{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T17:03:01Z","timestamp":1791306181203,"version":"4.3.1"},"reference-count":58,"publisher":"Springer Science and Business Media LLC","issue":"18","license":[{"start":{"date-parts":[[2013,5,27]],"date-time":"2013-05-27T00:00:00Z","timestamp":1369612800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2013,5,27]],"date-time":"2013-05-27T00:00:00Z","timestamp":1369612800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Oncogene"],"published-print":{"date-parts":[[2014,5,1]]},"DOI":"10.1038\/onc.2013.181","type":"journal-article","created":{"date-parts":[[2013,5,27]],"date-time":"2013-05-27T11:27:52Z","timestamp":1369654072000},"page":"2317-2328","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":47,"title":["HTLV-1 HBZ positively regulates the mTOR signaling pathway via inhibition of GADD34 activity in the cytoplasm"],"prefix":"10.1038","volume":"33","author":[{"given":"R","family":"Mukai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"Ohshima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2013,5,27]]},"reference":[{"key":"BFonc2013181_CR1","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1146\/annurev.immunol.15.1.15","volume":"15","author":"T Uchiyama","year":"1997","unstructured":"Uchiyama T . Human T cell leukemia virus type I (HTLV-1) and human diseases. Annu Rev Immunol 1997; 15: 15\u201337.","journal-title":"Annu Rev Immunol"},{"key":"BFonc2013181_CR2","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1007\/s12185-011-0937-1","volume":"94","author":"J Yasunaga","year":"2011","unstructured":"Yasunaga J, Matsuoka M . Molecular mechanisms of HTLV-1 infection and pathogenesis. Int J Hematol 2011; 94: 435\u2013442.","journal-title":"Int J Hematol"},{"key":"BFonc2013181_CR3","doi-asserted-by":"publisher","first-page":"3618","DOI":"10.1073\/pnas.80.12.3618","volume":"80","author":"M Seiki","year":"1983","unstructured":"Seiki M, Hattori S, Hirayama Y, Yoshida M . Human adult T-cell leukemia virus: complete nucleotide sequence of the provirus genome integrated in leukemia cell DNA. Proc Natl Acad Sci USA 1983; 80: 3618\u20133622.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFonc2013181_CR4","doi-asserted-by":"publisher","first-page":"396","DOI":"10.1128\/MMBR.66.3.396-406.2002","volume":"66","author":"B Albrecht","year":"2002","unstructured":"Albrecht B, Lairmore MD . Critical role of human T-lymphotropic virus type 1 accessory proteins in viral replication and pathogenesis. Microbiol Mol Biol Rev 2002; 66: 396\u2013406.","journal-title":"Microbiol Mol Biol Rev"},{"key":"BFonc2013181_CR5","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1146\/annurev.immunol.19.1.475","volume":"19","author":"M Yoshida","year":"2001","unstructured":"Yoshida M . Multiple viral strategies of HTLV-1 for dysregulation of cell growth control. Annu Rev Immunol 2001; 19: 475\u2013496.","journal-title":"Annu Rev Immunol"},{"key":"BFonc2013181_CR6","doi-asserted-by":"publisher","first-page":"5931","DOI":"10.1038\/sj.onc.1208981","volume":"24","author":"M Yoshida","year":"2005","unstructured":"Yoshida M . Discovery of HTLV-1, the first human retrovirus, its unique regulatory mechanisms, and insights into pathogenesis. Oncogene 2005; 24: 5931\u20135937.","journal-title":"Oncogene"},{"key":"BFonc2013181_CR7","doi-asserted-by":"publisher","first-page":"5976","DOI":"10.1038\/sj.onc.1208978","volume":"24","author":"R Grassmann","year":"2005","unstructured":"Grassmann R, Aboud M, Jeang