{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T01:36:27Z","timestamp":1792287387800,"version":"4.4.0"},"reference-count":83,"publisher":"Springer Science and Business Media LLC","issue":"35","license":[{"start":{"date-parts":[[2011,4,11]],"date-time":"2011-04-11T00:00:00Z","timestamp":1302480000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2011,4,11]],"date-time":"2011-04-11T00:00:00Z","timestamp":1302480000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Oncogene"],"published-print":{"date-parts":[[2011,9,1]]},"DOI":"10.1038\/onc.2011.89","type":"journal-article","created":{"date-parts":[[2011,4,11]],"date-time":"2011-04-11T06:19:50Z","timestamp":1302502790000},"page":"3766-3783","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":101,"title":["Type IV collagen-initiated signals provide survival and growth cues required for liver metastasis"],"prefix":"10.1038","volume":"30","author":[{"given":"J V","family":"Burnier","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R P","family":"Michel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Hassanain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Metrakos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"Antecka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M N","family":"Burnier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Ponton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Gallinger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Brodt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2011,4,11]]},"reference":[{"key":"BFonc201189_CR1","first-page":"1","volume":"43","author":"C All-Ericsson","year":"2002","unstructured":"All-Ericsson C, Girnita L, Seregard S, Bartolazzi A, Jager MJ, Larsson O . (2002). Insulin-like growth factor-1 receptor in uveal melanoma: a predictor for metastatic disease and a potential therapeutic target. Invest Ophthalmol Vis Sci 43: 1\u20138.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"BFonc201189_CR2","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.bbrc.2009.06.088","volume":"387","author":"S Andersson","year":"2009","unstructured":"Andersson S, D'Arcy P, Larsson O, Sehat B . (2009). Focal adhesion kinase (FAK) activates and stabilizes IGF-1 receptor. Biochem Biophys Res Commun 387: 36\u201341.","journal-title":"Biochem Biophys Res Commun"},{"key":"BFonc201189_CR3","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/S0140-6736(83)91708-7","volume":"1","author":"SH Barsky","year":"1983","unstructured":"Barsky SH, Togo S, Garbisa S, Liotta LA . (1983). Type IV collagenase immunoreactivity in invasive breast carcinoma. Lancet 1: 296\u2013297.","journal-title":"Lancet"},{"key":"BFonc201189_CR4","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1002\/jcp.22183","volume":"224","author":"J Beattie","year":"2010","unstructured":"Beattie J, McIntosh L, van der Walle CF . (2010). Cross-talk between the insulin-like growth factor (IGF) axis and membrane integrins to regulate cell physiology. J Cell Physiol 224: 605\u2013611.","journal-title":"J Cell Physiol"},{"key":"BFonc201189_CR5","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1038\/emm.2001.31","volume":"33","author":"DM Bissell","year":"2001","unstructured":"Bissell DM . (2001). Chronic liver injury, TGF-beta, and cancer. Exp Mol Med 33: 179\u2013190.","journal-title":"Exp Mol Med"},{"issue":"part 3","key":"BFonc201189_CR6","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1042\/bj3390481","volume":"339","author":"NJ Boudreau","year":"1999","unstructured":"Boudreau NJ, Jones PL . (1999). Extracellular matrix and integrin signalling: the shape of things to come. Biochem J 339 (part 3): 481\u2013488.","journal-title":"Biochem J"},{"key":"BFonc201189_CR7","doi-asserted-by":"crossref","first-page":"33608","DOI":"10.1074\/jbc.M102754200","volume":"276","author":"P Brodt","year":"2001","unstructured":"Brodt P, Fallavollita L, Khatib AM, Samani AA, Zhang D . (2001). Cooperative regulation of the invasive and metastatic phenotypes by different domains of the type I insulin-like growth factor receptor beta subunit. J Biol Chem 276: 33608\u201333615.","journal-title":"J Biol Chem"},{"key":"BFonc201189_CR8","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.acthis.2008.11.022","volume":"112","author":"SA Brooks","year":"2009","unstructured":"Brooks SA, Lomax-Browne HJ, Carter TM, Kinch CE, Hall DM . (2009). Molecular interactions in cancer cell metastasis. Acta Histochem 112: 3\u201325.","journal-title":"Acta