{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T04:11:44Z","timestamp":1789963904703,"version":"4.0.1"},"reference-count":56,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2017,9,11]],"date-time":"2017-09-11T00:00:00Z","timestamp":1505088000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Oncogene"],"published-print":{"date-parts":[[2018,1]]},"DOI":"10.1038\/onc.2017.327","type":"journal-article","created":{"date-parts":[[2017,9,11]],"date-time":"2017-09-11T15:05:11Z","timestamp":1505142311000},"page":"197-207","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":59,"title":["Membrane Mucin Muc4 promotes blood cell association with tumor cells and mediates efficient metastasis in a mouse model of breast cancer"],"prefix":"10.1038","volume":"37","author":[{"given":"A R","family":"Rowson-Hodel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J H","family":"Wald","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Hatakeyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W K","family":"O'Neal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J R","family":"Stonebraker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"VanderVorst","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M J","family":"Saldana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A D","family":"Borowsky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Sweeney","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"3rd","given":"K L","family":"Carraway","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,9,11]]},"reference":[{"key":"BFonc2017327_CR1","doi-asserted-by":"publisher","first-page":"1091","DOI":"10.1158\/2159-8290.CD-12-0329","volume":"2","author":"M Labelle","year":"2012","unstructured":"Labelle M, Hynes RO . The initial hours of metastasis: the importance of cooperative host-tumor cell interactions during hematogenous dissemination. Cancer Discov 2012; 2: 1091\u20131099.","journal-title":"Cancer Discov"},{"key":"BFonc2017327_CR2","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1038\/nrc865","volume":"2","author":"AF Chambers","year":"2002","unstructured":"Chambers AF, Groom AC, MacDonald IC . Dissemination and growth of cancer cells in metastatic sites. Nat Rev Cancer 2002; 2: 563\u2013572.","journal-title":"Nat Rev Cancer"},{"key":"BFonc2017327_CR3","first-page":"773","volume":"45","author":"IJ Fidler","year":"1970","unstructured":"Fidler IJ . Metastasis: quantitative analysis of distribution and fate of tumor emboli labeled with 125 I-5-iodo-2'-deoxyuridine. J Natl Cancer Inst 1970; 45: 773\u2013782.","journal-title":"J Natl Cancer Inst"},{"key":"BFonc2017327_CR4","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1016\/j.semcancer.2012.03.007","volume":"22","author":"G Lorusso","year":"2012","unstructured":"Lorusso G, R\u00fcegg C . New insights into the mechanisms of organ-specific breast cancer metastasis. Semin Cancer Biol 2012; 22: 226\u2013233.","journal-title":"Semin Cancer Biol"},{"key":"BFonc2017327_CR5","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1038\/nrc1886","volume":"6","author":"P Mehlen","year":"2006","unstructured":"Mehlen P, Puisieux A . Metastasis: a question of life or death. Nat Rev Cancer 2006; 6: 449\u2013458.","journal-title":"Nat Rev Cancer"},{"key":"BFonc2017327_CR6","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1038\/nrc2622","volume":"9","author":"DX Nguyen","year":"2009","unstructured":"Nguyen DX, Bos PD, Massague J . Metastasis: from dissemination to organ-specific colonization. Nat Rev Cancer 2009; 