{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T19:39:52Z","timestamp":1772134792209,"version":"3.50.1"},"reference-count":64,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2016,6,6]],"date-time":"2016-06-06T00:00:00Z","timestamp":1465171200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2016,6,6]],"date-time":"2016-06-06T00:00:00Z","timestamp":1465171200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Oncogene"],"published-print":{"date-parts":[[2017,1,5]]},"DOI":"10.1038\/onc.2016.183","type":"journal-article","created":{"date-parts":[[2016,6,6]],"date-time":"2016-06-06T08:41:45Z","timestamp":1465202505000},"page":"13-23","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["WNT5A: a motility-promoting factor in Hodgkin lymphoma"],"prefix":"10.1038","volume":"36","author":[{"given":"F","family":"Linke","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Zaunig","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M M","family":"Nietert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F","family":"von Bonin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Lutz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"Dullin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"Janovsk\u00e1","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T","family":"Beissbarth","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F","family":"Alves","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W","family":"Klapper","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V","family":"Bryja","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T","family":"Pukrop","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L","family":"Tr\u00fcmper","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Wilting","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D","family":"Kube","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2016,6,6]]},"reference":[{"key":"BFonc2016183_CR1","doi-asserted-by":"publisher","first-page":"3439","DOI":"10.1172\/JCI61245","volume":"122","author":"R K\u00fcppers","year":"2012","unstructured":"K\u00fcppers R, Engert A, Hansmann M-L . Hodgkin lymphoma. J Clin Invest 2012; 122: 3439\u20133447.","journal-title":"J Clin Invest"},{"key":"BFonc2016183_CR2","doi-asserted-by":"publisher","first-page":"1109","DOI":"10.1182\/blood.V99.4.1109","volume":"99","author":"UE H\u00f6pken","year":"2002","unstructured":"H\u00f6pken UE, Foss H-D, Meyer D, Hinz M, Leder K, Stein H et al. Up-regulation of the chemokine receptor CCR7 in classical but not in lymphocyte-predominant Hodgkin disease correlates with distinct dissemination of neoplastic cells in lymphoid organs. Blood 2002; 99: 1109\u20131116.","journal-title":"Blood"},{"key":"BFonc2016183_CR3","doi-asserted-by":"publisher","first-page":"462","DOI":"10.1038\/labinvest.2013.7","volume":"93","author":"MJ Kluk","year":"2013","unstructured":"Kluk MJ, Ryan KP, Wang B, Zhang G, Rodig SJ, Sanchez T . Sphingosine-1-phosphate receptor 1 in classical Hodgkin lymphoma: assessment of expression and role in cell migration. Lab Invest 2013; 93: 462\u2013471.","journal-title":"Lab Invest"},{"key":"BFonc2016183_CR4","doi-asserted-by":"publisher","first-page":"2973","DOI":"10.1182\/blood-2014-05-576140","volume":"124","author":"CW Fhu","year":"2014","unstructured":"Fhu CW, Graham AM, Yap CT, Al-Salam S, Castella A, Chong SM et al. Reed\u2013Sternberg cell-derived lymphotoxin-\u03b1 activates endothelial cells to enhance T cell recruitment in classical Hodgkin lymphoma. Blood 2014; 124: 2973\u20132982.","journal-title":"Blood"},{"key":"BFonc2016183_CR5","doi-asserted-by":"publisher","first-page":"2961","DOI":"10.1172\/JCI119849","volume":"100","author":"RC