{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T06:26:42Z","timestamp":1789972002976,"version":"4.0.1"},"reference-count":91,"publisher":"Springer Science and Business Media LLC","issue":"19","license":[{"start":{"date-parts":[[2016,11,28]],"date-time":"2016-11-28T00:00:00Z","timestamp":1480291200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Oncogene"],"published-print":{"date-parts":[[2017,5]]},"DOI":"10.1038\/onc.2016.421","type":"journal-article","created":{"date-parts":[[2016,11,28]],"date-time":"2016-11-28T18:37:56Z","timestamp":1480358276000},"page":"2680-2692","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":90,"title":["Blood vessel endothelium-directed tumor cell streaming in breast tumors requires the HGF\/C-Met signaling pathway"],"prefix":"10.1038","volume":"36","author":[{"given":"E","family":"Leung","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Xue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Rougerie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V P","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Eddy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0591-9767","authenticated-orcid":false,"given":"D","family":"Cox","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Condeelis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,11,28]]},"reference":[{"key":"BFonc2016421_CR1","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1038\/nrc2622","volume":"9","author":"DX Nguyen","year":"2009","unstructured":"Nguyen DX, Bos PD, Massague J . Metastasis: from dissemination to organ-specific colonization. Nat Rev Cancer. 2009; 9: 274\u2013284.","journal-title":"Nat Rev Cancer."},{"key":"BFonc2016421_CR2","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1038\/bonekey.2015.10","volume":"4","author":"PD Ottewell","year":"2015","unstructured":"Ottewell PD, O\/'Donnell L, Holen I . Molecular alterations that drive breast cancer metastasis to bone. BoneKEy Rep 2015; 4: 643.","journal-title":"BoneKEy Rep"},{"issue":"2","key":"BFonc2016421_CR3","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1006\/scbi.2001.0416","volume":"12","author":"Isaiah J. Fidler","year":"2002","unstructured":"Fidler IJ . Critical determinants of metastasis. Semin Cancer Biol 12: 89\u201396.","journal-title":"Seminars in Cancer Biology"},{"key":"BFonc2016421_CR4","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1111\/cyt.12158","volume":"25","author":"D Martins","year":"2002","unstructured":"Martins D, Beca F, Schmitt F . 2014. Metastatic breast cancer: mechanisms and opportunities for cytology. Cytopathology 2002; 25: 225\u2013230.","journal-title":"Cytopathology"},{"key":"BFonc2016421_CR5","doi-asserted-by":"crossref","first-page":"5649","DOI":"10.1158\/0008-5472.CAN-10-1040","volume":"70","author":"JE Talmadge","year":"2010","unstructured":"Talmadge JE, Fidler IJ . AACR centennial series: the biology of cancer metastasis: historical perspective. Cancer Res 2010; 70: 5649\u20135669.","journal-title":"Cancer Res"},{"key":"BFonc2016421_CR6","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1038\/nrc1670","volume":"5","author":"B Weigelt","year":"2005","unstructured":"Weigelt B, Peterse JL, van 't Veer LJ . Breast cancer metastasis: markers and models. Nat Rev Cancer 2005; 5: 591\u2013602.","journal-title":"Nat Rev Cancer"},{"key":"BFonc2016421_CR7","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1038\/nature11412","volume":"490","author":"Cancer Genome Atlas N","year":"2012","unstructured":"Cancer Genome Atlas N. Comprehensive molecular portraits of human breast tumours. Nature 2012; 490: 61\u201370.","journal-title":"Nature"},{"key":"BFonc2016421_CR8","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1038\/nrc1886","volume":"6","author":"P Mehlen","year":"2006","unstructured":"Mehlen P, Puisieux A . Metastasis: a question of life or death. Nat Rev Cancer 2006; 6: 449\u2013458.","journal-title":"Nat Rev Cancer"},{"key":"BFonc2016421_CR9","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1007\/s10585-011-9388-6","volume":"28","author":"ET Roussos","year":"2011","unstructured":"Roussos ET, Goswami S, Balsamo M, Wang Y, Stobezki R, Adler E et al. Mena invasive (Mena(INV)) and Mena11a isoforms play distinct roles in breast cancer cell cohesion and association with TMEM. Clin Exp Metastasis 2011; 28: 515\u2013527.","journal-title":"Clin Exp Metastasis"},{"key":"BFonc2016421_CR10","doi-asserted-by":"crossref","first-page":"9498","DOI":"10.1158\/0008-5472.CAN-09-1868","volume":"69","author":"A Patsialou","year":"2009","unstructured":"Patsialou A, Wyckoff J, Wang Y, Goswami S, Stanley ER, Condeelis JS . Invasion of human breast cancer cells in vivo requires both paracrine and autocrine loops involving the colony-stimulating factor-1 receptor. Cancer Res 2009; 69: 9498\u20139506.","journal-title":"Cancer Res"},{"key":"BFonc2016421_CR11","doi-asserted-by":"crossref","first-page":"e25294","DOI":"10.4161\/intv.25294","volume":"2","author":"A