9: 274\u2013284.","journal-title":"Nat Rev Cancer"},{"key":"BFonc2017327_CR7","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1016\/S0079-6603(02)71043-X","volume":"71","author":"KL Carraway","year":"2002","unstructured":"Carraway KL, Perez A, Idris N, Jepson S, Arango M, Komatsu M et al. Muc4\/sialomucin complex, the intramembrane ErbB2 ligand, in cancer and epithelia: to protect and to survive. Prog Nucleic Acid Res Mol Biol 2002; 71: 149\u2013185.","journal-title":"Prog Nucleic Acid Res Mol Biol"},{"key":"BFonc2017327_CR8","doi-asserted-by":"publisher","first-page":"R70","DOI":"10.1186\/bcr2364","volume":"11","author":"HC Workman","year":"2009","unstructured":"Workman HC, Miller JK, Ingalla EQ, Kaur RP, Yamamoto DI, Beckett LA et al. The membrane mucin MUC4 is elevated in breast tumor lymph node metastases relative to matched primary tumors and confers aggressive properties to breast cancer cells. Breast Cancer Res 2009; 11: R70\u2013R70.","journal-title":"Breast Cancer Res"},{"key":"BFonc2017327_CR9","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1158\/1541-7786.MCR-06-0353","volume":"5","author":"P Chaturvedi","year":"2007","unstructured":"Chaturvedi P, Singh AP, Moniaux N, Senapati S, Chakraborty S, Meza JL et al. MUC4 mucin potentiates pancreatic tumor cell proliferation, survival, and invasive properties and interferes with its interaction to extracellular matrix proteins. Mol Cancer Res 2007; 5: 309\u2013320.","journal-title":"Mol Cancer Res"},{"key":"BFonc2017327_CR10","doi-asserted-by":"publisher","first-page":"480","DOI":"10.1002\/1097-0215(20000815)87:4<480::AID-IJC4>3.0.CO;2-6","volume":"87","author":"M Komatsu","year":"2000","unstructured":"Komatsu M, Tatum L, Altman NH, Carothers Carraway CA, Carraway KL . Potentiation of metastasis by cell surface sialomucin complex (rat MUC4), a multifunctional anti-adhesive glycoprotein. Int J Cancer 2000; 87: 480\u2013486.","journal-title":"Int J Cancer"},{"key":"BFonc2017327_CR11","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1038\/sj.onc.1204106","volume":"20","author":"M Komatsu","year":"2001","unstructured":"Komatsu M, Jepson S, Arango ME, Carothers Carraway CA, Carraway KL . Muc4\/sialomucin complex, an intramembrane modulator of ErbB2\/HER2\/Neu, potentiates primary tumor growth and suppresses apoptosis in a xenotransplanted tumor. Oncogene 2001; 20: 461\u2013470.","journal-title":"Oncogene"},{"key":"BFonc2017327_CR12","doi-asserted-by":"publisher","first-page":"1953","DOI":"10.1093\/carcin\/bgs225","volume":"33","author":"S Rachagani","year":"2012","unstructured":"Rachagani S, Macha MA, Ponnusamy MP, Haridas D, Kaur S, Jain M et al. MUC4 potentiates invasion and metastasis of pancreatic cancer cells through stabilization of fibroblast growth factor receptor 1. Carcinogenesis 2012; 33: 1953\u20131964.","journal-title":"Carcinogenesis"},{"key":"BFonc2017327_CR13","doi-asserted-by":"publisher","first-page":"622","DOI":"10.1158\/0008-5472.CAN-03-2636","volume":"64","author":"AP Singh","year":"2004","unstructured":"Singh AP, Moniaux N, Chauhan SC, Meza JL, Batra SK . Inhibition of MUC4 expression suppresses pancreatic tumor cell growth and metastasis. Cancer Res 2004; 64: 622\u2013630.","journal-title":"Cancer Res"},{"key":"BFonc2017327_CR14","doi-asserted-by":"publisher","first-page":"33245","DOI":"10.1074\/jbc.272.52.33245","volume":"272","author":"M Komatsu","year":"1997","unstructured":"Komatsu M, Carraway CA, Fregien NL, Carraway KL . Reversible disruption of cell-matrix and cell-cell interactions