{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T17:18:21Z","timestamp":1773767901848,"version":"3.50.1"},"reference-count":28,"publisher":"Springer Science and Business Media LLC","issue":"20","license":[{"start":{"date-parts":[[2012,7,2]],"date-time":"2012-07-02T00:00:00Z","timestamp":1341187200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2012,7,2]],"date-time":"2012-07-02T00:00:00Z","timestamp":1341187200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Oncogene"],"published-print":{"date-parts":[[2013,5,16]]},"DOI":"10.1038\/onc.2012.263","type":"journal-article","created":{"date-parts":[[2012,7,2]],"date-time":"2012-07-02T15:36:19Z","timestamp":1341243379000},"page":"2586-2591","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Overexpression of the anti-apoptotic protein AVEN contributes to increased malignancy in hematopoietic neoplasms"],"prefix":"10.1038","volume":"32","author":[{"given":"M","family":"Ei\u00dfmann","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I M","family":"Melzer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S B M","family":"Fern\u00e1ndez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"Michel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Hrab\u011b de Angelis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"Hoefler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"Finkenwirth","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Jauch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B","family":"Schoell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Grez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Schmidt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C C","family":"Bartholomae","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Newrzela","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N","family":"Haetscher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M A","family":"Rieger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"Zachskorn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Mittelbronn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Z\u00f6rnig","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2012,7,2]]},"reference":[{"key":"BFonc2012263_CR1","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/S0092-8674(00)81683-9","volume":"100","author":"D Hanahan","year":"2000","unstructured":"Hanahan D, Weinberg RA . The hallmarks of cancer. Cell 2000; 100: 57\u201370.","journal-title":"Cell"},{"key":"BFonc2012263_CR2","doi-asserted-by":"publisher","first-page":"646","DOI":"10.1016\/j.cell.2011.02.013","volume":"144","author":"D Hanahan","year":"2011","unstructured":"Hanahan D, Weinberg RA . Hallmarks of cancer: the next generation. Cell 2011; 144: 646\u2013674.","journal-title":"Cell"},{"key":"BFonc2012263_CR3","doi-asserted-by":"publisher","first-page":"759","DOI":"10.1038\/cr.2007.52","volume":"17","author":"G Xu","year":"2007","unstructured":"Xu G, Shi Y . Apoptosis signaling pathways and lymphocyte homeostasis. Cell Res 2007; 17: 759\u2013771.","journal-title":"Cell Res"},{"key":"BFonc2012263_CR4","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1016\/S1044-579X(02)00131-1","volume":"13","author":"N Ozoren","year":"2003","unstructured":"Ozoren N, El-Deiry WS . Cell surface Death Receptor signaling in normal and cancer cells. Semin Cancer Biol 2003; 13: 135\u2013147.","journal-title":"Semin Cancer Biol"},{"key":"BFonc2012263_CR5","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1089\/cbr.2008.0598","volume":"24","author":"C Vangestel","year":"2009","unstructured":"Vangestel C, Van de Wiele C, Mees G, Peeters M . Forcing cancer cells to commit suicide. Cancer Biother Radiopharm 2009; 24: 395\u2013407.","journal-title":"Cancer Biother Radiopharm"},{"key":"BFonc2012263_CR6","doi-asserted-by":"publisher","first-page":"871","DOI":"10.1016\/j.ceb.2009.09.004","volume":"21","author":"D Brenner","year":"2009","unstructured":"Brenner D, Mak TW . Mitochondrial cell death effectors. Curr Opin Cell Biol 2009; 21: 871\u2013877.","journal-title":"Curr Opin Cell Biol"},{"key":"BFonc2012263_CR7","doi-asserted-by":"publisher","first-page":"691","DOI":"10.1023\/B:APPT.0000045786.98031.1d","volume":"9","author":"KM Hajra","year":"2004","unstructured":"Hajra KM, Liu JR . Apoptosome dysfunction in human cancer. Apoptosis 2004; 9: 