 are novel nuclear factor kappa B target genes during malignant progression of murine and human liver carcinogenesis. Hepatology 2009; 50: 1251\u20131262.","journal-title":"Hepatology"},{"key":"BFonc2011592_CR44","doi-asserted-by":"publisher","first-page":"6231","DOI":"10.1128\/MCB.13.10.6231","volume":"13","author":"J Hiscott","year":"1993","unstructured":"Hiscott J, Marois J, Garoufalis J, D\u2019Addario M, Roulston A, Kwan I et al. Characterization of a functional NF-kappa B site in the human interleukin 1 beta promoter: evidence for a positive autoregulatory loop. Mol Cell Biol 1993; 13: 6231\u20136240.","journal-title":"Mol Cell Biol"},{"key":"BFonc2011592_CR45","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1093\/carcin\/bgq251","volume":"32","author":"J Sun","year":"2011","unstructured":"Sun J, Liu J, Pan X, Quimby D, Zanesi N, Druck T et al. Effect of zinc supplementation on N-nitrosomethylbenzylamine-induced forestomach tumor development and progression in tumor suppressor-deficient mouse strains. Carcinogenesis 2011; 32: 351\u2013358.","journal-title":"Carcinogenesis"},{"key":"BFonc2011592_CR46","doi-asserted-by":"publisher","first-page":"554","DOI":"10.1093\/carcin\/bgr004","volume":"32","author":"LY Fong","year":"2011","unstructured":"Fong LY, Jiang Y, Rawahneh ML, Smalley KJ, Croce CM, Farber JL et al. Zinc supplementation suppresses 4-nitroquinoline 1-oxide-induced rat oral carcinogenesis. Carcinogenesis 2011; 32: 554\u2013560.","journal-title":"Carcinogenesis"},{"key":"BFonc2011592_CR47","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1093\/bioinformatics\/19.2.185","volume":"19","author":"BM Bolstad","year":"2003","unstructured":"Bolstad BM, Irizarry RA, Astrand M, Speed TP . A comparison of normalization methods for high density oligonucleotide array data based on variance and bias. Bioinformatics 2003; 19: 185\u2013193.","journal-title":"Bioinformatics"}],"container-title":["Oncogene"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/onc2011592.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/onc2011592","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/onc2011592.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,21]],"date-time":"2022-03-21T18:03:09Z","timestamp":1647885789000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/onc2011592"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,12,19]]},"references-count":47,"journal-issue":{"issue":"42","published-print":{"date-parts":[[2012,10,18]]}},"alternative-id":["BFonc2011592"],"URL":"https:\/\/doi.org\/10.1038\/onc.2011.592","relation":{},"ISSN":["0950-9232","1476-5594"],"issn-type":[{"value":"0950-9232","type":"print"},{"value":"1476-5594","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,12,19]]},"assertion":[{"value":"3 October 2011","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 November 2011","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 November 2011","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 December 2011","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}