Bargou","year":"1997","unstructured":"Bargou RC, Emmerich F, Krappmann D, Bommert K, Mapara MY, Arnold W et al. Constitutive nuclear factor-kappaB-RelA activation is required for proliferation and survival of Hodgkin\u2019s disease tumor cells. J Clin Invest 1997; 100: 2961\u20132969.","journal-title":"J Clin Invest"},{"key":"BFonc2016183_CR6","doi-asserted-by":"publisher","first-page":"3398","DOI":"10.1182\/blood.V99.9.3398","volume":"99","author":"F Jundt","year":"2002","unstructured":"Jundt F, Anagnostopoulos I, F\u00f6rster R, Mathas S, Stein H, D\u00f6rken B . Activated Notch1 signaling promotes tumor cell proliferation and survival in Hodgkin and anaplastic large cell lymphoma. Blood 2002; 99: 3398\u20133403.","journal-title":"Blood"},{"key":"BFonc2016183_CR7","doi-asserted-by":"publisher","first-page":"1019","DOI":"10.1182\/blood-2002-11-3507","volume":"102","author":"B Zheng","year":"2003","unstructured":"Zheng B, Fiumara P, Li Y V, Georgakis G, Snell V, Younes M et al. MEK\/ERK pathway is aberrantly active in Hodgkin disease : a signaling pathway shared by CD30, CD40, and RANK that regulates cell proliferation and survival. Blood 2003; 102: 1019\u20131027.","journal-title":"Blood"},{"key":"BFonc2016183_CR8","doi-asserted-by":"publisher","first-page":"762","DOI":"10.1182\/blood.V98.3.762","volume":"98","author":"D Kube","year":"2001","unstructured":"Kube D, Holtick U, Vockerodt M, Ahmadi T, Haier B, Behrmann I et al. STAT3 is constitutively activated in Hodgkin cell lines. Blood 2001; 98: 762\u2013771.","journal-title":"Blood"},{"key":"BFonc2016183_CR9","doi-asserted-by":"publisher","first-page":"4283","DOI":"10.1182\/blood-2002-01-0099","volume":"99","author":"BF Skinnider","year":"2002","unstructured":"Skinnider BF, Mak TW . The role of cytokines in classical Hodgkin lymphoma. Blood 2002; 99: 4283\u20134297.","journal-title":"Blood"},{"key":"BFonc2016183_CR10","doi-asserted-by":"publisher","first-page":"2536","DOI":"10.1182\/blood-2005-07-2694","volume":"107","author":"M Janz","year":"2006","unstructured":"Janz M, Hummel M, Truss M, Wollert-wulf B, Mathas S, Jo K et al. Classical Hodgkin lymphoma is characterized by high constitutive expression of activating transcription factor 3 (ATF3), which promotes viability of Hodgkin\/Reed\u2013Sternberg cells. Blood 2006; 107: 2536\u20132539.","journal-title":"Blood"},{"key":"BFonc2016183_CR11","doi-asserted-by":"publisher","first-page":"729","DOI":"10.1182\/blood-2006-04-015958","volume":"109","author":"A Chiu","year":"2007","unstructured":"Chiu A, Xu W, He B, Dillon SR, Gross J A, Sievers E et al. Hodgkin lymphoma cells express TACI and BCMA receptors and generate survival and proliferation signals in response to BAFF and APRIL. Blood 2007; 109: 729\u2013739.","journal-title":"Blood"},{"key":"BFonc2016183_CR12","doi-asserted-by":"publisher","first-page":"769","DOI":"10.1002\/ijc.23119","volume":"122","author":"D Aldinucci","year":"2008","unstructured":"Aldinucci D, Lorenzon D, Cattaruzza L, Pinto A, Gloghini A, Carbone A et al. Expression of CCR5 receptors on Reed\u2013Sternberg cells and Hodgkin lymphoma cell lines: involvement of CCL5\/Rantes in tumor cell growth and microenvironmental interactions. Int J Cancer 2008; 122: 769\u2013776.","journal-title":"Int J Cancer"},{"key":"BFonc2016183_CR13","doi-asserted-by":"publisher","first-page":"1685","DOI":"10.1016\/S0002-9440(10)65424-7","volume":"154","author":"A van den Berg","year":"1999","unstructured":"van den Berg A, Visser L, Poppema S . High expression of the CC chemokine TARC in Reed\u2013Sternberg Cells. Am J Pathol 1999; 154: 1685\u20131691.","journal-title":"Am J