{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T08:25:25Z","timestamp":1791015925192,"version":"4.1.0"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"38","license":[{"start":{"date-parts":[[2012,11,5]],"date-time":"2012-11-05T00:00:00Z","timestamp":1352073600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2012,11,5]],"date-time":"2012-11-05T00:00:00Z","timestamp":1352073600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Oncogene"],"published-print":{"date-parts":[[2013,9,19]]},"DOI":"10.1038\/onc.2012.477","type":"journal-article","created":{"date-parts":[[2012,11,5]],"date-time":"2012-11-05T14:59:47Z","timestamp":1352127587000},"page":"4586-4592","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":78,"title":["Chromatin H3K27me3\/H3K4me3 histone marks define gene sets in high-grade serous ovarian cancer that distinguish malignant, tumour-sustaining and chemo-resistant ovarian tumour cells"],"prefix":"10.1038","volume":"32","author":[{"given":"N","family":"Chapman-Rothe","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"Curry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Zeller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Liber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"Stronach","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"Gabra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Ghaem-Maghami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Brown","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2012,11,5]]},"reference":[{"key":"BFonc2012477_CR1","doi-asserted-by":"publisher","first-page":"751","DOI":"10.1016\/S0025-6196(11)61196-8","volume":"82","author":"GD Aletti","year":"2007","unstructured":"Aletti GD, Gallenberg MM, Cliby WA, Jatoi A, Hartmann LC . Current management strategies for ovarian cancer. Mayo Clin Proc 2007; 82: 751\u2013770.","journal-title":"Mayo Clin Proc"},{"key":"BFonc2012477_CR2","first-page":"426","volume":"50","author":"A Berkenblit","year":"2005","unstructured":"Berkenblit A, Cannistra SA . Advances in the management of epithelial ovarian cancer. J Reprod Med 2005; 50: 426\u2013438.","journal-title":"J Reprod Med"},{"key":"BFonc2012477_CR3","doi-asserted-by":"publisher","first-page":"502","DOI":"10.1038\/nrc1123","volume":"3","author":"R Agarwal","year":"2003","unstructured":"Agarwal R, Kaye SB . Ovarian cancer: strategies for overcoming resistance to chemotherapy. Nat Rev Cancer 2003; 3: 502\u2013516.","journal-title":"Nat Rev Cancer"},{"key":"BFonc2012477_CR4","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.cell.2006.02.041","volume":"125","author":"BE Bernstein","year":"2006","unstructured":"Bernstein BE, Mikkelsen TS, Xie X, Kamal M, Huebert DJ, Cuff J et al. A bivalent chromatin structure marks key developmental genes in embryonic stem cells. Cell 2006; 125: 315\u2013326.","journal-title":"Cell"},{"key":"BFonc2012477_CR5","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1038\/ng1972","volume":"39","author":"JE Ohm","year":"2007","unstructured":"Ohm JE, McGarvey KM, Yu X, Cheng L, Schuebel KE, Cope L et al. A stem cell-like chromatin pattern may predispose tumor suppressor genes to DNA hypermethylation and heritable silencing. Nat Genet 2007; 39: 237\u2013242.","journal-title":"Nat Genet"},{"key":"BFonc2012477_CR6","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1038\/ng1941","volume":"39","author":"M Widschwendter","year":"2007","unstructured":"Widschwendter M, Fiegl H, Egle D, Mueller-Holzner E, Spizzo G, Marth C et al. Epigenetic stem cell signature in cancer. Nat Genet 2007; 39: 157\u2013158.","journal-title":"Nat Genet"},{"key":"BFonc2012477_CR7","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1146\/annurev.genet.38.072902.091907","volume":"38","author":"L