KT . Molecular mechanisms of cellular transformation by HTLV-1 Tax. Oncogene 2005; 24: 5976\u20135985.","journal-title":"Oncogene"},{"key":"BFonc2013181_CR8","doi-asserted-by":"publisher","first-page":"466","DOI":"10.1038\/nm1389","volume":"12","author":"H Hasegawa","year":"2006","unstructured":"Hasegawa H, Sawa H, Lewis MJ, Orba Y, Sheehy N, Yamamoto Y et al. Thymus-derived leukemia-lymphoma in mice transgenic for the Tax gene of human T-lymphotropic virus type I. Nat Med 2006; 12: 466\u2013472.","journal-title":"Nat Med"},{"key":"BFonc2013181_CR9","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1186\/1742-4690-5-76","volume":"5","author":"M Boxus","year":"2008","unstructured":"Boxus M, Twizere JC, Leqros S, Dewulf JF, Kettmann R, Willems L . The HTLV-1 Tax interactome. Retrovirology 2008; 5: 76.","journal-title":"Retrovirology"},{"key":"BFonc2013181_CR10","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1186\/1742-4690-9-26","volume":"9","author":"N Simonins","year":"2012","unstructured":"Simonins N, Rual JF, Lemmens I, Boxus M, Hirozane-Kishikawa T, Gatot JS et al. Host\u2013pathogen interactome mapping for HTLV-1 and -2 retroviruses. Retrovirology 2012; 9: 26.","journal-title":"Retrovirology"},{"key":"BFonc2013181_CR11","doi-asserted-by":"crossref","first-page":"3065","DOI":"10.1182\/blood.V88.8.3065.bloodjournal8883065","volume":"88","author":"S Tamiya","year":"1996","unstructured":"Tamiya S, Matsuoka M, Etoh K, Watanabe T, Kamihira S, Yamaguchi K et al. Two types of defective human T-lymphotropic virus type I provirus in adult T-cell leukemia. Blood 1996; 88: 3065\u20133073.","journal-title":"Blood"},{"key":"BFonc2013181_CR12","doi-asserted-by":"publisher","first-page":"987","DOI":"10.1182\/blood.V97.4.987","volume":"97","author":"Y Furukawa","year":"2001","unstructured":"Furukawa Y, Kubota R, Tara M, Izumo S, Osame M . Existence of escape mutant in HTLV-I tax during the development of adult T-cell leukemia. Blood 2001; 97: 987\u2013993.","journal-title":"Blood"},{"key":"BFonc2013181_CR13","doi-asserted-by":"publisher","first-page":"9389","DOI":"10.1128\/JVI.76.18.9389-9397.2002","volume":"76","author":"T Koiwa","year":"2002","unstructured":"Koiwa T, Hamano-Usami A, Ishida T, Okayama A, Yamaguchi K, Kamihira S et al. 5\u2032-Long terminal repeat-selective CpG methylation of latent human T-cell leukemia virus type 1 provirus in vitro and in vivo. J Virol 2002; 76: 9389\u20139397.","journal-title":"J Virol"},{"key":"BFonc2013181_CR14","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1002\/ijc.20007","volume":"109","author":"S Takeda","year":"2004","unstructured":"Takeda S, Maeda M, Morikawa S, Taniguchi Y, Yasunaga J, Nosaka K et al. Genetic and epigenetic inactivation of tax gene in adult T-cell leukemia cells. Int J Cancer 2004; 109: 559\u2013567.","journal-title":"Int J Cancer"},{"key":"BFonc2013181_CR15","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1186\/1742-4690-2-64","volume":"2","author":"Y Taniguchi","year":"2005","unstructured":"Taniguchi Y, Nosaka K, Yasunaga J, Maeda M, Mueller N, Okayama A et al. Silencing of human T-cell leukemia virus type I gene transcription by epigenetic mechanisms. Retrovirology 2005; 2: 64.","journal-title":"Retrovirology"},{"key":"BFonc2013181_CR16","doi-asserted-by":"publisher","first-page":"12813","DOI":"10.1128\/JVI.76.24.12813-12822.2002","volume":"76","author":"G Gaudray","year":"2002","unstructured":"Gaudray G, Gachon F, Basbous J, Biard-Piechaczyk M, Devaux C, Mesnard