Patsialou","year":"2013","unstructured":"Patsialou A, Bravo-Cordero JJ, Wang Y, Entenberg D, Liu H, Clarke M et al. Intravital multiphoton imaging reveals multicellular streaming as a crucial component of in vivo cell migration in human breast tumors. Intravital 2013; 2: e25294.","journal-title":"Intravital"},{"key":"BFonc2016421_CR12","doi-asserted-by":"crossref","first-page":"2094","DOI":"10.1158\/0008-5472.CAN-15-2662","volume":"76","author":"Z Zhao","year":"2016","unstructured":"Zhao Z, Zhu X, Cui K, Mancuso J, Federley R, Fischer K et al. In vivo visualization and characterization of epithelial-mesenchymal transition in breast tumors. Cancer Res 2016; 76: 2094-2104.","journal-title":"Cancer Res"},{"key":"BFonc2016421_CR13","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1038\/nrm2720","volume":"10","author":"P Friedl","year":"2009","unstructured":"Friedl P, Gilmour D . Collective cell migration in morphogenesis, regeneration and cancer. Nat Rev Mol Cell Biol 2009; 10: 445\u2013457.","journal-title":"Nat Rev Mol Cell Biol"},{"key":"BFonc2016421_CR14","doi-asserted-by":"crossref","first-page":"77","DOI":"10.4161\/intv.22054","volume":"1","author":"VP Sharma","year":"2012","unstructured":"Sharma VP, Beaty BT, Patsialou A, Liu H, Clarke M, Cox D et al. Reconstitution of in vivo macrophage-tumor cell pairing and streaming motility on one-dimensional micro-patterned substrates. Intravital 2012; 1: 77\u201385.","journal-title":"Intravital"},{"key":"BFonc2016421_CR15","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1038\/nrc3078","volume":"11","author":"ET Roussos","year":"2011","unstructured":"Roussos ET, Condeelis JS, Patsialou A . Chemotaxis in cancer. Nat Rev Cancer. 2011; 11: 573\u2013587.","journal-title":"Nat Rev Cancer."},{"key":"BFonc2016421_CR16","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1038\/nmeth.1269","volume":"5","author":"D Kedrin","year":"2008","unstructured":"Kedrin D, Gligorijevic B, Wyckoff J, Verkhusha VV, Condeelis J, Segall JE et al. Intravital imaging of metastatic behavior through a mammary imaging window. Nat Methods 2008; 5: 1019\u20131021.","journal-title":"Nat Methods"},{"key":"BFonc2016421_CR17","doi-asserted-by":"crossref","first-page":"1500","DOI":"10.1038\/nprot.2011.376","volume":"6","author":"D Entenberg","year":"2011","unstructured":"Entenberg D, Wyckoff J, Gligorijevic B, Roussos ET, Verkhusha VV, Pollard JW et al. Setup and use of a two-laser multiphoton microscope for multichannel intravital fluorescence imaging. Nat Protoc 2011; 6: 1500\u20131520.","journal-title":"Nat Protoc"},{"key":"BFonc2016421_CR18","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1158\/2159-8290.CD-15-0012","volume":"5","author":"AS Harney","year":"2015","unstructured":"Harney AS, Arwert EN, Entenberg D, Wang Y, Guo P, Qian BZ et al. Real-time imaging reveals local, transient vascular permeability, and tumor cell intravasation stimulated by TIE2hi macrophage-derived VEGFA. Cancer Discov 2015; 5: 932\u2013943.","journal-title":"Cancer Discov"},{"issue":"Pt 13","key":"BFonc2016421_CR19","doi-asserted-by":"crossref","first-page":"2120","DOI":"10.1242\/jcs.086231","volume":"124","author":"ET Roussos","year":"2011","unstructured":"Roussos ET, Balsamo M, Alford SK, Wyckoff JB, Gligorijevic B, Wang Y et al. Mena invasive (MenaINV) promotes multicellular streaming motility and transendothelial migration in a mouse model of breast cancer. J Cell Sci 2011; 124 (Pt 13): 2120\u20132131.","journal-title":"J Cell Sci"},{"key":"BFonc2016421_CR20","doi-asserted-by":"crossref","first-page":"ra112","DOI":"10.1126\/scisignal.2005329","volume":"7","author":"J Pignatelli","year":"2014","unstructured":"Pignatelli J, Goswami S, Jones JG, Rohan TE, Pieri E, Chen X et al. Invasive breast carcinoma cells from patients exhibit MenaINV- and macrophage-dependent transendothelial migration. Sci Signal 2014; 7: ra112.","journal-title":"Sci Signal"},{"key":"BFonc2016421_CR21","doi-asserted-by":"crossref","first-page":"30715","DOI":"10.18632\/oncotarget.5568","volume":"6","author":"MJ Magbanua","year":"2015","unstructured":"Magbanua MJ, Das R, Polavarapu P, Park JW . Approaches to isolation and molecular characterization of disseminated tumor cells. Oncotarget 2015; 6: 30715\u201330729.","journal-title":"Oncotarget"},{"key":"BFonc2016421_CR22","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1038\/nrc2256","volume":"7","author":"JA Aguirre-Ghiso","year":"2007","unstructured":"Aguirre-Ghiso JA . Models, mechanisms and clinical evidence for cancer dormancy. Nat Rev Cancer 2007; 7: 834\u2013846.","journal-title":"Nat Rev Cancer"},{"key":"BFonc2016421_CR23","doi-asserted-by":"crossref","first-page":"2433","DOI":"10.1158\/1078-0432.CCR-08-2179","volume":"15","author":"BD Robinson","year":"2009","unstructured":"Robinson BD, Sica GL, Liu YF, Rohan TE, Gertler FB, Condeelis JS et al. Tumor microenvironment of metastasis in human breast carcinoma: a potential prognostic marker linked to hematogenous dissemination. Clin Cancer Res 2009; 15: 2433\u20132441.","journal-title":"Clin Cancer Res"},{"key":"BFonc2016421_CR24","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1369\/0022155411435153","volume":"60","author":"MH Oktay","year":"2012","unstructured":"Oktay MH, Gertler FB, Liu YF, Rohan TE, Condeelis JS, Jones JG . Correlated immunohistochemical and cytological assays for the prediction of hematogenous dissemination of breast cancer. J Histochem Cytochem. 