{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T01:58:38Z","timestamp":1789955918791,"version":"4.0.1"},"reference-count":47,"publisher":"Springer Science and Business Media LLC","issue":"29","license":[{"start":{"date-parts":[[2015,11,30]],"date-time":"2015-11-30T00:00:00Z","timestamp":1448841600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2015,11,30]],"date-time":"2015-11-30T00:00:00Z","timestamp":1448841600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Oncogene"],"published-print":{"date-parts":[[2016,7,21]]},"DOI":"10.1038\/onc.2015.442","type":"journal-article","created":{"date-parts":[[2015,11,30]],"date-time":"2015-11-30T06:04:19Z","timestamp":1448863459000},"page":"3771-3780","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":78,"title":["Inactivating mutations in GNA13 and RHOA in Burkitt\u2019s lymphoma and diffuse large B-cell lymphoma: a tumor suppressor function for the G\u03b113\/RhoA axis in B cells"],"prefix":"10.1038","volume":"35","author":[{"given":"M","family":"O'Hayre","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Inoue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I","family":"Kufareva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C M","family":"Mikelis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R A","family":"Drummond","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Avino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"Finkel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K W","family":"Kalim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"DiPasquale","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Aoki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M S","family":"Lionakis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A A","family":"Molinolo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J S","family":"Gutkind","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2015,11,30]]},"reference":[{"key":"BFonc2015442_CR1","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1038\/nrc2069","volume":"7","author":"RT Dorsam","year":"2007","unstructured":"Dorsam RT, Gutkind JS . G-protein-coupled receptors and cancer. Nat Rev Cancer 2007; 7: 79\u201394.","journal-title":"Nat Rev Cancer"},{"key":"BFonc2015442_CR2","doi-asserted-by":"publisher","first-page":"6697","DOI":"10.1074\/jbc.R114.613414","volume":"290","author":"M Garcia-Marcos","year":"2015","unstructured":"Garcia-Marcos M, Ghosh P, Farquhar MG . GIV\/Girdin transmits signals from multiple receptors by triggering trimeric G protein activation. J Biol Chem 2015; 290: 6697\u20136704.","journal-title":"J Biol Chem"},{"key":"BFonc2015442_CR3","doi-asserted-by":"publisher","first-page":"412","DOI":"10.1038\/nrc3521","volume":"13","author":"M O'Hayre","year":"2013","unstructured":"O'Hayre M, Vazquez-Prado J, Kufareva I, Stawiski EW, Handel TM, Seshagiri S et al. The emerging mutational landscape of G proteins and G-protein-coupled receptors in cancer. Nat Rev Cancer 2013; 13: 412\u2013424.","journal-title":"Nat Rev Cancer"},{"key":"BFonc2015442_CR4","doi-asserted-by":"publisher","first-page":"831","DOI":"10.1016\/j.ccr.2014.04.016","volume":"25","author":"X Feng","year":"2014","unstructured":"Feng X, Degese MS, Iglesias-Bartolome R, Vaque JP, Molinolo AA, Rodrigues M et al. Hippo-independent activation of YAP by the GNAQ uveal melanoma oncogene through a trio-regulated rho GTPase signaling circuitry. Cancer Cell 2014; 25: 831\u2013845.","journal-title":"Cancer Cell"},{"key":"BFonc2015442_CR5","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1038\/nature07586","volume":"457","author":"CD