Ringrose","year":"2004","unstructured":"Ringrose L, Paro R . Epigenetic regulation of cellular memory by the Polycomb and Trithorax group proteins. Annu Rev Genet 2004; 38: 413\u2013443.","journal-title":"Annu Rev Genet"},{"key":"BFonc2012477_CR8","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1186\/1471-2164-12-134","volume":"12","author":"JW Ho","year":"2011","unstructured":"Ho JW, Bishop E, Karchenko PV, Negre N, White KP, Park PJ . ChIP-chip versus ChIP-seq: lessons for experimental design and data analysis. BMC Genomics 2011; 12: 134.","journal-title":"BMC Genomics"},{"key":"BFonc2012477_CR9","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1158\/1535-7163.MCT-10-0788","volume":"10","author":"S Rizzo","year":"2011","unstructured":"Rizzo S, Hersey JM, Mellor P, Dai W, Santos-Silva A, Liber D et al. Ovarian cancer stem cell-like side populations are enriched following chemotherapy and overexpress EZH2. Mol Cancer Ther 2011; 10: 325\u2013335.","journal-title":"Mol Cancer Ther"},{"key":"BFonc2012477_CR10","doi-asserted-by":"publisher","first-page":"1276","DOI":"10.1038\/sj.bjc.6605626","volume":"102","author":"L Hu","year":"2010","unstructured":"Hu L, McArthur C, Jaffe RB . Ovarian cancer stem-like side-population cells are tumourigenic and chemoresistant. Br J Cancer 2010; 102: 1276\u20131283.","journal-title":"Br J Cancer"},{"key":"BFonc2012477_CR11","doi-asserted-by":"publisher","first-page":"11154","DOI":"10.1073\/pnas.0603672103","volume":"103","author":"PP Szotek","year":"2006","unstructured":"Szotek PP, Pieretti-Vanmarcke R, Masiakos PT, Dinulescu DM, Connolly D, Foster R et al. Ovarian cancer side population defines cells with stem cell-like characteristics and Mullerian Inhibiting Substance responsiveness. PNAS 2006; 103: 11154\u201311159.","journal-title":"PNAS"},{"key":"BFonc2012477_CR12","doi-asserted-by":"publisher","first-page":"4311","DOI":"10.1158\/0008-5472.CAN-08-0364","volume":"68","author":"S Zhang","year":"2008","unstructured":"Zhang S, Balch C, Chan MW, Lai HC, Matei D, Schilder JM et al. Identification and characterization of ovarian cancer-initiating cells from primary human tumors. Cancer Res 2008; 68: 4311\u20134320.","journal-title":"Cancer Res"},{"key":"BFonc2012477_CR13","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1016\/j.cell.2006.02.043","volume":"125","author":"TI Lee","year":"2006","unstructured":"Lee TI, Jenner RG, Boyer LA, Guenther MG, Levine SS, Kumar RM et al. Control of developmental regulators by Polycomb in human embryonic stem cells. Cell 2006; 125: 301\u2013313.","journal-title":"Cell"},{"key":"BFonc2012477_CR14","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1093\/biostatistics\/4.2.249","volume":"4","author":"RA Irizarry","year":"2003","unstructured":"Irizarry RA, Hobbs B, Collin F, Beazer-Barclay YD, Antonellis KJ, Scherf U et al. Exploration, normalization, and summaries of high density oligonucleotide array probe level data. Biostatistics 2003; 4: 249\u2013264.","journal-title":"Biostatistics"},{"key":"BFonc2012477_CR15","doi-asserted-by":"publisher","first-page":"609","DOI":"10.1038\/nature10166","volume":"474","author":"Cancer Genome Atlas Research Network","year":"2011","unstructured":"Cancer Genome Atlas Research Network, Integrated genomic analyses of ovarian carcinoma. Nature 2011; 474: 609\u2013615.","journal-title":"Nature"},{"key":"BFonc2012477_CR16","doi-asserted-by":"publisher","first-page":"286","DOI":"10.1016\/j.stem.2007.08.004","volume":"1","author":"XD Zhao","year":"2007","unstructured":"Zhao XD, Han X, Chew JL, Liu J, Chiu KP, Choo A et al. Whole-genome mapping of histone H3 Lys4 and 27 trimethylations reveals distinct genomic