2012; 60: 168\u2013173.","journal-title":"J Histochem Cytochem."},{"key":"BFonc2016421_CR25","doi-asserted-by":"crossref","unstructured":"Rohan TE, Xue X, Lin HM, D'Alfonso TM, Ginter PS, Oktay MH et al. Tumor microenvironment of metastasis and risk of distant metastasis of breast cancer. J Natl Cancer Inst; e-pub ahead of print 3 June 2014 doi:10.1093\/jnci\/dju136.","DOI":"10.1093\/jnci\/dju136"},{"key":"BFonc2016421_CR26","doi-asserted-by":"crossref","first-page":"7022","DOI":"10.1158\/0008-5472.CAN-04-1449","volume":"64","author":"J Wyckoff","year":"2004","unstructured":"Wyckoff J, Wang W, Lin EY, Wang Y, Pixley F, Stanley ER et al. A paracrine loop between tumor cells and macrophages is required for tumor cell migration in mammary tumors. Cancer Res 2004; 64: 7022\u20137029.","journal-title":"Cancer Res"},{"key":"BFonc2016421_CR27","doi-asserted-by":"crossref","first-page":"3221","DOI":"10.1158\/0008-5472.CAN-08-2871","volume":"69","author":"L Hernandez","year":"2009","unstructured":"Hernandez L, Smirnova T, Kedrin D, Wyckoff J, Zhu L, Stanley ER et al. The EGF\/CSF-1 paracrine invasion loop can be triggered by heregulin beta1 and CXCL12. Cancer Res 2009; 69: 3221\u20133227.","journal-title":"Cancer Res"},{"key":"BFonc2016421_CR28","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1007\/s10911-006-9021-5","volume":"11","author":"M Sidani","year":"2006","unstructured":"Sidani M, Wyckoff J, Xue C, Segall JE, Condeelis J . Probing the microenvironment of mammary tumors using multiphoton microscopy. J Mammary Gland Biol Neoplasia 2006; 11: 151\u2013163.","journal-title":"J Mammary Gland Biol Neoplasia"},{"key":"BFonc2016421_CR29","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1016\/j.ajpath.2010.12.013","volume":"178","author":"J Locker","year":"2011","unstructured":"Locker J, Segall JE . Breast cancer: the matrix is the message. Am J Pathol 2011; 178: 966\u2013968.","journal-title":"Am J Pathol"},{"key":"BFonc2016421_CR30","doi-asserted-by":"crossref","first-page":"5278","DOI":"10.1158\/0008-5472.CAN-04-1853","volume":"65","author":"S Goswami","year":"2005","unstructured":"Goswami S, Sahai E, Wyckoff JB, Cammer M, Cox D, Pixley FJ et al. Macrophages promote the invasion of breast carcinoma cells via a colony-stimulating factor-1\/epidermal growth factor paracrine loop. Cancer Res 2005; 65: 5278\u20135283.","journal-title":"Cancer Res"},{"key":"BFonc2016421_CR31","doi-asserted-by":"crossref","first-page":"2721","DOI":"10.1038\/onc.2014.226","volume":"34","author":"A Patsialou","year":"2015","unstructured":"Patsialou A, Wang Y, Pignatelli J, Chen X, Entenberg D, Oktay M et al. Autocrine CSF1R signaling mediates switching between invasion and proliferation downstream of TGFbeta in claudin-low breast tumor cells. Oncogene 2015; 34: 2721\u20132731.","journal-title":"Oncogene"},{"key":"BFonc2016421_CR32","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1039\/C5IB00201J","volume":"8","author":"H Knutsdottir","year":"2016","unstructured":"Knutsdottir H, Condeelis JS, Palsson E . 3-D individual cell based computational modeling of tumor cell-macrophage paracrine signaling mediated by EGF and CSF-1 gradients. Integr Biol (Camb) 2016; 8: 104\u2013119.","journal-title":"Integr Biol (Camb)"},{"key":"BFonc2016421_CR33","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1007\/978-1-4939-0928-5_10","volume":"1172","author":"VP Sharma","year":"2014","unstructured":"Sharma VP, Beaty BT, Cox D, Condeelis JS, Eddy RJ . An in vitro one-dimensional assay to study growth factor-regulated tumor cell-macrophage interaction. Methods Mol Biol 2014; 1172: 115\u2013123.","journal-title":"Methods Mol Biol"},{"key":"BFonc2016421_CR34","doi-asserted-by":"crossref","first-page":"3505","DOI":"10.1158\/0008-5472.CAN-06-3714","volume":"67","author":"W Wang","year":"2007","unstructured":"Wang W, Wyckoff JB, Goswami S, Wang Y, Sidani M, Segall JE et al. Coordinated regulation of pathways for enhanced cell motility and chemotaxis is conserved in rat and mouse mammary tumors. Cancer Res 2007; 67: 3505\u20133511.","journal-title":"Cancer Res"},{"key":"BFonc2016421_CR35","doi-asserted-by":"crossref","first-page":"R139","DOI":"10.1186\/bcr3344","volume":"14","author":"A Patsialou","year":"2012","unstructured":"Patsialou A, Wang Y, Lin J, Whitney K, Goswami S, Kenny PA et al. Selective