{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T06:30:08Z","timestamp":1789194608896,"version":"build-2803163510"},"reference-count":50,"publisher":"Springer Science and Business Media LLC","issue":"39","license":[{"start":{"date-parts":[[2012,10,29]],"date-time":"2012-10-29T00:00:00Z","timestamp":1351468800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2012,10,29]],"date-time":"2012-10-29T00:00:00Z","timestamp":1351468800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Oncogene"],"published-print":{"date-parts":[[2013,9,26]]},"DOI":"10.1038\/onc.2012.481","type":"journal-article","created":{"date-parts":[[2012,10,29]],"date-time":"2012-10-29T15:14:07Z","timestamp":1351523647000},"page":"4702-4711","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["mTORC1 enhancement of STIM1-mediated store-operated Ca2+ entry constrains tuberous sclerosis complex-related tumor development"],"prefix":"10.1038","volume":"32","author":[{"given":"H","family":"Peng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Q","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Duan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y","family":"Jing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Q","family":"Mao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K-F","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C L","family":"Walker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2012,10,29]]},"reference":[{"key":"BFonc2012481_CR1","doi-asserted-by":"publisher","first-page":"1345","DOI":"10.1056\/NEJMra055323","volume":"355","author":"PB Crino","year":"2006","unstructured":"Crino PB, Nathanson KL, Henske EP . The tuberous sclerosis complex. N Engl J Med 2006; 355: 1345\u20131356.","journal-title":"N Engl J Med"},{"key":"BFonc2012481_CR2","doi-asserted-by":"publisher","first-page":"1259","DOI":"10.1016\/S0960-9822(03)00506-2","volume":"13","author":"AR Tee","year":"2003","unstructured":"Tee AR, Manning BD, Roux PP, Cantley LC, Blenis J . Tuberous sclerosis complex gene products, Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb. Curr Biol 2003; 13: 1259\u20131268.","journal-title":"Curr Biol"},{"key":"BFonc2012481_CR3","doi-asserted-by":"publisher","first-page":"pe27","DOI":"10.1126\/scisignal.267pe27","volume":"2","author":"DR Alessi","year":"2009","unstructured":"Alessi DR, Pearce LR, Garcia-Martinez JM . New insights into mTOR signaling: mTORC2 and beyond. Sci Signal 2009; 2: pe27.","journal-title":"Sci Signal"},{"key":"BFonc2012481_CR4","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1016\/j.cell.2012.03.017","volume":"149","author":"M Laplante","year":"2012","unstructured":"Laplante M, Sabatini DM . mTOR signaling in growth control and disease. Cell 2012; 149: 274\u2013293.","journal-title":"Cell"},{"key":"BFonc2012481_CR5","first-page":"eg4","volume":"5","author":"NR Gough","year":"2012","unstructured":"Gough NR . Focus issue: TOR signaling, a tale of two complexes. Sci Signal 2012; 5: eg4.","journal-title":"Sci Signal"},{"key":"BFonc2012481_CR6","doi-asserted-by":"publisher","first-page":"2815","DOI":"10.1158\/0008-5472.CAN-10-4158","volume":"71","author":"JL Yecies","year":"2011","unstructured":"Yecies JL, Manning BD . Transcriptional control of cellular metabolism by mTOR signaling. Cancer Res 2011; 71: 2815\u20132820.","journal-title":"Cancer Res"},{"key":"BFonc2012481_CR7","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1038\/ncb2152","volume":"13","author":"J Kim","year":"2011","unstructured":"Kim J, Kundu