Van Raamsdonk","year":"2009","unstructured":"Van Raamsdonk CD, Bezrookove V, Green G, Bauer J, Gaugler L, O'Brien JM et al. Frequent somatic mutations of GNAQ in uveal melanoma and blue naevi. Nature 2009; 457: 599\u2013602.","journal-title":"Nature"},{"key":"BFonc2015442_CR6","doi-asserted-by":"publisher","first-page":"2191","DOI":"10.1056\/NEJMoa1000584","volume":"363","author":"CD Van Raamsdonk","year":"2010","unstructured":"Van Raamsdonk CD, Griewank KG, Crosby MB, Garrido MC, Vemula S, Wiesner T et al. Mutations in GNA11 in uveal melanoma. N Engl J Med 2010; 363: 2191\u20132199.","journal-title":"N Engl J Med"},{"key":"BFonc2015442_CR7","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1210\/edrv-16-3-259","volume":"16","author":"N Dhanasekaran","year":"1995","unstructured":"Dhanasekaran N, Heasley LE, Johnson GL . G protein-coupled receptor systems involved in cell growth and oncogenesis. Endocr Rev 1995; 16: 259\u2013270.","journal-title":"Endocr Rev"},{"key":"BFonc2015442_CR8","doi-asserted-by":"publisher","first-page":"8173","DOI":"10.1073\/pnas.0510254103","volume":"103","author":"P Kelly","year":"2006","unstructured":"Kelly P, Moeller BJ, Juneja J, Booden MA, Der CJ, Daaka Y et al. The G12 family of heterotrimeric G proteins promotes breast cancer invasion and metastasis. Proc Natl Acad Sci USA 2006; 103: 8173\u20138178.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFonc2015442_CR9","doi-asserted-by":"publisher","first-page":"26483","DOI":"10.1074\/jbc.M604376200","volume":"281","author":"P Kelly","year":"2006","unstructured":"Kelly P, Stemmle LN, Madden JF, Fields TA, Daaka Y, Casey PJ . A role for the G12 family of heterotrimeric G proteins in prostate cancer invasion. J Biol Chem 2006; 281: 26483\u201326490.","journal-title":"J Biol Chem"},{"key":"BFonc2015442_CR10","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1007\/978-1-4612-1802-9_6","volume-title":"G Proteins, Receptors, and Disease","author":"JS Gutkind","year":"1998","unstructured":"Gutkind JS, Coso OA, Xu N G12 and G13 \u03b1 subunits of heterotrimeric G proteins: a novel family of oncogenes In: SA M ed. G Proteins, Receptors, and Disease. Humana Press: Totowa, NJ, USA, 1998, pp 101\u2013117."},{"key":"BFonc2015442_CR11","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1111\/j.1476-5381.2009.00180.x","volume":"158","author":"J Juneja","year":"2009","unstructured":"Juneja J, Casey PJ . Role of G12 proteins in oncogenesis and metastasis. Br J Pharmacol 2009; 158: 32\u201340.","journal-title":"Br J Pharmacol"},{"key":"BFonc2015442_CR12","doi-asserted-by":"publisher","first-page":"6741","DOI":"10.1073\/pnas.90.14.6741","volume":"90","author":"N Xu","year":"1993","unstructured":"Xu N, Bradley L, Ambdukar I, Gutkind JS . A mutant alpha subunit of G12 potentiates the eicosanoid pathway and is highly oncogenic in NIH 3T3 cells. Proc Natl Acad Sci USA 1993; 90: 6741\u20136745.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFonc2015442_CR13","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1006\/bbrc.1994.1744","volume":"201","author":"N Xu","year":"1994","unstructured":"Xu N, Voyno-Yasenetskaya T, Gutkind JS . Potent transforming activity of the G13 alpha subunit defines a novel family of oncogenes. Biochem Biophys Res Commun 1994; 201: 603\u2013609.","journal-title":"Biochem Biophys Res Commun"},{"key":"BFonc2015442_CR14","doi-asserted-by":"publisher","first-page":"1321","DOI":"10.1038\/ng.2468","volume":"44","author":"C Love","year":"2012","unstructured":"Love C, Sun Z, Jima D, Li G, Zhang J, Miles R et al. The genetic landscape of mutations in Burkitt lymphoma. Nat Genet 2012; 44: 1321\u20131325.","journal-title":"Nat Genet"},{"key":"BFonc2015442_CR15","doi-asserted-by":"publisher","first-page":"3879","DOI":"10.1073\/pnas.1121343109","volume":"109","author":"JG Lohr","year":"2012","unstructured":"Lohr JG, Stojanov P, Lawrence MS, Auclair D, Chapuy B, Sougnez C et al. Discovery and prioritization of somatic mutations in diffuse large B-cell lymphoma (DLBCL) by whole-exome sequencing. Proc Natl Acad Sci USA 2012; 109: 3879\u20133884.