Histochem"},{"key":"BFonc201189_CR9","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1177\/002215540004800510","volume":"48","author":"C Catusse","year":"2000","unstructured":"Catusse C, Polette M, Coraux C, Burlet H, Birembaut P . (2000). Modified basement membrane composition during bronchopulmonary tumor progression. J Histochem Cytochem 48: 663\u2013669.","journal-title":"J Histochem Cytochem"},{"key":"BFonc201189_CR10","doi-asserted-by":"crossref","first-page":"1354","DOI":"10.1038\/jid.2008.75","volume":"128","author":"RA Clark","year":"2008","unstructured":"Clark RA . (2008). Synergistic signaling from extracellular matrix-growth factor complexes. J Invest Dermatol 128: 1354\u20131355.","journal-title":"J Invest Dermatol"},{"key":"BFonc201189_CR11","doi-asserted-by":"crossref","first-page":"1664","DOI":"10.1210\/en.2002-221102","volume":"144","author":"DR Clemmons","year":"2003","unstructured":"Clemmons DR, Maile LA . (2003). Minireview: integral membrane proteins that function coordinately with the insulin-like growth factor I receptor to regulate intracellular signaling. Endocrinology 144: 1664\u20131670.","journal-title":"Endocrinology"},{"key":"BFonc201189_CR12","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.2353\/ajpath.2008.080158","volume":"173","author":"NK Decker","year":"2008","unstructured":"Decker NK, Abdelmoneim SS, Yaqoob U, Hendrickson H, Hormes J, Bentley M et al. (2008). Nitric oxide regulates tumor cell cross-talk with stromal cells in the tumor microenvironment of the liver. Am J Pathol 173: 1002\u20131012.","journal-title":"Am J Pathol"},{"key":"BFonc201189_CR13","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/j.surg.2003.10.017","volume":"135","author":"MS Duxbury","year":"2004","unstructured":"Duxbury MS, Ito H, Zinner MJ, Ashley SW, Whang EE . (2004). Focal adhesion kinase gene silencing promotes anoikis and suppresses metastasis of human pancreatic adenocarcinoma cells. Surgery 135: 555\u2013562.","journal-title":"Surgery"},{"key":"BFonc201189_CR14","doi-asserted-by":"crossref","first-page":"1742","DOI":"10.1016\/S0140-6736(07)60781-8","volume":"369","author":"SA Eccles","year":"2007","unstructured":"Eccles SA, Welch DR . (2007). Metastasis: recent discoveries and novel treatment strategies. Lancet 369: 1742\u20131757.","journal-title":"Lancet"},{"key":"BFonc201189_CR15","doi-asserted-by":"crossref","first-page":"26646","DOI":"10.1074\/jbc.M702836200","volume":"282","author":"M Edderkaoui","year":"2007","unstructured":"Edderkaoui M, Hong P, Lee JK, Pandol SJ, Gukovskaya AS . (2007). Insulin-like growth factor-I receptor mediates the prosurvival effect of fibronectin. J Biol Chem 282: 26646\u201326655.","journal-title":"J Biol Chem"},{"key":"BFonc201189_CR16","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1016\/j.gassur.2004.08.016","volume":"8","author":"A Enns","year":"2004","unstructured":"Enns A, Gassmann P, Schluter K, Korb T, Spiegel HU, Senninger N et al. (2004). Integrins can directly mediate metastatic tumor cell adhesion within the liver sinusoids. J Gastrointest Surg 8: 1049\u20131059;discussion 1060.","journal-title":"J Gastrointest Surg"},{"key":"BFonc201189_CR17","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1002\/ijc.24131","volume":"124","author":"N Erin","year":"2009","unstructured":"Erin N, Wang N, Xin P, Bui V, Weisz J, Barkan GA et al. (2009). Altered gene expression in breast cancer liver metastases. Int J Cancer 124: 14.","journal-title":"Int J Cancer"},{"key":"BFonc201189_CR18","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1023\/A:1022983000355","volume":"20","author":"B Felding-Habermann","year":"2003","unstructured":"Felding-Habermann B . (2003). Integrin adhesion receptors in tumor metastasis. Clin Exp Metastasis 20: 203\u2013213.","journal-title":"Clin Exp Metastasis"},{"key":"BFonc201189_CR19","first-page":"15","volume":"11","author":"A Fenyvesi","year":"2003","unstructured":"Fenyvesi A . (2003). The prognostic significance of type IV collagen expression in colorectal carcinomas. Arch Oncol 11: 15.","journal-title":"Arch Oncol"},{"key":"BFonc201189_CR20","doi-asserted-by":"crossref","first-page":"3233","DOI":"10.1158\/1078-0432.CCR-04-1915","volume":"11","author":"M Furukawa","year":"2005","unstructured":"Furukawa M, Raffeld M, Mateo C, Sakamoto A, Moody TW, Ito T et al. (2005). Increased expression of insulin-like growth factor I and\/or its receptor in gastrinomas is associated with low curability, increased