691\u2013704.","journal-title":"Apoptosis"},{"key":"BFonc2012263_CR8","doi-asserted-by":"publisher","first-page":"420","DOI":"10.1158\/1078-0432.CCR-08-1172","volume":"15","author":"EC Ledgerwood","year":"2009","unstructured":"Ledgerwood EC, Morison IM . Targeting the apoptosome for cancer therapy. Clin Cancer Res 2009; 15: 420\u2013424.","journal-title":"Clin Cancer Res"},{"key":"BFonc2012263_CR9","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1038\/sj.cdd.4402028","volume":"14","author":"Q Bao","year":"2007","unstructured":"Bao Q, Shi Y . Apoptosome: a platform for the activation of initiator caspases. Cell Death Differ 2007; 14: 56\u201365.","journal-title":"Cell Death Differ"},{"issue":"Part 19","key":"BFonc2012263_CR10","doi-asserted-by":"publisher","first-page":"3209","DOI":"10.1242\/jcs.073643","volume":"123","author":"SB Bratton","year":"2010","unstructured":"Bratton SB, Salvesen GS . Regulation of the Apaf-1-caspase-9 apoptosome. J Cell Sci 2010; 123 (Part 19): 3209\u20133214.","journal-title":"J Cell Sci"},{"key":"BFonc2012263_CR11","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/S1097-2765(05)00021-3","volume":"6","author":"BN Chau","year":"2000","unstructured":"Chau BN, Cheng EH, Kerr DA, Hardwick JM . Aven, a novel inhibitor of caspase activation, binds Bcl-xL and Apaf-1. Mol Cell 2000; 6: 31\u201340.","journal-title":"Mol Cell"},{"key":"BFonc2012263_CR12","doi-asserted-by":"publisher","first-page":"3913","DOI":"10.4161\/cc.9.19.13138","volume":"9","author":"AM Esmaili","year":"2010","unstructured":"Esmaili AM, Johnson EL, Thaivalappil SS, Kuhn HM, Kornbluth S, Irusta PM . Regulation of the ATM-activator protein Aven by CRM1-dependent nuclear export. Cell Cycle 2010; 9: 3913\u20133920.","journal-title":"Cell Cycle"},{"key":"BFonc2012263_CR13","doi-asserted-by":"publisher","first-page":"933","DOI":"10.1016\/j.cub.2008.05.045","volume":"18","author":"JY Guo","year":"2008","unstructured":"Guo JY, Yamada A, Kajino T, Wu JQ, Tang W, Freel CD et al. Aven-dependent activation of ATM following DNA damage. Curr Biol 2008; 18: 933\u2013942.","journal-title":"Curr Biol"},{"key":"BFonc2012263_CR14","doi-asserted-by":"publisher","first-page":"1045","DOI":"10.1093\/annonc\/mdg277","volume":"14","author":"S Paydas","year":"2003","unstructured":"Paydas S, Tanriverdi K, Yavuz S, Disel U, Sahin B, Burgut R . Survivin and aven: two distinct antiapoptotic signals in acute leukemias. Ann Oncol 2003; 14: 1045\u20131050.","journal-title":"Ann Oncol"},{"key":"BFonc2012263_CR15","doi-asserted-by":"publisher","first-page":"1019","DOI":"10.1016\/j.leukres.2005.11.001","volume":"30","author":"J Choi","year":"2006","unstructured":"Choi J, Hwang YK, Sung KW, Kim DH, Yoo KH, Jung HL et al. Aven overexpression: association with poor prognosis in childhood acute lymphoblastic leukemia. Leuk Res 2006; 30: 1019\u20131025.","journal-title":"Leuk Res"},{"key":"BFonc2012263_CR16","doi-asserted-by":"publisher","first-page":"653","DOI":"10.1111\/j.1365-2141.2009.08006.x","volume":"149","author":"B Burkhardt","year":"2010","unstructured":"Burkhardt B . Paediatric lymphoblastic T-cell leukaemia and lymphoma: one or two diseases? Br J Haematol 2010; 149: 653\u2013668.","journal-title":"Br J Haematol"},{"key":"BFonc2012263_CR17","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1186\/1476-4598-9-105","volume":"9","author":"AL Cleaver","year":"2010","unstructured":"Cleaver AL, Beesley AH, Firth MJ, Sturges NC, O\u2019Leary RA, Hunger SP et al. Gene-based outcome prediction in multiple cohorts of pediatric T-cell acute lymphoblastic leukemia: a Children's Oncology Group study. Mol Cancer 2010; 9: 105.","journal-title":"Mol Cancer"},{"key":"BFonc2012263_CR18","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1016\/j.critrevonc.2009.01.002","volume":"72","author":"L de Leval","year":"2009","unstructured":"de Leval L, Bisig B, Thielen C, Boniver J, Gaulard P . Molecular classification of T-cell lymphomas. Crit Rev Oncol Hematol 2009; 72: 125\u2013143.","journal-title":"Crit Rev Oncol Hematol"},{"key":"BFonc2012263_CR19","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1053\/j.semdp.2011.02.008","volume":"28","author":"S Paolini","year":"2011","unstructured":"Paolini S, Gazzola A, Sabattini E, Bacci F, Pileri S, Piccaluga PP . Pathobiology of acute lymphoblastic leukemia. Semin Diagn