gene-expression profiling of migratory tumor cells in vivo predicts clinical outcome in breast cancer patients. Breast Cancer Res 2012; 14: R139.","journal-title":"Breast Cancer Res"},{"key":"BFonc2016421_CR36","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/S0092-8674(00)81341-0","volume":"87","author":"FB Gertler","year":"1996","unstructured":"Gertler FB, Niebuhr K, Reinhard M, Wehland J, Soriano P . Mena, a relative of VASP and Drosophila enabled, is implicated in the control of microfilament dynamics. Cell 1996; 87: 227\u2013239.","journal-title":"Cell"},{"key":"BFonc2016421_CR37","doi-asserted-by":"crossref","first-page":"2533","DOI":"10.1091\/mbc.e01-10-0102","volume":"13","author":"JJ Loureiro","year":"2002","unstructured":"Loureiro JJ, Rubinson DA, Bear JE, Baltus GA, Kwiatkowski AV, Gertler FB . Critical roles of phosphorylation and actin binding motifs, but not the central proline-rich region, for Ena\/vasodilator-stimulated phosphoprotein (VASP) function during cell migration. Mol Biol Cell 2002; 13: 2533\u20132546.","journal-title":"Mol Biol Cell"},{"key":"BFonc2016421_CR38","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1038\/nrm3609","volume":"14","author":"JJ Bravo-Cordero","year":"2013","unstructured":"Bravo-Cordero JJ, Magalhaes MA, Eddy RJ, Hodgson L, Condeelis J . Functions of cofilin in cell locomotion and invasion. Nat Rev Mol Cell Biol 2013; 14: 405\u2013415.","journal-title":"Nat Rev Mol Cell Biol"},{"key":"BFonc2016421_CR39","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1083\/jcb.201202079","volume":"198","author":"SL Gupton","year":"2012","unstructured":"Gupton SL, Riquelme D, Hughes-Alford SK, Tadros J, Rudina SS, Hynes RO et al. Mena binds alpha5 integrin directly and modulates alpha5beta1 function. J Cell Biol 2012; 198: 657\u2013676.","journal-title":"J Cell Biol"},{"key":"BFonc2016421_CR40","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1007\/s10585-008-9225-8","volume":"26","author":"S Goswami","year":"2009","unstructured":"Goswami S, Philippar U, Sun D, Patsialou A, Avraham J, Wang W et al. Identification of invasion specific splice variants of the cytoskeletal protein Mena present in mammary tumor cells during invasion in vivo. Clin Exp Metastasis 2009; 26: 153\u2013159.","journal-title":"Clin Exp Metastasis"},{"key":"BFonc2016421_CR41","doi-asserted-by":"crossref","first-page":"3867","DOI":"10.1091\/mbc.E15-06-0442","volume":"26","author":"SK Hughes","year":"2015","unstructured":"Hughes SK, Oudin MJ, Tadros J, Neil J, Del Rosario A, Joughin BA et al. PTP1B-dependent regulation of receptor tyrosine kinase signaling by the actin-binding protein Mena. Mol Biol Cell 2015; 26: 3867\u20133878.","journal-title":"Mol Biol Cell"},{"key":"BFonc2016421_CR42","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1016\/j.devcel.2008.09.003","volume":"15","author":"U Philippar","year":"2008","unstructured":"Philippar U, Roussos ET, Oser M, Yamaguchi H, Kim HD, Giampieri S et al. A Mena invasion isoform potentiates EGF-induced carcinoma cell invasion and metastasis. Dev Cell 2008; 15: 813\u2013828.","journal-title":"Dev Cell"},{"key":"BFonc2016421_CR43","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1186\/s12885-015-1468-6","volume":"15","author":"CL Forse","year":"2015","unstructured":"Forse CL, Agarwal S, Pinnaduwage D, Gertler F, Condeelis JS, Lin J et al. Menacalc, a quantitative method of metastasis assessment, as a prognostic marker for axillary node-negative breast cancer. BMC Cancer 2015; 15: 483.","journal-title":"BMC Cancer"},{"key":"BFonc2016421_CR44","doi-asserted-by":"crossref","first-page":"R124","DOI":"10.1186\/bcr3318","volume":"14","author":"S Agarwal","year":"2012","unstructured":"Agarwal S, Gertler FB, Balsamo M, Condeelis JS, Camp RL, Xue X et al. Quantitative assessment of invasive mena isoforms (Menacalc) as an independent prognostic marker in breast cancer. Breast Cancer Res 2012; 14: R124.","journal-title":"Breast Cancer Res"},{"key":"BFonc2016421_CR45","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1186\/s13058-015-0547-6","volume":"17","author":"CM Ho-Yen","year":"2015","unstructured":"Ho-Yen CM, Jones JL, Kermorgant S . The clinical and functional significance of c-Met in breast cancer: a review. Breast Cancer Res 2015; 17: 52.","journal-title":"Breast Cancer Res"},{"key":"BFonc2016421_CR46","doi-asserted-by":"crossref","first-page":"R128","DOI":"10.1186\/bcr3074","volume":"13","author":"L Hernandez","year":"2011","unstructured":"Hernandez L, Magalhaes MA, Coniglio SJ, Condeelis JS, Segall JE . Opposing roles of CXCR4 and CXCR7 in breast cancer metastasis. Breast Cancer Res 2011; 13: R128.","journal-title":"Breast Cancer Res"},{"key":"BFonc2016421_CR47","doi-asserted-by":"crossref","first-page":"e1001995","DOI":"10.1371\/journal.pbio.1001995","volume":"12","author":"B Gligorijevic","year":"2014","unstructured":"Gligorijevic B, Bergman A, Condeelis J . Multiparametric classification links tumor microenvironments with tumor cell phenotype. PLoS Biol 2014; 12: e1001995.","journal-title":"PLoS Biol"},{"key":"BFonc2016421_CR48","doi-asserted-by":"crossref","first-page":"2649","DOI":"10.1158\/0008-5472.CAN-06-1823","volume":"67","author":"JB Wyckoff","year":"2007","unstructured":"Wyckoff JB, Wang Y, Lin EY, Li JF, Goswami S, Stanley ER et al. Direct visualization of macrophage-assisted tumor cell intravasation in mammary tumors. Cancer Res 2007; 67: 2649\u20132656.","journal-title":"Cancer Res"},{"key":"BFonc2016421_CR49","doi-asserted-by":"crossref","first-page":"8585","DOI":"10.1158\/0008-5472.CAN-04-1136","volume":"64","author":"W Wang","year":"2004","unstructured":"Wang W, Goswami S, Lapidus K, Wells AL, Wyckoff JB, Sahai E et al. Identification and testing of a gene expression signature of invasive carcinoma cells within primary mammary tumors. Cancer Res 2004; 64: 8585\u20138594.","journal-title":"Cancer Res"},{"key":"BFonc2016421_CR50","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1007\/BF00157687","volume":"14","author":"JE Segall","year":"1996","unstructured":"Segall JE, Tyerech S, Boselli L, Masseling S, Helft J, Chan A et al. EGF stimulates lamellipod extension in metastatic mammary adenocarcinoma cells by an actin-dependent mechanism. Clin Exp Metastasis 1996; 14: 61\u201372.","journal-title":"Clin Exp Metastasis"},{"key":"BFonc2016421_CR51","doi-asserted-by":"crossref","first-page":"2207","DOI":"10.1158\/1078-0432.CCR-08-1306","volume":"15","author":"JP Eder","year":"2009","unstructured":"Eder JP, Vande Woude GF, Boerner SA, LoRusso PM . Novel therapeutic inhibitors of the c-Met signaling pathway in cancer. Clin Cancer Res 2009; 15: 2207\u20132214.","journal-title":"Clin Cancer Res"},{"key":"BFonc2016421_CR52","doi-asserted-by":"crossref","first-page":"5339","DOI":"10.1021\/bi900438w","volume":"48","author":"SL Timofeevski","year":"2009","unstructured":"Timofeevski SL, McTigue MA, Ryan K, Cui J, Zou HY, Zhu JX et al. Enzymatic characterization of c-Met receptor tyrosine kinase oncogenic mutants and kinetic studies with aminopyridine and triazolopyrazine inhibitors. Biochemistry 2009; 48: 5339\u20135349.","journal-title":"Biochemistry"},{"key":"BFonc2016421_CR53","doi-asserted-by":"crossref","first-page":"7","DOI":"10.2174\/1871520611009010007","volume":"10","author":"TL Underiner","year":"2010","unstructured":"Underiner TL, Herbertz T, Miknyoczki SJ . Discovery of small molecule c-Met inhibitors: evolution and profiles of clinical candidates. Anticancer Agents Med Chem 2010; 10: 7\u201327.","journal-title":"Anticancer Agents Med Chem"},{"key":"BFonc2016421_CR54","doi-asserted-by":"crossref","first-page":"2023","DOI":"10.1158\/1535-7163.MCT-14-1105","volume":"14","author":"BD Smith","year":"2015","unstructured":"Smith BD, Kaufman MD, Leary CB, Turner BA, Wise SC, Ahn YM et al. Altiratinib inhibits tumor growth, invasion, angiogenesis, and microenvironment-mediated drug resistance via balanced inhibition of MET, TIE2, and VEGFR2. Mol Cancer Ther 2015; 14: 2023\u20132034.","journal-title":"Mol Cancer Ther"},{"key":"BFonc2016421_CR55","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/0014-4827(92)90095-P","volume":"202","author":"H Tajima","year":"1992","unstructured":"Tajima H, Matsumoto K, Nakamura T . Regulation of cell growth and motility by hepatocyte growth factor and receptor expression in various cell species. Exp Cell Res 1992; 202: 423\u2013431.","journal-title":"Exp Cell Res"},{"key":"BFonc2016421_CR56","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/0014-5793(92)80257-H","volume":"301","author":"O Higuchi","year":"1992","unstructured":"Higuchi O, Mizuno K, Vande Woude GF, Nakamura T . Expression of c-met proto-oncogene in COS cells induces the signal transducing high-affinity receptor for hepatocyte growth factor. FEBS Lett 1992; 301: 282\u2013286.","journal-title":"FEBS Lett"},{"key":"BFonc2016421_CR57","unstructured":"Flynn DL, Ahn YM, Berger MSTC, Hood MM, Kaufman MD et al. Rebastinib and DCC-2701: Targeting of resistance mechanisms in cancer treatment [abstract]. ACS National Meeting; 8 April 2013; New Orleans (abstract MEDI 209)."