M, Viollet B, Guan KL . AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1. Nat Cell Biol 2011; 13: 132\u2013141.","journal-title":"Nat Cell Biol"},{"key":"BFonc2012481_CR8","doi-asserted-by":"publisher","first-page":"ra42","DOI":"10.1126\/scisignal.2002790","volume":"5","author":"A Roczniak-Ferguson","year":"2012","unstructured":"Roczniak-Ferguson A, Petit CS, Froehlich F, Qian S, Ky J, Angarola B et al. The transcription factor TFEB links mTORC1 signaling to transcriptional control of lysosome homeostasis. Sci Signal 2012; 5: ra42.","journal-title":"Sci Signal"},{"key":"BFonc2012481_CR9","doi-asserted-by":"publisher","first-page":"1926","DOI":"10.1101\/gad.1212704","volume":"18","author":"N Hay","year":"2004","unstructured":"Hay N, Sonenberg N . Upstream and downstream of mTOR. Genes Dev 2004; 18: 1926\u20131945.","journal-title":"Genes Dev"},{"key":"BFonc2012481_CR10","doi-asserted-by":"publisher","first-page":"666","DOI":"10.1038\/cr.2007.64","volume":"17","author":"Q Yang","year":"2007","unstructured":"Yang Q, Guan K-L . Expanding mTOR signaling. Cell Res 2007; 17: 666\u2013681.","journal-title":"Cell Res"},{"key":"BFonc2012481_CR11","doi-asserted-by":"publisher","first-page":"4071","DOI":"10.1158\/1078-0432.CCR-11-0445","volume":"17","author":"DM Davies","year":"2011","unstructured":"Davies DM, de Vries PJ, Johnson SR, McCartney DL, Cox JA, Serra AL et al. Sirolimus therapy for angiomyolipoma in tuberous sclerosis and sporadic lymphangioleiomyomatosis: a phase 2 trial. Clin Cancer Res 2011; 17: 4071\u20134081.","journal-title":"Clin Cancer Res"},{"key":"BFonc2012481_CR12","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1056\/NEJMoa063564","volume":"358","author":"JJ Bissler","year":"2008","unstructured":"Bissler JJ, McCormack FX, Young LR, Elwing JM, Chuck G, Leonard JM et al. Sirolimus for angiomyolipoma in tuberous sclerosis complex or lymphangioleiomyomatosis. N Engl J Med 2008; 358: 140\u2013151.","journal-title":"N Engl J Med"},{"key":"BFonc2012481_CR13","doi-asserted-by":"publisher","first-page":"567","DOI":"10.4161\/cc.8.4.7659","volume":"8","author":"AY Choo","year":"2009","unstructured":"Choo AY, Blenis J . Not all substrates are treated equally: implications for mTOR, rapamycin-resistance and cancer therapy. Cell Cycle 2009; 8: 567\u2013572.","journal-title":"Cell Cycle"},{"key":"BFonc2012481_CR14","doi-asserted-by":"publisher","first-page":"730","DOI":"10.1172\/JCI28984","volume":"117","author":"H Zhang","year":"2007","unstructured":"Zhang H, Bajraszewski N, Wu E, Wang H, Moseman AP, Dabora SL et al. PDGFRs are critical for PI3K\/Akt activation and negatively regulated by mTOR. J Clin Invest 2007; 117: 730\u2013738.","journal-title":"J Clin Invest"},{"key":"BFonc2012481_CR15","doi-asserted-by":"publisher","first-page":"1650","DOI":"10.1016\/j.cub.2004.08.026","volume":"14","author":"OJ Shah","year":"2004","unstructured":"Shah OJ, Wang Z, Hunter T . Inappropriate activation of the TSC\/Rheb\/mTOR\/S6K cassette induces IRS1\/2 depletion, insulin resistance, and cell survival deficiencies. Curr Biol 2004; 14: 1650\u20131656.","journal-title":"Curr Biol"},{"key":"BFonc2012481_CR16","doi-asserted-by":"publisher","first-page":"1317","DOI":"10.1126\/science.1199498","volume":"332","author":"PP Hsu","year":"2011","unstructured":"Hsu PP, Kang SA, Rameseder J, Zhang Y, Ottina KA, Lim D et al. The mTOR-regulated phosphoproteome reveals a mechanism of mTORC1-mediated inhibition of growth factor signaling. Science 2011; 332: 