Pathol"},{"key":"BFonc2016183_CR14","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1111\/j.1600-065X.1989.tb00015.x","volume":"108","author":"ST Pals","year":"1989","unstructured":"Pals ST, Horst E, Scheper RIKJ, Meijer CJLM . Mechanisms of human lymphocyte migration and their role in the pathogenesis of disease. Immunol Rev 1989; 108: 111\u2013133.","journal-title":"Immunol Rev"},{"key":"BFonc2016183_CR15","doi-asserted-by":"publisher","first-page":"3102","DOI":"10.1182\/blood-2007-05-075176","volume":"110","author":"ST Pals","year":"2007","unstructured":"Pals ST, de Gorter DJJ, Spaargaren M . Lymphoma dissemination: the other face of lymphocyte homing. Blood 2007; 110: 3102\u20133111.","journal-title":"Blood"},{"key":"BFonc2016183_CR16","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1042\/BJ20131182","volume":"457","author":"R Mayor","year":"2014","unstructured":"Mayor R, Theveneau E . The role of the non-canonical Wnt-planar cell polarity pathway in neural crest migration. Biochem J 2014; 457: 19\u201326.","journal-title":"Biochem J"},{"key":"BFonc2016183_CR17","doi-asserted-by":"publisher","first-page":"767","DOI":"10.1038\/nrm3470","volume":"13","author":"C Niehrs","year":"2012","unstructured":"Niehrs C . The complex world of WNT receptor signalling. Nat Rev Mol Cell Biol 2012; 13: 767\u2013779.","journal-title":"Nat Rev Mol Cell Biol"},{"key":"BFonc2016183_CR18","doi-asserted-by":"publisher","first-page":"462","DOI":"10.1189\/jlb.1203652","volume":"76","author":"S Lopez-Giral","year":"2004","unstructured":"Lopez-Giral S, Quintana NE, Cabrerizo M, Alfonso-perez M, Sala-Valdes M, Gomez Garcia de Soria V et al. Chemokine receptors that mediate B cell homing to secondary lymphoid tissues are highly expressed in B cell chronic lymphocytic leukemia and non-Hodgkin lymphomas with widespread nodular dissemination. J Leukoc Biol 2004; 76: 462\u2013471.","journal-title":"J Leukoc Biol"},{"key":"BFonc2016183_CR19","doi-asserted-by":"publisher","first-page":"586","DOI":"10.1158\/1078-0432.CCR-12-1935","volume":"19","author":"S Xargay-Torrent","year":"2013","unstructured":"Xargay-Torrent S, L\u00f3pez-Guerra M, Montraveta A, Saborit-Villarroya I, Rosich L, Navarro A et al. Sorafenib inhibits cell migration and stroma-mediated bortezomib resistance by interfering B-cell receptor signaling and protein translation in mantle cell lymphoma. Clin Cancer Res 2013; 19: 586\u2013597.","journal-title":"Clin Cancer Res"},{"key":"BFonc2016183_CR20","doi-asserted-by":"publisher","first-page":"1491","DOI":"10.1158\/0008-5472.CAN-12-1752","volume":"73","author":"M Kauck\u00e1","year":"2013","unstructured":"Kauck\u00e1 M, Plevov\u00e1 K, Pavlov\u00e1 S, Janovsk\u00e1 P, Mishra A, Verner J et al. The planar cell polarity pathway drives pathogenesis of chronic lymphocytic leukemia by the regulation of B-lymphocyte migration. Cancer Res 2013; 73: 1491\u20131501.","journal-title":"Cancer Res"},{"key":"BFonc2016183_CR21","doi-asserted-by":"publisher","first-page":"1786","DOI":"10.1182\/blood-2005-01-0049","volume":"106","author":"Y Qiang","year":"2005","unstructured":"Qiang Y, Walsh K, Yao L, Kedei N, Blumberg PM, Rubin JS et al. Wnts induce migration and invasion of myeloma plasma cells. Blood 2005; 106: 1786\u20131794.","journal-title":"Blood"},{"key":"BFonc2016183_CR22","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1016\/S1534-5807(02)00197-1","volume":"2","author":"JB Wallingford","year":"2002","unstructured":"Wallingford JB, Fraser SE, Harland RM . Convergent extension: the molecular control of polarized cell movement during embryonic development. Dev Cell 2002; 2: 695\u2013706.","journal-title":"Dev