by overexpression of sialomucin complex. J Biol Chem 1997; 272: 33245\u201333254.","journal-title":"J Biol Chem"},{"key":"BFonc2017327_CR15","doi-asserted-by":"publisher","first-page":"5741","DOI":"10.1038\/onc.2010.309","volume":"29","author":"MP Ponnusamy","year":"2010","unstructured":"Ponnusamy MP, Lakshmanan I, Jain M, Das S, Chakraborty S, Dey P et al. MUC4 mucin-induced epithelial to mesenchymal transition: a novel mechanism for metastasis of human ovarian cancer cells. Oncogene 2010; 29: 5741\u20135754.","journal-title":"Oncogene"},{"key":"BFonc2017327_CR16","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1016\/j.tcb.2006.07.006","volume":"16","author":"PK Singh","year":"2006","unstructured":"Singh PK, Hollingsworth MA . Cell surface-associated mucins in signal transduction. Trends Cell Biol 2006; 16: 467\u2013476.","journal-title":"Trends Cell Biol"},{"key":"BFonc2017327_CR17","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1158\/1078-0432.CCR-10-1937","volume":"17","author":"S Senapati","year":"2011","unstructured":"Senapati S, Chaturvedi P, Chaney WG, Chakraborty S, Gnanapragassam VS, Sasson AR et al. Novel INTeraction of MUC4 and galectin: potential pathobiological implications for metastasis in lethal pancreatic cancer. Clin Cancer Res 2011; 17: 267\u2013274.","journal-title":"Clin Cancer Res"},{"key":"BFonc2017327_CR18","doi-asserted-by":"publisher","first-page":"28","DOI":"10.3389\/fonc.2014.00028","volume":"4","author":"I Hauselmann","year":"2014","unstructured":"Hauselmann I, Borsig L . Altered tumor-cell glycosylation promotes metastasis. Front Oncol 2014; 4: 28.","journal-title":"Front Oncol"},{"key":"BFonc2017327_CR19","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1186\/1476-4598-9-154","volume":"9","author":"Q Zhao","year":"2010","unstructured":"Zhao Q, Barclay M, Hilkens J, Guo X, Barrow H, Rhodes JM et al. Interaction between circulating galectin-3 and cancer-associated MUC1 enhances tumour cell homotypic aggregation and prevents anoikis. Mol Cancer 2010; 9: 154.","journal-title":"Mol Cancer"},{"key":"BFonc2017327_CR20","doi-asserted-by":"publisher","first-page":"2845","DOI":"10.1158\/0008-5472.CAN-08-2089","volume":"69","author":"HC Workman","year":"2009","unstructured":"Workman HC, Sweeney C, Carraway KL . The membrane mucin Muc4 inhibits apoptosis induced by multiple insults via ErbB2-dependent and ErbB2-independent mechanisms. Cancer Res 2009; 69: 2845\u20132852.","journal-title":"Cancer Res"},{"key":"BFonc2017327_CR21","doi-asserted-by":"publisher","first-page":"5263","DOI":"10.1074\/jbc.274.9.5263","volume":"274","author":"KL Carraway","year":"1999","unstructured":"Carraway KL, Rossi EA, Komatsu M, Price-Schiavi SA, Huang D, Guy PM et al. An intramembrane modulator of the ErbB2 Receptor Tyrosine Kinase That Potentiates Neuregulin Signaling. J Biol Chem 1999; 274: 5263\u20135266.","journal-title":"J Biol Chem"},{"key":"BFonc2017327_CR22","doi-asserted-by":"publisher","first-page":"2065","DOI":"10.1158\/0008-5472.CAN-07-6041","volume":"68","author":"P Chaturvedi","year":"2008","unstructured":"Chaturvedi P, Singh AP, Chakraborty S, Chauhan SC, Bafna S, Meza JL et al. MUC4 mucin interacts with and stabilizes the HER2 oncoprotein in human pancreatic cancer cells. Cancer Res 2008 68 2065\u20132070.","journal-title":"Cancer Res"},{"key":"BFonc2017327_CR23","doi-asserted-by":"publisher","first-page":"19310","DOI":"10.1074\/jbc.M603225200","volume":"281","author":"M Funes","year":"2006","unstructured":"Funes M, Miller JK, Lai C, Carraway KL 