Pathol 2011; 28: 124\u2013134.","journal-title":"Semin Diagn Pathol"},{"key":"BFonc2012263_CR20","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1186\/1476-4598-9-181","volume":"9","author":"I Riz","year":"2010","unstructured":"Riz I, Hawley TS, Luu TV, Lee NH, TLX1 Hawley RG . and NOTCH coregulate transcription in T cell acute lymphoblastic leukemia cells. Mol Cancer 2010; 9: 181.","journal-title":"Mol Cancer"},{"key":"BFonc2012263_CR21","volume-title":"WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues","author":"SH Swerdlow","year":"2008","unstructured":"Swerdlow SH, Campo E, Harris NL, Jaffe ES, Pileri SA, Stein H et al WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues 4th edn WHO Press, Geneva, Switzerland, 2008."},{"key":"BFonc2012263_CR22","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1002\/j.1460-2075.1995.tb07001.x","volume":"14","author":"KA Swan","year":"1995","unstructured":"Swan KA, Alberola-Ila J, Gross JA, Appleby MW, Forbush KA, Thomas JF et al. Involvement of p21ras distinguishes positive and negative selection in thymocytes. EMBO J 1995; 14: 276\u2013285.","journal-title":"EMBO J"},{"key":"BFonc2012263_CR23","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1006\/scbi.1996.0035","volume":"7","author":"LA Donehower","year":"1996","unstructured":"Donehower LA . The p53-deficient mouse: a model for basic and applied cancer studies. Semin Cancer Biol 1996; 7: 269\u2013278.","journal-title":"Semin Cancer Biol"},{"key":"BFonc2012263_CR24","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1038\/356215a0","volume":"356","author":"LA Donehower","year":"1992","unstructured":"Donehower LA, Harvey M, Slagle BL, McArthur MJ, Montgomery CA, Butel JS et al. Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours. Nature 1992; 356: 215\u2013221.","journal-title":"Nature"},{"key":"BFonc2012263_CR25","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S0960-9822(00)00002-6","volume":"4","author":"T Jacks","year":"1994","unstructured":"Jacks T, Remington L, Williams BO, Schmitt EM, Halachmi S, Bronson RT et al. Tumor spectrum analysis in p53-mutant mice. Curr Biol 1994; 4: 1\u20137.","journal-title":"Curr Biol"},{"key":"BFonc2012263_CR26","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1007\/BF02982640","volume":"77","author":"K Imada","year":"2003","unstructured":"Imada K . Immunodeficient mouse models of lymphoid tumors. Int J Hematol 2003; 77: 336\u2013341.","journal-title":"Int J Hematol"},{"key":"BFonc2012263_CR27","doi-asserted-by":"crossref","first-page":"2031","DOI":"10.1182\/blood.V77.9.2031.2031","volume":"77","author":"H Asou","year":"1991","unstructured":"Asou H, Tashiro S, Hamamoto K, Otsuji A, Kita K, Kamada N . Establishment of a human acute myeloid leukemia cell line (Kasumi-1) with 8;21 chromosome translocation. Blood 1991; 77: 2031\u20132036.","journal-title":"Blood"},{"key":"BFonc2012263_CR28","doi-asserted-by":"publisher","first-page":"1458","DOI":"10.1038\/nprot.2006.238","volume":"1","author":"C Riccardi","year":"2006","unstructured":"Riccardi C, Nicoletti I . Analysis of apoptosis by propidium iodide staining and flow cytometry. Nat Protoc 2006; 1: 1458\u20131461.","journal-title":"Nat Protoc"}],"container-title":["Oncogene"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/onc2012263.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/onc2012263","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/onc2012263.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,21]],"date-time":"2022-03-21T18:14:29Z","timestamp":1647886469000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/onc2012263"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,7,2]]},"references-count":28,"journal-issue":{"issue":"20","published-print":{"date-parts":[[2013,5,16]]}},"alternative-id":["BFonc2012263"],"URL":"https:\/\/doi.org\/10.1038\/onc.2012.263","relation":{},"ISSN":["0950-9232","1476-5594"],"issn-type":[{"value":"0950-9232","type":"print"},{"value":"1476-5594","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,7,2]]},"assertion":[{"value":"30 November 2011","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 May 2012","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 May 2012","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 July 2012","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}