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFonc2015442_CR16","doi-asserted-by":"publisher","first-page":"672","DOI":"10.1038\/ni.2047","volume":"12","author":"JA Green","year":"2011","unstructured":"Green JA, Suzuki K, Cho B, Willison LD, Palmer D, Allen CD et al. The sphingosine 1-phosphate receptor S1P(2) maintains the homeostasis of germinal center B cells and promotes niche confinement. Nat Immunol 2011; 12: 672\u2013680.","journal-title":"Nat Immunol"},{"key":"BFonc2015442_CR17","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1038\/nature13765","volume":"516","author":"JR Muppidi","year":"2014","unstructured":"Muppidi JR, Schmitz R, Green JA, Xiao W, Larsen AB, Braun SE et al. Loss of signalling via Galpha13 in germinal centre B-cell-derived lymphoma. Nature 2014; 516: 254\u2013258.","journal-title":"Nature"},{"key":"BFonc2015442_CR18","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1038\/ng.2916","volume":"46","author":"HY Yoo","year":"2014","unstructured":"Yoo HY, Sung MK, Lee SH, Kim S, Lee H, Park S et al. A recurrent inactivating mutation in RHOA GTPase in angioimmunoblastic T cell lymphoma. Nat Genet 2014; 46: 371\u2013375.","journal-title":"Nat Genet"},{"key":"BFonc2015442_CR19","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1038\/ng.2872","volume":"46","author":"M Sakata-Yanagimoto","year":"2014","unstructured":"Sakata-Yanagimoto M, Enami T, Yoshida K, Shiraishi Y, Ishii R, Miyake Y et al. Somatic RHOA mutation in angioimmunoblastic T cell lymphoma. Nat Genet 2014; 46: 171\u2013175.","journal-title":"Nat Genet"},{"key":"BFonc2015442_CR20","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1038\/ng.2937","volume":"46","author":"J Cools","year":"2014","unstructured":"Cools J . RHOA mutations in peripheral T cell lymphoma. Nat Genet 2014; 46: 320\u2013321.","journal-title":"Nat Genet"},{"key":"BFonc2015442_CR21","doi-asserted-by":"publisher","first-page":"2893","DOI":"10.1182\/blood-2014-02-555946","volume":"123","author":"R Manso","year":"2014","unstructured":"Manso R, Sanchez-Beato M, Monsalvo S, Gomez S, Cereceda L, Llamas P et al. The RHOA G17V gene mutation occurs frequently in peripheral T-cell lymphoma and is associated with a characteristic molecular signature. Blood 2014; 123: 2893\u20132894.","journal-title":"Blood"},{"key":"BFonc2015442_CR22","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1038\/ng.2873","volume":"46","author":"T Palomero","year":"2014","unstructured":"Palomero T, Couronne L, Khiabanian H, Kim MY, Ambesi-Impiombato A, Perez-Garcia A et al. Recurrent mutations in epigenetic regulators, RHOA and FYN kinase in peripheral T cell lymphomas. Nat Genet 2014; 46: 166\u2013170.","journal-title":"Nat Genet"},{"key":"BFonc2015442_CR23","doi-asserted-by":"publisher","first-page":"10098","DOI":"10.1073\/pnas.94.19.10098","volume":"94","author":"C Fromm","year":"1997","unstructured":"Fromm C, Coso OA, Montaner S, Xu N, Gutkind JS . The small GTP-binding protein Rho links G protein-coupled receptors and Galpha12 to the serum response element and to cellular transformation. Proc Natl Acad Sci USA 1997; 94: 10098\u201310103.