3rd, Sweeney C . The mucin Muc4 potentiates neuregulin signaling by increasing the cell-surface populations of ErbB2 and ErbB3. J Biol Chem 2006; 281: 19310\u201319319.","journal-title":"J Biol Chem"},{"key":"BFonc2017327_CR24","doi-asserted-by":"publisher","first-page":"520","DOI":"10.1038\/sj.bjc.6604517","volume":"99","author":"MP Ponnusamy","year":"2008","unstructured":"Ponnusamy MP, Singh AP, Jain M, Chakraborty S, Moniaux N, Batra SK . MUC4 activates HER2 signalling and enhances the motility of human ovarian cancer cells. Br J Cancer 2008; 99: 520\u2013526.","journal-title":"Br J Cancer"},{"key":"BFonc2017327_CR25","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1757-2215-4-7","volume":"4","author":"MP Ponnusamy","year":"2011","unstructured":"Ponnusamy MP, Seshacharyulu P, Vaz A, Dey P, Batra SK . MUC4 stabilizes HER2 expression and maintains the cancer stem cell population in ovarian cancer cells. J Ovarian Res 2011; 4: 1\u201310.","journal-title":"J Ovarian Res"},{"key":"BFonc2017327_CR26","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1016\/S0014-4827(02)00099-X","volume":"284","author":"T Holbro","year":"2003","unstructured":"Holbro T, Civenni G, Hynes NE . The ErbB receptors and their role in cancer progression. Exp Cell Res 2003; 284: 99\u2013110.","journal-title":"Exp Cell Res"},{"key":"BFonc2017327_CR27","first-page":"1199","volume":"57","author":"M Tan","year":"1997","unstructured":"Tan M, Yao J, Yu D . Overexpression of the c-erbB-2 gene enhanced intrinsic metastasis potential in human breast cancer cells without increasing their transformation abilities. Cancer Res 1997; 57: 1199\u20131205.","journal-title":"Cancer Res"},{"key":"BFonc2017327_CR28","doi-asserted-by":"publisher","first-page":"10578","DOI":"10.1073\/pnas.89.22.10578","volume":"89","author":"CT Guy","year":"1992","unstructured":"Guy CT, Webster MA, Schaller M, Parsons TJ, Cardiff RD, Muller WJ . Expression of the neu protooncogene in the mammary epithelium of transgenic mice induces metastatic disease. Proc Natl Acad Sci 1992; 89: 10578\u201310582.","journal-title":"Proc Natl Acad Sci"},{"key":"BFonc2017327_CR29","doi-asserted-by":"publisher","first-page":"2149","DOI":"10.1093\/emboj\/18.8.2149","volume":"18","author":"PM Siegel","year":"1999","unstructured":"Siegel PM, Ryan ED, Cardiff RD, Muller WJ . Elevated expression of activated forms of Neu\/ErbB-2 and ErbB-3 are involved in the induction of mammary tumors in transgenic mice: implications for human breast cancer. EMBO J 1999; 18: 2149\u20132164.","journal-title":"EMBO J"},{"key":"BFonc2017327_CR30","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1038\/nrm1911","volume":"7","author":"A-K Olsson","year":"2006","unstructured":"Olsson A-K, Dimberg A, Kreuger J, Claesson-Welsh L . VEGF receptor signalling in control of vascular function. Nat Rev Mol Cell Biol 2006; 7: 359\u2013371.","journal-title":"Nat Rev Mol Cell Biol"},{"key":"BFonc2017327_CR31","doi-asserted-by":"crossref","first-page":"2003","DOI":"10.1242\/dev.129.8.2003","volume":"129","author":"MT Mitjavila-Garcia","year":"2002","unstructured":"Mitjavila-Garcia MT, Cailleret M, Godin I, Nogueira MM, Cohen-Solal K, Schiavon V et al. Expression of CD41 on hematopoietic progenitors derived from embryonic hematopoietic cells. Development 2002; 129: 2003\u20132013.","journal-title":"Development"},{"key":"BFonc2017327_CR32","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1038\/nrc3004","volume":"11","author":"LJ Gay","year":"2011","unstructured":"Gay LJ, Felding-Habermann