JM . The complementary strand of the human T-cell leukemia virus type 1 RNA genome encodes a bZIP transcription factor that down-regulates viral transcription. J Virol 2002; 76: 12813\u201312822.","journal-title":"J Virol"},{"key":"BFonc2013181_CR17","doi-asserted-by":"publisher","first-page":"720","DOI":"10.1073\/pnas.0507631103","volume":"103","author":"Y Satou","year":"2006","unstructured":"Satou Y, Yasunaga J, Yoshida M, Matsuoka M . HTLV-I basic leucine zipper factor gene mRNA supports proliferation of adult T cell leukemia cells. Proc Natl Acad Sci USA 2006; 103: 720\u2013725.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFonc2013181_CR18","doi-asserted-by":"publisher","first-page":"4855","DOI":"10.1182\/blood-2010-11-316463","volume":"117","author":"F Rende","year":"2011","unstructured":"Rende F, Cavallari I, Corrandin A, Silic-Benussi M, Toulza F, Toulza F et al. Kinetics and intracellular compartmentalization of HTLV-1 gene expression: nuclear retention of HBZ mRNA. Blood 2011; 117: 4855\u20134859.","journal-title":"Blood"},{"key":"BFonc2013181_CR19","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1186\/1742-4690-9-74","volume":"9","author":"C Bender","year":"2012","unstructured":"Bender C, Rende F, Cotena A, Righi P, Ronzi P, Cavallari I et al. Temporal regulation of HTLV-2 expression in infected cell lines and patients: evidence for distinct expression kinetics with nuclear accumulation of APH-2 mRNA. Retrovirology 2012; 9: 74.","journal-title":"Retrovirology"},{"key":"BFonc2013181_CR20","doi-asserted-by":"publisher","first-page":"1355","DOI":"10.1242\/jcs.01727","volume":"118","author":"P Hivin","year":"2005","unstructured":"Hivin P, Fr\u00e9d\u00e9ric M, Arpin-Andr\u00e9 C, Basbous J, Gay B, Th\u00e9bault S et al. Nuclear localization of HTLV-I bZIP factor (HBZ) is mediated by three distinct motifs. J Cell Sci 2005; 118: 1355\u20131362.","journal-title":"J Cell Sci"},{"key":"BFonc2013181_CR21","doi-asserted-by":"publisher","first-page":"43620","DOI":"10.1074\/jbc.M307275200","volume":"278","author":"J Basbous","year":"2003","unstructured":"Basbous J, Arpin C, Gaudray G, Piechaczyk M, Devaux C, Mesnard JM . The HBZ factor of human T-cell leukemia virus type I dimerizes with transcription factors JunB and c-Jun and modulates their transcriptional activity. J Biol Chem 2003; 278: 43620\u201343627.","journal-title":"J Biol Chem"},{"key":"BFonc2013181_CR22","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1016\/S0014-5793(04)00225-X","volume":"562","author":"S Th\u00e9bault","year":"2004","unstructured":"Th\u00e9bault S, Basbous J, Hivin P, Devaux C, Mesnard JM . HBZ interacts with JunD and stimulates its transcriptional activity. FEBS Lett 2004; 562: 165\u2013170.","journal-title":"FEBS Lett"},{"key":"BFonc2013181_CR23","doi-asserted-by":"publisher","first-page":"1001","DOI":"10.1038\/sj.onc.1208297","volume":"24","author":"J Matsumoto","year":"2005","unstructured":"Matsumoto J, Ohshima T, Isono O, Shimotohno K . HTLV-1 HBZ suppresses AP-1 activity by impairing both the DNA-binding ability and the stability of c-Jun protein. Oncogene 2005; 24: 1001\u20131010.","journal-title":"Oncogene"},{"key":"BFonc2013181_CR24","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1186\/1742-4690-6-71","volume":"6","author":"M Matsuoka","year":"2009","unstructured":"Matsuoka M, Green PL . The HBZ gene, a key player in HTLV-1 pathogenesis. Retrovirology 2009; 6: 