Cell"},{"key":"BFonc2016183_CR23","doi-asserted-by":"publisher","first-page":"10439","DOI":"10.1158\/0008-5472.CAN-06-2359","volume":"66","author":"M Kurayoshi","year":"2006","unstructured":"Kurayoshi M, Oue N, Yamamoto H, Kishida M, Inoue A, Asahara T et al. Expression of Wnt-5a is correlated with aggressiveness of gastric cancer by stimulating cell migration and invasion. Cancer Res 2006; 66: 10439\u201310448.","journal-title":"Cancer Res"},{"key":"BFonc2016183_CR24","doi-asserted-by":"crossref","first-page":"10239","DOI":"10.18632\/oncotarget.3518","volume":"6","author":"L Qin","year":"2015","unstructured":"Qin L, Yin Y, Zheng F, Peng L, Yang C, Bao Y-N et al. WNT5A promotes stemness characteristics in nasopharyngeal carcinoma cells leading to metastasis and tumorigenesis. Oncotarget 2015; 6: 10239\u201310252.","journal-title":"Oncotarget"},{"key":"BFonc2016183_CR25","doi-asserted-by":"publisher","first-page":"434","DOI":"10.1093\/carcin\/bgq269","volume":"32","author":"F Klemm","year":"2011","unstructured":"Klemm F, Bleckmann A, Siam L, Chuang HN, Rietk\u00a8tter E, Behme D et al. \u03b2-Catenin-independent WNT signaling in basal-like breast cancer and brain metastasis. Carcinogenesis 2011; 32: 434\u2013442.","journal-title":"Carcinogenesis"},{"key":"BFonc2016183_CR26","doi-asserted-by":"publisher","first-page":"996","DOI":"10.3109\/10428194.2011.634046","volume":"53","author":"K Sohlbach","year":"2012","unstructured":"Sohlbach K, Moll R, Go\u00dfmann J, Nowak O, Barth P, Neubauer A et al. \u03b2-Catenin signaling: no relevance in Hodgkin lymphoma? Leuk Lymphoma 2012; 53: 996\u2013998.","journal-title":"Leuk Lymphoma"},{"key":"BFonc2016183_CR27","doi-asserted-by":"publisher","first-page":"4609","DOI":"10.1182\/blood-2012-05-428896","volume":"120","author":"E Tiacci","year":"2012","unstructured":"Tiacci E, D\u00f6ring C, Brune V, van Noesel CJM, Klapper W, Mechtersheimer G et al. Analyzing primary Hodgkin and Reed\u2013Sternberg cells to capture the molecular and cellular pathogenesis of classical Hodgkin lymphoma. Blood 2012; 120: 4609\u20134620.","journal-title":"Blood"},{"key":"BFonc2016183_CR28","doi-asserted-by":"publisher","first-page":"2251","DOI":"10.1084\/jem.20080809","volume":"205","author":"V Brune","year":"2008","unstructured":"Brune V, Tiacci E, Pfeil I, D\u00f6ring C, Eckerle S, van Noesel CJM et al. Origin and pathogenesis of nodular lymphocyte-predominant Hodgkin lymphoma as revealed by global gene expression analysis. J Exp Med 2008; 205: 2251\u20132268.","journal-title":"J Exp Med"},{"key":"BFonc2016183_CR29","doi-asserted-by":"publisher","first-page":"6789","DOI":"10.1074\/jbc.M114.612648","volume":"290","author":"JP Dijksterhuis","year":"2015","unstructured":"Dijksterhuis JP, Baljinnyam B, Stanger K, Sercan HO, Ji Y, Andres O et al. Systematic mapping of WNT-FZD protein interactions reveals functional selectivity by distinct WNT-FZD pairs. J Biol Chem 2015; 290: 6789\u20136798.","journal-title":"J Biol Chem"},{"key":"BFonc2016183_CR30","doi-asserted-by":"publisher","first-page":"4757","DOI":"10.1128\/MCB.24.11.4757-4768.2004","volume":"24","author":"JM Gonzalez-Sancho","year":"2004","unstructured":"Gonzalez-Sancho JM, Brennan KR, Castelo-soccio LA, Brown AMC . Wnt proteins induce dishevelled phosphorylation via an LRP5\/6-independent mechanism, irrespective of their ability to stabilize b-catenin. Mol Cell Biol 2004; 24: 4757\u20134768.","journal-title":"Mol Cell Biol"},{"key":"BFonc2016183_CR31","doi-asserted-by":"publisher","first-page":"586","DOI":"10.1242\/jcs.03368","volume":"120","author":"V Bryja","year":"2007","unstructured":"Bryja V, Schulte G, Rawal N, Grahn A, Arenas E . Wnt-5a induces dishevelled