{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T14:55:41Z","timestamp":1778511341023,"version":"3.51.4"},"reference-count":68,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2012,11,26]],"date-time":"2012-11-26T00:00:00Z","timestamp":1353888000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2012,11,26]],"date-time":"2012-11-26T00:00:00Z","timestamp":1353888000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Oncogene"],"published-print":{"date-parts":[[2014,1,2]]},"DOI":"10.1038\/onc.2012.538","type":"journal-article","created":{"date-parts":[[2012,11,26]],"date-time":"2012-11-26T12:19:16Z","timestamp":1353932356000},"page":"85-96","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":61,"title":["The role of insulin-like growth factor binding protein-3 in the breast cancer cell response to DNA-damaging agents"],"prefix":"10.1038","volume":"33","author":[{"given":"M Z","family":"Lin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K A","family":"Marzec","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J L","family":"Martin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R C","family":"Baxter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2012,11,26]]},"reference":[{"key":"BFonc2012538_CR1","doi-asserted-by":"publisher","first-page":"624","DOI":"10.1136\/bmj.321.7261.624","volume":"321","author":"K McPherson","year":"2000","unstructured":"McPherson K, Steel CM, Dixon JM . Breast cancer\u2014epidemiology, risk factors, and genetics. BMJ 2000; 321: 624\u2013628.","journal-title":"BMJ"},{"key":"BFonc2012538_CR2","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1016\/S0140-6736(10)62231-3","volume":"377","author":"MP Coleman","year":"2011","unstructured":"Coleman MP, Forman D, Bryant H, Butler J, Rachet B, Maringe C et al. Cancer survival in Australia, Canada, Denmark, Norway, Sweden, and the UK, 1995\u20132007 (The International Cancer Benchmarking Partnership): An analysis of population-based cancer registry data. Lancet 2011; 377: 127\u2013138.","journal-title":"Lancet"},{"key":"BFonc2012538_CR3","doi-asserted-by":"publisher","first-page":"409","DOI":"10.3322\/caac.20134","volume":"61","author":"C DeSantis","year":"2011","unstructured":"DeSantis C, Siegel R, Bandi P, Jemal A . Breast cancer statistics, 2011. CA Cancer J Clin 2011; 61: 409\u2013418.","journal-title":"CA Cancer J Clin"},{"key":"BFonc2012538_CR4","doi-asserted-by":"publisher","first-page":"24323","DOI":"10.1074\/jbc.M010544200","volume":"276","author":"S Chen","year":"2001","unstructured":"Chen S, Inamdar KV, Pfeiffer P, Feldmann E, Hannah MF, Yu Y et al. Accurate in vitro end joining of a DNA double strand break with partially cohesive 3\u2032-overhangs and 3\u2032-phosphoglycolate termini. Effect of Ku on repair fidelity. J Biol Chem 2001; 276: 24323\u201324330.","journal-title":"J Biol Chem"},{"key":"BFonc2012538_CR5","doi-asserted-by":"publisher","first-page":"31182","DOI":"10.1074\/jbc.M506591200","volume":"280","author":"K Dittmann","year":"2005","unstructured":"Dittmann K, Mayer C, Fehrenbacher B, Schaller M, Raju U, Milas L et al. Radiation-induced epidermal growth factor receptor nuclear import is linked to activation of DNA-dependent protein kinase. J Biol Chem 2005; 280: 31182\u201331189.","journal-title":"J Biol Chem"},{"key":"BFonc2012538_CR6","doi-asserted-by":"publisher","first-page":"1268","DOI":"10.1200\/JCO.2008.17.5984","volume":"27","author":"MJ van den Bent","year":"2009","unstructured":"van den Bent MJ, Brandes AA, Rampling R, Kouwenhoven MCM, Kros JM, Carpentier AF et al. Randomized phase II trial of erlotinib versus temozolomide or carmustine in recurrent glioblastoma: EORTC brain tumor group study 26034. J Clin Oncol 2009; 27: 1268\u20131274.","journal-title":"J