},{"key":"BFonc2016421_CR58","doi-asserted-by":"crossref","unstructured":"Flynn DL, Kaufman MD, Leary CB, Hood MM, Lu WP, Turner BA et al. Rebastinib,a selective TIE2 kinase inhibitor, decreases TIE2-expressing macrophages,reduces metastasis, and increases survival in murine cancer models. [abstract]. AACR Special Conference on Cellular Heterogeneity in the Tumor Microenvironment; 26 February-1 March 2014; San Diego, CA. AACR: Philadelphia, PA, USA (abstract PR01).","DOI":"10.1158\/1538-7445.CHTME14-PR01"},{"key":"BFonc2016421_CR59","doi-asserted-by":"crossref","unstructured":"Smith BD, Hood MM, Kaufman MD, Berger M, Flynn DL, Wise SC . Rebastinib, a small molecule TIE2 kinase inhibitor, prevents primary tumor growth and lung metastasis in the PyMT breast cancer model [abstract]. Proceedings of the AACR Special Conference on Tumor Invasion and Metastasis; 20-23 January 2013; San Diego, CA. AACR: Philadelphia, PA, USA (abstract B78).","DOI":"10.1158\/1538-7445.TIM2013-B78"},{"issue":"24 Supplement","key":"BFonc2016421_CR60","first-page":"P4-15-12-P4-15-","volume":"73","author":"BD Smith","year":"2013","unstructured":"Smith BD, Leary CB, Kaufman MD, Hood MM, Lu WP, Turner BA et al. Rebastinib in combination with eribulin ablates TIE2-expressing macrophages, reduces metastasis, and increases survival in the PyMT metastatic breast cancer model. Cancer Res 2013; 73 (24 Suppl): abstract P4-15-12.","journal-title":"Cancer Research"},{"key":"BFonc2016421_CR61","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.yexcr.2004.05.020","volume":"299","author":"W Eichler","year":"2004","unstructured":"Eichler W, Yafai Y, Keller T, Wiedemann P, Reichenbach A . PEDF derived from glial Muller cells: a possible regulator of retinal angiogenesis. Exp Cell Res 2004; 299: 68\u201378.","journal-title":"Exp Cell Res"},{"key":"BFonc2016421_CR62","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1182\/blood-2002-10-3257","volume":"102","author":"N Giuliani","year":"2003","unstructured":"Giuliani N, Colla S, Lazzaretti M, Sala R, Roti G, Mancini C et al. Proangiogenic properties of human myeloma cells: production of angiopoietin-1 and its potential relationship to myeloma-induced angiogenesis. Blood 2003; 102: 638\u2013645.","journal-title":"Blood"},{"key":"BFonc2016421_CR63","first-page":"2257","volume":"119","author":"T Minami","year":"2009","unstructured":"Minami T, Yano K, Miura M, Kobayashi M, Suehiro J, Reid PC et al. The Down syndrome critical region gene 1 short variant promoters direct vascular bed-specific gene expression during inflammation in mice. J Clin Investig 2009; 119: 2257\u20132270.","journal-title":"J Clin Investig"},{"key":"BFonc2016421_CR64","doi-asserted-by":"crossref","first-page":"2973","DOI":"10.1182\/blood-2003-08-2742","volume":"103","author":"H Araki","year":"2004","unstructured":"Araki H, Katayama N, Yamashita Y, Mano H, Fujieda A, Usui E et al. Reprogramming of human postmitotic neutrophils into macrophages by growth factors. Blood 2004; 103: 2973\u20132980.","journal-title":"Blood"},{"key":"BFonc2016421_CR65","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1002\/cm.20361","volume":"66","author":"V Desmarais","year":"2009","unstructured":"Desmarais V, Yamaguchi H, Oser M, Soon L, Mouneimne G, Sarmiento C et al. N-WASP and cortactin are involved in invadopodium-dependent chemotaxis to EGF in breast tumor cells. Cell Motil Cytoskelet 2009; 66: 303\u2013316.","journal-title":"Cell Motil Cytoskelet"},{"key":"BFonc2016421_CR66","doi-asserted-by":"crossref","first-page":"2193","DOI":"10.1016\/j.cub.2006.09.016","volume":"16","author":"G Mouneimne","year":"2006","unstructured":"Mouneimne G, DesMarais V, Sidani M, Scemes E, Wang W, Song X et al. Spatial and temporal control of cofilin activity is required for directional sensing during chemotaxis. Curr Biol 2006; 16: 2193\u20132205.","journal-title":"Curr Biol"},{"key":"BFonc2016421_CR67","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1083\/jcb.200707009","volume":"179","author":"M Sidani","year":"2007","unstructured":"Sidani M, Wessels D, Mouneimne G, Ghosh M, Goswami S, Sarmiento C et al. Cofilin determines the migration behavior and turning frequency of metastatic cancer cells. J Cell Biol 2007; 179: 777\u2013791.","journal-title":"J Cell Biol"},{"key":"BFonc2016421_CR68","first-page":"1232","volume":"2011","author":"J Wyckoff","year":"2011","unstructured":"Wyckoff J, Gligorijevic B, Entenberg D, Segall J, Condeelis J . The in vivo invasion assay: preparation and handling of collection needles. Cold Spring Harb Protoc 2011; 2011: 1232\u20131234.","journal-title":"Cold Spring Harb Protoc"},{"issue":"1 Supplement","key":"BFonc2016421_CR69","doi-asserted-by":"crossref","first-page":"A53","DOI":"10.1158\/1538-7445.CHTME14-A53","volume":"75","author":"BD Smith","year":"2015","unstructured":"Smith BD, Kaufman MD, Leary CB, Hood MM, Lu W-P, Turner BA et al. Abstract A53: the specific FMS kinase inhibitor, DCC-3014, durably inhibits FMS kinase in vivo and blocks cancer bone invasiveness. Cancer Res 2015; 75 (1 Supplement): A53\u2013A53.","journal-title":"Cancer Res"},{"key":"BFonc2016421_CR70","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1083\/jcb.200407076","volume":"168","author":"H Yamaguchi","year":"2005","unstructured":"Yamaguchi H, Lorenz M, Kempiak S, Sarmiento C, Coniglio S, Symons M et al. Molecular mechanisms of invadopodium formation: the role of the N-WASP-Arp2\/3 complex pathway and cofilin. J Cell Biol 2005; 168: 441\u2013452.","journal-title":"J Cell Biol"},{"key":"BFonc2016421_CR71","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1002\/ijc.1557","volume":"94","author":"NG