phosphorylation and dopaminergic differentiation via a CK1-dependent mechanism. J Cell Sci 2007; 120: 586\u2013595.","journal-title":"J Cell Sci"},{"key":"BFonc2016183_CR32","doi-asserted-by":"publisher","first-page":"e37823","DOI":"10.1371\/journal.pone.0037823","volume":"7","author":"Y Zhu","year":"2012","unstructured":"Zhu Y, Tian Y, Du J, Hu Z, Yang L, Liu J et al. Dvl2-dependent activation of Daam1 and RhoA regulates Wnt5a-induced breast cancer cell migration. PLoS One 2012; 7: e37823.","journal-title":"PLoS One"},{"key":"BFonc2016183_CR33","doi-asserted-by":"publisher","first-page":"711","DOI":"10.1038\/ncb1019","volume":"5","author":"E Sahai","year":"2003","unstructured":"Sahai E, Marshall CJ . Differing modes of tumour cell invasion have distinct requirements for Rho\/ROCK signalling and extracellular proteolysis. Nat Cell Biol 2003; 5: 711\u2013719.","journal-title":"Nat Cell Biol"},{"key":"BFonc2016183_CR34","doi-asserted-by":"publisher","first-page":"502","DOI":"10.1158\/0008-5472.CAN-12-2258","volume":"73","author":"KD Proffitt","year":"2013","unstructured":"Proffitt KD, Madan B, Ke Z, Pendharkar V, Ding L, Lee MA et al. Pharmacological inhibition of the Wnt acyltransferase PORCN prevents growth of WNT-driven mammary cancer. Cancer Res 2013; 73: 502\u2013507.","journal-title":"Cancer Res"},{"key":"BFonc2016183_CR35","doi-asserted-by":"publisher","first-page":"598","DOI":"10.1093\/carcin\/bgv025","volume":"36","author":"A Long","year":"2015","unstructured":"Long A, Giroux V, Whelan K A, Hamilton KE, Tetreault M-P, Tanaka K et al. WNT10A promotes an invasive and self-renewing phenotype in esophageal squamous cell carcinoma. Carcinogenesis 2015; 36: 598\u2013606.","journal-title":"Carcinogenesis"},{"key":"BFonc2016183_CR36","doi-asserted-by":"publisher","first-page":"3246","DOI":"10.1038\/onc.2012.351","volume":"32","author":"O Aprelikova","year":"2013","unstructured":"Aprelikova O, Palla J, Hibler B, Yu X, Greer YE, Yi M et al. Silencing of miR-148a in cancer-associated fibroblasts results in WNT10B-mediated stimulation of tumor cell motility. Oncogene 2013; 32: 3246\u20133253.","journal-title":"Oncogene"},{"key":"BFonc2016183_CR37","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1126\/science.1151250","volume":"320","author":"ES Witze","year":"2008","unstructured":"Witze ES, Litman ES, Argast GM, Moon RT, Ahn NG . Wnt5a control of cell polarity and directional movement by polarized redistribution of adhesion receptors. Science 2008; 320: 365\u2013369.","journal-title":"Science"},{"key":"BFonc2016183_CR38","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1016\/S1535-6108(02)00045-4","volume":"1","author":"AT Weeraratna","year":"2002","unstructured":"Weeraratna AT, Jiang Y, Hostetter G, Rosenblatt K, Duray P, Bittner M et al. Wnt5a signaling directly affects cell motility and invasion of metastatic melanoma. Cancer Cell 2002; 1: 279\u2013288.","journal-title":"Cancer Cell"},{"key":"BFonc2016183_CR39","doi-asserted-by":"publisher","first-page":"19473","DOI":"10.1073\/pnas.0909409106","volume":"106","author":"V Jenei","year":"2009","unstructured":"Jenei V, Sherwood V, Howlin J, Linnskog R, S\u00e4fholm A, Axelsson L et al. A t-butyloxycarbonyl-modified Wnt5a-derived hexapeptide functions as a potent antagonist of Wnt5a-dependent melanoma cell invasion. Proc Natl Acad Sci USA 2009; 106: 19473\u201319478.