71.","journal-title":"Retrovirology"},{"key":"BFonc2013181_CR25","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1186\/1742-4690-8-19","volume":"8","author":"K Hagiya","year":"2011","unstructured":"Hagiya K, Yasunaga J, Satou Y, Ohshima K, Matsuoka M . ATF3, an HTLV-1 bZip factor binding protein, promotes proliferation of adult T-cell leukemia cells. Retrovirology 2011; 8: 19.","journal-title":"Retrovirology"},{"key":"BFonc2013181_CR26","doi-asserted-by":"publisher","first-page":"34273","DOI":"10.1074\/jbc.M802527200","volume":"283","author":"O Isono","year":"2008","unstructured":"Isono O, Ohshima T, Saeki Y, Matsumoto J, Hijikata M, Tanaka K et al. Human T-cell leukemia virus type 1 HBZ protein bypasses the targeting function of ubiquitination. J Biol Chem 2008; 283: 34273\u201334282.","journal-title":"J Biol Chem"},{"key":"BFonc2013181_CR27","doi-asserted-by":"publisher","first-page":"5247","DOI":"10.1073\/pnas.91.12.5247","volume":"91","author":"J Chou","year":"1994","unstructured":"Chou J, Roizman B . Herpes simplex virus 1 gamma(1)34.5 gene function, which blocks the host response to infection, maps in the homologous domain of the genes expressed during growth arrest and DNA damage. Proc Natl Acad Sci USA 1994; 91: 5247\u20135251.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFonc2013181_CR28","first-page":"475","volume":"19","author":"R Watanabe","year":"2007","unstructured":"Watanabe R, Tambe Y, Inoue H, Isono T, Haneda M, Isobe K et al. GADD34 inhibits mammalian target of rapamycin signaling via tuberous sclerosis complex and controls cell survival under bioenergetic stress. Int J Mol Med 2007; 19: 475\u2013483.","journal-title":"Int J Mol Med"},{"key":"BFonc2013181_CR29","doi-asserted-by":"publisher","first-page":"2495","DOI":"10.1128\/JVI.80.5.2495-2505.2006","volume":"80","author":"K Murata","year":"2006","unstructured":"Murata K, Hayashibara T, Sugahara K, Uemura A, Yamaguchi T, Harasawa H et al. A novel alternative splicing isoform of human T-cell leukemia virus type 1 bZIP factor (HBZ-SI) targets distinct subnuclear localization. J Virol 2006; 80: 2495\u20132505.","journal-title":"J Virol"},{"key":"BFonc2013181_CR30","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1186\/1742-4690-3-15","volume":"3","author":"MH Cavanagh","year":"2006","unstructured":"Cavanagh MH, Landry S, Audet B, Arpin-Andr\u00e9 C, Hivin P, Par\u00e9 ME et al. HTLV-1 antisense transcripts initiating in the 3\u2032LTR are alternatively spliced and polyadenylated. Retrovirology 2006; 3: 15.","journal-title":"Retrovirology"},{"key":"BFonc2013181_CR31","doi-asserted-by":"publisher","first-page":"9359","DOI":"10.1128\/JVI.00242-08","volume":"19","author":"M Yoshida","year":"2008","unstructured":"Yoshida M, Satou Y, Yasunaga J, Fujisawa J, Matsuoka M . Transcriptional control of spliced and unspliced human T-cell leukemia virus type 1 bZIP factor (HBZ) gene. J Virol 2008; 19: 9359\u20136368.","journal-title":"J Virol"},{"key":"BFonc2013181_CR32","doi-asserted-by":"publisher","first-page":"21687","DOI":"10.1074\/jbc.M110.212787","volume":"256","author":"W Zhou","year":"2011","unstructured":"Zhou W, Brush MH, Choy MS, Shenolikar S . Association with endoplasmic reticulum promotes proteasomal degradation of GADD34 protein. J Biol Chem 2011; 256: 21687\u201321696.","journal-title":"J Biol Chem"},{"key":"BFonc2013181_CR33","doi-asserted-by":"publisher","first-page":"1287","DOI":"10.1016\/j.febslet.2010.01.017","volume":"584","author":"CH Jung","year":"2010","unstructured":"Jung CH, Ro SH, Cao J, Otto NM, Kim