compartments in human embryonic stem cells. Cell Stem Cell 2007; 1: 286\u2013298.","journal-title":"Cell Stem Cell"},{"key":"BFonc2012477_CR17","doi-asserted-by":"publisher","first-page":"W645","DOI":"10.1093\/nar\/gkl229","volume":"34","author":"PD Thomas","year":"2006","unstructured":"Thomas PD, Kejariwal A, Guo N, Mi H, Campbell MJ, Muruganujan A et al. Applications for protein sequence-function evolution data: mRNA\/protein expression analysis and coding SNP scoring tools. Nucleic Acids Res 2006; 34: W645\u2013W650.","journal-title":"Nucleic Acids Res"},{"key":"BFonc2012477_CR18","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1038\/nrg1981","volume":"8","author":"YB Schwartz","year":"2007","unstructured":"Schwartz YB, Pirrotta V . Polycomb silencing mechanisms and the management of genomic programmes. Nat Rev Genet 2007; 8: 9\u201322.","journal-title":"Nat Rev Genet"},{"key":"BFonc2012477_CR19","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1177\/0962280209351908","volume":"18","author":"RA Irizarry","year":"2009","unstructured":"Irizarry RA, Wang C, Zhou Y, Speed TP . Gene set enrichment analysis made simple. Stat Methods Med Res 2009; 18: 565\u2013575.","journal-title":"Stat Methods Med Res"},{"key":"BFonc2012477_CR20","doi-asserted-by":"publisher","first-page":"5198","DOI":"10.1158\/1078-0432.CCR-08-0196","volume":"14","author":"RW Tothill","year":"2008","unstructured":"Tothill RW, Tinker AV, George J, Brown R, Fox SB, Lade S et al. Novel molecular subtypes of serous and endometrioid ovarian cancer linked to clinical outcome. Clin Cancer Res 2008; 14: 5198\u20135208.","journal-title":"Clin Cancer Res"},{"key":"BFonc2012477_CR21","first-page":"6166","volume":"48","author":"SP Langdon","year":"1988","unstructured":"Langdon SP, Lawrie SS, Hay FG, Hawkes MM, McDonald A, Hayward IP et al. Characterization and properties of nine human ovarian adenocarcinoma cell lines. Cancer Res 1988; 48: 6166\u20136172.","journal-title":"Cancer Res"},{"key":"BFonc2012477_CR22","doi-asserted-by":"publisher","first-page":"4412","DOI":"10.1158\/0008-5472.CAN-10-4111","volume":"71","author":"EA Stronach","year":"2011","unstructured":"Stronach EA, Alfraidi A, Rama N, Datler C, Studd JB, Agarwal R et al. HDAC4-Regulated STAT1 activation mediates platinum resistance in ovarian cancer. Cancer Res 2011; 71: 4412\u20134422.","journal-title":"Cancer Res"},{"key":"BFonc2012477_CR23","doi-asserted-by":"publisher","first-page":"3","DOI":"10.2202\/1544-6115.1027","volume":"3","author":"GK Smyth","year":"2004","unstructured":"Smyth GK . Linear models and empirical bayes methods for assessing differential expression in microarray experiments. Stat Appl Genet Molec Biol 2004; 3: 3.","journal-title":"Stat Appl Genet Molec Biol"},{"key":"BFonc2012477_CR24","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1101\/gr.108803.110","volume":"21","author":"N Matsumura","year":"2011","unstructured":"Matsumura N, Huang Z, Mori S, Baba T, Fujii S, Konishi I et al. Epigenetic suppression of the TGF-beta pathway revealed by transcriptome profiling in ovarian cancer. Genome Res 2011; 21: 74\u201382.","journal-title":"Genome Res"},{"key":"BFonc2012477_CR25","doi-asserted-by":"publisher","first-page":"2262","DOI":"10.1016\/j.cellsig.2006.05.019","volume":"18","author":"Q Meng","year":"2006","unstructured":"Meng Q, Xia C, Fang J, Rojanasakul Y, Jiang BH . Role of PI3K and AKT specific isoforms in ovarian cancer cell migration, invasion and proliferation through the p70S6K1 pathway. Cell Signal 2006; 18: 2262\u20132271.","journal-title":"Cell Signal"},{"key":"BFonc2012477_CR26","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1016\/j.ejogrb.2009.04.035","volume":"146","author":"HY