B . Contribution of platelets to tumour metastasis. Nat Rev Cancer 2011; 11: 123\u2013134.","journal-title":"Nat Rev Cancer"},{"key":"BFonc2017327_CR33","doi-asserted-by":"publisher","first-page":"300","DOI":"10.1016\/j.ccr.2011.08.012","volume":"20","author":"Z Granot","year":"2011","unstructured":"Granot Z, Henke E, Comen EA, King TA, Norton L, Benezra R . Tumor entrained neutrophils inhibit seeding in the premetastatic lung. Cancer Cell 2011; 20: 300\u2013314.","journal-title":"Cancer Cell"},{"key":"BFonc2017327_CR34","doi-asserted-by":"publisher","first-page":"2193","DOI":"10.1073\/pnas.261704098","volume":"99","author":"L Borsig","year":"2002","unstructured":"Borsig L, Wong R, Hynes RO, Varki NM, Varki A . Synergistic effects of L- and P-selectin in facilitating tumor metastasis can involve non-mucin ligands and implicate leukocytes as enhancers of metastasis. Proc Natl Acad Sci USA 2002; 99: 2193\u20132198.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFonc2017327_CR35","doi-asserted-by":"publisher","first-page":"3164","DOI":"10.1182\/blood-2011-08-376426","volume":"119","author":"AM Gil-Bernabe","year":"2012","unstructured":"Gil-Bernabe AM, Ferjancic S, Tlalka M, Zhao L, Allen PD, Im JH et al. Recruitment of monocytes\/macrophages by tissue factor-mediated coagulation is essential for metastatic cell survival and premetastatic niche establishment in mice. Blood 2012; 119: 3164\u20133175.","journal-title":"Blood"},{"key":"BFonc2017327_CR36","doi-asserted-by":"publisher","first-page":"e6562","DOI":"10.1371\/journal.pone.0006562","volume":"4","author":"B Qian","year":"2009","unstructured":"Qian B, Deng Y, Im JH, Muschel RJ, Zou Y, Li J et al. A distinct macrophage population mediates metastatic breast cancer cell extravasation, establishment and growth. PloS One 2009; 4: e6562.","journal-title":"PloS One"},{"key":"BFonc2017327_CR37","doi-asserted-by":"publisher","first-page":"361ra138","DOI":"10.1126\/scitranslmed.aag1711","volume":"8","author":"J Park","year":"2016","unstructured":"Park J, Wysocki RW, Amoozgar Z, Maiorino L, Fein MR, Jorns J et al. Cancer cells induce metastasis-supporting neutrophil extracellular DNA traps. Sci Transl Med 2016; 8: 361ra138.","journal-title":"Sci Transl Med"},{"key":"BFonc2017327_CR38","doi-asserted-by":"publisher","first-page":"7043","DOI":"10.1002\/adma.201503323","volume":"27","author":"Q Hu","year":"2015","unstructured":"Hu Q, Sun W, Qian C, Wang C, Bomba HN, Gu Z . Anticancer platelet-mimicking 528 nanovehicles. Adv Mater 2015; 27: 7043\u20137050.","journal-title":"Adv Mater"},{"key":"BFonc2017327_CR39","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1016\/j.biomaterials.2015.10.046","volume":"76","author":"J Li","year":"2016","unstructured":"Li J, Ai Y, Wang L, Bu P, Sharkey CC, Wu Q et al. Targeted drug delivery to circulating tumor cells via platelet membrane-functionalized particles. Biomaterials 2016; 76: 52\u201365.","journal-title":"Biomaterials"},{"key":"BFonc2017327_CR40","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1016\/j.jconrel.2016.02.036","volume":"228","author":"J Li","year":"2016","unstructured":"Li J, Sharkey CC, Wun B, Liesveld JL, King MR . Genetic engineering of platelets to neutralize circulating tumor cells. J Control Release 2016; 228: 38\u201347.","journal-title":"J Control Release"},{"key":"BFonc2017327_CR41","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1093\/jb\/mvs108","volume":"152","author":"N Fujita","year":"2012","unstructured":"Fujita N, Takagi S . The impact of Aggrus\/podoplanin