DH . mTOR regulation of autophagy. FEBS Lett 2010; 584: 1287\u20131295.","journal-title":"FEBS Lett"},{"key":"BFonc2013181_CR34","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1016\/j.cmet.2010.05.001","volume":"11","author":"P Kapahi","year":"2010","unstructured":"Kapahi P, Chen D, Rogers AN, Katewa SD, Li PW, Thomas EL et al. With TOR, less is more: a key role for the conserved nutrient-sensing TOR pathway in aging. Cell Metab 2010; 11: 453\u2013465.","journal-title":"Cell Metab"},{"key":"BFonc2013181_CR35","doi-asserted-by":"publisher","first-page":"692","DOI":"10.1016\/j.bbrc.2011.03.077","volume":"407","author":"MN Uddin","year":"2011","unstructured":"Uddin MN, Ito S, Nishio N, Suganya T, Isobe K . Gadd34 induces autophagy through the suppression of the mTOR pathway during starvation. Biochem Biophys Res Commun 2011; 407: 692\u2013698.","journal-title":"Biochem Biophys Res Commun"},{"key":"BFonc2013181_CR36","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/j.drup.2008.03.001","volume":"11","author":"BH Jiang","year":"2008","unstructured":"Jiang BH, Liu LZ . Role of mTOR in anticancer drug resistance: perspectives for improved drug treatment. Drug Resist Updat 2008; 11: 63\u201376.","journal-title":"Drug Resist Updat"},{"key":"BFonc2013181_CR37","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1111\/j.1349-7006.2011.02123.x","volume":"103","author":"M Yoshita","year":"2012","unstructured":"Yoshita M, Higuchi M, Takahashi M, Oie M, Tanaka Y, Fujii M . Activation of mTOR by human T-cell leukemia virus type 1 Tax is important for the transformation of mouse T cells to interleukin-2-independent growth. Cancer Sci 2012; 103: 369\u2013374.","journal-title":"Cancer Sci"},{"key":"BFonc2013181_CR38","doi-asserted-by":"publisher","first-page":"868","DOI":"10.1038\/nrd3531","volume":"10","author":"D Benjamin","year":"2011","unstructured":"Benjamin D, Colombi M, Moroni C, Hall MN . Rapamycin passes the torch: a new generation of mTOR inhibitors. Nat Rev Drug Discov 2011; 10: 868\u2013880.","journal-title":"Nat Rev Drug Discov"},{"key":"BFonc2013181_CR39","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1016\/j.cell.2012.03.017","volume":"149","author":"M Laplante","year":"2012","unstructured":"Laplante M, Sabatini DM . mTOR signaling in growth control and disease. Cell 2012; 149: 274\u2013293.","journal-title":"Cell"},{"key":"BFonc2013181_CR40","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1111\/j.1365-2443.2010.01482.x","volume":"16","author":"M Hardt","year":"2011","unstructured":"Hardt M, Chantaravisoot N, Tamanoi F . Activating mutations of TOR (target of rapamycin). Genes Cells 2011; 16: 141\u2013151.","journal-title":"Genes Cells"},{"key":"BFonc2013181_CR41","doi-asserted-by":"publisher","first-page":"821","DOI":"10.1111\/j.1365-2893.2011.01530.x","volume":"18","author":"SM Alavian","year":"2011","unstructured":"Alavian SM, Ande SR, Coombs KM, Yeganeh B, Davoodpour P, Hashemi M et al. Virus-triggered autophagy in viral hepatitis\u2014possible novel strategies for drug development. J Virol Hepat 2011; 18: 821\u2013830.","journal-title":"J Virol Hepat"},{"key":"BFonc2013181_CR42","doi-asserted-by":"publisher","first-page":"990","DOI":"10.1126\/science.1099993","volume":"306","author":"T Shintani","year":"2004","unstructured":"Shintani T, Klionsky DJ . Autophagy in health and disease: a double-edged sword. Science 2004; 306: 990\u2013995.","journal-title":"Science"},{"key":"BFonc2013181_CR43","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.cell.2007.12.018","volume":"132","author":"B