{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T19:55:14Z","timestamp":1791057314214,"version":"4.1.0"},"reference-count":45,"publisher":"Springer Science and Business Media LLC","issue":"21","license":[{"start":{"date-parts":[[2012,7,2]],"date-time":"2012-07-02T00:00:00Z","timestamp":1341187200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2012,7,2]],"date-time":"2012-07-02T00:00:00Z","timestamp":1341187200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Oncogene"],"published-print":{"date-parts":[[2013,5,23]]},"DOI":"10.1038\/onc.2012.279","type":"journal-article","created":{"date-parts":[[2012,7,2]],"date-time":"2012-07-02T11:36:19Z","timestamp":1341228979000},"page":"2682-2689","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":95,"title":["Role of AMPK in UVB-induced DNA damage repair and growth control"],"prefix":"10.1038","volume":"32","author":[{"given":"C L","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"Qiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Ming","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B","family":"Viollet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y Y","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2012,7,2]]},"reference":[{"key":"BFonc2012279_CR1","first-page":"RE2","volume":"2003","author":"AM Bode","year":"2003","unstructured":"Bode AM, Dong Z . Mitogen-activated protein kinase activation in UV-induced signal transduction. Sci STKE 2003; 2003: RE2.","journal-title":"Sci STKE"},{"key":"BFonc2012279_CR2","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1038\/nrc1253","volume":"4","author":"GT Bowden","year":"2004","unstructured":"Bowden GT . Prevention of non-melanoma skin cancer by targeting ultraviolet-B-light signalling. Nat Rev Cancer 2004; 4: 23\u201335.","journal-title":"Nat Rev Cancer"},{"key":"BFonc2012279_CR3","doi-asserted-by":"publisher","first-page":"681","DOI":"10.1016\/S0190-9622(98)70196-3","volume":"38","author":"TM Johnson","year":"1998","unstructured":"Johnson TM, Dolan OM, Hamilton TA, Lu MC, Swanson NA, Lowe L . Clinical and histologic trends of melanoma. J Am Acad Dermatol 1998; 38: 681\u2013686.","journal-title":"J Am Acad Dermatol"},{"key":"BFonc2012279_CR4","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1111\/1523-1747.ep12477095","volume":"91","author":"HJ Niggli","year":"1988","unstructured":"Niggli HJ, Rothlisberger R . Cyclobutane-type pyrimidine photodimer formation and induction of ornithine decarboxylase in human skin fibroblasts after UV irradiation. J Invest Dermatol 1988; 91: 579\u2013584.","journal-title":"J Invest Dermatol"},{"key":"BFonc2012279_CR5","doi-asserted-by":"publisher","first-page":"861","DOI":"10.1093\/carcin\/12.5.861","volume":"12","author":"AA Vink","year":"1991","unstructured":"Vink AA, Berg RJ, de Gruijl FR, Roza L, Baan RA . Induction, repair and accumulation of thymine dimers in the skin of UV-B-irradiated hairless mice. Carcinogenesis 1991; 12: 861\u2013864.","journal-title":"Carcinogenesis"},{"key":"BFonc2012279_CR6","doi-asserted-by":"publisher","first-page":"3952","DOI":"10.1038\/sj.emboj.7600849","volume":"24","author":"GA Garinis","year":"2005","unstructured":"Garinis GA, Mitchell JR, Moorhouse MJ, Hanada K, de Waard H, Vandeputte D et al. Transcriptome analysis reveals cyclobutane pyrimidine dimers as a major source of UV-induced DNA breaks. EMBO J 2005; 24: 3952\u20133962.","journal-title":"EMBO J"},{"key":"BFonc2012279_CR7","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1038\/35017595","volume":"406","author":"G Ries","year":"2000","unstructured":"Ries G, Heller W, Puchta H, Sandermann H, Seidlitz HK, Hohn B . Elevated UV-B radiation reduces genome stability in plants. Nature 2000; 406: 98\u2013101.","journal-title":"Nature"},{"key":"BFonc2012279_CR8","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1073\/pnas.94.1.11","volume":"94","author":"KH Kraemer","year":"1997","unstructured":"Kraemer KH . Sunlight and skin cancer: another link revealed. Proc Natl Acad Sci USA 1997; 94: 11\u201314.