1317\u20131322.","journal-title":"Science"},{"key":"BFonc2012481_CR17","doi-asserted-by":"publisher","first-page":"1322","DOI":"10.1126\/science.1199484","volume":"332","author":"Y Yu","year":"2011","unstructured":"Yu Y, Yoon SO, Poulogiannis G, Yang Q, Ma XM, Villen J et al. Phosphoproteomic analysis identifies Grb10 as an mTORC1 substrate that negatively regulates insulin signaling. Science 2011; 332: 1322\u20131326.","journal-title":"Science"},{"key":"BFonc2012481_CR18","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/j.tibs.2004.11.003","volume":"30","author":"LS Harrington","year":"2005","unstructured":"Harrington LS, Findlay GM, Lamb RF . Restraining PI3K: mTOR signalling goes back to the membrane. Trends Biochem Sci 2005; 30: 35\u201342.","journal-title":"Trends Biochem Sci"},{"key":"BFonc2012481_CR19","doi-asserted-by":"publisher","first-page":"1047","DOI":"10.1016\/j.cell.2007.11.028","volume":"131","author":"DE Clapham","year":"2007","unstructured":"Clapham DE . Calcium signaling. Cell 2007; 131: 1047\u20131058.","journal-title":"Cell"},{"key":"BFonc2012481_CR20","doi-asserted-by":"publisher","first-page":"757","DOI":"10.1152\/physrev.00057.2003","volume":"85","author":"AB Parekh","year":"2005","unstructured":"Parekh AB, Putney JW . Store-operated calcium channels. Physiol Rev 2005; 85: 757\u2013810.","journal-title":"Physiol Rev"},{"key":"BFonc2012481_CR21","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1038\/nature05637","volume":"446","author":"RS Lewis","year":"2007","unstructured":"Lewis RS . The molecular choreography of a store-operated calcium channel. Nature 2007; 446: 284\u2013287.","journal-title":"Nature"},{"key":"BFonc2012481_CR22","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1007\/978-94-007-2888-2_16","volume":"740","author":"I Derler","year":"2012","unstructured":"Derler I, Madl J, Schutz G, Romanin C . Structure, regulation and biophysics of I(CRAC), STIM\/Orai1. Adv Exp Med Biol 2012; 740: 383\u2013410.","journal-title":"Adv Exp Med Biol"},{"key":"BFonc2012481_CR23","doi-asserted-by":"publisher","first-page":"1613","DOI":"10.2741\/4007","volume":"17","author":"A Engh","year":"2012","unstructured":"Engh A, Somasundaram A, Prakriya M . Permeation and gating mechanisms in store-operated CRAC channels. Front Biosci 2012; 17: 1613\u20131626.","journal-title":"Front Biosci"},{"key":"BFonc2012481_CR24","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1016\/j.clim.2010.01.011","volume":"135","author":"S Feske","year":"2010","unstructured":"Feske S, Picard C, Fischer A . Immunodeficiency due to mutations in ORAI1 and STIM1. Clin Immunol 2010; 135: 169\u2013182.","journal-title":"Clin Immunol"},{"key":"BFonc2012481_CR25","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1038\/nrc2171","volume":"7","author":"GR Monteith","year":"2007","unstructured":"Monteith GR, McAndrew D, Faddy HM, Roberts-Thomson SJ . Calcium and cancer: targeting Ca2+ transport. Nat Rev Cancer 2007; 7: 519\u2013530.","journal-title":"Nat Rev Cancer"},{"key":"BFonc2012481_CR26","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1038\/nrc2374","volume":"8","author":"HL Roderick","year":"2008","unstructured":"Roderick HL, Cook SJ . Ca2+ signalling checkpoints in cancer: remodelling Ca2+ for cancer cell proliferation and survival. Nat Rev Cancer 2008; 8: 361\u2013375.","journal-title":"Nat Rev Cancer"},{"key":"BFonc2012481_CR27","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1007\/s00424-009-0777-5","volume":"460","author":"S