Levine","year":"2008","unstructured":"Levine B, Kroemer G . Autophagy in the pathogenesis of disease. Cell 2008; 132: 27\u201342.","journal-title":"Cell"},{"key":"BFonc2013181_CR44","doi-asserted-by":"publisher","first-page":"1069","DOI":"10.1038\/nature06639","volume":"451","author":"N Mizushima","year":"2008","unstructured":"Mizushima N, Levine B, Cuervo AM, Klionsky DJ . Autophagy fights disease through cellular self-digestion. Nature 2008; 451: 1069\u20131075.","journal-title":"Nature"},{"key":"BFonc2013181_CR45","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/j.coi.2008.01.001","volume":"20","author":"HK Lee","year":"2008","unstructured":"Lee HK, Iwasaki A . Autophagy and antiviral immunity. Curr Opin Immunol 2008; 20: 23\u201329.","journal-title":"Curr Opin Immunol"},{"key":"BFonc2013181_CR46","doi-asserted-by":"publisher","first-page":"870","DOI":"10.4161\/auto.9046","volume":"5","author":"MP Taylor","year":"2009","unstructured":"Taylor MP, Jackson WT . Viruses and arrested autophagosomes development. Autophagy 2009; 5: 870\u2013871.","journal-title":"Autophagy"},{"key":"BFonc2013181_CR47","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1002\/rmv.630","volume":"19","author":"SB Kudchodkar","year":"2009","unstructured":"Kudchodkar SB, Levine B . Viruses and autophagy. Rev Med Virol 2009; 19: 359\u2013378.","journal-title":"Rev Med Virol"},{"key":"BFonc2013181_CR48","first-page":"267","volume":"335","author":"A Orvedahl","year":"2009","unstructured":"Orvedahl A, Levine B . Autophagy in mammalian antiviral immunity. Curr Top Microbiol Immunol 2009; 335: 267\u2013285.","journal-title":"Curr Top Microbiol Immunol"},{"key":"BFonc2013181_CR49","first-page":"323","volume":"335","author":"K Kirkegaard","year":"2009","unstructured":"Kirkegaard K . Subversion of the cellular autophagy pathway by viruses. Curr Top Microbiol Immunol 2009; 335: 323\u2013333.","journal-title":"Curr Top Microbiol Immunol"},{"key":"BFonc2013181_CR50","doi-asserted-by":"crossref","first-page":"8586","DOI":"10.1128\/JVI.72.11.8586-8596.1998","volume":"72","author":"XH Liang","year":"1998","unstructured":"Liang XH, Kleeman LK, Jiang HH, Gordon G, Goldman JE, Berry G et al. Protection against fatal Sindbis virus encephalitis by Beclin, a novel Bcl-2-interacting protein. J Virol 1998; 72: 8586\u20138596.","journal-title":"J Virol"},{"key":"BFonc2013181_CR51","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1073\/pnas.012485299","volume":"99","author":"Z Tall\u00f3czy","year":"2002","unstructured":"Tall\u00f3czy Z, Jiang W, Virgin HW IV, Leib DA, Scheuner D, Kaufman RJ et al. Regulation of starvation- and virus-induced autophagy by the eIF2alpha kinase signaling pathway. Proc Natl Acad Sci USA 2002; 99: 190\u2013195.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFonc2013181_CR52","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1016\/j.chom.2010.01.007","volume":"7","author":"A Orvedahl","year":"2010","unstructured":"Orvedahl A, MacPherson S, Sumpter R Jr, Tall\u00f3czy Z, Zou Z, Levine B . Autophagy protects against Sindbis virus infection of the central nervous system. Cell Host Microbe 2010; 7: 115\u2013127.","journal-title":"Cell Host Microbe"},{"key":"BFonc2013181_CR53","doi-asserted-by":"publisher","first-page":"46","DOI":"10.4161\/auto.5184","volume":"4","author":"M Chaumorcel","year":"2008","unstructured":"Chaumorcel M, Souqu\u00e8re S, Pierron G, Codogno