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFonc2012279_CR9","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1016\/j.cub.2005.01.001","volume":"15","author":"J Jans","year":"2005","unstructured":"Jans J, Schul W, Sert YG, Rijksen Y, Rebel H, Eker AP et al. Powerful skin cancer protection by a CPD-photolyase transgene. Curr Biol 2005; 15: 105\u2013115.","journal-title":"Curr Biol"},{"key":"BFonc2012279_CR10","doi-asserted-by":"publisher","first-page":"44688","DOI":"10.1074\/jbc.M107696200","volume":"276","author":"YH You","year":"2001","unstructured":"You YH, Lee DH, Yoon JH, Nakajima S, Yasui A, Pfeifer GP . Cyclobutane pyrimidine dimers are responsible for the vast majority of mutations induced by UVB irradiation in mammalian cells. J Biol Chem 2001; 276: 44688\u201344694.","journal-title":"J Biol Chem"},{"key":"BFonc2012279_CR11","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1093\/carcin\/5.4.511","volume":"5","author":"KH Kraemer","year":"1984","unstructured":"Kraemer KH, Lee MM, Scotto J . DNA repair protects against cutaneous and internal neoplasia: evidence from xeroderma pigmentosum. Carcinogenesis 1984; 5: 511\u2013514.","journal-title":"Carcinogenesis"},{"key":"BFonc2012279_CR12","doi-asserted-by":"publisher","first-page":"1018","DOI":"10.1001\/archderm.1994.01690080084012","volume":"130","author":"KH Kraemer","year":"1994","unstructured":"Kraemer KH, Lee MM, Andrews AD, Lambert WC . The role of sunlight and DNA repair in melanoma and nonmelanoma skin cancer. The xeroderma pigmentosum paradigm. Arch Dermatol 1994; 130: 1018\u20131021.","journal-title":"Arch Dermatol"},{"key":"BFonc2012279_CR13","doi-asserted-by":"publisher","first-page":"3680","DOI":"10.1038\/sj.onc.1209384","volume":"25","author":"YY He","year":"2006","unstructured":"He YY, Pi J, Huang JL, Diwan BA, Waalkes MP, Chignell CF . Chronic UVA irradiation of human HaCaT keratinocytes induces malignant transformation associated with acquired apoptotic resistance. Oncogene 2006; 25: 3680\u20133688.","journal-title":"Oncogene"},{"key":"BFonc2012279_CR14","doi-asserted-by":"publisher","first-page":"4269","DOI":"10.1038\/onc.2008.70","volume":"27","author":"K Wischermann","year":"2008","unstructured":"Wischermann K, Popp S, Moshir S, Scharfetter-Kochanek K, Wlaschek M, de Gruijl F et al. UVA radiation causes DNA strand breaks, chromosomal aberrations and tumorigenic transformation in HaCaT skin keratinocytes. Oncogene 2008; 27: 4269\u20134280.","journal-title":"Oncogene"},{"key":"BFonc2012279_CR15","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1016\/S1097-2765(00)80132-X","volume":"2","author":"K Sugasawa","year":"1998","unstructured":"Sugasawa K, Ng JM, Masutani C, Iwai S, van der Spek PJ, Eker AP et al. Xeroderma pigmentosum group C protein complex is the initiator of global genome nucleotide excision repair. Mol Cell 1998; 2: 223\u2013232.","journal-title":"Mol Cell"},{"key":"BFonc2012279_CR16","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1007\/s10735-006-9044-7","volume":"37","author":"K Sugasawa","year":"2006","unstructured":"Sugasawa K . UV-induced ubiquitylation of XPC complex, the UV-DDB-ubiquitin ligase complex, and DNA repair. J Mol Histol 2006; 37: 189\u2013202.","journal-title":"J Mol Histol"},{"key":"BFonc2012279_CR17","doi-asserted-by":"publisher","first-page":"564","DOI":"10.1038\/nrc1652","volume":"5","author":"JE Cleaver","year":"2005","unstructured":"Cleaver JE . Cancer in xeroderma pigmentosum and related disorders of DNA repair. Nat Rev Cancer 2005; 5: 564\u2013573.","journal-title":"Nat Rev Cancer"},{"key":"BFonc2012279_CR18","doi-asserted-by":"publisher","first-page":"756","DOI":"10.1038\/nrg2663","volume":"10","author":"JE Cleaver","year":"2009","unstructured":"Cleaver JE, Lam ET, Revet I . Disorders of nucleotide excision repair: the genetic and molecular basis of heterogeneity. Nat Rev Genet 2009; 10: 756\u2013768.","journal-title":"Nat Rev Genet"},{"key":"BFonc2012279_CR19","doi-asserted-by":"publisher","first-page":"1016","DOI":"10.1038\/ncb2329","volume":"13","author":"MM Mihaylova","year":"2011","unstructured":"Mihaylova MM, Shaw RJ . The AMPK signalling pathway coordinates cell growth, autophagy and metabolism. Nat Cell Biol 