Anderson","year":"2001","unstructured":"Anderson NG, Ahmad T, Chan K, Dobson R, Bundred NJ . ZD1839 (Iressa), a novel epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor, potently inhibits the growth of EGFR-positive cancer cell lines with or without erbB2 overexpression. Int J Cancer 2001; 94: 774\u2013782.","journal-title":"Int J Cancer"},{"key":"BFonc2016421_CR72","doi-asserted-by":"crossref","unstructured":"Williams JK, Entenberg D, Wang Y, Padgen MR, Clark A, Castracane J et al. Validation of a device for the active manipulation of the tumor microenvironment during intravital imaging. Intravital 2015, In Press.","DOI":"10.1080\/21659087.2016.1182271"},{"key":"BFonc2016421_CR73","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1002\/ijc.20598","volume":"113","author":"E Lengyel","year":"2005","unstructured":"Lengyel E, Prechtel D, Resau JH, Gauger K, Welk A, Lindemann K et al. c-Met overexpression in node-positive breast cancer identifies patients with poor clinical outcome independent of Her2\/neu. Int J Cancer 2005; 113: 678\u2013682.","journal-title":"Int J Cancer"},{"key":"BFonc2016421_CR74","first-page":"1101","volume":"63","author":"JY Kang","year":"2003","unstructured":"Kang JY, Dolled-Filhart M, Ocal IT, Singh B, Lin CY, Dickson RB et al. Tissue microarray analysis of hepatocyte growth factor\/Met pathway components reveals a role for Met, matriptase, and hepatocyte growth factor activator inhibitor 1 in the progression of node-negative breast cancer. Cancer Res 2003; 63: 1101\u20131105.","journal-title":"Cancer Res"},{"key":"BFonc2016421_CR75","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1002\/(SICI)1097-0142(19980415)82:8<1513::AID-CNCR13>3.0.CO;2-7","volume":"82","author":"RA Ghoussoub","year":"1998","unstructured":"Ghoussoub RA, Dillon DA, D'Aquila T, Rimm EB, Fearon ER, Rimm DL . Expression of c-met is a strong independent prognostic factor in breast carcinoma. Cancer 1998; 82: 1513\u20131520.","journal-title":"Cancer"},{"key":"BFonc2016421_CR76","doi-asserted-by":"crossref","first-page":"R82","DOI":"10.1186\/bcr3476","volume":"15","author":"P Casbas-Hernandez","year":"2013","unstructured":"Casbas-Hernandez P, D'Arcy M, Roman-Perez E, Brauer HA, McNaughton K, Miller SM et al. Role of HGF in epithelial-stromal cell interactions during progression from benign breast disease to ductal carcinoma in situ. Breast Cancer Res 2013; 15: R82.","journal-title":"Breast Cancer Res"},{"key":"BFonc2016421_CR77","doi-asserted-by":"crossref","first-page":"R23","DOI":"10.1186\/bcr3108","volume":"14","author":"PJ Boimel","year":"2012","unstructured":"Boimel PJ, Smirnova T, Zhou ZN, Wyckoff J, Park H, Coniglio SJ et al. Contribution of CXCL12 secretion to invasion of breast cancer cells. Breast Cancer Res 2012; 14: R23.","journal-title":"Breast Cancer Res"},{"key":"BFonc2016421_CR78","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.2217\/fon.12.119","volume":"8","author":"MC Cassatella","year":"2012","unstructured":"Cassatella MC, Zorzino L, Sandri MT . Single circulating tumor cell profiling: a new perspective for targeted therapy? Future Oncol 2012; 8: 1253\u20131256.","journal-title":"Future Oncol"},{"key":"BFonc2016421_CR79","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1038\/35065016","volume":"410","author":"A Muller","year":"2001","unstructured":"Muller A, Homey B, Soto H, Ge N, Catron D, Buchanan M et al. Involvement of chemokine receptors in breast cancer metastasis. Nature 2001; 410: 50\u201356.","journal-title":"Nature"},{"key":"BFonc2016421_CR80","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1016\/j.ijrobp.2004.12.001","volume":"62","author":"JP Brooks","year":"2005","unstructured":"Brooks JP, Danforth DN, Albert P, Sciuto LC, Smith SL, Camphausen KA et al. Early ipsilateral breast tumor recurrences after breast conservation affect survival: an analysis of the National Cancer Institute randomized trial. Int J Radiat Oncol Biol Phys 2005; 62: 785\u2013789.","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"BFonc2016421_CR81","doi-asserted-by":"crossref","first-page":"841s","DOI":"10.1200\/jco.2004.22.14_suppl.9525","volume":"22","author":"N Cabioglu","year":"2004","unstructured":"Cabioglu N, Yazici MS, Arun BK, Smith TL, Hortobagyi GN, Price JE et al. Expression of CXCR4 predicts lymph node metastasis in early breast cancer. J Clin Oncol 2004; 22: 841s\u2013841ss.","journal-title":"J Clin Oncol"},{"key":"BFonc2016421_CR82","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1158\/0008-5472.CAN-10-3185","volume":"71","author":"LV Rhodes","year":"2011","unstructured":"Rhodes LV, Short SP, Neel NF, Salvo VA, Zhu Y, Elliott S et al. Cytokine receptor CXCR4 mediates estrogen-independent tumorigenesis, metastasis, and resistance to endocrine therapy in human breast cancer. Cancer Res 2011; 71: 603\u2013613.","journal-title":"Cancer Res"},{"key":"BFonc2016421_CR83","first-page":"213","volume":"7","author":"A