growth, and development of metastases. Clin Cancer Res 11: 3233\u20133242.","journal-title":"Clin Cancer Res"},{"key":"BFonc201189_CR21","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1023\/A:1023725029589","volume":"22","author":"V Gabarra-Niecko","year":"2003","unstructured":"Gabarra-Niecko V, Schaller MD, Dunty JM . (2003). FAK regulates biological processes important for the pathogenesis of cancer. Cancer Metastasis Rev 22: 359\u2013374.","journal-title":"Cancer Metastasis Rev"},{"key":"BFonc201189_CR22","doi-asserted-by":"crossref","first-page":"6692","DOI":"10.1158\/0008-5472.CAN-04-4315","volume":"65","author":"HL Goel","year":"2005","unstructured":"Goel HL, Breen M, Zhang J, Das I, Aznavoorian-Cheshire S, Greenberg NM et al. (2005). beta1A integrin expression is required for type 1 insulin-like growth factor receptor mitogenic and transforming activities and localization to focal contacts. Cancer Res 65: 6692\u20136700.","journal-title":"Cancer Res"},{"key":"BFonc201189_CR23","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1083\/jcb.200403003","volume":"166","author":"HL Goel","year":"2004","unstructured":"Goel HL, Fornaro M, Moro L, Teider N, Rhim JS, King M et al. (2004). Selective modulation of type 1 insulin-like growth factor receptor signaling and functions by beta1 integrins. J Cell Biol 166: 407\u2013418.","journal-title":"J Cell Biol"},{"key":"BFonc201189_CR24","doi-asserted-by":"crossref","first-page":"3009","DOI":"10.1038\/onc.2009.172","volume":"28","author":"A Gualberto","year":"2009","unstructured":"Gualberto A, Pollak M . (2009). Emerging role of insulin-like growth factor receptor inhibitors in oncology: early clinical trial results and future directions. Oncogene 28: 3009\u20133021.","journal-title":"Oncogene"},{"key":"BFonc201189_CR25","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1007\/s10585-004-3171-x","volume":"21","author":"MV Gulubova","year":"2004","unstructured":"Gulubova MV . (2004). Collagen type IV, laminin, alpha-smooth muscle actin (alphaSMA), alpha1 and alpha6 integrins expression in the liver with metastases from malignant gastrointestinal tumours. Clin Exp Metastasis 21: 485\u2013494.","journal-title":"Clin Exp Metastasis"},{"key":"BFonc201189_CR26","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1203\/01.PDR.0000111282.98401.93","volume":"55","author":"H Gydee","year":"2004","unstructured":"Gydee H, O'Neill JT, Patel A, Bauer AJ, Tuttle RM, Francis GL . (2004). Differentiated thyroid carcinomas from children and adolescents express IGF-I and the IGF-I receptor (IGF-I-R). Cancers with the most intense IGF-I-R expression may be more aggressive. Pediatr Res 55: 709\u2013715.","journal-title":"Pediatr Res"},{"key":"BFonc201189_CR27","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1016\/S1359-6446(01)02023-2","volume":"6","author":"M Habeck","year":"2001","unstructured":"Habeck M . (2001). Targeting the extracellular matrix to stop tumour progression. Drug Discov Today 6: 1077\u20131078.","journal-title":"Drug Discov Today"},{"key":"BFonc201189_CR28","doi-asserted-by":"crossref","first-page":"2207","DOI":"10.1002\/1097-0142(19881115)62:10<2207::AID-CNCR2820621023>3.0.CO;2-L","volume":"62","author":"MG Havenith","year":"1988","unstructured":"Havenith MG, Arends JW, Simon R, Volovics A, Wiggers T, Bosman FT . (1988). Type IV collagen immunoreactivity in colorectal cancer. Prognostic value of basement membrane deposition. Cancer 62: 2207\u20132211.","journal-title":"Cancer"},{"key":"BFonc201189_CR29","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1046\/j.1440-1827.2002.01341.x","volume":"52","author":"Y Hiki","year":"2002","unstructured":"Hiki Y, Iyama K, Tsuruta J, Egami H, Kamio T, Suko S et al. (2002). Differential distribution of basement membrane type IV collagen alpha1(IV), alpha2(IV), alpha5(IV) and alpha6(IV) chains in colorectal epithelial tumors. Pathol Int 52: 224\u2013233.","journal-title":"Pathol Int"},{"key":"BFonc201189_CR30","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1046\/j.1523-1755.2002.00528.x","volume":"62","author":"MC Iglesias-de la Cruz","year":"2002","unstructured":"Iglesias-de la Cruz MC, Ziyadeh FN, Isono M, Kouahou M, Han DC, Kalluri R et al. (2002). Effects of high glucose and TGF-[bgr]1 on the expression of collagen IV and vascular endothelial growth factor in mouse podocytes. Kidney Int 62: 901\u2013913.","journal-title":"Kidney Int"},{"key":"BFonc201189_CR31","doi-asserted-by":"crossref","first-page":"856","DOI":"10.2353\/ajpath.2006.050384","volume":"168","author":"K