2011; 13: 1016\u20131023.","journal-title":"Nat Cell Biol"},{"key":"BFonc2012279_CR20","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/j.tips.2004.12.011","volume":"26","author":"Z Luo","year":"2005","unstructured":"Luo Z, Saha AK, Xiang X, NB Ruderman . AMPK, the metabolic syndrome and cancer. Trends Pharmacol Sci 2005; 26: 69\u201376.","journal-title":"Trends Pharmacol Sci"},{"key":"BFonc2012279_CR21","doi-asserted-by":"publisher","first-page":"457","DOI":"10.2217\/fon.09.174","volume":"6","author":"Z Luo","year":"2010","unstructured":"Luo Z, Zang M, Guo W . AMPK as a metabolic tumor suppressor: control of metabolism and cell growth. Future Oncol 2010; 6: 457\u2013470.","journal-title":"Future Oncol"},{"key":"BFonc2012279_CR22","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1016\/j.molcel.2005.03.027","volume":"18","author":"RG Jones","year":"2005","unstructured":"Jones RG, Plas DR, Kubek S, Buzzai M, Mu J, Xu Y et al. AMP-activated protein kinase induces a p53-dependent metabolic checkpoint. Mol Cell 2005; 18: 283\u2013293.","journal-title":"Mol Cell"},{"key":"BFonc2012279_CR23","doi-asserted-by":"publisher","first-page":"784","DOI":"10.1038\/leu.2008.348","volume":"23","author":"E Drakos","year":"2009","unstructured":"Drakos E, Atsaves V, Li J, Leventaki V, Andreeff M, Medeiros LJ et al. Stabilization and activation of p53 downregulates mTOR signaling through AMPK in mantle cell lymphoma. Leukemia 2009; 23: 784\u2013790.","journal-title":"Leukemia"},{"key":"BFonc2012279_CR24","doi-asserted-by":"publisher","first-page":"e2009","DOI":"10.1371\/journal.pone.0002009","volume":"3","author":"X Fu","year":"2008","unstructured":"Fu X, Wan S, Lyu YL, Liu LF, Qi H . Etoposide induces ATM-dependent mitochondrial biogenesis through AMPK activation. PLoS One 2008; 3: e2009.","journal-title":"PLoS One"},{"key":"BFonc2012279_CR25","doi-asserted-by":"publisher","first-page":"193","DOI":"10.2337\/dc08-9025","volume":"32","author":"DM Nathan","year":"2009","unstructured":"Nathan DM, Buse JB, Davidson MB, Ferrannini E, Holman RR, Sherwin R et al. Medical management of hyperglycemia in type 2 diabetes: a consensus algorithm for the initiation and adjustment of therapy: a consensus statement of the American Diabetes Association and the European Association for the Study of Diabetes. Diabetes Care 2009; 32: 193\u2013203.","journal-title":"Diabetes Care"},{"key":"BFonc2012279_CR26","doi-asserted-by":"publisher","first-page":"2355","DOI":"10.1172\/JCI40671","volume":"120","author":"M Foretz","year":"2010","unstructured":"Foretz M, Hebrard S, Leclerc J, Zarrinpashneh E, Soty M, Mithieux G et al. Metformin inhibits hepatic gluconeogenesis in mice independently of the LKB1\/AMPK pathway via a decrease in hepatic energy state. J Clin Invest 2010; 120: 2355\u20132369.","journal-title":"J Clin Invest"},{"key":"BFonc2012279_CR27","doi-asserted-by":"publisher","first-page":"2267","DOI":"10.1172\/JCI43661","volume":"120","author":"RA Miller","year":"2010","unstructured":"Miller RA, Birnbaum MJ . An energetic tale of AMPK-independent effects of metformin. J Clin Invest 2010; 120: 2267\u20132270.","journal-title":"J Clin Invest"},{"key":"BFonc2012279_CR28","doi-asserted-by":"publisher","first-page":"1060","DOI":"10.1158\/1940-6207.CAPR-10-0175","volume":"3","author":"M Pollak","year":"2010","unstructured":"Pollak M . Metformin and other biguanides in oncology: advancing the research agenda. Cancer Prev Res (Phila) 2010; 3: 1060\u20131065.","journal-title":"Cancer Prev Res (Phila)"},{"key":"BFonc2012279_CR29","doi-asserted-by":"publisher","first-page":"1092","DOI":"10.1158\/1535-7163.MCT-09-1186","volume":"9","author":"I Ben Sahra","year":"2010","unstructured":"Ben Sahra I, Le Marchand-Brustel Y, Tanti JF, Bost F . Metformin in cancer therapy: a new perspective for an old antidiabetic drug? Mol Cancer Ther 2010; 9: 1092\u20131099.","journal-title":"Mol Cancer Ther"},{"key":"BFonc2012279_CR30","doi-asserted-by":"publisher","first-page":"12932","DOI":"10.1073\/pnas.0906606106","volume":"106","author":"D Guo","year":"2009","unstructured":"Guo D, Hildebrandt IJ, Prins RM, Soto H, Mazzotta MM, Dang J et al. The AMPK agonist AICAR inhibits the growth of EGFRvIII-expressing glioblastomas by inhibiting lipogenesis. Proc Natl Acad Sci USA 2009; 106: 12932\u201312937.