Sawano","year":"1996","unstructured":"Sawano A, Takahashi T, Yamaguchi S, Aonuma M, Shibuya M . Flt-1 but not KDR\/Flk-1 tyrosine kinase is a receptor for placenta growth factor, which is related to vascular endothelial growth factor. Cell Growth Differ 1996; 7: 213\u2013221.","journal-title":"Cell Growth Differ"},{"key":"BFonc2016421_CR84","doi-asserted-by":"crossref","first-page":"877","DOI":"10.4049\/jimmunol.160.2.877","volume":"160","author":"J Hesselgesser","year":"1998","unstructured":"Hesselgesser J, Liang M, Hoxie J, Greenberg M, Brass LF, Orsini MJ et al. Identification and characterization of the CXCR4 chemokine receptor in human T cell lines: ligand binding, biological activity, and HIV-1 infectivity. J Immunol 1998; 160: 877\u2013883.","journal-title":"J Immunol"},{"key":"BFonc2016421_CR85","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1016\/S0092-8674(00)81812-7","volume":"87","author":"S Davis","year":"1996","unstructured":"Davis S, Aldrich TH, Jones PF, Acheson A, Compton DL, Jain V et al. Isolation of angiopoietin-1, a ligand for the TIE2 receptor, by secretion-trap expression cloning. Cell 1996; 87: 1161\u20131169.","journal-title":"Cell"},{"key":"BFonc2016421_CR86","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1126\/science.277.5322.55","volume":"277","author":"PC Maisonpierre","year":"1997","unstructured":"Maisonpierre PC, Suri C, Jones PF, Bartunkova S, Wiegand SJ, Radziejewski C et al. Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis. Science 1997; 277: 55\u201360.","journal-title":"Science"},{"key":"BFonc2016421_CR87","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1007\/BF00865207","volume":"1","author":"EH Hellen","year":"1991","unstructured":"Hellen EH, Axelrod D . Kinetics of epidermal growth factor\/receptor binding on cells measured by total internal reflection\/fluorescence recovery after photobleaching. J Fluoresc 1991; 1: 113\u2013128.","journal-title":"J Fluoresc"},{"key":"BFonc2016421_CR88","doi-asserted-by":"crossref","first-page":"5348","DOI":"10.1128\/MCB.13.9.5348","volume":"13","author":"ZE Wang","year":"1993","unstructured":"Wang ZE, Myles GM, Brandt CS, Lioubin MN, Rohrschneider L . Identification of the ligand-binding regions in the macrophage colony-stimulating factor receptor extracellular domain. Mol Cell Biol 1993; 13: 5348\u20135359.","journal-title":"Mol Cell Biol"},{"key":"BFonc2016421_CR89","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1016\/j.ccr.2011.03.003","volume":"19","author":"WW Chan","year":"2011","unstructured":"Chan WW, Wise SC, Kaufman MD, Ahn YM, Ensinger CL, Haack T et al. Conformational control inhibition of the BCR-ABL1 tyrosine kinase, including the gatekeeper T315I mutant, by the switch-control inhibitor DCC-2036. Cancer Cell 2011; 19: 556\u2013568.","journal-title":"Cancer Cell"},{"key":"BFonc2016421_CR90","first-page":"5401","volume":"60","author":"JB Wyckoff","year":"2000","unstructured":"Wyckoff JB, Segall JE, Condeelis JS . The collection of the motile population of cells from a living tumor. Cancer Res 2000; 60: 5401\u20135404.","journal-title":"Cancer Res"},{"key":"BFonc2016421_CR91","first-page":"1167","volume":"2011","author":"J Wyckoff","year":"2011","unstructured":"Wyckoff J, Gligorijevic B, Entenberg D, Segall J, Condeelis J . High-resolution multiphoton imaging of tumors in vivo. Cold Spring Harb Protoc 2011; 2011: 1167\u20131184.","journal-title":"Cold Spring Harb Protoc"}],"container-title":["Oncogene"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/onc2016421","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/onc2016421.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/doifinder\/10.1038\/onc.2016.421","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/www.nature.com\/articles\/onc2016421.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T02:48:28Z","timestamp":1692586108000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/onc2016421"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,11,28]]},"references-count":91,"journal-issue":{"issue":"19","published-print":{"date-parts":[[2017,5]]}},"alternative-id":["BFonc2016421"],"URL":"https:\/\/doi.org\/10.1038\/onc.2016.421","relation":{},"ISSN":["0950-9232","1476-5594"],"issn-type":[{"value":"0950-9232","type":"print"},{"value":"1476-5594","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,11,28]]},"assertion":[{"value":"12 April 2016","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 September 2016","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 September 2016","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 November 2016","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"J Condeelis is a consultant\/advisory board member for Deciphera Pharmaceuticals and MetaStat. No potential conflicts of interest were disclosed by the other authors.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}