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFonc2015442_CR24","doi-asserted-by":"publisher","first-page":"2112","DOI":"10.1126\/science.280.5372.2112","volume":"280","author":"MJ Hart","year":"1998","unstructured":"Hart MJ, Jiang X, Kozasa T, Roscoe W, Singer WD, Gilman AG et al. Direct stimulation of the guanine nucleotide exchange activity of p115 RhoGEF by Galpha13. Science 1998; 280: 2112\u20132114.","journal-title":"Science"},{"key":"BFonc2015442_CR25","doi-asserted-by":"publisher","first-page":"2109","DOI":"10.1126\/science.280.5372.2109","volume":"280","author":"T Kozasa","year":"1998","unstructured":"Kozasa T, Jiang X, Hart MJ, Sternweis PM, Singer WD, Gilman AG et al. p115 RhoGEF, a GTPase activating protein for Galpha12 and Galpha13. Science 1998; 280: 2109\u20132111.","journal-title":"Science"},{"key":"BFonc2015442_CR26","doi-asserted-by":"publisher","first-page":"5163","DOI":"10.1073\/pnas.0700293104","volume":"104","author":"BN Armbruster","year":"2007","unstructured":"Armbruster BN, Li X, Pausch MH, Herlitze S, Roth BL . Evolving the lock to fit the key to create a family of G protein-coupled receptors potently activated by an inert ligand. Proc Natl Acad Sci USA 2007; 104: 5163\u20135168.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFonc2015442_CR27","doi-asserted-by":"publisher","first-page":"1021","DOI":"10.1038\/nmeth.2172","volume":"9","author":"A Inoue","year":"2012","unstructured":"Inoue A, Ishiguro J, Kitamura H, Arima N, Okutani M, Shuto A et al. TGFalpha shedding assay: an accurate and versatile method for detecting GPCR activation. Nat Methods 2012; 9: 1021\u20131029.","journal-title":"Nat Methods"},{"key":"BFonc2015442_CR28","doi-asserted-by":"publisher","first-page":"506","DOI":"10.1182\/asheducation-2011.1.506","volume":"2011","author":"ES Jaffe","year":"2011","unstructured":"Jaffe ES, Pittaluga S . Aggressive B-cell lymphomas: a review of new and old entities in the WHO classification. Hematology 2011; 2011: 506\u2013514.","journal-title":"Hematology"},{"key":"BFonc2015442_CR29","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1038\/nrclinonc.2013.197","volume":"11","author":"M Roschewski","year":"2014","unstructured":"Roschewski M, Staudt LM, Wilson WH . Diffuse large B-cell lymphoma-treatment approaches in the molecular era. Nat Rev Clin Oncol 2014; 11: 12\u201323.","journal-title":"Nat Rev Clin Oncol"},{"key":"BFonc2015442_CR30","doi-asserted-by":"publisher","first-page":"7986","DOI":"10.1074\/jbc.M112.437749","volume":"288","author":"SA Rasheed","year":"2013","unstructured":"Rasheed SA, Teo CR, Beillard EJ, Voorhoeve PM, Casey PJ . MicroRNA-182 and microRNA-200a control G-protein subunit alpha-13 (GNA13) expression and cell invasion synergistically in prostate cancer cells. J Biol Chem 2013; 288: 7986\u20137995.","journal-title":"J Biol Chem"},{"key":"BFonc2015442_CR31","doi-asserted-by":"publisher","first-page":"6677","DOI":"10.1021\/bi700235f","volume":"46","author":"P Kelly","year":"2007","unstructured":"Kelly P, Casey PJ, Meigs TE . Biologic functions of the G12 subfamily of heterotrimeric g proteins: growth, migration, and metastasis. Biochemistry 2007; 46: 6677\u20136687.","journal-title":"Biochemistry"},{"key":"BFonc2015442_CR32","doi-asserted-by":"publisher","first-page":"ra60","DOI":"10.1126\/scisignal.2002221","volume":"4","author":"H Yagi","year":"2011","unstructured":"Yagi H, Tan W, Dillenburg-Pilla P, Armando S, Amornphimoltham P, Simaan M et al. A synthetic biology approach reveals a CXCR4-G13-Rho signaling axis driving transendothelial migration of metastatic breast cancer cells. Science