Feske","year":"2010","unstructured":"Feske S . CRAC channelopathies. Pflugers Arch 2010; 460: 417\u2013435.","journal-title":"Pflugers Arch"},{"key":"BFonc2012481_CR28","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1016\/j.ccr.2008.12.019","volume":"15","author":"S Yang","year":"2009","unstructured":"Yang S, Zhang JJ, Orai1 Huang XY . and STIM1 are critical for breast tumor cell migration and metastasis. Cancer Cell 2009; 15: 124\u2013134.","journal-title":"Cancer Cell"},{"key":"BFonc2012481_CR29","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1016\/j.cell.2010.08.040","volume":"143","author":"M Feng","year":"2010","unstructured":"Feng M, Grice DM, Faddy HM, Nguyen N, Leitch S, Wang Y et al. Store-independent activation of orai1 by SPCA2 in mammary tumors. Cell 2010; 143: 84\u201398.","journal-title":"Cell"},{"key":"BFonc2012481_CR30","doi-asserted-by":"publisher","first-page":"2068","DOI":"10.1002\/hep.22263","volume":"47","author":"C El Boustany","year":"2008","unstructured":"El Boustany C, Bidaux G, Enfissi A, Delcourt P, Prevarskaya N, Capiod T . Capacitative calcium entry and transient receptor potential canonical 6 expression control human hepatoma cell proliferation. Hepatology 2008; 47: 2068\u20132077.","journal-title":"Hepatology"},{"key":"BFonc2012481_CR31","doi-asserted-by":"publisher","first-page":"15225","DOI":"10.1073\/pnas.1103315108","volume":"108","author":"YF Chen","year":"2011","unstructured":"Chen YF, Chiu WT, Chen YT, Lin PY, Huang HJ, Chou CY et al. Calcium store sensor stromal-interaction molecule 1-dependent signaling plays an important role in cervical cancer growth, migration, and angiogenesis. Proc Natl Acad Sci USA 2011; 108: 15225\u201315230.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFonc2012481_CR32","doi-asserted-by":"publisher","first-page":"1223","DOI":"10.1172\/JCI200317222","volume":"112","author":"H Zhang","year":"2003","unstructured":"Zhang H, Cicchetti G, Onda H, Koon HB, Asrican K, Bajraszewski N et al. Loss of Tsc1\/Tsc2 activates mTOR and disrupts PI3K-Akt signaling through downregulation of PDGFR. J Clin Invest 2003; 112: 1223\u20131233.","journal-title":"J Clin Invest"},{"key":"BFonc2012481_CR33","doi-asserted-by":"publisher","first-page":"3436","DOI":"10.1158\/0008-5472.CAN-03-3609","volume":"64","author":"N El-Hashemite","year":"2004","unstructured":"El-Hashemite N, Zhang H, Walker V, Hoffmeister KM, Kwiatkowski DJ . Perturbed IFN-gamma-Jak-signal transducers and activators of transcription signaling in tuberous sclerosis mouse models: synergistic effects of rapamycin-IFN-gamma treatment. Cancer Res 2004; 64: 3436\u20133443.","journal-title":"Cancer Res"},{"key":"BFonc2012481_CR34","doi-asserted-by":"publisher","first-page":"2378","DOI":"10.1093\/hmg\/ddp176","volume":"18","author":"K Pollizzi","year":"2009","unstructured":"Pollizzi K, Malinowska-Kolodziej I, Doughty C, Betz C, Ma J, Goto J et al. A hypomorphic allele of Tsc2 highlights the role of TSC1\/TSC2 in signaling to AKT and models mild human TSC2 alleles. Hum Mol Genet 2009; 18: 2378\u20132387.","journal-title":"Hum Mol Genet"},{"key":"BFonc2012481_CR35","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1002\/gcc.20118","volume":"42","author":"L Lee","year":"2005","unstructured":"Lee L, Sudentas P, Donohue B, Asrican K, Worku A, Walker V et al. Efficacy of a rapamycin analog (CCI-779) and IFN-gamma in tuberous sclerosis mouse models. Genes Chromosomes Cancer 2005; 42: 213\u2013227.","journal-title":"Genes