Ikeda","year":"2006","unstructured":"Ikeda K, Iyama K, Ishikawa N, Egami H, Nakao M, Sado Y et al. (2006). Loss of expression of type IV collagen alpha5 and alpha6 chains in colorectal cancer associated with the hypermethylation of their promoter region. Am J Pathol 168: 856\u2013865.","journal-title":"Am J Pathol"},{"key":"BFonc201189_CR32","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1093\/biostatistics\/4.2.249","volume":"4","author":"RA Irizarry","year":"2003","unstructured":"Irizarry RA, Hobbs B, Collin F, Beazer-Barclay YD, Antonellis KJ, Scherf U et al. (2003). Exploration, normalization, and summaries of high density oligonucleotide array probe level data. Biostatistics 4: 249\u2013264.","journal-title":"Biostatistics"},{"key":"BFonc201189_CR33","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1111\/j.1067-1927.2005.130309.x","volume":"13","author":"MG Jeschke","year":"2005","unstructured":"Jeschke MG, Schubert T, Krickhahn M, Polykandriotis E, Klein D, Perez-Polo JR et al. (2005). Interaction of exogenous liposomal insulin-like growth factor-I cDNA gene transfer with growth factors on collagen expression in acute wounds. Wound Repair Regen 13: 269\u2013277.","journal-title":"Wound Repair Regen"},{"key":"BFonc201189_CR34","doi-asserted-by":"crossref","first-page":"3969","DOI":"10.1038\/sj.onc.1205472","volume":"21","author":"O Kahana","year":"2002","unstructured":"Kahana O, Micksche M, Witz IP, Yron I . (2002). The focal adhesion kinase (P125FAK) is constitutively active in human malignant melanoma. Oncogene 21: 3969\u20133977.","journal-title":"Oncogene"},{"key":"BFonc201189_CR35","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1002\/jemt.20564","volume":"71","author":"J Khoshnoodi","year":"2008","unstructured":"Khoshnoodi J, Pedchenko V, Hudson BG . (2008). Mammalian collagen IV. Microsc Res Tech 71: 357\u2013370.","journal-title":"Microsc Res Tech"},{"key":"BFonc201189_CR36","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1002\/(SICI)1097-0215(19990209)80:4<546::AID-IJC11>3.0.CO;2-9","volume":"80","author":"K Krensel","year":"1999","unstructured":"Krensel K, Lichtner RB . (1999). Selective increase of alpha2-integrin sub-unit expression on human carcinoma cells upon EGF-receptor activation. Int J Cancer 80: 546\u2013552.","journal-title":"Int J Cancer"},{"key":"BFonc201189_CR37","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1038\/sj.onc.1210709","volume":"27","author":"G Kurban","year":"2008","unstructured":"Kurban G, Duplan E, Ramlal N, Hudon V, Sado Y, Ninomiya Y et al. (2008). Collagen matrix assembly is driven by the interaction of von Hippel-Lindau tumor suppressor protein with hydroxylated collagen IV alpha 2. Oncogene 27: 1004\u20131012.","journal-title":"Oncogene"},{"key":"BFonc201189_CR38","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/j.cellbi.2008.01.292","volume":"32","author":"G Liu","year":"2008","unstructured":"Liu G, Meng X, Jin Y, Bai J, Zhao Y, Cui X et al. (2008). Inhibitory role of focal adhesion kinase on anoikis in the lung cancer cell A549. Cell Biol Int 32: 663\u2013670.","journal-title":"Cell Biol Int"},{"key":"BFonc201189_CR39","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1093\/carcin\/bgn026","volume":"29","author":"W Liu","year":"2008","unstructured":"Liu W, Bloom DA, Cance WG, Kurenova EV, Golubovskaya VM, Hochwald SN . (2008). FAK and IGF-IR interact to provide survival signals in human pancreatic adenocarcinoma cells. Carcinogenesis 29: 1096\u20131107.","journal-title":"Carcinogenesis"},{"key":"BFonc201189_CR40","first-page":"1006","volume":"55","author":"L Long","year":"1995","unstructured":"Long L, Rubin R, Baserga R, Brodt P . (1995). Loss of the metastatic phenotype in murine carcinoma cells expressing an antisense RNA to the insulin-like growth factor receptor. Cancer Res 55: 1006\u20131009.","journal-title":"Cancer Res"},{"key":"BFonc201189_CR41","doi-asserted-by":"crossref","first-page":"1366","DOI":"10.1016\/j.addr.2007.08.015","volume":"59","author":"L Macri","year":"2007","unstructured":"Macri L, Silverstein D, Clark RA . (2007). Growth factor binding to the pericellular matrix and its importance in tissue engineering. Adv Drug Deliv Rev 59: 1366\u20131381.","journal-title":"Adv Drug Deliv Rev"},{"key":"BFonc201189_CR42","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1016\/1357-2725(96)00042-8","volume":"28","author":"KM Malinda","year":"1996","unstructured":"Malinda KM, Kleinman HK . (1996). The laminins. Int J Biochem Cell Biol 28: 957\u2013959.","journal-title":"Int J Biochem Cell Biol"},{"key":"BFonc201189_CR43","doi-asserted-by":"crossref","first-page":"4890","DOI":"10.1167\/iovs.07-0215","volume":"48","author":"T Meir","year":"2007","unstructured":"Meir T, Dror R, Yu X, Qian J, Simon I, Pe'er J et al. (2007). Molecular characteristics of liver metastases from uveal melanoma. Invest Ophthalmol Vis Sci 48: 4890\u20134896.