Clin Oncol"},{"key":"BFonc2012538_CR7","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1007\/s11060-009-9950-0","volume":"96","author":"D Reardon","year":"2010","unstructured":"Reardon D, Desjardins A, Vredenburgh J, Gururangan S, Friedman A, Herndon J et al. Phase 2 trial of erlotinib plus sirolimus in adults with recurrent glioblastoma. J Neuro-Oncol 2010; 96: 219\u2013230.","journal-title":"J Neuro-Oncol"},{"key":"BFonc2012538_CR8","doi-asserted-by":"publisher","first-page":"1984","DOI":"10.1210\/en.2002-220798","volume":"144","author":"LJ Schedlich","year":"2003","unstructured":"Schedlich LJ, Nilsen T, John AP, Jans DA, Baxter RC . Phosphorylation of insulin-like growth factor binding protein-3 by deoxyribonucleic acid-dependent protein kinase reduces ligand binding and enhances nuclear accumulation. Endocrinology 2003; 144: 1984\u20131993.","journal-title":"Endocrinology"},{"key":"BFonc2012538_CR9","doi-asserted-by":"publisher","first-page":"2969","DOI":"10.1074\/jbc.M210739200","volume":"278","author":"JL Martin","year":"2003","unstructured":"Martin JL, Weenink SM, Baxter RC . Insulin-like growth factor-binding protein-3 potentiates epidermal growth factor action in MCF-10A mammary epithelial cells. J Biol Chem 2003; 278: 2969\u20132976.","journal-title":"J Biol Chem"},{"key":"BFonc2012538_CR10","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/1043-2760(93)90085-S","volume":"4","author":"RC Baxter","year":"1993","unstructured":"Baxter RC . Circulating binding proteins for the insulinlike growth factors. Trends Endocrinol Metab 1993; 4: 91\u201396.","journal-title":"Trends Endocrinol Metab"},{"key":"BFonc2012538_CR11","doi-asserted-by":"publisher","first-page":"824","DOI":"10.1210\/er.2001-0033","volume":"23","author":"SM Firth","year":"2002","unstructured":"Firth SM, Baxter RC . Cellular actions of the insulin-like growth factor binding proteins. Endocr Rev 2002; 23: 824\u2013854.","journal-title":"Endocr Rev"},{"key":"BFonc2012538_CR12","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1097\/MPA.0b013e31815750f0","volume":"36","author":"A Xue","year":"2008","unstructured":"Xue A, Scarlett CJ, Jackson CJ, Allen BJ, Smith RC . Prognostic significance of growth factors and the urokinase-type plasminogen activator system in pancreatic ductal adenocarcinoma. Pancreas 2008; 36: 160\u2013167.","journal-title":"Pancreas"},{"key":"BFonc2012538_CR13","doi-asserted-by":"publisher","first-page":"3078","DOI":"10.1158\/1535-7163.MCT-06-0424","volume":"5","author":"Y Xi","year":"2006","unstructured":"Xi Y, Nakajima G, Hamil T, Fodstad O, Riker A, Ju J . Association of insulin-like growth factor binding protein-3 expression with melanoma progression. Mol Cancer Ther 2006; 5: 3078\u20133084.","journal-title":"Mol Cancer Ther"},{"key":"BFonc2012538_CR14","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1016\/S1535-6108(02)00030-2","volume":"1","author":"D Singh","year":"2002","unstructured":"Singh D, Febbo PG, Ross K, Jackson DG, Manola J, Ladd C et al. Gene expression correlates of clinical prostate cancer behavior. Cancer Cell 2002; 1: 203\u2013209.","journal-title":"Cancer Cell"},{"key":"BFonc2012538_CR15","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1016\/j.juro.2007.09.106","volume":"179","author":"ST Chuang","year":"2008","unstructured":"Chuang ST, Patton KT, Schafernak KT, Papavero V, Lin F, Baxter RC et al. Over expression of insulin-like growth factor binding protein 3 in clear cell renal cell carcinoma. J Urol 2008; 179: 445\u2013449.","journal-title":"J Urol"},{"key":"BFonc2012538_CR16","doi-asserted-by":"publisher","first-page":"601","DOI":"10.1093\/jnci\/88.9.601","volume":"88","author":"RL Rocha","year":"1996","unstructured":"Rocha