Zhang","year":"2009","unstructured":"Zhang HY, Zhang PN, Sun H . Aberration of the PI3K\/AKT\/mTOR signaling in epithelial ovarian cancer and its implication in cisplatin-based chemotherapy. Eur J Obstet Gynaecol Reprod Biol 2009; 146: 81\u201386.","journal-title":"Eur J Obstet Gynaecol Reprod Biol"},{"key":"BFonc2012477_CR27","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1016\/j.ccr.2010.06.016","volume":"18","author":"C Lu","year":"2010","unstructured":"Lu C, Han HD, Mangala LS, Ali-Fehmi R, Newton CS, Ozbun L et al. Regulation of tumor angiogenesis by EZH2. Cancer Cell 2010; 18: 185\u2013197.","journal-title":"Cancer Cell"},{"key":"BFonc2012477_CR28","doi-asserted-by":"publisher","first-page":"4567","DOI":"10.1038\/onc.2011.611","volume":"31","author":"C Zeller","year":"2012","unstructured":"Zeller C, Dai W, Steele NL, Siddiq A, Walley AJ, Wilhelm-Benartzi CS et al. Candidate DNA methylation drivers of acquired cisplatin resistance in ovarian cancer identified by methylome and expression profiling. Oncogene 2012; 31: 4567\u20134576.","journal-title":"Oncogene"},{"key":"BFonc2012477_CR29","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1038\/nprot.2006.27","volume":"1","author":"JD Nelson","year":"2006","unstructured":"Nelson JD, Denisenko O, Bomsztyk K . Protocol for the fast chromatin immunoprecipitation (ChIP) method. Nat Protoc 2006; 1: 179\u2013185.","journal-title":"Nat Protoc"},{"key":"BFonc2012477_CR30","doi-asserted-by":"publisher","first-page":"R25","DOI":"10.1186\/gb-2009-10-3-r25","volume":"10","author":"B Langmead","year":"2009","unstructured":"Langmead B, Trapnell C, Pop M, Salzberg SL . Ultrafast and memory-efficient alignment of short DNA sequences to the human genome. Genome Biol 2009; 10: R25.","journal-title":"Genome Biol"},{"key":"BFonc2012477_CR31","doi-asserted-by":"publisher","first-page":"1952","DOI":"10.1093\/bioinformatics\/btp340","volume":"25","author":"C Zang","year":"2009","unstructured":"Zang C, Schones DE, Zeng C, Cui K, Zhao K, Peng W . A clustering approach for identification of enriched domains from histone modification ChIP-Seq data. Bioinformatics 2009; 25: 1952\u20131958.","journal-title":"Bioinformatics"},{"key":"BFonc2012477_CR32","doi-asserted-by":"publisher","first-page":"2176","DOI":"10.1093\/bioinformatics\/btq401","volume":"26","author":"D Wu","year":"2010","unstructured":"Wu D, Lim E, Vaillant F, Asselin-Labat M-L, Visvader JE, Smyth GK . ROAST: rotation gene set tests for complex microarray experiments. Bioinformatics 2010; 26: 2176\u20132182.","journal-title":"Bioinformatics"}],"container-title":["Oncogene"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/onc2012477.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/onc2012477","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/onc2012477.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,21]],"date-time":"2022-03-21T18:16:50Z","timestamp":1647886610000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/onc2012477"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,11,5]]},"references-count":32,"journal-issue":{"issue":"38","published-print":{"date-parts":[[2013,9,19]]}},"alternative-id":["BFonc2012477"],"URL":"https:\/\/doi.org\/10.1038\/onc.2012.477","relation":{},"ISSN":["0950-9232","1476-5594"],"issn-type":[{"value":"0950-9232","type":"print"},{"value":"1476-5594","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,11,5]]},"assertion":[{"value":"20 January 2012","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 August 2012","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 September 2012","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 November 2012","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}