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFonc2012279_CR31","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1016\/j.bbrc.2010.06.052","volume":"398","author":"J Woodard","year":"2010","unstructured":"Woodard J, Platanias LC . AMP-activated kinase (AMPK)-generated signals in malignant melanoma cell growth and survival. Biochem Biophys Res Commun 2010; 398: 135\u2013139.","journal-title":"Biochem Biophys Res Commun"},{"key":"BFonc2012279_CR32","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1016\/j.bbrc.2006.08.107","volume":"349","author":"AK Saha","year":"2006","unstructured":"Saha AK, Persons K, Safer JD, Luo Z, Holick MF, Ruderman NB . AMPK regulation of the growth of cultured human keratinocytes. Biochem Biophys Res Commun 2006; 349: 519\u2013524.","journal-title":"Biochem Biophys Res Commun"},{"key":"BFonc2012279_CR33","doi-asserted-by":"publisher","first-page":"22623","DOI":"10.1073\/pnas.1010377108","volume":"107","author":"M Ming","year":"2010","unstructured":"Ming M, Shea CR, Guo X, Li X, Soltani K, Han W et al. Regulation of global genome nucleotide excision repair by SIRT1 through xeroderma pigmentosum C. Proc Natl Acad Sci USA 2010; 107: 22623\u201322628.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFonc2012279_CR34","doi-asserted-by":"publisher","first-page":"5287","DOI":"10.1158\/0008-5472.CAN-10-4614","volume":"71","author":"M Ming","year":"2011","unstructured":"Ming M, Feng L, Shea CR, Soltani K, Zhao B, Han W et al. PTEN positively regulates UVB-induced DNA damage repair. Cancer Res 2011; 71: 5287\u20135295.","journal-title":"Cancer Res"},{"key":"BFonc2012279_CR35","doi-asserted-by":"publisher","first-page":"974","DOI":"10.1002\/mc.20450","volume":"47","author":"J Zhang","year":"2008","unstructured":"Zhang J, Bowden GT . UVB irradiation regulates Cox-2 mRNA stability through AMPK and HuR in human keratinocytes. Mol Carcinog 2008; 47: 974\u2013983.","journal-title":"Mol Carcinog"},{"key":"BFonc2012279_CR36","doi-asserted-by":"publisher","first-page":"19102","DOI":"10.1074\/jbc.M011579200","volume":"276","author":"J Kim","year":"2001","unstructured":"Kim J, Yoon MY, Choi SL, Kang I, Kim SS, Kim YS et al. Effects of stimulation of AMP-activated protein kinase on insulin-like growth factor 1- and epidermal growth factor-dependent extracellular signal-regulated kinase pathway. J Biol Chem 2001; 276: 19102\u201319110.","journal-title":"J Biol Chem"},{"key":"BFonc2012279_CR37","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1016\/j.bbrc.2008.01.099","volume":"368","author":"J Du","year":"2008","unstructured":"Du J, Guan T, Zhang H, Xia Y, Liu F, Zhang Y . Inhibitory crosstalk between ERK and AMPK in the growth and proliferation of cardiac fibroblasts. Biochem Biophys Res Commun 2008; 368: 402\u2013407.","journal-title":"Biochem Biophys Res Commun"},{"key":"BFonc2012279_CR38","doi-asserted-by":"publisher","first-page":"21412","DOI":"10.1074\/jbc.M109.026013","volume":"284","author":"J Wang","year":"2009","unstructured":"Wang J, Whiteman MW, Lian H, Wang G, Singh A, Huang D et al. A non-canonical MEK\/ERK signaling pathway regulates autophagy via regulating Beclin 1. J Biol Chem 2009; 284: 21412\u201321424.","journal-title":"J Biol Chem"},{"key":"BFonc2012279_CR39","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1038\/nrc2676","volume":"9","author":"DB Shackelford","year":"2009","unstructured":"Shackelford DB, Shaw RJ . The LKB1-AMPK pathway: metabolism and growth control in tumour suppression. Nat Rev Cancer 2009; 9: 563\u2013575.","journal-title":"Nat Rev Cancer"},{"key":"BFonc2012279_CR40","doi-asserted-by":"publisher","first-page":"4262","DOI":"10.1182\/blood-2010-02-269837","volume":"116","author":"AS Green","year":"2010","unstructured":"Green AS, Chapuis N, Maciel TT, Willems L, Lambert M, Arnoult C et al. The LKB1\/AMPK signaling pathway has tumor suppressor activity in acute myeloid leukemia through the repression of