RL, Hilsenbeck SG, Jackson JG, Lee AV, Figueroa JA, Yee D . Correlation of insulin-like growth factor-binding protein-3 messenger RNA with protein expression in primary breast cancer tissues: Detection of higher levels in tumors with poor prognostic features. J Nat Cancer Inst 1996; 88: 601\u2013606.","journal-title":"J Nat Cancer Inst"},{"key":"BFonc2012538_CR17","doi-asserted-by":"publisher","first-page":"1242","DOI":"10.1038\/bjc.1996.523","volume":"74","author":"H Yu","year":"1996","unstructured":"Yu H, Levesque MA, Khosravi MJ, Papanastasiou DA, Clark GM, Diamandis EP . Associations between insulin-like growth factors and their binding proteins and other prognostic indicators in breast cancer. Brit J Cancer 1996; 74: 1242\u20131247.","journal-title":"Brit J Cancer"},{"key":"BFonc2012538_CR18","first-page":"1131","volume":"29","author":"SM Sheen-Chen","year":"2009","unstructured":"Sheen-Chen SM, Zhang H, Huang CC, Tang RP . Insulin-like growth factor-binding protein-3 in breast cancer: Analysis with tissue microarray. Anticancer Res 2009; 29: 1131\u20131135.","journal-title":"Anticancer Res"},{"issue":"19","key":"BFonc2012538_CR19","doi-asserted-by":"publisher","first-page":"2412","DOI":"10.1038\/onc.2012.264","volume":"32","author":"S Grkovic","year":"2012","unstructured":"Grkovic S, O\u2019Reilly VC, Han S, Hong M, Baxter RC, Firth SM . IGFBP-3 binds GRP78, stimulates autophagy and promotes the survival of breast cancer cells exposed to adverse microenvironments. Oncogene 2012 doi:10.1038\/onc.2012.264.","journal-title":"Oncogene"},{"key":"BFonc2012538_CR20","doi-asserted-by":"publisher","first-page":"25542","DOI":"10.1074\/jbc.M109.007120","volume":"284","author":"JL Martin","year":"2009","unstructured":"Martin JL, Lin MZ, McGowan EM, Baxter RC . Potentiation of growth factor signaling by insulin-like growth factor-binding protein-3 in breast epithelial cells requires sphingosine kinase activity. J Biol Chem 2009; 284: 25542\u201325552.","journal-title":"J Biol Chem"},{"key":"BFonc2012538_CR21","doi-asserted-by":"publisher","first-page":"1950","DOI":"10.1210\/jc.2003-030914","volume":"89","author":"AJ Butt","year":"2004","unstructured":"Butt AJ, Martin JL, Dickson KA, McDougall F, Firth SM, Baxter RC . Insulin-like growth factor binding protein-3 expression is associated with growth stimulation of T47D human breast cancer cells: the role of altered epidermal growth factor signaling. J Clin Endocrinol Metab 2004; 89: 1950\u20131956.","journal-title":"J Clin Endocrinol Metab"},{"key":"BFonc2012538_CR22","doi-asserted-by":"publisher","first-page":"10878","DOI":"10.1158\/0008-5472.CAN-06-0585","volume":"66","author":"LJ Cobb","year":"2006","unstructured":"Cobb LJ, Liu B, Lee K-W, Cohen P . Phosphorylation by DNA-dependent protein kinase is critical for apoptosis induction by insulin-like growth factor binding protein-3. Cancer Res 2006; 66: 10878\u201310884.","journal-title":"Cancer Res"},{"key":"BFonc2012538_CR23","doi-asserted-by":"publisher","first-page":"14709","DOI":"10.1074\/jbc.M408827200","volume":"280","author":"BPC Chen","year":"2005","unstructured":"Chen BPC, Chan DW, Kobayashi J, Burma S, Asaithamby A, Morotomi-Yano K et al. Cell cycle dependence of DNA-dependent protein kinase phosphorylation in response to DNA double strand breaks. J Biol Chem 2005; 280: 14709\u201314715.","journal-title":"J Biol Chem"},{"key":"BFonc2012538_CR24","doi-asserted-by":"publisher","first-page":"3024","DOI":"10.1158\/0008-5472.CAN-05-2013","volume":"66","author":"FR Santer","year":"2006","unstructured":"Santer FR, Bacher N, Moser B, Morandell D, Ressler S, Firth SM et al. Nuclear insulin-like growth factor binding protein-3 induces apoptosis and is targeted to ubiquitin\/proteasome-dependent