Signal 2011; 4: ra60.","journal-title":"Science Signal"},{"key":"BFonc2015442_CR33","doi-asserted-by":"publisher","first-page":"8686","DOI":"10.1158\/0008-5472.CAN-09-1110","volume":"69","author":"G Cattoretti","year":"2009","unstructured":"Cattoretti G, Mandelbaum J, Lee N, Chaves AH, Mahler AM, Chadburn A et al. Targeted disruption of the S1P2 sphingosine 1-phosphate receptor gene leads to diffuse large B-cell lymphoma formation. Cancer Res 2009; 69: 8686\u20138692.","journal-title":"Cancer Res"},{"key":"BFonc2015442_CR34","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1038\/nature10351","volume":"476","author":"RD Morin","year":"2011","unstructured":"Morin RD, Mendez-Lago M, Mungall AJ, Goya R, Mungall KL, Corbett RD et al. Frequent mutation of histone-modifying genes in non-Hodgkin lymphoma. Nature 2011; 476: 298\u2013303.","journal-title":"Nature"},{"key":"BFonc2015442_CR35","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1097\/PPO.0b013e31826aee97","volume":"18","author":"MP Menon","year":"2012","unstructured":"Menon MP, Pittaluga S, Jaffe ES . The histological and biological spectrum of diffuse large B-cell lymphoma in the World Health Organization classification. Cancer J 2012; 18: 411\u2013420.","journal-title":"Cancer J"},{"key":"BFonc2015442_CR36","doi-asserted-by":"publisher","first-page":"911","DOI":"10.1002\/gcc.22202","volume":"53","author":"M Rohde","year":"2014","unstructured":"Rohde M, Richter J, Schlesner M, Betts MJ, Claviez A, Bonn BR et al. Recurrent RHOA mutations in pediatric Burkitt lymphoma treated according to the NHL-BFM protocols. Genes Chromosomes Cancer 2014; 53: 911\u2013916.","journal-title":"Genes Chromosomes Cancer"},{"key":"BFonc2015442_CR37","doi-asserted-by":"publisher","first-page":"1661","DOI":"10.1038\/sj.onc.1204182","volume":"20","author":"S Fukuhara","year":"2001","unstructured":"Fukuhara S, Chikumi H, Gutkind JS . RGS-containing RhoGEFs: the missing link between transforming G proteins and Rho? Oncogene 2001; 20: 1661\u20131668.","journal-title":"Oncogene"},{"key":"BFonc2015442_CR38","doi-asserted-by":"publisher","first-page":"12232","DOI":"10.1074\/jbc.M112.428599","volume":"288","author":"CM Mikelis","year":"2013","unstructured":"Mikelis CM, Palmby TR, Simaan M, Li W, Szabo R, Lyons R et al. PDZ-RhoGEF and LARG are essential for embryonic development and provide a link between thrombin and LPA receptors and Rho activation. J Biol Chem 2013; 288: 12232\u201312243.","journal-title":"J Biol Chem"},{"key":"BFonc2015442_CR39","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1038\/sj.cr.7290262","volume":"15","author":"J Liu","year":"2005","unstructured":"Liu J, Lin A . Role of JNK activation in apoptosis: a double-edged sword. Cell Res 2005; 15: 36\u201342.","journal-title":"Cell Res"},{"key":"BFonc2015442_CR40","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1097\/01.cco.0000143682.45316.ae","volume":"17","author":"KE Bachman","year":"2005","unstructured":"Bachman KE, Park BH . Duel nature of TGF-beta signaling: tumor suppressor vs. tumor promoter. Curr Opin Oncol 2005; 17: 49\u201354.","journal-title":"Curr Opin Oncol"},{"key":"BFonc2015442_CR41","doi-asserted-by":"publisher","first-page":"1117","DOI":"10.1126\/science.1261064","volume":"347","author":"L Qin","year":"2015","unstructured":"Qin L, Kufareva I, Holden LG, Wang C, Zheng Y, Zhao C et al. Structural biology. Crystal structure of the chemokine receptor CXCR4 in complex with a viral chemokine. Science 2015; 347: 1117\u20131122.","journal-title":"Science"},{"key":"BFonc2015442_CR42","doi-asserted-by":"publisher","first-page":"1108","DOI":"10.1016\/j.str.2011.05.012","volume":"19","author":"I