Chromosomes Cancer"},{"key":"BFonc2012481_CR36","doi-asserted-by":"publisher","first-page":"2073","DOI":"10.1016\/j.cub.2006.08.085","volume":"16","author":"M Vig","year":"2006","unstructured":"Vig M, Beck A, Billingsley JM, Lis A, Parvez S, Peinelt C et al. CRACM1 multimers form the ion-selective pore of the CRAC channel. Curr Biol 2006; 16: 2073\u20132079.","journal-title":"Curr Biol"},{"key":"BFonc2012481_CR37","doi-asserted-by":"publisher","first-page":"1003","DOI":"10.1038\/ncb1454","volume":"8","author":"GN Huang","year":"2006","unstructured":"Huang GN, Zeng W, Kim JY, Yuan JP, Han L, Muallem S et al. STIM1 carboxyl-terminus activates native SOC, Icrac and TRPC1 channels. Nat Cell Biol 2006; 8: 1003\u20131010.","journal-title":"Nat Cell Biol"},{"key":"BFonc2012481_CR38","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1016\/j.critrevonc.2007.01.006","volume":"62","author":"R Roskoski","year":"2007","unstructured":"Roskoski R . Vascular endothelial growth factor (VEGF) signaling in tumor progression. Crit Rev Oncol Hematol 2007; 62: 179\u2013213.","journal-title":"Crit Rev Oncol Hematol"},{"key":"BFonc2012481_CR39","first-page":"1568","volume":"146","author":"SR Howe","year":"1995","unstructured":"Howe SR, Gottardis MM, Everitt JI, Goldsworthy TL, Wolf DC, Walker C . Rodent model of reproductive tract leiomyomata. Establishment and characterization of tumor-derived cell lines. Am J Pathol 1995; 146: 1568\u20131579.","journal-title":"Am J Pathol"},{"key":"BFonc2012481_CR40","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1038\/ng0195-70","volume":"9","author":"T Kobayashi","year":"1995","unstructured":"Kobayashi T, Hirayama Y, Kobayashi E, Kubo Y, Hino O . A germline insertion in the tuberous sclerosis (Tsc2) gene gives rise to the Eker rat model of dominantly inherited cancer. Nat Genet 1995; 9: 70\u201374.","journal-title":"Nat Genet"},{"key":"BFonc2012481_CR41","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1172\/JCI37964","volume":"120","author":"J Ma","year":"2010","unstructured":"Ma J, Meng Y, Kwiatkowski DJ, Chen X, Peng H, Sun Q et al. Mammalian target of rapamycin regulates murine and human cell differentiation through STAT3\/p63\/Jagged\/Notch cascade. J Clin Invest 2010; 120: 103\u2013114.","journal-title":"J Clin Invest"},{"key":"BFonc2012481_CR42","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.ccr.2007.05.008","volume":"12","author":"DA Guertin","year":"2007","unstructured":"Guertin DA, Sabatini DM . Defining the role of mTOR in cancer. Cancer Cell 2007; 12: 9\u201322.","journal-title":"Cancer Cell"},{"key":"BFonc2012481_CR43","doi-asserted-by":"publisher","first-page":"C405","DOI":"10.1152\/ajpcell.00337.2011","volume":"302","author":"A Ogawa","year":"2012","unstructured":"Ogawa A, Firth AL, Smith KA, Maliakal MV, Yuan JX . PDGF enhances store-operated Ca2+ entry by upregulating STIM1\/Orai1 via activation of Akt\/mTOR in human pulmonary arterial smooth muscle cells. Am J Physiol Cell Physiol 2012; 302: C405\u2013C411.","journal-title":"Am J Physiol Cell Physiol"},{"key":"BFonc2012481_CR44","first-page":"4493","volume":"57","author":"S Sabbioni","year":"1997","unstructured":"Sabbioni S, Barbanti-Brodano G, Croce CM, Negrini M . GOK: a gene at 11p15 involved in rhabdomyosarcoma and rhabdoid tumor development. Cancer Res 1997; 57: 4493\u20134497.","journal-title":"Cancer Res"},{"key":"BFonc2012481_CR45","doi-asserted-by":"publisher","first-page":"38083","DOI":"10.1074\/jbc.C400313200","volume":"279","author":"E