proteolysis. Cancer Res 2006; 66: 3024\u20133033.","journal-title":"Cancer Res"},{"key":"BFonc2012538_CR25","doi-asserted-by":"publisher","first-page":"384","DOI":"10.4161\/nucl.21055","volume":"3","author":"C Andrin","year":"2012","unstructured":"Andrin C, McDonald D, Attwood KM, Rodrigue A, Ghosh S, Mirzayans R et al. A requirement for polymerized actin in DNA double-strand break repair. Nucleus 2012; 3: 384\u2013395.","journal-title":"Nucleus"},{"key":"BFonc2012538_CR26","doi-asserted-by":"publisher","first-page":"39174","DOI":"10.1074\/jbc.M908888199","volume":"275","author":"AJ Butt","year":"2000","unstructured":"Butt AJ, Firth SM, King MA, Baxter RC . Insulin-like growth factor-binding protein-3 modulates expression of Bax and Bcl-2 and potentiates p53-independent radiation-induced apoptosis in human breast cancer cells. J Biol Chem 2000; 275: 39174\u201339181.","journal-title":"J Biol Chem"},{"key":"BFonc2012538_CR27","first-page":"22","volume":"60","author":"AC Williams","year":"2000","unstructured":"Williams AC, Collard TJ, Perks CM, Newcomb P, Moorghen M, Holly JM et al. Increased p53-dependent apoptosis by the insulin-like growth factor binding protein IGFBP-3 in human colonic adenoma-derived cells. Cancer Res 2000; 60: 22\u201327.","journal-title":"Cancer Res"},{"key":"BFonc2012538_CR28","doi-asserted-by":"publisher","first-page":"763","DOI":"10.1038\/386761a0","volume":"386","author":"KW Kinzler","year":"1997","unstructured":"Kinzler KW, Vogelstein B . Cancer-susceptibility genes. Gatekeepers and caretakers. Nature 1997; 386: 763.","journal-title":"Nature"},{"key":"BFonc2012538_CR29","doi-asserted-by":"publisher","first-page":"30636","DOI":"10.1074\/jbc.274.43.30636","volume":"274","author":"C Mineo","year":"1999","unstructured":"Mineo C, Gill GN, Anderson RGW . Regulated migration of epidermal growth factor receptor from caveolae. J Biol Chem 1999; 274: 30636\u201330643.","journal-title":"J Biol Chem"},{"key":"BFonc2012538_CR30","doi-asserted-by":"publisher","first-page":"951","DOI":"10.1038\/sj.jid.5700282","volume":"126","author":"X-Q Wang","year":"2006","unstructured":"Wang X-Q, Paller AS . Lipid rafts: membrane triage centers. J Invest Dermatol 2006; 126: 951\u2013953.","journal-title":"J Invest Dermatol"},{"key":"BFonc2012538_CR31","doi-asserted-by":"publisher","first-page":"2098","DOI":"10.1016\/j.febslet.2007.03.019","volume":"581","author":"MF Hanzal-Bayer","year":"2007","unstructured":"Hanzal-Bayer MF, Hancock JF . Lipid rafts and membrane traffic. FEBS Lett 2007; 581: 2098\u20132104.","journal-title":"FEBS Lett"},{"key":"BFonc2012538_CR32","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1074\/jbc.M307316200","volume":"279","author":"KW Lee","year":"2004","unstructured":"Lee KW, Liu B, Ma L, Li H, Bang P, Koeffler HP et al. Cellular internalization of insulin-like growth factor binding protein-3: distinct endocytic pathways facilitate re-uptake and nuclear localization. J Biol Chem 2004; 279: 469\u2013476.","journal-title":"J Biol Chem"},{"key":"BFonc2012538_CR33","doi-asserted-by":"publisher","first-page":"1645","DOI":"10.1091\/mbc.11.5.1645","volume":"11","author":"AK Kenworthy","year":"2000","unstructured":"Kenworthy AK, Petranova N, Edidin M . High-resolution FRET microscopy of cholera toxin b-subunit and GPI-anchored proteins in cell plasma membranes. Mol Biol Cell 2000; 11: 1645\u20131655.","journal-title":"Mol Biol Cell"},{"key":"BFonc2012538_CR34","doi-asserted-by":"publisher","first-page":"6967","DOI":"10.1038\/sj.onc.1207911","volume":"23","author":"A Abulrob","year":"2004","unstructured":"Abulrob A, Giuseppin S, Andrade MF, McDermid A, Moreno M, Stanimirovic D . Interactions of EGFR and caveolin-1 in human glioblastoma cells: evidence