on platelet aggregation and tumour metastasis. J Biochem 2012; 152: 407\u2013413.","journal-title":"J Biochem"},{"key":"BFonc2017327_CR42","first-page":"2229","volume":"59","author":"M Komatsu","year":"1999","unstructured":"Komatsu M, Yee L, Carraway KL . Overexpression of sialomucin complex, a rat homologue of MUC4, inhibits tumor killing by lymphokine-activated killer cells. Cancer Res 1999; 59: 2229\u20132236.","journal-title":"Cancer Res"},{"key":"BFonc2017327_CR43","doi-asserted-by":"publisher","first-page":"966","DOI":"10.1096\/fj.07-9673rev","volume":"22","author":"P Chaturvedi","year":"2008","unstructured":"Chaturvedi P, Singh AP, Batra SK . Structure, evolution, and biology of the MUC4 mucin. FASEB J 2008; 22: 966\u2013981.","journal-title":"FASEB J"},{"key":"BFonc2017327_CR44","doi-asserted-by":"publisher","first-page":"18475","DOI":"10.1038\/srep18475","volume":"5","author":"A Lundmark","year":"2015","unstructured":"Lundmark A, Davanian H, B\u00e5ge T, Johannsen G, Koro C, Lundeberg J et al. Transcriptome analysis reveals mucin 4 to be highly associated with periodontitis and identifies pleckstrin as a link to systemic diseases. Sci Rep 2015; 5: 18475.","journal-title":"Sci Rep"},{"key":"BFonc2017327_CR45","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1002\/jcp.20277","volume":"204","author":"J Zhang","year":"2005","unstructured":"Zhang J, Perez A, Yasin M, Soto P, Rong M, Theodoropoulos G et al. Presence of MUC4 in human milk and at the luminal surfaces of blood vessels. J Cell Physiol 2005; 204: 166\u2013177.","journal-title":"J Cell Physiol"},{"key":"BFonc2017327_CR46","doi-asserted-by":"publisher","first-page":"1011","DOI":"10.1080\/02713680601052155","volume":"31","author":"J Zhang","year":"2006","unstructured":"Zhang J, Carraway CA, Carraway KL . Muc4 expression during blood vessel formation in damaged rat cornea. Curr Eye Res 2006; 31: 1011\u20131014.","journal-title":"Curr Eye Res"},{"key":"BFonc2017327_CR47","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1016\/j.canlet.2013.12.021","volume":"346","author":"X Zhi","year":"2014","unstructured":"Zhi X, Tao J, Xie K, Zhu Y, Li Z, Tang J et al. MUC4-induced nuclear translocation of beta-catenin: a novel mechanism for growth, metastasis and angiogenesis in pancreatic cancer. Cancer Lett 2014; 346: 104\u2013113.","journal-title":"Cancer Lett"},{"key":"BFonc2017327_CR48","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/S0093-7754(01)90279-9","volume":"28","author":"R Kumar","year":"2001","unstructured":"Kumar R, Yarmand-Bagheri R . The role of HER2 in angiogenesis. Semin Oncol 2001; 28: 27\u201332.","journal-title":"Semin Oncol"},{"key":"BFonc2017327_CR49","doi-asserted-by":"publisher","first-page":"6469","DOI":"10.1038\/sj.onc.1210477","volume":"26","author":"MM Moasser","year":"2007","unstructured":"Moasser MM . The oncogene HER2; Its signaling and transforming functions and its role in human cancer pathogenesis. Oncogene 2007; 26: 6469\u20136487.","journal-title":"Oncogene"},{"key":"BFonc2017327_CR50","doi-asserted-by":"publisher","first-page":"2932","DOI":"10.1038\/onc.2015.345","volume":"35","author":"N Yokdang","year":"2016","unstructured":"Yokdang N, Hatakeyama J, Wald JH, Simion C, Tellez JD, Chang DZ et al. LRIG1 opposes epithelial-to-mesenchymal transition and inhibits invasion of basal-like breast cancer cells. Oncogene 2016; 35: 2932\u20132947.","journal-title":"Oncogene"},{"issue":"36","key":"BFonc2017327_CR51","doi-asserted-by":"publisher","first-page":"5158","DOI":"10.1038\/onc.2017.126","volume":"36","author":"J