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFonc2016183_CR40","doi-asserted-by":"publisher","first-page":"875","DOI":"10.1056\/NEJMoa0905680","volume":"362","author":"C Steidl","year":"2010","unstructured":"Steidl C, Lee T, Shah SP, Farinha P, Han G, Nayar T et al. Tumor-associated makrophages and survival in classic Hodgkin\u2019s lymphoma. N Engl J Med 2010; 362: 875\u2013885.","journal-title":"N Engl J Med"},{"key":"BFonc2016183_CR41","doi-asserted-by":"publisher","first-page":"2610","DOI":"10.1101\/gad.12.16.2610","volume":"12","author":"JD Axelrod","year":"1998","unstructured":"Axelrod JD, Miller JR, Shulman JM, Moon RT, Perrimon N . Differential recruitment of Dishevelled provides signaling specificity in the planar cell polarity and Wingless signaling pathways. GENES Dev 1998; 12: 2610\u20132622.","journal-title":"GENES Dev"},{"key":"BFonc2016183_CR42","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1186\/1471-2407-14-339","volume":"14","author":"M Klingenberg","year":"2014","unstructured":"Klingenberg M, Becker J, Eberth S, Kube D, Wilting J . The chick chorioallantoic membrane as an in vivo xenograft model for Burkitt lymphoma. BMC Cancer 2014; 14: 339.","journal-title":"BMC Cancer"},{"key":"BFonc2016183_CR43","doi-asserted-by":"publisher","first-page":"2189","DOI":"10.1182\/blood-2013-08-523886","volume":"123","author":"R Koch","year":"2014","unstructured":"Koch R, Demant M, Aung T, Diering N, Cicholas A, Chapuy B et al. Populational equilibrium through exosome-mediated Wnt signaling in tumor progression of diffuse large B-cell lymphoma. Blood 2014; 123: 2189\u20132199.","journal-title":"Blood"},{"key":"BFonc2016183_CR44","doi-asserted-by":"publisher","first-page":"4431","DOI":"10.1200\/JCO.2013.49.8246","volume":"31","author":"B B\u00f6ll","year":"2013","unstructured":"B\u00f6ll B, Goergen H, Arndt N, Meissner J, Krause SW, Schnell R et al. Relapsed hodgkin lymphoma in older patients: a comprehensive analysis from the German Hodgkin study group. J Clin Oncol 2013; 31: 4431\u20134437.","journal-title":"J Clin Oncol"},{"key":"BFonc2016183_CR45","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1148\/radiographics.21.1.g01ja02161","volume":"21","author":"A Guermazi","year":"2001","unstructured":"Guermazi A, Brice P, de Kerviler EE, Ferm\u00e9 C, Hennequin C, Meignin V et al. Extranodal Hodgkin disease: spectrum of disease. Radiographics 2001; 21: 161\u2013179.","journal-title":"Radiographics"},{"key":"BFonc2016183_CR46","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1016\/j.jaad.2005.11.1055","volume":"58","author":"CE Introcaso","year":"2008","unstructured":"Introcaso CE, Kantor J, Porter DL, Junkins-Hopkins JM . Cutaneous Hodgkin\u2019s disease. J Am Acad Dermatol 2008; 58: 295\u2013298.","journal-title":"J Am Acad Dermatol"},{"key":"BFonc2016183_CR47","doi-asserted-by":"publisher","first-page":"759","DOI":"10.1089\/scd.2008.0270","volume":"18","author":"PM Corrigan","year":"2009","unstructured":"Corrigan PM, Dobbin E, Freeburn RW, Wheadon H . Patterns of Wnt\/Fzd\/LRP gene expression during embryonic hematopoiesis. Stem Cells Dev 2009; 18: 759\u2013772.","journal-title":"Stem Cells Dev"},{"key":"BFonc2016183_CR48","doi-asserted-by":"publisher","first-page":"392","DOI":"10.1038\/nature12631","volume":"503","author":"MC Florian","year":"2013","unstructured":"Florian MC, Nattamai KJ, D\u00f6rr K, Marka G, Uberle B, Vas V et al. A canonical to non-canonical Wnt signalling switch in haematopoietic stem-cell ageing. Nature 2013; 503: 392\u2013396.","journal-title":"Nature"},{"key":"BFonc2016183_CR49","doi-asserted-by":"publisher","first-page":"3955","DOI":"10.4049\/jimmunol.181.6.3955","volume":"181","author":"S Malhotra","year":"2008","unstructured":"Malhotra S, Baba Y, Garrett KP, Staal FJT, Gerstein R, Kincade PW . Contrasting responses of lymphoid progenitors to canonical and noncanonical Wnt signals. J Immunol 2008; 181: 3955\u20133964.","journal-title":"J