Kufareva","year":"2011","unstructured":"Kufareva I, Rueda M, Katritch V, Stevens RC, Abagyan R . Status of GPCR modeling and docking as reflected by community-wide GPCR Dock 2010 assessment. Structure 2011; 19: 1108\u20131126.","journal-title":"Structure"},{"key":"BFonc2015442_CR43","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1016\/j.cell.2009.06.016","volume":"138","author":"C Mayr","year":"2009","unstructured":"Mayr C, Bartel DP . Widespread shortening of 3'UTRs by alternative cleavage and polyadenylation activates oncogenes in cancer cells. Cell 2009; 138: 673\u2013684.","journal-title":"Cell"},{"key":"BFonc2015442_CR44","doi-asserted-by":"publisher","first-page":"3587","DOI":"10.1093\/nar\/18.12.3587","volume":"18","author":"JP Morgenstern","year":"1990","unstructured":"Morgenstern JP, Land H . Advanced mammalian gene transfer: high titre retroviral vectors with multiple drug selection markers and a complementary helper-free packaging cell line. Nucleic Acids Res 1990; 18: 3587\u20133596.","journal-title":"Nucleic Acids Res"},{"key":"BFonc2015442_CR45","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1083\/jcb.151.2.209","volume":"151","author":"S Tokumaru","year":"2000","unstructured":"Tokumaru S, Higashiyama S, Endo T, Nakagawa T, Miyagawa JI, Yamamori K et al. Ectodomain shedding of epidermal growth factor receptor ligands is required for keratinocyte migration in cutaneous wound healing. J Cell Biol 2000; 151: 209\u2013220.","journal-title":"J Cell Biol"},{"key":"BFonc2015442_CR46","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1093\/jnci\/dju215","volume":"106","author":"Z Wang","year":"2014","unstructured":"Wang Z, Martin D, Molinolo AA, Patel V, Iglesias-Bartolome R, Degese MS et al. mTOR co-targeting in cetuximab resistance in head and neck cancers harboring PIK3CA and RAS mutations. J Natl Cancer Inst 2014; 106: 1\u201311.","journal-title":"J Natl Cancer Inst"},{"key":"BFonc2015442_CR47","doi-asserted-by":"publisher","first-page":"4248","DOI":"10.1038\/emboj.2011.296","volume":"30","author":"A Inoue","year":"2011","unstructured":"Inoue A, Arima N, Ishiguro J, Prestwich GD, Arai H, Aoki J . LPA-producing enzyme PA-PLA(1)alpha regulates hair follicle development by modulating EGFR signalling. EMBO J 2011; 30: 4248\u20134260.","journal-title":"EMBO J"}],"container-title":["Oncogene"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/onc2015442.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/onc2015442","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/onc2015442.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,21]],"date-time":"2022-03-21T16:12:20Z","timestamp":1647879140000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/onc2015442"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,11,30]]},"references-count":47,"journal-issue":{"issue":"29","published-print":{"date-parts":[[2016,7,21]]}},"alternative-id":["BFonc2015442"],"URL":"https:\/\/doi.org\/10.1038\/onc.2015.442","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.725972227.793522719","asserted-by":"object"}]},"ISSN":["0950-9232","1476-5594"],"issn-type":[{"value":"0950-9232","type":"print"},{"value":"1476-5594","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,11,30]]},"assertion":[{"value":"22 July 2015","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 September 2015","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 October 2015","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 November 2015","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}