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"BFonc201189_CR44","doi-asserted-by":"crossref","first-page":"2247","DOI":"10.1242\/dev.01112","volume":"131","author":"JH Miner","year":"2004","unstructured":"Miner JH, Li C, Mudd JL, Go G, Sutherland AE . (2004). Compositional and structural requirements for laminin and basement membranes during mouse embryo implantation and gastrulation. Development 131: 2247\u20132256.","journal-title":"Development"},{"key":"BFonc201189_CR45","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1007\/978-0-387-68969-2_23","volume":"622","author":"S Miyamoto","year":"2008","unstructured":"Miyamoto S, Yagi H, Yotsumoto F, Kawarabayashi T, Mekada E . (2008). Heparin-binding epidermal growth factor-like growth factor as a new target molecule for cancer therapy. Adv Exp Med Biol 622: 281\u2013295.","journal-title":"Adv Exp Med Biol"},{"key":"BFonc201189_CR46","doi-asserted-by":"crossref","first-page":"5832","DOI":"10.3748\/wjg.v13.i44.5832","volume":"13","author":"C Nadal","year":"2007","unstructured":"Nadal C, Maurel J, Gascon P . (2007). Is there a genetic signature for liver metastasis in colorectal cancer? World J Gastroenterol 13: 5832\u20135844.","journal-title":"World J Gastroenterol"},{"key":"BFonc201189_CR47","first-page":"281","volume":"79","author":"S Nakano","year":"1999","unstructured":"Nakano S, Iyama K, Ogawa M, Yoshioka H, Sado Y, Oohashi T et al. (1999). Differential tissular expression and localization of type IV collagen alpha1(IV), alpha2(IV), alpha5(IV), and alpha6(IV) chains and their mRNA in normal breast and in benign and malignant breast tumors. Lab Invest 79: 281\u2013292.","journal-title":"Lab Invest"},{"key":"BFonc201189_CR48","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1155\/2001\/870205","volume":"15","author":"K Neubauer","year":"2001","unstructured":"Neubauer K, Saile B, Ramadori G . (2001). Liver fibrosis and altered matrix synthesis. Can J Gastroenterol 15: 187\u2013193.","journal-title":"Can J Gastroenterol"},{"key":"BFonc201189_CR49","first-page":"359","volume":"20","author":"T Oshima","year":"2008","unstructured":"Oshima T, Akaike M, Yoshihara K, Shiozawa M, Yamamoto N, Sato T et al. (2008). Clinicopathological significance of the gene expression of matrix metalloproteinase-7, insulin-like growth factor-1, insulin-like growth factor-2 and insulin-like growth factor-1 receptor in patients with colorectal cancer: insulin-like growth factor-1 receptor gene expression is a useful predictor of liver metastasis from colorectal cancer. Oncol Rep 20: 359\u2013364.","journal-title":"Oncol Rep"},{"key":"BFonc201189_CR50","first-page":"98","volume":"8","author":"S Paget","year":"1989","unstructured":"Paget S . (1989). The distribution of secondary growths in cancer of the breast. 1889. Cancer Metastasis Rev 8: 98\u2013101.","journal-title":"Cancer Metastasis Rev"},{"key":"BFonc201189_CR51","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.critrevonc.2003.10.008","volume":"49","author":"M Polette","year":"2004","unstructured":"Polette M, Nawrocki-Raby B, Gilles C, Clavel C, Birembaut P . (2004). Tumour invasion and matrix metalloproteinases. Crit Rev Oncol Hematol 49: 179\u2013186.","journal-title":"Crit Rev Oncol Hematol"},{"key":"BFonc201189_CR52","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.1242\/dev.01037","volume":"131","author":"E Poschl","year":"2004","unstructured":"Poschl E, Schlotzer-Schrehardt U, Brachvogel B, Saito K, Ninomiya Y, Mayer U . (2004). Collagen IV is essential for basement membrane stability but dispensable for initiation of its assembly during early development. Development 131: 1619\u20131628.","journal-title":"Development"},{"key":"BFonc201189_CR53","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1593\/neo.07898","volume":"10","author":"F Rosenow","year":"2008","unstructured":"Rosenow F, Ossig R, Thormeyer D, Gasmann P, Schluter K, Brunner G et al. (2008). Integrins as antimetastatic targets of RGD-independent snake