Suyama","year":"2004","unstructured":"Suyama E, Wadhwa R, Kaur K, Miyagishi M, Kaul SC, Kawasaki H et al. Identification of metastasis-related genes in a mouse model using a library of randomized ribozymes. J Biol Chem 2004; 279: 38083\u201338086.","journal-title":"J Biol Chem"},{"key":"BFonc2012481_CR46","doi-asserted-by":"publisher","first-page":"e75","DOI":"10.1038\/cddis.2010.52","volume":"1","author":"M Flourakis","year":"2010","unstructured":"Flourakis M, Lehen\u2019kyi V, Beck B, Raphael M, Vandenberghe M, Abeele FV et al. Orai1 contributes to the establishment of an apoptosis-resistant phenotype in prostate cancer cells. Cell Death Dis 2010; 1: e75.","journal-title":"Cell Death Dis"},{"key":"BFonc2012481_CR47","doi-asserted-by":"publisher","first-page":"23629","DOI":"10.1074\/jbc.M110.108696","volume":"285","author":"K Gilio","year":"2010","unstructured":"Gilio K, van Kruchten R, Braun A, Berna-Erro A, Feijge MA, Stegner D et al. Roles of platelet STIM1 and Orai1 in glycoprotein VI- and thrombin-dependent procoagulant activity and thrombus formation. J Biol Chem 2010; 285: 23629\u201323638.","journal-title":"J Biol Chem"},{"key":"BFonc2012481_CR48","doi-asserted-by":"publisher","first-page":"3540","DOI":"10.1172\/JCI32312","volume":"117","author":"J Grosse","year":"2007","unstructured":"Grosse J, Braun A, Varga-Szabo D, Beyersdorf N, Schneider B, Zeitlmann L et al. An EF hand mutation in Stim1 causes premature platelet activation and bleeding in mice. J Clin Invest 2007; 117: 3540\u20133550.","journal-title":"J Clin Invest"},{"key":"BFonc2012481_CR49","first-page":"5173","volume":"63","author":"N El-Hashemite","year":"2003","unstructured":"El-Hashemite N, Walker V, Zhang H, Kwiatkowski DJ . Loss of Tsc1 or Tsc2 induces vascular endothelial growth factor production through mammalian target of rapamycin. Cancer Res 2003; 63: 5173\u20135177.","journal-title":"Cancer Res"},{"key":"BFonc2012481_CR50","doi-asserted-by":"publisher","first-page":"4129","DOI":"10.1073\/pnas.1014769108","volume":"108","author":"Q Sun","year":"2011","unstructured":"Sun Q, Chen X, Ma J, Peng H, Wang F, Zha X et al. Mammalian target of rapamycin up-regulation of pyruvate kinase isoenzyme type M2 is critical for aerobic glycolysis and tumor growth. Proc Natl Acad Sci USA 2011; 108: 4129\u20134134.","journal-title":"Proc Natl Acad Sci USA"}],"container-title":["Oncogene"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/onc2012481.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/onc2012481","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/onc2012481.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,21]],"date-time":"2022-03-21T18:18:32Z","timestamp":1647886712000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/onc2012481"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,10,29]]},"references-count":50,"journal-issue":{"issue":"39","published-print":{"date-parts":[[2013,9,26]]}},"alternative-id":["BFonc2012481"],"URL":"https:\/\/doi.org\/10.1038\/onc.2012.481","relation":{},"ISSN":["0950-9232","1476-5594"],"issn-type":[{"value":"0950-9232","type":"print"},{"value":"1476-5594","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,10,29]]},"assertion":[{"value":"17 February 2012","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 August 2012","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 September 2012","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 October 2012","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}