that tyrosine phosphorylation regulates EGFR association with caveolae. Oncogene 2004; 23: 6967\u20136979.","journal-title":"Oncogene"},{"key":"BFonc2012538_CR35","doi-asserted-by":"publisher","first-page":"5572","DOI":"10.1038\/sj.onc.1204767","volume":"20","author":"DO Ferguson","year":"2001","unstructured":"Ferguson DO, Alt FW . DNA double strand break repair and chromosomal translocation: lessons from animal models. Oncogene 2001; 20: 5572\u20135579.","journal-title":"Oncogene"},{"key":"BFonc2012538_CR36","doi-asserted-by":"publisher","first-page":"916","DOI":"10.1101\/gad.13.8.916","volume":"13","author":"GCM Smith","year":"1999","unstructured":"Smith GCM, Jackson SP . The DNA-dependent protein kinase. Genes Devel 1999; 13: 916\u2013934.","journal-title":"Genes Devel"},{"key":"BFonc2012538_CR37","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1038\/35056049","volume":"2","author":"DC van Gent","year":"2001","unstructured":"van Gent DC, Hoeijmakers JHJ, Kanaar R . Chromosomal stability and the DNA double-stranded break connection. Nat Rev Genet 2001; 2: 196\u2013206.","journal-title":"Nat Rev Genet"},{"key":"BFonc2012538_CR38","doi-asserted-by":"publisher","first-page":"1556","DOI":"10.1016\/j.yexcr.2008.09.027","volume":"315","author":"G Carpenter","year":"2009","unstructured":"Carpenter G, Liao H-J . Trafficking of receptor tyrosine kinases to the nucleus. Exptl Cell Research 2009; 315: 1556\u20131566.","journal-title":"Exptl Cell Research"},{"key":"BFonc2012538_CR39","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s00066-009-2026-4","volume":"186","author":"K Dittmann","year":"2010","unstructured":"Dittmann K, Mayer C, Rodemann H . Nuclear EGFR as novel therapeutic target. Strahlenther Onkol 2010; 186: 1\u20136.","journal-title":"Strahlenther Onkol"},{"key":"BFonc2012538_CR40","doi-asserted-by":"crossref","first-page":"2213","DOI":"10.1182\/blood.V92.7.2213","volume":"92","author":"C Muller","year":"1998","unstructured":"Muller C, Christodoulopoulos G, Salles B, Panasci L . DNA-dependent protein kinase activity correlates with clinical and in vitro sensitivity of chronic lymphocytic leukemia lymphocytes to nitrogen mustards. Blood 1998; 92: 2213\u20132219.","journal-title":"Blood"},{"key":"BFonc2012538_CR41","doi-asserted-by":"publisher","first-page":"S80","DOI":"10.2307\/3579810","volume":"150","author":"PA Jeggo","year":"1998","unstructured":"Jeggo PA . Identification of genes involved in repair of DNA double-strand breaks in mammalian cells. Radiat Res 1998; 150: S80\u2013S91.","journal-title":"Radiat Res"},{"key":"BFonc2012538_CR42","first-page":"249","volume":"1","author":"SC Hsu","year":"2009","unstructured":"Hsu SC, Miller SA, Wang Y, Hung MC . Nuclear EGFR is required for cisplatin resistance and DNA repair. Am J Transl Res 2009; 1: 249\u2013258.","journal-title":"Am J Transl Res"},{"key":"BFonc2012538_CR43","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1158\/1535-7163.MCT-05-0239","volume":"5","author":"BJ Friedmann","year":"2006","unstructured":"Friedmann BJ, Caplin M, Savic B, Shah T, Lord CJ, Ashworth A et al. Interaction of the epidermal growth factor receptor and the DNA-dependent protein kinase pathway following gefitinib treatment. Mol Cancer Ther 2006; 5: 209\u2013218.","journal-title":"Mol Cancer Ther"},{"key":"BFonc2012538_CR44","doi-asserted-by":"publisher","first-page":"1604","DOI":"10.1038\/sj.bjc.6603141","volume":"94","author":"F Ciardiello","year":"2006","unstructured":"Ciardiello F, Troiani T, Caputo F, De Laurentiis M, Tortora G, Palmieri G et al. Phase II study of gefitinib in combination with docetaxel as first-line therapy in metastatic breast cancer. Br J Cancer 2006; 94: 1604\u20131609.","journal-title":"Br J