H Wald","year":"2017","unstructured":"Wald JH, Hatakeyama J, Printsev I, Cuevas A, Fry WHD, Saldana MJ et al. Suppression of planar cell polarity signaling and migration in glioblastoma by Nrdp1-mediated Dvl polyubiquitination. Oncogene 2017; epub ahead of print 8 May 2017; doi: 10.1038\/onc.2017.126.","journal-title":"Oncogene"},{"key":"BFonc2017327_CR52","doi-asserted-by":"publisher","first-page":"562","DOI":"10.1186\/s12885-015-1572-7","volume":"15","author":"AR Rowson-Hodel","year":"2015","unstructured":"Rowson-Hodel AR, Manjarin R, Trott JF, Cardiff RD, Borowsky AD, Hovey RC . Neoplastic transformation of porcine mammary epithelial cells in vitro and tumor formation in vivo. BMC Cancer 2015; 15: 562.","journal-title":"BMC Cancer"},{"key":"BFonc2017327_CR53","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1016\/j.canlet.2016.02.042","volume":"375","author":"AR Rowson-Hodel","year":"2016","unstructured":"Rowson-Hodel AR, Berg AL, Wald JH, Hatakeyama J, VanderVorst K, Curiel DA et al. Hexamethylene amiloride engages a novel reactive oxygen species- and lysosome-dependent programmed necrotic mechanism to selectively target breast cancer cells. Cancer Lett 2016; 375: 62\u201372.","journal-title":"Cancer Lett"},{"key":"BFonc2017327_CR54","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1016\/j.jim.2008.10.005","volume":"340","author":"CT Damsgaard","year":"2009","unstructured":"Damsgaard CT, Lauritzen L, Calder PC, Kjaer TM, Frokiaer H . Whole-blood culture is a valid low-cost method to measure monocytic cytokines - a comparison of cytokine production in cultures of human whole-blood, mononuclear cells and monocytes. J Immunol Methods 2009; 340: 95\u2013101.","journal-title":"J Immunol Methods"},{"key":"BFonc2017327_CR55","doi-asserted-by":"publisher","first-page":"R23","DOI":"10.1186\/bcr3108","volume":"14","author":"PJ Boimel","year":"2012","unstructured":"Boimel PJ, Smirnova T, Zhou ZN, Wyckoff J, Park H, Coniglio SJ et al. Contribution of CXCL12 secretion to invasion of breast cancer cells. Breast Cancer Res 2012; 14: R23.","journal-title":"Breast Cancer Res"},{"key":"BFonc2017327_CR56","doi-asserted-by":"crossref","unstructured":"Mohanty S, Xu L . Experimental Metastasis Assay, 2010; e1942.","DOI":"10.3791\/1942"}],"container-title":["Oncogene"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/onc2017327.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/onc2017327","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/doifinder\/10.1038\/onc.2017.327","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/www.nature.com\/articles\/onc2017327.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,19]],"date-time":"2023-05-19T05:01:59Z","timestamp":1684472519000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/onc2017327"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,9,11]]},"references-count":56,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2018,1]]}},"alternative-id":["BFonc2017327"],"URL":"https:\/\/doi.org\/10.1038\/onc.2017.327","relation":{},"ISSN":["0950-9232","1476-5594"],"issn-type":[{"value":"0950-9232","type":"print"},{"value":"1476-5594","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,9,11]]},"assertion":[{"value":"18 January 2017","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 June 2017","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 August 2017","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 September 2017","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}