Immunol"},{"key":"BFonc2016183_CR50","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/S1074-7613(00)00004-2","volume":"13","author":"T Reya","year":"2000","unstructured":"Reya T, O\u2019Riordan M, Okamura R, Devaney E, Willert K, Nusse R et al. Wnt signaling regulates B lymphocyte proliferation through a LEF-1 dependent mechanism. Immunity 2000; 13: 15\u201324.","journal-title":"Immunity"},{"key":"BFonc2016183_CR51","doi-asserted-by":"publisher","first-page":"6315","DOI":"10.1038\/srep06315","volume":"4","author":"CD MacMillan","year":"2014","unstructured":"MacMillan CD, Leong HS, Dales DW, Robertson AE, Lewis JD, Chambers AF et al. Stage of breast cancer progression influences cellular response to activation of the WNT\/ planar cell polarity pathway. Sci Rep 2014; 4: 6315.","journal-title":"Sci Rep"},{"key":"BFonc2016183_CR52","doi-asserted-by":"publisher","first-page":"966","DOI":"10.1091\/mbc.E14-06-1089","volume":"26","author":"M Gentzel","year":"2015","unstructured":"Gentzel M, Schille C, Rauschenberger V, Schambony A . Distinct functionality of dishevelled isoforms on Ca2+\/calmodulin-dependent protein kinase 2 (CamKII) in Xenopus gastrulation. Mol Biol Cell 2015; 26: 966\u2013977.","journal-title":"Mol Biol Cell"},{"key":"BFonc2016183_CR53","doi-asserted-by":"publisher","first-page":"10635","DOI":"10.3390\/ijms150610635","volume":"15","author":"A Kafka","year":"2014","unstructured":"Kafka A, Tomas D, Bero\u0161 V, Pe\u0107ina HI, Zeljko M, Pe\u0107ina-\u0160laus N . Brain metastases from lung cancer show increased expression of DVL1, DVL3 and beta-catenin and down-regulation of E-cadherin. Int J Mol Sci 2014; 15: 10635\u201310651.","journal-title":"Int J Mol Sci"},{"key":"BFonc2016183_CR54","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1016\/j.bbrc.2009.06.033","volume":"386","author":"I Samarzija","year":"2009","unstructured":"Samarzija I, Sini P, Schlange T, Macdonald G, Hynes NE . Wnt3a regulates proliferation and migration of HUVEC via canonical and non-canonical Wnt signaling pathways. Biochem Biophys Res Commun 2009; 386: 449\u2013454.","journal-title":"Biochem Biophys Res Commun"},{"key":"BFonc2016183_CR55","first-page":"832562","volume":"2014","author":"L Yao","year":"2014","unstructured":"Yao L, Sun B, Zhao XX, Zhao XX, Gu Q, Dong X et al. Overexpression of Wnt5a promotes angiogenesis in NSCLC. Biomed Res Int 2014; 2014: 832562.","journal-title":"Biomed Res Int"},{"key":"BFonc2016183_CR56","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1186\/1476-4598-13-88","volume":"13","author":"EJ Ekstr\u00f6m","year":"2014","unstructured":"Ekstr\u00f6m EJ, Bergenfelz C, von B\u00fclow V, Serifler F, Carlemalm E, J\u00f6nsson G et al. WNT5A induces release of exosomes containing pro-angiogenic and immunosuppressive factors from malignant melanoma cells. Mol Cancer 2014; 13: 88.","journal-title":"Mol Cancer"},{"key":"BFonc2016183_CR57","doi-asserted-by":"publisher","first-page":"5726","DOI":"10.1038\/sj.onc.1209582","volume":"25","author":"NO Carragher","year":"2006","unstructured":"Carragher NO, Walker SM, Scott Carragher LA, Harris F, Sawyer TK, Brunton VG et al. Calpain 2 and Src dependence distinguishes mesenchymal and amoeboid modes of tumour cell invasion: a link to integrin function. Oncogene 2006; 25: 5726\u20135740.","journal-title":"Oncogene"},{"key":"BFonc2016183_CR58","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1038\/sj.gene.6363803","volume":"2","author":"M Vockerodt","year":"2001","unstructured":"Vockerodt M, Tesch H, Kube D . Epstein\u2013Barr virus latent membrane protein-1 activates CD25 expression in lymphoma cells involving the NFkappaB pathway. Genes Immun 2001; 2: 