Cancer"},{"key":"BFonc2012538_CR45","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1136\/jcp.2008.056291","volume":"62","author":"JB Arnes","year":"2009","unstructured":"Arnes JB, Begin LR, Stefansson I, Brunet JS, Nielsen TO, Foulkes WD et al. Expression of epidermal growth factor receptor in relation to BRCA1 status, basal-like markers and prognosis in breast cancer. J Clin Pathol 2009; 62: 139\u2013146.","journal-title":"J Clin Pathol"},{"key":"BFonc2012538_CR46","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1038\/modpathol.3800255","volume":"18","author":"TC Putti","year":"2004","unstructured":"Putti TC, El-Rehim DMA, Rakha EA, Paish CE, Lee AHS, Pinder SE et al. Estrogen receptor-negative breast carcinomas: a review of morphology and immunophenotypical analysis. Mod Pathol 2004; 18: 26\u201335.","journal-title":"Mod Pathol"},{"key":"BFonc2012538_CR47","doi-asserted-by":"publisher","first-page":"2679","DOI":"10.1210\/endo-127-6-2679","volume":"127","author":"DR Clemmons","year":"1990","unstructured":"Clemmons DR, Camacho-H\u00fcbner C, Coronado E, Osborne CK . Insulin-like growth factor binding protein secretion by breast carcinoma cell lines: correlation with estrogen receptor status. Endocrinology 1990; 127: 2679\u20132686.","journal-title":"Endocrinology"},{"key":"BFonc2012538_CR48","doi-asserted-by":"publisher","first-page":"2532","DOI":"10.1210\/en.2006-1335","volume":"148","author":"JL Martin","year":"2007","unstructured":"Martin JL, Baxter RC . Expression of insulin-like growth factor binding protein-2 by MCF-7 breast cancer cells is regulated through the phosphatidylinositol 3-kinase\/Akt\/mammalian target of rapamycin pathway. Endocrinology 2007; 148: 2532\u20132541.","journal-title":"Endocrinology"},{"key":"BFonc2012538_CR49","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1677\/erc.1.01150","volume":"13","author":"S Rinaldi","year":"2006","unstructured":"Rinaldi S, Peeters PHM, Berrino F, Dossus L, Biessy C, Olsen A et al. IGF-I, IGFBP-3 and breast cancer risk in women: the european prospective investigation into cancer and nutrition (EPIC). Endocr Relat Cancer 2006; 13: 593\u2013605.","journal-title":"Endocr Relat Cancer"},{"key":"BFonc2012538_CR50","doi-asserted-by":"publisher","first-page":"1346","DOI":"10.1016\/S0140-6736(04)16044-3","volume":"363","author":"AG Renehan","year":"2004","unstructured":"Renehan AG, Zwahlen M, Minder C, O\u2019Dwyer ST, Shalet SM, Egger M . Insulin-like growth factor (IGF)-I, IGF binding protein-3, and cancer risk: systematic review and meta-regression analysis. Lancet 2004; 363: 1346\u20131353.","journal-title":"Lancet"},{"key":"BFonc2012538_CR51","doi-asserted-by":"publisher","first-page":"1025","DOI":"10.1158\/1078-0432.CCR-09-0957","volume":"16","author":"NM Probst-Hensch","year":"2010","unstructured":"Probst-Hensch NM, Steiner JHB, Schraml P, Varga Z, Z\u00fcrrer-H\u00e4rdi U, Storz M et al. IGFBP2 and IGFBP3 protein expressions in human breast cancer: association with hormonal factors and obesity. Clin Cancer Res 2010; 16: 1025\u20131032.","journal-title":"Clin Cancer Res"},{"key":"BFonc2012538_CR52","doi-asserted-by":"publisher","first-page":"394","DOI":"10.3109\/08977190903185032","volume":"27","author":"MK O\u2019Han","year":"2009","unstructured":"O\u2019Han MK, Baxter RC, Schedlich LJ . Effects of endogenous insulin-like growth factor binding protein-3 on cell cycle regulation in breast cancer cells. Growth Factors 2009; 27: 394\u2013408.","journal-title":"Growth Factors"},{"key":"BFonc2012538_CR53","doi-asserted-by":"publisher","first-page":"1139","DOI":"10.4161\/cc.7.9.5807","volume":"7","author":"P Hasty","year":"2008","unstructured":"Hasty P . Is NHEJ a tumor suppressor or an aging suppressor? Cell Cycle 2008; 7: 