P, Esclatine A . Human cytomegalovirus controls a new autophagy-dependent cellular antiviral defense mechanism. Autophagy 2008; 4: 46\u201354.","journal-title":"Autophagy"},{"key":"BFonc2013181_CR54","doi-asserted-by":"publisher","first-page":"2627","DOI":"10.1101\/gad.1978310","volume":"24","author":"U Chuluubaatar","year":"2010","unstructured":"Chuluubaatar U, Roller R, Feldman ME, Brown S, Shokat KM, Mohr I . Constitutive mTORC1 activation by a herpesvirus Akt surrogate stimulates mRNA translation and Viral replication. Genes Dev 2010; 24: 2627\u20132639.","journal-title":"Genes Dev"},{"key":"BFonc2013181_CR55","doi-asserted-by":"publisher","first-page":"22911","DOI":"10.1074\/jbc.274.33.22911","volume":"274","author":"EW Harhaj","year":"1999","unstructured":"Harhaj EW, Sun SC . IKKgamma serves as a docking subunit of the IkappaB kinase (IKK) and mediates interaction of IKK with the human T-cell leukemia virus Tax protein. J Biol Chem 1999; 274: 22911\u201322914.","journal-title":"J Biol Chem"},{"key":"BFonc2013181_CR56","doi-asserted-by":"publisher","first-page":"2392","DOI":"10.1128\/MCB.18.4.2392","volume":"18","author":"F Bex","year":"1998","unstructured":"Bex F, Yin MJ, Burny A, Gaynor RB . Differential transcriptional activation by human T-cell leukemia virus type 1 Tax mutants is mediated by distinct interactions with CREB binding protein and p300. Mol Cell Biol 1998; 18: 2392\u20132405.","journal-title":"Mol Cell Biol"},{"key":"BFonc2013181_CR57","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1152\/ajpcell.00067.2011","volume":"301","author":"J Li","year":"2011","unstructured":"Li J, Liu J, Song J, Wang X, Weiss HL, Townsend CM Jr et al. mTORC1 inhibition increases neurotensin secretion and gene expression through activation of the MEK\/ERK\/c-Jun pathway in the human endocrine cell line BON. Am J Physiol Cell Physiol 2011; 301: 213\u2013226.","journal-title":"Am J Physiol Cell Physiol"},{"key":"BFonc2013181_CR58","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1002\/jcb.22687","volume":"111","author":"T Ohshima","year":"2010","unstructured":"Ohshima T, Mukai R, Nakahara N, Matsumoto J, Isono O, Kobayashi Y et al. HTLV-1 basic leucine-zipper factor, HBZ, interacts with MafB and suppresses transcription through a Maf recognition element. J Cell Biochem 2010; 111: 187\u2013194.","journal-title":"J Cell Biochem"}],"container-title":["Oncogene"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/onc2013181.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/onc2013181","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/onc2013181.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,21]],"date-time":"2022-03-21T19:18:26Z","timestamp":1647890306000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/onc2013181"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,5,27]]},"references-count":58,"journal-issue":{"issue":"18","published-print":{"date-parts":[[2014,5,1]]}},"alternative-id":["BFonc2013181"],"URL":"https:\/\/doi.org\/10.1038\/onc.2013.181","relation":{},"ISSN":["0950-9232","1476-5594"],"issn-type":[{"value":"0950-9232","type":"print"},{"value":"1476-5594","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,5,27]]},"assertion":[{"value":"26 October 2012","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 March 2013","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 April 2013","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 May 2013","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}