mTOR-dependent oncogenic mRNA translation. Blood 2010; 116: 4262\u20134273.","journal-title":"Blood"},{"key":"BFonc2012279_CR41","doi-asserted-by":"publisher","first-page":"4366","DOI":"10.1158\/0008-5472.CAN-10-1769","volume":"71","author":"I Ben Sahra","year":"2011","unstructured":"Ben Sahra I, Regazzetti C, Robert G, Laurent K, Le Marchand-Brustel Y, Auberger P et al. Metformin, independent of AMPK, induces mTOR inhibition and cell-cycle arrest through REDD1. Cancer Res 2011; 71: 4366\u20134372.","journal-title":"Cancer Res"},{"key":"BFonc2012279_CR42","doi-asserted-by":"publisher","first-page":"5336","DOI":"10.1128\/MCB.00166-06","volume":"26","author":"KR Laderoute","year":"2006","unstructured":"Laderoute KR, Amin K, Calaoagan JM, Knapp M, Le T, Orduna J et al. 5'-AMP-activated protein kinase (AMPK) is induced by low-oxygen and glucose deprivation conditions found in solid-tumor microenvironments. Mol Cell Biol 2006; 26: 5336\u20135347.","journal-title":"Mol Cell Biol"},{"key":"BFonc2012279_CR43","doi-asserted-by":"publisher","first-page":"492","DOI":"10.1038\/onc.2009.357","volume":"29","author":"M Ming","year":"2010","unstructured":"Ming M, Han W, Maddox J, Soltani K, Shea CR, Freeman DM et al. UVB-induced ERK\/AKT-dependent PTEN suppression promotes survival of epidermal keratinocytes. Oncogene 2010; 29: 492\u2013502.","journal-title":"Oncogene"},{"key":"BFonc2012279_CR44","doi-asserted-by":"publisher","first-page":"22825","DOI":"10.1074\/jbc.M111.222349","volume":"286","author":"W Han","year":"2011","unstructured":"Han W, Ming M, He YY . Caffeine promotes UVB-induced apoptosis in human keratinocytes without complete DNA repair. J Biol Chem 2011; 286: 22825\u201322832.","journal-title":"J Biol Chem"},{"key":"BFonc2012279_CR45","doi-asserted-by":"publisher","first-page":"1490","DOI":"10.1046\/j.0022-202x.2001.01562.x","volume":"117","author":"T Maeda","year":"2001","unstructured":"Maeda T, Chua PP, Chong MT, Sim AB, Nikaido O, Tron VA . Nucleotide excision repair genes are upregulated by low-dose artificial ultraviolet B: evidence of a photoprotective SOS response? J Invest Dermatol 2001; 117: 1490\u20131497.","journal-title":"J Invest Dermatol"}],"updated-by":[{"DOI":"10.1038\/onc.2012.279","type":"expression_of_concern","label":"Expression of concern","source":"publisher","updated":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T00:00:00Z","timestamp":1768435200000}},{"DOI":"10.1038\/s41388-026-03675-2","type":"expression_of_concern","label":"Expression of concern","source":"publisher","updated":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T00:00:00Z","timestamp":1768435200000}}],"container-title":["Oncogene"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/onc2012279.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/onc2012279","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/onc2012279.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T11:11:28Z","timestamp":1772709088000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/onc2012279"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,7,2]]},"references-count":45,"journal-issue":{"issue":"21","published-print":{"date-parts":[[2013,5,23]]}},"alternative-id":["BFonc2012279"],"URL":"https:\/\/doi.org\/10.1038\/onc.2012.279","relation":{},"ISSN":["0950-9232","1476-5594"],"issn-type":[{"value":"0950-9232","type":"print"},{"value":"1476-5594","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,7,2]]},"assertion":[{"value":"27 March 2012","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 May 2012","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 July 2012","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 January 2026","order":4,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"ExpressionOfConcern","order":5,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"An Editorial Expression of Concern to this paper has been published:","order":6,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"https:\/\/doi.org\/10.1038\/s41388-026-03675-2","URL":"https:\/\/doi.org\/10.1038\/s41388-026-03675-2","order":7,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}