433\u2013441.","journal-title":"Genes Immun"},{"key":"BFonc2016183_CR59","doi-asserted-by":"publisher","first-page":"762","DOI":"10.1182\/blood.V98.3.762","volume":"98","author":"D Kube","year":"2001","unstructured":"Kube D, Holtick U, Vockerodt M, Ahmadi T, Haier B, Behrmann I et al. STAT3 is constitutively activated in Hodgkin cell lines. Blood 2001; 98: 762\u2013770.","journal-title":"Blood"},{"key":"BFonc2016183_CR60","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1016\/j.diff.2012.06.004","volume":"84","author":"R Najdi","year":"2012","unstructured":"Najdi R, Proffitt K, Sprowl S, Kaur S, Yu J, Covey TM et al. A uniform human Wnt expression library reveals a shared secretory pathway and unique signaling activities. Differentiation 2012; 84: 203\u2013213.","journal-title":"Differentiation"},{"key":"BFonc2016183_CR61","doi-asserted-by":"publisher","first-page":"18122","DOI":"10.1074\/jbc.M114.575027","volume":"289","author":"BT MacDonald","year":"2014","unstructured":"MacDonald BT, Hien A, Zhang X, Iranloye O, Virshup DM, Waterman ML et al. Disulfide bond requirements for active Wnt ligands. J Biol Chem 2014; 289: 18122\u201318136.","journal-title":"J Biol Chem"},{"key":"BFonc2016183_CR62","doi-asserted-by":"publisher","first-page":"23520","DOI":"10.1074\/jbc.M114.590638","volume":"289","author":"O Bernat\u00edk","year":"2014","unstructured":"Bernat\u00edk O, \u0160edov\u00e1 K, Schille C, Ganji RS, \u010cervenka I, Trant\u00edrek L et al. Functional analysis of dishevelled-3 phosphorylation identifies distinct mechanisms driven by casein kinase 1\u03b5 and frizzled5. J Biol Chem 2014; 289: 23520\u201323533.","journal-title":"J Biol Chem"},{"key":"BFonc2016183_CR63","doi-asserted-by":"publisher","first-page":"215","DOI":"10.4161\/cam.5.3.14648","volume":"5","author":"A Zepeda-Moreno","year":"2014","unstructured":"Zepeda-Moreno A, Taubert I, Hellwig I, Hoang V, Pietsch L, Lakshmanan VK et al. Innovative method for quantification of cell-cell adhesion in 96-well plates. Cell Adh Migr 2014; 5: 215\u2013219.","journal-title":"Cell Adh Migr"},{"key":"BFonc2016183_CR64","doi-asserted-by":"publisher","first-page":"2105","DOI":"10.1093\/carcin\/bgi192","volume":"26","author":"M Hecht","year":"2005","unstructured":"Hecht M, Schulte JH, Eggert A, Wilting J, Schweigerer L . The neurotrophin receptor TrkB cooperates with c-Met in enhancing neuroblastoma invasiveness. Carcinogenesis 2005; 26: 2105\u20132115.","journal-title":"Carcinogenesis"}],"container-title":["Oncogene"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/onc2016183.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/onc2016183","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/onc2016183.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,21]],"date-time":"2022-03-21T16:58:58Z","timestamp":1647881938000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/onc2016183"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,6,6]]},"references-count":64,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,1,5]]}},"alternative-id":["BFonc2016183"],"URL":"https:\/\/doi.org\/10.1038\/onc.2016.183","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.726406935.793522721","asserted-by":"object"}]},"ISSN":["0950-9232","1476-5594"],"issn-type":[{"value":"0950-9232","type":"print"},{"value":"1476-5594","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,6,6]]},"assertion":[{"value":"19 October 2015","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 March 2016","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 April 2016","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 June 2016","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}