venom components in liver metastasis [corrected]. Neoplasia 10: 168\u2013176.","journal-title":"Neoplasia"},{"key":"BFonc201189_CR54","doi-asserted-by":"crossref","first-page":"374","DOI":"10.2144\/03342mt01","volume":"34","author":"AI Saeed","year":"2003","unstructured":"Saeed AI, Sharov V, White J, Li J, Liang W, Bhagabati N et al. (2003). TM4: a free, open-source system for microarray data management and analysis. Biotechniques 34: 374\u2013378.","journal-title":"Biotechniques"},{"key":"BFonc201189_CR55","doi-asserted-by":"crossref","first-page":"3380","DOI":"10.1158\/0008-5472.CAN-03-3780","volume":"64","author":"AA Samani","year":"2004","unstructured":"Samani AA, Chevet E, Fallavollita L, Galipeau J, Brodt P . (2004). Loss of tumorigenicity and metastatic potential in carcinoma cells expressing the extracellular domain of the type 1 insulin-like growth factor receptor. Cancer Res 64: 3380\u20133385.","journal-title":"Cancer Res"},{"key":"BFonc201189_CR56","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1210\/er.2006-0001","volume":"28","author":"AA Samani","year":"2007","unstructured":"Samani AA, Yakar S, LeRoith D, Brodt P . (2007). The role of the IGF system in cancer growth and metastasis: overview and recent insights. Endocr Rev 28: 20\u201347.","journal-title":"Endocr Rev"},{"key":"BFonc201189_CR57","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1006\/excr.2000.5043","volume":"261","author":"SK Sastry","year":"2000","unstructured":"Sastry SK, Burridge K . (2000). Focal adhesions: a nexus for intracellular signaling and cytoskeletal dynamics. Exp Cell Res 261: 25\u201336.","journal-title":"Exp Cell Res"},{"key":"BFonc201189_CR58","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.jss.2007.03.023","volume":"144","author":"H Sawai","year":"2008","unstructured":"Sawai H, Okada Y, Funahashi H, Takahashi H, Matsuo Y, Yasuda A et al. (2008). Basement membrane proteins play an important role in the invasive processes of human pancreatic cancer cells. J Surg Res 144: 117\u2013123.","journal-title":"J Surg Res"},{"key":"BFonc201189_CR59","doi-asserted-by":"crossref","first-page":"2583","DOI":"10.1002\/1097-0142(19901215)66:12<2583::AID-CNCR2820661222>3.0.CO;2-S","volume":"66","author":"RF Schapers","year":"1990","unstructured":"Schapers RF, Pauwels RP, Havenith MG, Smeets AW, van den Brandt PA, Bosman FT . (1990). Prognostic significance of type IV collagen and laminin immunoreactivity in urothelial carcinomas of the bladder. Cancer 66: 2583\u20132588.","journal-title":"Cancer"},{"key":"BFonc201189_CR60","doi-asserted-by":"crossref","first-page":"13612","DOI":"10.1073\/pnas.94.25.13612","volume":"94","author":"DR Senger","year":"1997","unstructured":"Senger DR, Claffey KP, Benes JE, Perruzzi CA, Sergiou AP, Detmar M . (1997). Angiogenesis promoted by vascular endothelial growth factor: regulation through alpha1beta1 and alpha2beta1 integrins. Proc Natl Acad Sci USA 94: 13612\u201313617.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFonc201189_CR61","doi-asserted-by":"crossref","first-page":"10290","DOI":"10.1073\/pnas.0904227106","volume":"106","author":"T Shibue","year":"2009","unstructured":"Shibue T, Weinberg RA . (2009). Integrin beta1-focal adhesion kinase signaling directs the proliferation of metastatic cancer cells disseminated in the lungs. Proc Natl Acad Sci USA 106: 10290\u201310295.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFonc201189_CR62","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.canlet.2008.05.029","volume":"272","author":"CD Simpson","year":"2008","unstructured":"Simpson CD, Anyiwe K, Schimmer AD . (2008). Anoikis resistance and tumor metastasis. Cancer Lett 272: 177\u2013185.","journal-title":"Cancer Lett"},{"key":"BFonc201189_CR63","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1038\/nm1469","volume":"12","author":"PS Steeg","year":"2006","unstructured":"Steeg PS . (2006). Tumor metastasis: mechanistic insights and clinical challenges. Nat Med 12: 895\u2013904.","journal-title":"Nat Med"},{"key":"BFonc201189_CR64","doi-asserted-by":"crossref","first-page":"84","DOI":"10.2353\/ajpath.2010.090767","volume":"177","author":"BM Steenhard","year":"2010","unstructured":"Steenhard BM, Isom K, Stroganova L, St John PL, Zelenchuk A, Freeburg PB et al. (2010). Deletion of von Hippel-Lindau in glomerular podocytes results in glomerular basement membrane thickening, ectopic subepithelial deposition of collagen [alpha]1[alpha]2[alpha]1(IV), expression of