1139\u20131145.","journal-title":"Cell Cycle"},{"key":"BFonc2012538_CR54","doi-asserted-by":"publisher","first-page":"86","DOI":"10.4161\/cc.9.1.10350","volume":"9","author":"C Dominguez-Brauer","year":"2010","unstructured":"Dominguez-Brauer C, Brauer PM, Chen YJ, Pimkina J, Raychaudhuri P . Tumor suppression by ARF: gatekeeper and caretaker. Cell Cycle 2010; 9: 86\u201389.","journal-title":"Cell Cycle"},{"key":"BFonc2012538_CR55","doi-asserted-by":"publisher","first-page":"418","DOI":"10.1016\/j.tibs.2012.06.007","volume":"37","author":"ML Li","year":"2012","unstructured":"Li ML, Greenberg RA . Links between genome integrity and BRCA1 tumor suppression. Trends Biochem Sci 2012; 37: 418\u2013424.","journal-title":"Trends Biochem Sci"},{"key":"BFonc2012538_CR56","doi-asserted-by":"publisher","first-page":"1761","DOI":"10.1016\/j.biocel.2012.06.026","volume":"44","author":"RI Yarden","year":"2012","unstructured":"Yarden RI, Metsuyanim S, Pickholtz I, Shabbeer S, Tellio H, Papa MZ . BRCA1-dependent Chk1 phosphorylation triggers partial chromatin disassociation of phosphorylated Chk1 and facilitates S-phase cell cycle arrest. Int J Biochem Cell Biol 2012; 44: 1761\u20131769.","journal-title":"Int J Biochem Cell Biol"},{"key":"BFonc2012538_CR57","doi-asserted-by":"publisher","first-page":"38788","DOI":"10.1074\/jbc.M110.177311","volume":"285","author":"J McIntosh","year":"2010","unstructured":"McIntosh J, Dennison G, Holly JMP, Jarrett C, Frankow A, Foulstone EJ et al. IGFBP-3 can either inhibit or enhance EGF-mediated growth of breast epithelial cells dependent upon the presence of fibronectin. J Biol Chem 2010; 285: 38788\u201338800.","journal-title":"J Biol Chem"},{"key":"BFonc2012538_CR58","doi-asserted-by":"publisher","first-page":"747","DOI":"10.1016\/j.bcp.2011.12.029","volume":"83","author":"JH Yoon","year":"2012","unstructured":"Yoon JH, Ahn SG, Lee BH, Jung SH, Oh SH . Role of autophagy in chemoresistance: regulation of the ATM-mediated DNA-damage signaling pathway through activation of DNA-PKcs and PARP-1. Biochem Pharmacol 2012; 83: 747\u2013757.","journal-title":"Biochem Pharmacol"},{"key":"BFonc2012538_CR59","doi-asserted-by":"publisher","first-page":"18347","DOI":"10.1074\/jbc.273.29.18347","volume":"273","author":"LJ Schedlich","year":"1998","unstructured":"Schedlich LJ, Young TF, Firth SM, Baxter RC . Insulin-like growth factor binding protein (IGFBP)-3 and IGFBP-5 share a common nuclear transport pathway in T47D human breast carcinoma cells. J Biol Chem 1998; 273: 18347\u201318352.","journal-title":"J Biol Chem"},{"key":"BFonc2012538_CR60","doi-asserted-by":"publisher","first-page":"23462","DOI":"10.1074\/jbc.M002208200","volume":"275","author":"LJ Schedlich","year":"2000","unstructured":"Schedlich LJ, Le Page SL, Firth SM, Briggs LJ, Jans DA, Baxter RC . Nuclear import of insulin-like growth factor-binding protein-3 and -5 is mediated by the importin beta subunit. J Biol Chem 2000; 275: 23462\u201323470.","journal-title":"J Biol Chem"},{"key":"BFonc2012538_CR61","doi-asserted-by":"publisher","first-page":"1103","DOI":"10.1158\/0008-5472.CAN-10-2384","volume":"71","author":"G Liccardi","year":"2011","unstructured":"Liccardi G, Hartley JA, Hochhauser D . EGFR nuclear translocation modulates DNA repair following cisplatin and ionizing radiation treatment. Cancer Res 2011; 71: 1103\u20131114.","journal-title":"Cancer Res"},{"key":"BFonc2012538_CR62","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1186\/1476-4598-7-69","volume":"7","author":"K Dittmann","year":"2008","unstructured":"Dittmann K, Mayer C, Kehlbach R, Rodemann HP . Radiation-induced caveolin-1associated EGFR internalization is linked with nuclear EGFR transport and activation of DNA-PK. Mol Cancer 