neuroglobin, and proteinuria. Am J Pathol 177: 84\u201396.","journal-title":"Am J Pathol"},{"key":"BFonc201189_CR65","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1023\/A:1026428010104","volume":"29","author":"K Tanaka","year":"1997","unstructured":"Tanaka K, Iyama K, Kitaoka M, Ninomiya Y, Oohashi T, Sado Y et al. (1997). Differential expression of alpha 1(IV), alpha 2(IV), alpha 5(IV) and alpha 6(IV) collagen chains in the basement membrane of basal cell carcinoma. Histochem J 29: 563\u2013570.","journal-title":"Histochem J"},{"key":"BFonc201189_CR66","first-page":"1166","volume":"63","author":"Y Tang","year":"2003","unstructured":"Tang Y, Zhang D, Fallavollita L, Brodt P . (2003). Vascular endothelial growth factor C expression and lymph node metastasis are regulated by the type I insulin-like growth factor receptor. Cancer Res 63: 1166\u20131171.","journal-title":"Cancer Res"},{"key":"BFonc201189_CR67","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1053\/jhep.2001.25758","volume":"34","author":"N Theret","year":"2001","unstructured":"Theret N, Musso O, Turlin B, Lotrian D, Bioulac-Sage P, Campion JP et al. (2001). Increased extracellular matrix remodeling is associated with tumor progression in human hepatocellular carcinomas. Hepatology 34: 82\u201388.","journal-title":"Hepatology"},{"key":"BFonc201189_CR68","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1007\/s00432-004-0614-3","volume":"131","author":"B Tian","year":"2005","unstructured":"Tian B, Li Y, Ji XN, Chen J, Xue Q, Ye SL et al. (2005). Basement membrane proteins play an active role in the invasive process of human hepatocellular carcinoma cells with high metastasis potential. J Cancer Res Clin Oncol 131: 80\u201386.","journal-title":"J Cancer Res Clin Oncol"},{"key":"BFonc201189_CR69","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1038\/modpathol.3800582","volume":"19","author":"S Ueda","year":"2006","unstructured":"Ueda S, Hatsuse K, Tsuda H, Ogata S, Kawarabayashi N, Takigawa T et al. (2006). Potential crosstalk between insulin-like growth factor receptor type 1 and epidermal growth factor receptor in progression and metastasis of pancreatic cancer. Mod Pathol 19: 788\u2013796.","journal-title":"Mod Pathol"},{"key":"BFonc201189_CR70","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1007\/s004410100417","volume":"305","author":"A van der Flier","year":"2001","unstructured":"van der Flier A, Sonnenberg A . (2001). Function and interactions of integrins. Cell Tissue Res 305: 285\u2013298.","journal-title":"Cell Tissue Res"},{"key":"BFonc201189_CR71","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1083\/jcb.113.6.1475","volume":"113","author":"P Vandenberg","year":"1991","unstructured":"Vandenberg P, Kern A, Ries A, Luckenbill-Edds L, Mann K, Kuhn K . (1991). Characterization of a type IV collagen major cell binding site with affinity to the alpha 1 beta 1 and the alpha 2 beta 1 integrins. J Cell Biol 113: 1475\u20131483.","journal-title":"J Cell Biol"},{"key":"BFonc201189_CR72","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1007\/s12307-008-0011-6","volume":"1","author":"F Vidal-Vanaclocha","year":"2008","unstructured":"Vidal-Vanaclocha F . (2008). The prometastatic microenvironment of the liver. Cancer Microenviron 1: 113\u2013129.","journal-title":"Cancer Microenviron"},{"key":"BFonc201189_CR73","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1038\/mt.2009.82","volume":"17","author":"N Wang","year":"2009","unstructured":"Wang N, Fallavollita L, Nguyen L, Burnier J, Rafei M, Galipeau J et al. (2009). Autologous bone marrow stromal cells genetically engineered to secrete an igf-I receptor decoy prevent the growth of liver metastases. Mol Ther 17: 1241\u20131249.","journal-title":"Mol Ther"},{"key":"BFonc201189_CR74","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1002\/jnr.20712","volume":"83","author":"JY Wang","year":"2006","unstructured":"Wang JY, Grabacka M, Marcinkiewicz C, Staniszewska I, Peruzzi F, Khalili K et al. (2006a). Involvement of alpha1beta1 integrin in insulin-like growth factor-1-mediated protection of PC12 neuronal processes from tumor necrosis factor-alpha-induced injury. J Neurosci Res 83: 7\u201318.","journal-title":"J Neurosci Res"},{"key":"BFonc201189_CR75","doi-asserted-by":"crossref","first-page":"3062","DOI":"10.1158\/0008-5472.CAN-05-2638","volume":"66","author":"N Wang","year":"2006","unstructured":"Wang N, Thuraisingam T, Fallavollita L, Ding A, Radzioch D, Brodt P . (2006b). The secretory leukocyte protease inhibitor is a type 1 insulin-like growth factor receptor-regulated protein that protects against liver metastasis by attenuating the host proinflammatory response. Cancer Res 66: 3062\u20133070.","journal-title":"Cancer Res"},{"key":"BFonc201189_CR76","doi-asserted-by":"crossref","first-page":"2448","DOI":"10.1093\/bioinformatics\/btg345","volume":"19","author":"GW Wright","year":"2003","unstructured":"Wright GW, Simon RM . (2003). A random variance model for detection of differential gene expression in small microarray experiments. Bioinformatics 19: 2448\u20132455.","journal-title":"Bioinformatics"},{"key":"BFonc201189_CR77","first-page":"3588","volume":"59","author":"Y Xie","year":"1999","unstructured":"Xie Y, Skytting B, Nilsson G, Brodin B, Larsson O . (1999). Expression of insulin-like growth factor-1 receptor in synovial sarcoma: association with an aggressive phenotype. Cancer Res 59: 3588\u20133591.","journal-title":"Cancer Res"},{"key":"BFonc201189_CR78","doi-asserted-by":"crossref","first-page":"5826","DOI":"10.1210\/en.2006-0311","volume":"147","author":"S Yakar","year":"2006","unstructured":"Yakar S, Nunez NP, Pennisi P, Brodt P, Sun H, Fallavollita L et al. (2006). Increased tumor growth in mice with diet-induced obesity: impact of ovarian hormones. Endocrinology 147: 5826\u20135834.","journal-title":"Endocrinology"},{"key":"BFonc201189_CR79","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1053\/gast.2003.50012","volume":"124","author":"C Yang","year":"2003","unstructured":"Yang C, Zeisberg M, Mosterman B, Sudhakar A, Yerramalla U, Holthaus K et al. (2003). Liver fibrosis: insights into migration of hepatic stellate cells in response to extracellular matrix and growth factors. Gastroenterology 124: 147\u2013159.","journal-title":"Gastroenterology"},{"key":"BFonc201189_CR80","doi-asserted-by":"crossref","first-page":"7320","DOI":"10.1158\/0008-5472.CAN-09-0315","volume":"69","author":"K Yoshimura","year":"2009","unstructured":"Yoshimura K, Meckel KF, Laird LS, Chia CY, Park JJ, Olino KL et al. (2009). Integrin alpha2 mediates selective metastasis to the liver. Cancer Res 69: 7320\u20137328.","journal-title":"Cancer Res"},{"key":"BFonc201189_CR81","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1007\/s11010-006-2677-8","volume":"283","author":"M Zeisberg","year":"2006","unstructured":"Zeisberg M, Kramer K, Sindhi N, Sarkar P, Upton M, Kalluri R . (2006). De-differentiation of primary human hepatocytes depends on the composition of specialized liver basement membrane. Mol Cell Biochem 283: 181\u2013189.","journal-title":"Mol Cell Biochem"},{"key":"BFonc201189_CR82","doi-asserted-by":"crossref","first-page":"2512","DOI":"10.1158\/1078-0432.CCR-09-2232","volume":"16","author":"J Zha","year":"2010","unstructured":"Zha J, Lackner MR . (2010). Targeting the insulin-like growth factor receptor-1R pathway for cancer therapy. Clin Cancer Res 16: 2512\u20132517.","journal-title":"Clin Cancer Res"},{"key":"BFonc201189_CR83","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1038\/sj.onc.1206197","volume":"22","author":"D Zhang","year":"2003","unstructured":"Zhang D, Brodt P . (2003). Type 1 insulin-like growth factor regulates MT1-MMP synthesis and tumor invasion via PI 3-kinase\/Akt signaling. Oncogene 22: 974\u2013982.","journal-title":"Oncogene"}],"container-title":["Oncogene"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/onc201189.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/onc201189","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/onc201189.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,21]],"date-time":"2022-03-21T14:12:02Z","timestamp":1647871922000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/onc201189"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,4,11]]},"references-count":83,"journal-issue":{"issue":"35","published-print":{"date-parts":[[2011,9,1]]}},"alternative-id":["BFonc201189"],"URL":"https:\/\/doi.org\/10.1038\/onc.2011.89","relation":{},"ISSN":["0950-9232","1476-5594"],"issn-type":[{"value":"0950-9232","type":"print"},{"value":"1476-5594","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,4,11]]},"assertion":[{"value":"14 July 2010","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 February 2011","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 February 2011","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 April 2011","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}