2008; 7: 69.","journal-title":"Mol Cancer"},{"key":"BFonc2012538_CR63","doi-asserted-by":"publisher","first-page":"P40","DOI":"10.1186\/bcr1924","volume":"10","author":"G Dennison","year":"2008","unstructured":"Dennison G, Holly J, McIntosh J, Winters Z, Perks C . Insulin-like growth factor binding protein 3 modulates epidermal growth factor (EGF)-induced growth of breast epithelial cells by altering EGF receptor internalization. Breast Cancer Res 2008; 10: P40.","journal-title":"Breast Cancer Res"},{"key":"BFonc2012538_CR64","doi-asserted-by":"publisher","first-page":"1544","DOI":"10.1002\/ijc.26149","volume":"130","author":"L Micutkova","year":"2012","unstructured":"Micutkova L, Hermann M, Offterdinger M, Hess MW, Matscheski A, Pircher H et al. Analysis of the cellular uptake and nuclear delivery of insulin-like growth factor binding protein-3 in human osteosarcoma cells. Int J Cancer 2012; 130: 1544\u20131557.","journal-title":"Int J Cancer"},{"key":"BFonc2012538_CR65","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1677\/ERC-09-0106","volume":"17","author":"V Paharkova-Vatchkova","year":"2010","unstructured":"Paharkova-Vatchkova V, Lee K-W . Nuclear export and mitochondrial and endoplasmic reticulum localization of IGF-binding protein 3 regulate its apoptotic properties. Endocr Relat Cancer 2010; 17: 293\u2013302.","journal-title":"Endocr Relat Cancer"},{"key":"BFonc2012538_CR66","doi-asserted-by":"publisher","first-page":"2316","DOI":"10.1002\/jcp.22570","volume":"226","author":"ME Irwin","year":"2011","unstructured":"Irwin ME, Mueller KL, Bohin N, Ge Y, Boerner JL . Lipid raft localization of EGFR alters the response of cancer cells to the EGFR tyrosine kinase inhibitor gefitinib. J Cell Physiol 2011; 226: 2316\u20132328.","journal-title":"J Cell Physiol"},{"key":"BFonc2012538_CR67","doi-asserted-by":"publisher","first-page":"2585","DOI":"10.1093\/nar\/28.13.2585","volume":"28","author":"E Feldmann","year":"2000","unstructured":"Feldmann E, Schmiemann V, Goedecke W, Reichenberger S, Pfeiffer P . DNA double-strand break repair in cell-free extracts from Ku80-deficient cells: implications for Ku serving as an alignment factor in non-homologous DNA end joining. Nucleic Acids Res 2000; 28: 2585\u20132596.","journal-title":"Nucleic Acids Res"},{"key":"BFonc2012538_CR68","doi-asserted-by":"publisher","first-page":"25017","DOI":"10.1074\/jbc.M401805200","volume":"279","author":"C Andrin","year":"2004","unstructured":"Andrin C, Hendzel MJ . F-actin-dependent insolubility of chromatin-modifying components. J Biol Chem 2004; 279: 25017\u201325023.","journal-title":"J Biol Chem"}],"container-title":["Oncogene"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/onc2012538.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/onc2012538","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/onc2012538.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,21]],"date-time":"2022-03-21T19:03:40Z","timestamp":1647889420000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/onc2012538"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,11,26]]},"references-count":68,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,1,2]]}},"alternative-id":["BFonc2012538"],"URL":"https:\/\/doi.org\/10.1038\/onc.2012.538","relation":{},"ISSN":["0950-9232","1476-5594"],"issn-type":[{"value":"0950-9232","type":"print"},{"value":"1476-5594","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,11,26]]},"assertion":[{"value":"21 June 2012","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 October 2012","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 October 2012","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 November 2012","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}